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Empagliflozin
Jardiance
Jardiance (empagliflozin) is an FDA-approved prescription medication used to control high blood sugar levels in patients with type 2 diabetes. It also helps prevent the severe complications associated with diabetes. It contains empagliflozin, an orally active inhibitor of the SGLT2 class. It is used alone or with other medicines to treat the condition. It is used alongside a proper diet and exercise plan. It is available as an oral prescription medicine that comes in two doses, 10 mg and 25 mg, to be taken every morning, with or without food. Your doctor will decide the proper dosage for you based on your medical condition and response to treatment.
Product Overview
Jardiance is an FDA-approved prescription medicine containing the active ingredient empagliflozin. It is used to control high blood sugar levels in adults and children over ten years of age with type 2 diabetes. Empagliflozin works by increasing the removal of sugar and sodium by the kidneys, thereby reducing blood sugar levels and the risk of complications such as kidney damage, nerve problems, and cardiovascular disease.
Jardiance is available in two strengths: 10 mg and 25 mg daily. It is taken orally once a day, preferably in the morning, with or without food. The initial dosage is typically 10 mg, which may be increased to 25 mg based on the patient’s response to treatment and glycemic control needs.
Common side effects of Jardiance include vaginal infections, urinary tract infections, and dehydration. It is essential to consult your doctor if you experience adverse side effects such as little or no urination, signs of dehydration, or symptoms of bladder infection. Jardiance should be used with caution in pregnant or breastfeeding women and is contraindicated in patients with severe renal impairment, end-stage renal disease, or a history of hypersensitivity to empagliflozin. In case of a missed dose, take it as soon as possible, but skip it if the next dose is near. For overdose, seek immediate medical attention. Store Jardiance at room temperature, away from heat, light, and moisture, and keep it out of reach of children and pets. Always follow your healthcare provider’s instructions for proper usage and dosage.
Uses of Jardiance
Jardiance is used to:
- Control high blood sugar levels in type 2 patients.
- Reduce the risk of hospitalization and death due to heart failure, cardiovascular disease, and stroke.
How to Use Jardiance?
Dosage
It comes in the form of an oral tablet. It is available in two strengths:
- Jardiance 10 mg tablets
- Jardiance 25 mg tablets
Recommended Dosage for Different Patients
For Adult Patients With Type 2 Diabetes
- Initially Dose: 10 mg daily
- The dose will be increased once the patient tolerates therapy and needs additional glycemic control.
For Adult Patients For Cardiovascular Risk Reduction
- Recommended Dose: 10 mg daily
For Adult Patients With Chronic Kidney Disease
- Recommended Dose: 10 mg daily
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
Before you start taking Jardiance, make sure to read the patient information and instructions carefully. This will help you understand how the medication should be used.
- Take Jardiance by mouth, either with or without food.
- The recommended time to take Jardiance is in the morning.
- Your doctor will decide the proper dosage for you based on your medical condition and response to treatment.
- It’s important to take Jardiance regularly to get the most benefit from it. Try to take it at the same time each day.
Remember, always follow your doctor’s instructions when taking Jardiance. If you have any questions or need further clarification, don’t hesitate to ask your doctor or pharmacist.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Jardiance Work?
Jardiance 10 mg tablet is an antidiabetic prescription medicine that reduces blood sugar levels by increasing the removal of sugar by your kidneys and excretes all excess glucose through urine. SGLT2 inhibitors effectively lower the hB1AC levels and help regulate weight loss and blood pressure. They also help prevent chronic kidney disease by reducing the reabsorption of the excess sugar and sodium from the kidney, hence protecting it.
Important Safety Information
Side Effects
Common side effects of Jardiance may include:
- Urinating more frequently than usual
- Mild urinary tract infection
- Producing more urine than usual
- Mild fungal infection of the male genitals
- Mild vaginal yeast infection
Mild side effects of Jardiance may include:
- Producing more urine than usual
- Mild urinary tract infection
- Joint pain
- Excessive thirst
- Mild fungal infection of the male genitals
- Urinating more frequently than usual
- Nausea
- Mild allergic reaction
- Mild vaginal yeast infection
Serious side effects of Jardiance may include:
- Severe allergic reaction
- Hypoglycemia (low blood sugar)
- High cholesterol
- Diabetic ketoacidosis (high levels of ketones in your blood or urine)
- Dehydration
- Severe hypotension (low blood pressure)
- Kidney problems
- Severe infection in the perineum (the area between and around the anus and genitals)
- Severe urinary tract infection
[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
Consult your doctor and discuss all your disease-related or medication-related queries. You can also refer to the medication guide to learn more about the warnings if you have severe symptoms like stomach pain, vomiting, fatigue, or difficulty breathing. Contact your doctor and seek medical attention immediately. Jardiance can also cause serious infections in the genital area. Contact your doctor if you have severe redness, itching, burning, or rashes in such areas.
Precautions
It is essential to inform your doctor and pharmacist if you:
- Have any allergies to Jardiance.
- Are taking Other prescription and non-prescription medications currently, especially if you take any other diabetes medicine.
