Rifaximin

Zaxine

Zaxine is an FDA-approved medication that contains rifaximin, which belongs to a class of medications called antibacterial agents. It is used in addition to lactulose to reduce the risk of hepatic encephalopathy recurrence in adults. Hepatic encephalopathy is a condition that frequently develops when a person has chronic liver disease, and the body is unable to get rid of the waste product, ammonia, easily. This prescription medication is available in 550 mg strength and can be taken orally. Zaxine may be available under different brand names or forms, so consulting a medical professional is important for effective results. If you want to buy Zaxine online from a Canadian pharmacy, you must first get a valid prescription from your doctor.

Product Overview

Zaxine is a prescription medication used in addition to lactulose, which is mainly indicated to minimize the risk of hepatic encephalopathy recurrence in adults. This condition occurs when a person has long-term liver disease, and the body lacks the ability to excrete waste product, i.e., ammonia. Additionally, doctors also prescribe Zaxine to treat irritable bowel syndrome with diarrhea (IBS-D). Zaxine contains rifaximin as its active ingredient, which belongs to the category of antibacterial agents. It is available in an oral tablet form with a standard strength of 550 mg. 

Doctors usually advise taking the medication three times a day, continuing it for 14 straight days, with or without food. While suitable for adults, its dosage may vary based on the severity and the other medical conditions of the individual. Zaxibne is an effective medication for improving digestive health without systemic absorption. It works by balancing gut bacteria to reduce the symptoms associated with IBS-D, restoring digestive balance effectively.

Despite its benefits, Zaxine can cause certain side effects, including bloating, dizziness, and vomiting. These side effects are the common reactions of the body to the drug, which do not require immediate medical assistance, but if you experience any serious reactions like Black, tarry stools, or Bloody/cloudy urine, seek immediate medical assistance. Moreover, patients with liver diseases or those who experienced antibiotic-related diarrhea are advised to take certain precautions before starting this medication. Lastly, if you order Zaxine tablets from online pharmacies, talk to your doctor and discuss every risk and benefit associated with the medication.

What Are the Common Uses of Zaxine (Rifaximin)?

Zaxine is used to treat or manage the following conditions:

• To minimize the likelihood of adults experiencing a recurrence of hepatic encephalopathy.
• For the treatment of IBS-D (Irritable Bowel Syndrome with Diarrhea).

What Forms & Strengths Does Zaxine (Rifaximin) Come In?

Zaxine comes in the form of an oral tablet with a standard strength of 550 mg.

What Are the Recommended Dosage of Zaxine?

While Zaxine is available in one strength, its dosages for different patients may vary. This difference may be caused by several factors, including the brand of rifaximin you use or the severity of your condition. That is why consulting a medical professional before starting this medication is crucial for best results. The following section includes only the recommended Zaxine dose; if you have been prescribed a different dose, do not change it without consulting your doctor.

Dosage for Hepatic Encephalopathy 

The recommended starting dose is 550 mg twice daily. 

Dosage for Irritable Bowel Syndrome with Diarrhea for IBS-D

Take one tablet (550 mg) three times a day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Do You Take Zaxine?

When you order Zaxine tablets online, knowing the proper administration steps is essential. Here are the guidelines on how you can take this medication: 

• Read the medication guide carefully. Doing this can give you detailed insights on how to take the medicine effectively.
• Follow the doses exactly as mentioned on your prescription label.
• Take 550 mg of Zaxine twice a day if you’re an adult, with or without food, as your doctor advises.
• Swallow the tablets as a whole with a glass of water unless your doctor instructs otherwise.
• If you are unable to swallow your medicine, talk to a medical professional. They will suggest alternate options depending on your body’s needs. 

• Remember always to take Zaxine on an empty stomach.
• Don’t crush, chew, break, or split your tablets. Doing so may release the drugs at once, causing potential side effects. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Zaxine Work?

Zaxine 550 mg doesn’t get into the bloodstream much when you take it by mouth. Instead, it mainly works in the intestines to fight off harmful bacteria. Rifaximin, the active ingredient, targets and slows down the growth of certain bacteria, helping you assist against issues like traveler’s diarrhea and irritable bowel syndrome with diarrhea. 

Important Safety Information for Using Zaxine

What Are the Side Effects of Zaxine?

