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What is Zebeta Tablets?

Zebeta is a brand name for the medication bisoprolol, which belongs to the class of drugs known as beta-blockers and is used to treat high blood pressure. It works by obstructing natural substances in the body, reducing heart rate and strain on the heart. As a doctor guides, Zebeta should be taken orally once daily with or without food. The dosage depends on the medical condition and response to treatment, and it must be taken consistently for full effect, even if feeling well.

Dosage, Uses, and Storage of Zebeta from Canada

When taking Zebeta, it is essential to be mindful of the appropriate dosage to ensure the best possible outcome. The recommended dosage of Zebeta varies between 5-20 mg per day, contingent on the patient’s medical status.

It is essential to always confer with a healthcare professional before beginning any fresh medication plan.

Uses of Zebeta

Bisoprolol (Zebeta) is widely administered to manage the following:

  • Hypertension
  • pre-eclampsia/eclampsia
  • cardiovascular malady
  • hypertensive congestive heart failure
  • hypertensive heart
  • renal disorder
  • renovascular hypertension
  • hypertensive encephalopathy
  • hypertensive heart disease

 It obstructs the activity of certain hormones that cause vessels to constrict and tighten, which can lead to high blood pressure.

Zebeta is also utilized in various other circumstances, such as angina, chest distress, arrhythmia, or irregular heartbeat. It can be taken orally, but some people may require an injection for faster results.

How to store Zebeta

It is essential to securely store Zebeta at 20 to 25°C to preserve its potency. The tablets should be kept in airtight containers, away from humidity and direct sunlight. When handling Zebeta, it is critical to bear in mind the following:

  • Keep it out of reach of children or pets
  • Avoid extreme temperatures
  • Don’t mix with other medications or supplements.

Under the right conditions, Zebeta will remain effective for up to two years from the date of manufacture printed on the packaging label. It’s also suggested that unused medication be discarded following local environmental safety regulations.

Side Effects of Zebeta

Taking Bisoprolol, brand name Zebeta, can cause serious consequences, including:

  • shortness of breath
  • puffiness
  • rapid weight gain
  • slow pulse
  • pounding heartbeats
  • numbness/tingling/cold sensation in hands or feet
  • lightheadedness
  • eye pain/vision complications
  • bronchospasm

These should be taken into account when utilizing this medication. Other potential consequences may incorporate headache, tiredness, sleep issues, joint pain, and cold indications. Pregnant women should avoid taking Zebeta as it is classified as a pregnancy risk category C drug. Taking an excessive dose of Zebeta can have potentially life-threatening outcomes, so it is essential to consult a doctor before taking any medication for hypertension.

Warnings and Precautions of Using Zebeta Canada

Due to its potential grave side effects, Zebeta Canada should be handled with care. That said, Zebeta is contraindicated for use in patients with cardiogenic shock, pronounced sinus bradycardia, and AV block of the second or third extent. Consequently, it is essential to discuss the possible hazards of taking this medication with a healthcare professional before the commencement of treatment to guarantee the potential advantages surpass any potential risks.

Cardiogenic shock

Cardiogenic shock is a severe condition characterized by an inadequate supply of oxygenated blood to the body’s tissues. In certain patients with the CYP2D6 variant, it can be triggered by bisoprolol. This was demonstrated in a case study of a 66-year-old man who had been admitted with congestive heart failure and treated with diuretics and verapamil, but to no avail in controlling his heart rate.

Bisoprolol has been used for heart failure, but it may need caution to avoid hemodynamic deterioration. In our case, refractory shock and acute liver injury were induced by bisoprolol.

After taking 2.5mg of bisoprolol, he developed fatigue, sinus bradycardia, and shock, necessitating catecholamines, intra-aortic balloon pumping, and a pacemaker. His blood sample showed unusually high concentrations of bisoprolol, as it was discovered he was a heterozygote for CYP2D6*. Thus, using bisoprolol is contraindicated in cardiogenic shock. Further research should be done on the relationship between CYP2D6 polymorphism and such unfavorable reactions.

Marked sinus bradycardia

Marked sinus bradycardia is a potentially life-threatening side effect of certain antiarrhythmic medications, such as beta-blockers and sodium channel blockers. These substances can cause extreme bradycardia even months after they were first implemented, with drug levels that do not increase QRS width still resulting in this issue.

This is a significant but inadequately understood clinical issue witnessed in older people, particularly when undergoing combination therapy with these agents.

Patients may feel chest unease, somnolence, unquantifiable blood pressure, and extreme bradycardia resulting in syncope, cardiogenic shock, or heart failure. To manage marked sinus bradycardia, mechanical ventilation, and transcutaneous pacing are carried out while intravenous medications are administered.

Laboratory assessment discloses elevated creatinine levels and increased aspartate aminotransferase and alanine transaminase values, while the echocardiogram is normal and coronary angiography shows no narrowing. The implicated medications are typically discontinued, and other drugs may be prescribed to hinder the recurrence of bradycardia during follow-up visits.

Second or third-degree AV block

Zebeta is contraindicated for use in patients with Second or third-degree AV block. Third-degree AV block, also called complete heart block, stands for a complete absence of conduction between the sinus node and the ventricles, causing both atrial and ventricular rates to stay constant.

While the underlying cause remains unknown in many cases, it is known to be associated with myocarditis, Lyme disease, Doberman Pinschers, and calcium channel blocker overdose. Symptoms may range from none to fainting or asystole. Electrocardiography and cardiac troponin I levels are used to make a diagnosis. Treatment options include medication to reduce the parasympathetic activity, sympathomimetic drugs, glucagon for calcium channel blocker overdose, and when other therapies prove to be ineffective, temporary or permanent pacing generators.

Interactions with Other Medications

Zebeta may interact with other drugs, comprising beta-blockers, heart medicines, clonidine, digitalis, and insulin—exercise caution when taking any of these concomitantly. Beta-blockers can modify the effect of Zebeta by diminishing its antihypertensive action. Heart medicines, such as digoxin, can increase the risk of bradycardia.

Clonidine should not be employed in combination with Zebeta as it can cause a decrease in blood pressure and aggravate ailments related to heart failure. Digitalis may raise the danger of side effects related to Zebeta, such as dizziness or fainting. Insulin doses may necessitate adjustment while taking Zebeta due to its probable hypoglycemic effect. Patients must always inform their doctor about their medications before beginning therapy with Zebeta.

Frequently Asked Questions

How quickly will I receive my order of Zebeta from Canada?

Usually, orders from in Canada are delivered in 3-5 business days.

What payment methods are accepted when buying Zebeta from Canada?

When purchasing Zebeta from Canadian pharmacies such as, accepted payment methods generally comprise major credit cards, debit cards, and various online payment services such as PayPal and Apple Pay. 

Is a prescription necessary to buy Zebeta online from Canada?

Obtaining Zebeta in Canada necessitates a prescription. This is due to the possibility of misuse and the side effects which could arise without medical guidance. It is essential to note that the drug must be taken under the supervision of a healthcare provider.

Is Zebeta available in different strengths from Canada?

Zebeta is available in many doses in Canada, including 2.5 mg, 5 mg, 10 mg, and 20 mg tablets. The strength prescribed is customarily decided by a healthcare professional based on the person’s medical needs. 


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