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zebeta

Zebeta

Zebeta is an FDA-approved antihypertensive drug used primarily to treat hypertension (high blood pressure) and other heart conditions such as arrhythmia and angina. It can be used alone or in combination with other high blood pressure medications. This drug contains the active ingredient Bisoprolol which is a beta-blocker and it works by slowing down the heart rate. It then lowers the blood pressure and improves blood flow and oxygen supply to the heart. Zebeta is available in 5 mg and 10 mg oral tablets and is typically taken once daily, with dosage adjusted based on the patient’s response and condition. Common side effects include dizziness, headache, and fatigue. It’s essential to consult a healthcare professional for proper dosage and to monitor for any adverse effects or drug interactions.

Product Overview

Zebeta (bisoprolol fumarate) is a beta-adrenergic receptor blocker, commonly known as a beta-blocker, used to manage hypertension and various cardiovascular conditions such as arrhythmia, angina, and heart failure. High blood pressure puts extra strain on the heart and arteries. If this pressure is too high for too long, it can cause the heart and arteries to not work correctly. This can lead to damage in the blood vessels of the heart, brain, and kidneys, which can result in heart failure, stroke, or kidney failure. High blood pressure can also increase the risk of heart attacks. Controlling blood pressure can help reduce the likelihood of these health issues.

It is available in oral tablet form with 5 mg and 10 mg strengths. The medication works by reducing the heart rate and dilating blood vessels, which helps lower blood pressure and decrease the heart’s workload. Zebeta should be taken consistently, preferably in the morning, with or without food. Abrupt discontinuation should be avoided as it can lead to a sudden increase in blood pressure and potential heart complications. Long-term use is common, and the medication may be prescribed for life in some cases.

Common side effects include dizziness, headache, fatigue, and gastrointestinal disturbances. Serious side effects, such as severe allergic reactions, heart problems, and respiratory issues, should be reported to a healthcare professional immediately. Patients with certain medical conditions, such as severe heart failure, asthma, or diabetes, should use Zebeta cautiously and under close medical supervision. The medication may interact with other drugs, including other heart medications, alpha-blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs), so it’s crucial to inform healthcare providers of all medicines being taken. Alternatives to Zebeta include other beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, calcium channel blockers, and diuretics, among others. The choice of medication depends on the individual’s specific health condition and medical history.

Uses of Zebeta

Zebeta is used to treat:

  • Hypertension
  • Eclampsia and Pre-eclampsia
  • Renal Disorders and renovascular hypertension
  • Cardiovascular Conditions, including hypertensive congestive heart failure and other related conditions
  • Arrhythmia (irregular heartbeats) and Angina (chest discomfort)

How to Use Zebeta?

Dosage

It comes in the form of an oral tablet and has the two following strengths:

  • 5 mg
  • 10 mg

Recommended Dosage for Different Patients

Dosage for High Blood Pressure (Hypertension)

For Children (0 to 17 Years)

  • A healthcare professional will decide the appropriate use and dosage of this medication.

For Adults (18 to 64 Years)

  • Initial Dosage: 5 mg once daily
  • Dosage Increases: If you are not responding to your initial dosage, your doctor can increase the dose to 10 mg once daily.
  • Maximum Dosage: 20 mg daily

For Seniors (65 Years & Older)

  • As you get older, your organs, like the kidneys and liver, might not function as effectively as before. This can lead to a higher amount of medication remaining in your body. To address this, your doctor may prescribe a lower dosage to start with.

Dosage Considerations for People with Health Conditions

Asthma or Respiratory Disease

Your doctor will probably begin your treatment with a small dose of bisoprolol, typically 2.5 mg daily, and gradually increase it. If the dose becomes too high, bisoprolol may affect not only your heart but also your lungs.