Common Side Effects of Zaxine: Like all medications, Zaxine can cause several side effects. These reactions are generally temporary and disappear within a few days or weeks. Since these are common side effects, immediate medical attention is not required. However, if these reactions persist for a long time and start bothering you, consult a medical professional. Common side effects of Zaxine may include:

• • Bloating: It is indicated by a sense of fullness or swelling in the abdomen, which often happens because of gas accumulation. Rifaximin disturbs gut bacteria, affecting digestion and gas production, which further leads to bloating. To manage this side effect, consume smaller and more frequent meals and avoid gas-producing foods like beans and carbonated drinks. If the bloating persists or worsens, talk to your doctor.
  • Dizziness: Rifaximin can impact your central nervous system, resulting in dizziness in certain patients. This is a common side effect and usually happens at the start of the treatment. To avoid dizziness, rise slowly from sitting or lying positions and avoid sudden movements.  
  • Vomiting: Vomiting can occur due to gastrointestinal irritation or imbalance caused by the drug. This side effect will disappear within a few days or weeks once your body adjusts to the medication’s effects. To prevent this, take the medication with food unless otherwise directed, stay hydrated, and avoid foods that may irritate the stomach.
• Chromaturia: This condition can cause urine to have an unusual color, like reddish or brown discoloration. This effect is due to the drug’s pigmentation and is not harmful, meaning it does not require immediate medical attention. However, if you have any concerns related to this side effect, consult your healthcare provider.

Mild Side Effects of Zaxine: Mild side effects are usually minor adverse effects that occur during your treatment with certain medications. Unlike common effects, mild ones are not experienced by many patients, but if you notice any unusual signs after taking Zaxine, report them to your doctor. Mild side effects of Zaxine may include: 

• Itchiness: Also known as pruritus, this side effect is caused by an allergic reaction to rifaximin. It usually happens from the body’s immune response to the medication. This side effect is not experienced by many patients, but if you notice mild irritation, use over-the-counter antihistamines or topical anti-rich creams. If the condition persists, discontinue the use and talk to your doctor.
• Diarrhea: If you are using Zaxine for IBS or gut health, you must know that the medication can cause diarrhea as its side effect, often caused by an imbalance in the gut microbiota. This disruption can lead to loose or frequent stools, resulting in the removal of excess fluid from the body or dehydration. To prevent dehydration, maintain enough fluid intake. Consuming probiotics or yogurt with live cultures may help restore beneficial gut bacteria. If the side effect is associated with symptoms like fever or blood in the stool, seek medical attention promptly.
• Headache: This is one of the most prevalent mild side effects of Zaxine, which occurs due to the body’s response to the medication or changes in gut bacteria. These headaches range from mild to moderate and can be treated with over-the-counter pain relievers. If you don’t want to take other drugs, drink plenty of drinks and get proper rest. However, if the condition persists or worsens over time, talk to your medical professional.
• Nausea: Nausea can result from gastrointestinal irritation caused by rifaximin. Taking the medication with food may help reduce this side effect. Eating smaller, more frequent meals & avoiding rich or spicy foods can also be beneficial. If nausea persists or is severe, discuss alternative treatments or supportive care options with your healthcare provider.
• Reduced Reflexes: This is not commonly experienced by individuals taking Zaxine. If you notice any reduced reflexes or motor coordination, discontinue the medication and report the signs to a medical expert. 

Serious Side Effects of Zaxine: Zaxine contains rifaximin as its active ingredient. This component can cause various severe side effects in patients, which, if left untreated, can lead to life-threatening situations. These are more severe than mild side effects and require immediate medical attention. Some of the serious side effects of Zaxine may include:

• Severe Allergic Reactions: Certain patients may experience hypersensitivity reactions to rifaximin, often resulting in symptoms like hives, rash, itching, difficulty breathing or swallowing, and swelling on different body parts. This side effect usually occurs when your immune system overreacts to the medication and triggers allergic reactions. To prevent this condition, inform your healthcare provider of any pre-existing allergies to rifaximin or similar antibiotics before you plan to buy Zaxine online.
• Severe Diarrhea: Rifaximin can disrupt the balance of good gut bacteria, potentially causing clostridioides difficile-associated diarrhea (CDAD). This condition is indicated by watery or bloody diarrhea, stomach cramps, and fever and may occur during treatment or two months after starting the treatment. To minimize the risk, use antibiotics only as prescribed and avoid unnecessary use. If the condition becomes severe, contact your medical provider right away. They may recommend discontinuing the medication and starting appropriate treatment for CDAD.
• Signs of Liver Problems: While rare, Zaxine may cause liver issues, especially in people with existing liver conditions. If left untreated, it can result in life-threatening situations. Some of its symptoms may include loss of appetite, unusual tiredness/weakness, pain in the upper right side of the stomach, jaundice, and dark urine. Therefore, it is advisable to inform your doctor about your medical conditions. They will monitor your liver function tests carefully during the treatment to detect issues early. 
• Severe Abdominal Pain: Zaxine users may experience intense abdominal pain during their treatment. This side effect may be an indication of a serious underlying condition of bowel inflammation or infection. This pain could result from the body’s response to rifaximin. If you experience any pain after your treatment with Zaxine, seek immediate medical attention.
• Fever: A high fever during rifaximin treatment may suggest an infection or other serious condition. Fever can result from the body’s immune response to infection. Monitor your temperature regularly, and if a high fever develops, contact your doctor to evaluate the cause and know the appropriate ways to manage this side effect.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Zaxine?