- Have a medical history, especially if you have ever had high cholesterol, liver problems, kidney problems, dehydration, low blood pressure, heart failure, or a history of yeast infections in the vagina or penis.
- Have any history of alcohol abuse.
Additionally, be aware of the following:
- Low or high blood sugar levels can cause blurred vision, dizziness, or drowsiness. It is essential to avoid driving, operating machinery, or any other activities that require clear vision or alertness.
- Drinking alcohol while taking Jardiance may increase the risk of developing low blood sugar. It is recommended to limit alcohol intake while taking this medication.
- Older adults may be more sensitive to the side effects of Jardiance. It is crucial for older adults to closely monitor their condition and inform their doctor if they experience any unusual symptoms.
- During pregnancy, Jardiance should only be used when needed. It is essential to consult with a healthcare professional before using this medication during pregnancy.
Jardiance Contraindications
Jardiance is contraindicated in patients who have:
- Allergy to Jardiance or any of its active ingredients
- History of hypersensitivity to empagliflozin and any inactive ingredients
- Severe renal impairment
- End-stage renal disease
- Undergoing dialysis
Missed Dose
- If you miss a dose, take it as soon as you remember.
- If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- For the best results, take your medicines regularly.
- Do not take two doses together to compensate for the missed dose.
[Note: If you have missed a dose of Jardiance and are still determining when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
If someone has passed out or has serious symptoms of an overdose like difficulty breathing, severe nausea, or infection, seek immediate emergency medical attention.
[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]
Storage
- You may keep Jardiance at room temperature.
- Make sure to store it away from children’s reach.
- Additionally, it is important to note that heat, air, light, and moisture can damage your medicine.
- Store the medicine in a cool and dry place.
[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]
Jardiance Interactions
It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Jardiance. They can assess potential drug interactions and adjust your treatment plan accordingly to ensure your safety and the effectiveness of the medication. Here are some notable drug interactions with Jardiance tablet:
- Combining Jardiance with insulin or insulin-secretagogues (like, sulfonylureas like glipizide or glyburide) can elevate the risk of hypoglycemia (low blood sugar).
- Some diabetes medications, such as DPP-4 inhibitors (such as sitagliptin) or GLP-1 receptor agonists (like exenatide), may interact with Jardiance. Your doctor will consider these interactions when determining your treatment plan.
- Combining it with other diuretics may lead to excessive fluid loss and dehydration. Your healthcare provider may need to adjust your diuretic dose.
- When taken with other medications that lower blood pressure (such as ACE inhibitors, angiotensin receptor blockers), there may be an additive effect, causing further blood pressure reduction.
- It can affect kidney function, so combining it with other medicines may increase the risk of kidney problems.
- Medications that affect blood volume, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, can interact with Jardiance and affect kidney function.
[Note: This isn’t a complete list, and there could be other drugs that interact with Jardiance. Tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Jardiance Alternatives
- Glucophage (metformin)
- Januvia (sitagliptin)
- Victoza (liraglutide)
- Starlix (nateglinide)
- Actos (pioglitazone)
- Glyset (miglitol)
- Precose (acarbose)
- Trulicity (dulaglutide)
- Ozempic (semaglutide)
[Note: Your doctor will choose what’s best for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
Does Jardiance help with heart failure?
Yes, Jardiance is used to treat heart failure. It helps reduce the risk of cardiovascular death and hospitalization for heart failure in adults with heart failure. This medicine helps improve the heart’s ability to pump blood, improving and preventing complications. In addition to reducing the risk of cardiovascular death and hospitalization, Jardiance can also help manage heart failure symptoms and reduce the risk of heart failure-related events. Moreover, it is not recommended for anyone 18 years or younger to use it.
What drugs interact with Jardiance?
Here are the drugs that may interact with Jardiance:
- Diuretics
- Other diabetes drugs [linagliptin (Tradjenta), canagliflozin (Invokana), semaglutide (Ozempic)]
- Certain antibiotics
- Insulin
- Monoamine oxidase inhibitors (MAOIs)
- Lithium (Lithobid)
- Hydroxychloroquine (Plaquenil)
- Fluoxetine (Prozac)
Always consult with your doctor before taking any of these medications.
How to store this medication?
To store this medication, it is important to keep it at room temperature. The ideal storage temperature range for Jardiance is between 68F to 77F (20C to 25C). Please make sure to store it away from the reach of children. Additionally, it is important to note that heat, air, light, and moisture can damage your medicine. Therefore, storing the medicine in a cool, dry place is recommended. Suitable storage locations include a kitchen cabinet or dresser drawer away from the sink, stove, and hot appliances. Also, you can use a shelf, a storage box, or in a closet. By following these instructions, you can ensure that your medication remains safe and effective when needed.
Can Jardiance cause weight loss?
Jardiance might lead to a slight weight loss according to reports from people who participated in clinical trials. However, it’s not entirely certain if this weight loss is directly caused by Jardiance or other factors like changes in diet and exercise. If you’re worried about losing weight while taking Jardiance, it’s best to discuss it with your doctor. They can offer advice on managing your weight and may suggest alternative medications if needed. It’s important to have open communication with your healthcare provider to ensure the best treatment plan for your condition.
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