Kidney or Liver Problems

Your doctor may start you on 2.5 mg of Zebeta per day. Your doctor will take care when increasing your dosage.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • You should generally take Zebeta once a day in the morning. 
  • Your doctor might suggest taking your first dose at bedtime to see if it makes you dizzy. If you don’t feel it after the first dose, continue taking it in the morning.
  • You can take Zebeta with or without food, as it doesn’t typically upset the stomach. 
  • Swallow the tablets with water. 
  • Some Zebeta tablets have a score line to help you break them for easier swallowing; check the information leaflet for your specific brand to see if this applies.
  • This medication is usually prescribed for long-term use, potentially for life. 
  • Stopping Zebeta abruptly can increase your blood pressure, raising your risk of heart attack and stroke. If you’re considering stopping the medication, talk to your doctor first. 
  • This medication can be refilled without a new prescription. Your doctor will specify the number of refills allowed on your prescription.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Zebeta Work?

Zebeta is called a beta-blocker, which works by changing how your body responds to nerve signals, particularly in your heart. This slows down your heart rate and lowers your blood pressure. When your blood pressure is reduced, your heart receives more blood and oxygen, which is beneficial for its health. This further helps in reducing the risks of cardiovascular events such as heart failure and heart stroke.

Important Safety Information

Side Effects

The common side effects of Zebeta include:

  • Diarrhea
  • Dry Or Burning Eyes
  • Cold Or Flu Symptoms
  • Dizziness
  • Headache
  • Swelling In Any Part Of Your Body
  • Anxiety
  • Changes In Sex Drive Or Performance
  • Nausea
  • Weakness
  • Tiredness
  • Slower Heart Rate

These side effects might disappear in a few days or weeks if they are not severe. However, if they are serious or persist, you should consult your doctor or pharmacist.

Contact your doctor immediately if you experience severe side effects. Severe side effects and their symptoms may include the following:

  • Allergic reactions symptoms are:
    • Itching
    • Swelling of your face, lips, or tongue
    • Hives
    • Skin rash
  • Heart problem symptoms are:
    • Chest pain
    • Swollen ankles or legs
    • Breathing problems
  • Changes to your heart rate symptoms are:
    • Feeling dizzy
    • Slow or irregular heart rate
    • Fainting
  • Sweating
  • Tremors
  • Cold, tingling, or numbness in your hands or feet
  • Muscle aches and pains
  • Confusion
  • Vomiting

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

  • Cardiac Failure: Zebeta, which is a beta-blocker, can sometimes make heart failure worse because it can decrease the heart’s ability to pump blood. Generally, patients with severe heart failure should not use beta-blockers. However, in some cases where heart failure is under control, beta-blockers may be needed but should be used cautiously.
  • For Patients Without Heart Failure History: In some patients, beta-blockers can lead to heart failure. If you start showing signs of heart failure while taking Zebeta, you should consider stopping the medication. If heart failure develops, beta-blocker therapy might continue while treating the heart failure with other medicines.
  • Abrupt Cessation of Therapy: Stopping beta-blockers suddenly can worsen Angina (chest pain), cause a heart attack, or lead to irregular heartbeats in patients with heart disease. If you need to stop taking Zebeta, do it gradually over about a week, under close medical supervision. If you experience withdrawal symptoms, you may need to start taking Zebeta again temporarily.
  • Peripheral Vascular Disease (Poor Blood Circulation): Beta-blockers can worsen symptoms in patients with poor blood circulation in their limbs. Be cautious if you have this condition.
  • Bronchospastic Disease (Asthma and Breathing Problems): Generally, patients with asthma or other breathing problems should avoid beta-blockers. Zebeta may be used with caution in some patients with breathing problems who cannot tolerate other blood pressure medications. Since Zebeta mainly affects the heart and not the lungs, it may be safer, but it should be used at the lowest effective dose. Always have a fast-acting inhaler (bronchodilator) available.
  • Before Major Surgery: If you are taking beta-blockers regularly, do not stop them before major surgery. Stopping them can increase the risks associated with anesthesia and surgery because the heart may not respond well to stress.
  • Diabetes And Hypoglycemia: Beta-blockers can hide signs of low blood sugar, especially a fast heartbeat. They can also make low blood sugar worse and slow down recovery. Zebeta is less likely to do this because it is selective for the heart, but patients with diabetes or those prone to low blood sugar should be cautious.
  • Thyrotoxicosis (Overactive Thyroid): Medicines containing beta-blockers can hide signs of an overactive thyroid, like a fast heartbeat. Stopping them suddenly can make thyroid symptoms worse or trigger a thyroid crisis.