Before you order Zaxine tablets online, tell your doctor about any health problems, allergies, or other medicines you’re using. Doing so can help minimize the risk of potentially life-threatening complications. Some of the warnings associated with the use of Zaxine include:

• Antibiotic-Related Diarrhea: Like some other antibiotics, rifaximin may cause severe diarrhea linked to a condition called pseudomembranous colitis. If you get severe diarrhea while taking this medicine or within a few weeks of using it, contact your doctor.
• Liver Issues: If you have liver problems, this medicine might build up in your body and cause side effects. Discuss with your doctor how it might affect you, how your liver condition can influence the dosage and effectiveness, and whether special monitoring is necessary. Your doctor may want to check your liver function regularly with blood tests while you’re on this medicine.
• Not for Systemic Infections: Zaxine targets gut bacteria, specifically within the intestines. It is not meant to treat infections affecting the entire body, i.e., systemic bacterial infections. These infections develop in the bloodstream or other organs. Therefore, when considering treatment with this medication, consult a medical professional to get detailed insights on the drug’s usage. 
• Intestinal Obstruction: Doctors do not recommend Zaxine for intestinal obstruction (blocked intestines), as there is no clear evidence of its safety and effectiveness, meaning the medication is not safe for use in such conditions. Since intestinal obstruction can alter how medications move through the digestive system, using Zaxine in these cases could lead to unpredictable effects or complications. If you notice a blockage or experience severe abdominal pain, bloating, vomiting, or inability to pass stool or gas, seek medical advice.

What Are the FDA Boxed Warning for Zaxine?

Black box warnings are the most stringent warnings issued by the FDA to alert doctors and patients about the harmful effects of prescription medications. Knowing these important alerts avoids the risk of life-threatening situations. Zaxine does not carry any FDA-boxed warning, indicating its safe and effective use. While this medication is well-tolerated, it is essential to use it under the guidance of a healthcare professional and follow the prescribed dosages accordingly.

What Are the Precautions for Zaxine?

If you are using Zaxine for IBS or gut health, you must know the important precautions to avoid any potential risks. Here are some of the precautions for Zaxine:

• Hypersensitivity Reactions: Patients using this medication can experience acute hypersensitivity reactions, such as rash, pruritus, angioedema, dyspnea, and anaphylaxis. If you are allergic to Zaxine or any ingredients in its formulation, inform your doctor beforehand. The product contains specific components that can cause severe allergic reactions or worsen existing ones.
• Medical Conditions: When considering treatment with rifaximin, tell the medical professional about your medical history. Doing so may prevent the risk of developing adverse side effects.
• Surgical Procedure: If you are undergoing any surgery or medical procedure, let your doctor know about the products you use. This includes all prescription drugs, over-the-counter medications & herbal supplements. 
• Pregnancy: Avoid using this medicine during pregnancy unless the benefits are greater than the risks. If you become pregnant while using it, contact your doctor right away.
• Breastfeeding: It’s unclear if rifaximin passes into breast milk. If you’re breastfeeding and taking this medicine, talk to your doctor about whether you should continue.
• Children: The safety and effectiveness of this medicine for children have not been proven.

What Is the Contraindication of Rifaximin Tablet?

Zaxine is contraindicated in one condition only. Patients with hypersensitivity problems to rifaximin or any of the medication’s ingredients should avoid using Zaxine.

What If You Missed a Dose of Zaxine?

If you forget to take a dose, take it as soon as you remember and stick to your usual schedule. If it’s nearly time for your next dose, just skip the missed one and stick to your regular routine. Don’t take two doses to make up for the one you missed. If you’re unsure about what to do, ask your doctor or pharmacist for guidance.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Zaxine?

If you think you’ve taken Zaxine (rifaximin) more than the recommended dose, it’s really important to get help from a doctor right away. Taking too much of this medicine can be very serious. Additionally, make sure to mention any symptoms or discomfort you’re experiencing, as this information will help the medical professionals assist you better.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

What Is the Storage Condition for Zaxine (Rifaximin)?

Proper storage conditions are important to maintain the safety and longevity of the medication. If you plan to buy Zaxine online, you must follow the below storage instructions for long-term use of the medication:

• Keep this medicine at room temperature of 20 to 25°C with excursions permitted to 15 to 30°C. 
• Store the tablets in a tightly closed or locked container.
• Protect the medicine from extreme heat, light, and moisture. 
• Make sure it’s not accessible to children while storing.
• Avoid using the tablets when not in use or reaches the expiration date.
• Discard the product safely without damaging the environment. Ask a medical expert for detailed information on how to dispose of the medication.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Zaxine?

When you take two or more medications simultaneously, drug interactions can occur. In this process, the effects of one medicine are altered by the presence of another substance. As a result, these interactions can improve or reduce the effectiveness of the drugs. This can lead to a high risk of side effects or entirely new effects that neither drug would cause on its own. If you decide to order Zaxine tablets online, you must be aware of the drugs it can interact with. Some of the drugs are mentioned below:

• Quinidine
• Warfarin
• BCG vaccine
• Quinine
• Eliglustat
• Hepatitis C Antivirals
• Macrolide Antibiotics
• Dronedarone
• Flibanserin
• Lapatinib
• Cyclosporine
• Verapamil
• Elagolix
• Lumacaftor and Ivacaftor
• Amiodarone
• Erdafitinib
• Carvedilol
• Azole” Antifungal Medications
• Propafenone
• Ritonavir
• Osimertinib
• Sodium Picosulfate

What Are the Other Zaxine Interactions?

Other than the above drugs, Zaxine can interact with several foods, herbs, supplements, vitamins, and diseases. These interactions are mentioned below:

• Cannabis: Concurrent use of Zaxine with cannabis products like cannabidiol has shown interactions in studies. This interaction can reduce the action of P-glycoprotein (a kind of protein) responsible for removing Zaxine from the body, leading to drug buildup in the body. Patients with liver problems are at high risk of experiencing the side effects caused by Zaxine. 
• Diseases Interactions: Using rifaximin while having certain medical conditions can lead to various side effects. These conditions include:
  • Colitis
  • Liver disease
  • Renal dysfunction

[Note: This isn’t a complete list, and there could be other drugs that interact with (drug name). Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Zaxine Alternatives?

Drug alternatives offer a convenient option to patients wanting to switch from one treatment option to another. This decision is influenced by various factors, including when patients are not getting the desired results or due to other medical conditions. However, when switching treatment, it is important to consult a medical professional. They will determine the best drug based on the individual’s response. Here are some popular drugs that can be taken in place of Zaxine:  

• Septra (trimethoprim-sulfamethoxazole)
• Noroxin (norfloxacin)
• Flagyl (metronidazole)
• Actisite (tetracycline)
• Augmentin (amoxicillin-clavulanic acid)
• Sibofix (rifaximin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Zaxine Cost & Coupons

Zaxine is an effective antibacterial medication used to treat IBS and gut health, but its high prices in the US can become a hurdle for many patients. To manage these costs, US residents can consider purchasing Zaxien from Canadian pharmacies. Reliable platforms like Polar Bear Meds offer competitive prices on various medications. If you reside in the US, you can order Zaxine tablets online at affordable prices. Additionally, by using their coupon code “WELCOMEPB10” at checkout, customers can save up to 10% on their first purchase. Enjoy the benefits of these cost-saving opportunities without needing any medical claims and reduce your expenses on important medications.

Frequently Asked Questions

Should Zaxine be taken with food?

No, you should not take this medicine with food. Follow your doctor’s instructions precisely when taking this medicine. 

How is rifaximin excreted?

The majority of the antibacterial activity in the bile is attributed to this metabolite. However, Rifampicin is excreted almost equally in both bile and urine, with the recovery in these two fluids being of similar magnitude.

What is the half-life of rifaximin?

The average half-life of rifaximin in individuals without health conditions was found to be 5.6 hours, while in patients with irritable bowel syndrome with diarrhea (IBS-D), it extended to 6 hours. This indicates that the elimination rate of rifaximin varies between healthy subjects and those with IBS-D.

Is rifaximin safe for kidneys?

Although rifaximin has shown protective effects against acute kidney injury (AKI) and hepatorenal syndrome (HRS) in cirrhosis induced by alcohol, its impact on the long-term renal function of cirrhotic patients with other etiologies remains unclear.

Is it possible to take Zaxine with other antibiotics? 

A healthcare provider should be consulted before taking Zaxine with other antibiotics. Treatment outcomes may be affected if antibiotics are combined and have additive effects. To ensure safe and effective treatment, inform your healthcare provider about all medications you’re taking. If you mix antibiotics without professional advice, their effectiveness can be affected, and side effects may occur.

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