Precautions

  • For People with Heart Problems: Avoid using this medication if you have difficulty pumping blood, active heart failure, a second or third-degree heart block, or a slow heartbeat (bradycardia). These conditions mean your heart is already struggling to function properly. Taking bisoprolol could worsen your situation by making it harder for your heart to pump blood. If you have heart failure that’s under control with medication (compensated heart failure), this drug might make your heart failure worse.
  • For People with Lung Diseases: If you have lung conditions like asthma or other breathing issues, you should generally avoid taking bisoprolol. However, if you can’t tolerate other high blood pressure medications, your doctor might let you use them at the lowest possible dose. Make sure to have a beta-agonist inhaler, like albuterol, on hand.
  • For People with Peripheral Vascular Disease: This medication could make the symptoms of your condition worse. 
  • For People with Hyperactive Thyroid: Bisoprolol may hide the signs of an overactive thyroid (hyperthyroidism). If you stop taking bisoprolol suddenly, your thyroid symptoms could become more severe, or you could develop a serious condition known as thyroid storm.
  • For People with Diabetes: This medication can hide signs of low blood sugar (hypoglycemia). It may also delay the time it takes for your blood sugar to return to normal levels. If you have diabetes, especially if you are using insulin or other medications that lower blood sugar, you should use Bisoprolol carefully.
  • For People with Pain, Cough, Cold, or Allergies: Speak with your healthcare provider or pharmacist. They can assist you in finding a safe medication to use alongside bisoprolol.

Other Important Precautions

  • Alcoholism: Drinking alcohol can lower your blood pressure. If you take bisoprolol, drinking alcohol might make your blood pressure too low.
  • Pregnancy: If you are pregnant or planning to get pregnant, talk to your doctor. Research in animals has shown harm to the baby when the mother takes this medication. There isn’t enough information from human studies to know how it might affect the baby. This medication should only be used if the benefits outweigh the risks.
  • Breastfeeding: It’s not known if bisoprolol passes into breast milk. If it does, it could harm a breastfed baby. You and your doctor should decide whether you should take bisoprolol or breastfeed.
  • Children: The safety and effectiveness of bisoprolol in people under 18 years old haven’t been established.
  • Surgery: If you’re going to have surgery, tell your doctor. They will need to keep an eye on your heart and blood pressure and check for any interactions with other drugs.

Zebeta Contraindications

This medication is contraindicated in patients with:

  • Overt cardiac failure
  • Cardiogenic shock
  • Second or third-degree AV block
  • Marked sinus bradycardia

Missed Dose

In case of a missed dose:

  1. Take it immediately when you remember.
  2. If the next dose is approaching, omit the missed dose and proceed with the next scheduled dose.
  3. Avoid taking a double dose.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdose

If you think you have taken too much of this medication, contact your doctor right away. Call 911 or go to the nearest emergency room immediately if you have severe symptoms. Common signs of an overdose include:

  • A slower-than-normal heart rate
  • Lower than-normal blood pressure
  • Heart failure
  • Lower than-expected blood sugar levels
  • Bronchospasm (a condition where the airways in your lungs tighten, making it difficult to breathe)

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Storage

  • Keep this medication at an average room temperature, between 68°F and 77°F (20°C and 25°C). 
  • Avoid storing it in wet or humid places, like bathrooms.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Zebeta Interactions

Zebeta oral tablets can affect or be affected by other medicines, vitamins, or herbal supplements you’re taking. When two substances interact, they can change how a drug works, which might be harmful or stop the drug from being effective. To avoid any problems, your doctor should carefully manage all your medicines. There are certain drugs that can interact with bisoprolol, the active ingredient in Zebeta. Some examples are listed below:

Heart Rhythm Drugs: These medications can cause a slower heart rate or more side effects when taken with bisoprolol. If you are prescribed these medications alongside bisoprolol, your doctor will closely monitor your condition. They may also adjust the dosage of your medications. Examples of these drugs include:

  • Digoxin
  • Bretylium
  • Propafenone
  • Disopyramide
  • Flecainide
  • Amiodarone
  • Quinidine
  • Sotalol
  • Procainamide
  • Encainide

Beta-blockers: Bisoprolol should not be combined with other beta-blockers, as this can excessively reduce your heart rate. Examples of these drugs are:

  • Clonidine
  • Metoprolol
  • Atenolol
  • Carvedilol
  • Reserpine
  • Propranolol
  • Diltiazem
  • Acebutolol
  • Non-dihydropyridine calcium channel blockers
  • Dihydropyridine calcium channel blockers

Anti-infective drug: Taking rifampin together with bisoprolol can increase the speed at which bisoprolol is eliminated from your body. This may reduce the effectiveness of bisoprolol in treating your condition.

Alpha-blockers: Taking these medications can lead to a decrease in your blood pressure when you move from a sitting to a standing position or from lying down to sitting up. This increases your risk of falling. Examples of these drugs include:

  • Prazosin
  • Terazosin
  • Doxazosin

Anesthetic: Bisoprolol can interfere with how your body removes the numbing medication lidocaine, potentially leading to harmful levels of lidocaine in your blood. If you are taking both medications, your doctor may monitor your blood levels to ensure your safety.

Malaria drug: Taking mefloquine (malaria drug) together can lead to irregular heartbeats, and there’s a risk that your heart might stop functioning.

Stimulants: Avoid using stimulants with bisoprolol, as they can interfere with its effectiveness. Taking them together may result in both drugs not working as intended. Some examples of these stimulants include:

  • Phenylephrine
  • Norepinephrine

Nonsteroidal anti-inflammatory drugs (NSAIDs): These medications can reduce the effectiveness of bisoprolol in lowering blood pressure. Examples of these medications include:

  • Nabumetone
  • Sulindac
  • Indomethacin
  • Piroxicam
  • Naproxen

[Note: This isn’t a complete list, and there could be other drugs that interact with Zebeta. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Zebeta Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

Is bisoprolol the same as metoprolol?

Bisoprolol and metoprolol succinate are both types of beta-blockers commonly used for patients with atrial fibrillation. They are convenient because they only need to be taken once a day and don’t need dosage changes for patients with kidney problems. However, bisoprolol is often the preferred choice because it specifically targets the heart more than metoprolol and may lead to a slower heart rate.

What should I avoid while taking bisoprolol?

You should avoid certain medications that can interfere with the effectiveness of bisoprolol. These include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, steroids such as prednisolone, and cough medicines containing pseudoephedrine or xylometazoline. Consult your healthcare provider for alternative options if needed.

What foods should you avoid while taking beta-blockers?

When taking beta-blockers, avoiding foods and drinks with caffeine, such as coffee, tea, and some sodas, is essential. Also, stay away from over-the-counter medicines that contain aluminum for coughs, colds, allergies, and heartburn. Additionally, avoid drinking alcohol, as it can reduce the effectiveness of beta-blockers

Can bisoprolol be used for anxiety?

Propranolol and atenolol are the two main beta-blockers used to treat anxiety. Sometimes, doctors may recommend other beta-blockers like bisoprolol, acebutolol, carvedilol, or metoprolol, especially if propranolol or atenolol isn’t a good fit for the patient.

How long after taking Zebeta does it work?

Zebeta helps slow down your heart rate and makes it easier for your heart to pump blood throughout your body. You may start to notice its effects around 2 hours after taking it, mainly in reducing high blood pressure. However, it can take between 2 to 6 weeks for the full benefits to be felt.

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