Empagliflozin & Linagliptin

Glyxambi

Glyxambi is an FDA-approved combination of empagliflozin and linagliptin designed to improve glycemic control in patients with type 2 diabetes mellitus. This oral tablet comes in two strengths: 10 mg empagliflozin/5 mg linagliptin and 25 mg empagliflozin/5 mg linagliptin. It is taken once daily in the morning, with or without food. Avoid using this medication if you are allergic to empagliflozin, linagliptin, or any other ingredient in Glyxambi. Regular monitoring of blood sugar and ketone levels is crucial, particularly during illness, stress, or other conditions that may impact glucose control. Always consult your doctor or healthcare provider for personalized advice on usage, dosage, and storage. Explore Glyxambi for type 2 diabetes treatment or consider options to buy Glyxambi online for your diabetes management needs.

Product Overview

Glyxambi is a combination oral medication containing empagliflozin and linagliptin, specifically formulated to improve glycemic control in adults with type 2 diabetes mellitus. Glyxambi works through a dual-action mechanism: empagliflozin helps the kidneys eliminate glucose from the bloodstream, while linagliptin enhances insulin levels after meals and reduces glucose production by the liver. This comprehensive approach effectively regulates blood sugar levels, particularly when combined with a healthy diet, regular exercise, and weight management, as a healthcare provider advises.

The medication is available in tablet form in two strengths: 10 mg empagliflozin/5 mg linagliptin and 25 mg empagliflozin/5 mg linagliptin. Glyxambi dosage is typically once daily, preferably at the same time each day, with or without food. Regular monitoring of blood sugar and ketone levels is crucial, especially during conditions like illness or stress, which may affect glucose control.

Glyxambi side effects may include bladder infections, depression, nausea, and headaches. Patients with kidney or liver issues or those who consume excessive alcohol should exercise caution when taking Glyxambi. In case of a missed dose, take it as soon as remembered unless it’s close to the next scheduled dose. For an overdose, seek immediate medical attention. Store Glyxambi at room temperature, away from moisture and heat, and dispose of it responsibly when no longer needed. For more information on Glyxambi, consult your healthcare provider. Learn more about Glyxambi for type 2 diabetes treatment, find where to buy Glyxambi online, and see how it aids in controlling glucose levels to manage diabetes effectively.

What Are the Uses of Glyxambi?

Targeted Treatment 

• It improves glycemic control in patients with type 2 diabetes mellitus.

Benefits

• It improves blood sugar levels in adults with type 2 diabetes. 
• It reduces the risk of death and hospitalization from cardiovascular disease if you have type 2 diabetes. 
• It prevents serious complications associated with diabetes, such as vision problems, loss of limbs, and nerve & sexual function issues.
• It regulates insulin levels after eating and assists the kidneys in getting rid of glucose from the bloodstream.

[Note: Do not take Glyxambi without consulting your doctor. They will determine whether you need this medication based on your conditions.]

What Are the Forms & Strengths of Glyxambi?

Form: Oral tablet 

Strength: It has these two following strengths:

• 10 mg empagliflozin/5 mg linagliptin
• 25 mg empagliflozin/5 mg linagliptin

What Are the Recommended Dosages of Glyxambi?

Managing type 2 diabetes requires precision and the right medication strategy. Glyxambi offers a powerful combination of empagliflozin and linagliptin to help adults maintain healthier blood sugar levels. Review the recommended dosages below, and be sure to consult with your healthcare provider for a personalized treatment plan.

For Diabetes 2 Type Patients

• Initial adult dose: Empagliflozin 10 mg-linagliptin 5 mg to be taken orally once daily, with or without food. 
• Maximum adult dose: Empagliflozin 25 mg-linagliptin 5 mg per day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

• Before using Glyxambi for the first time and after getting refills, carefully read the patient information leaflet given by your pharmacist and follow the instructions provided by your doctor for safe and efficient use of the medication. 
• You must take this medication by mouth as directed by your doctor, typically once daily in the morning, with or without a meal. If you have any queries or concerns regarding this medication, ask your doctor or healthcare provider before use. 
• Monitor your blood sugar regularly. You may also be required to test for ketone levels in your urine, as Glyxambi may cause life-threatening ketoacidosis. Even if your blood glucose levels are satisfactory, contact your doctor if a urine test indicates high levels of ketones. 
• The dose of the medication depends on your age, condition, and body’s response to treatment. 
• Glyxambi can affect your blood sugar levels, especially if your body is under stress due to illness, surgery, exercise, alcoholism, or skipping meals. 
• Hypoglycemia can make you feel dizzy, irritable, hungry, or shaky. To get quick relief from low blood sugar, eat or drink sugar-containing food items and beverages. In case of severe hypoglycemia, your doctor may prescribe a glucagon injection. 
• If you have been ill for a long time, if your food intake is less than usual, or if you are sick with severe vomiting or diarrhea, you may be dehydrated.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Glyxambi Work?

Glyxambi is a combination of two antidiabetic medications: Empagliflozin and Linagliptin. Empagliflozin removes excess glucose from your body, and Linagliptin regulates the insulin levels after a meal. Linagliptin works by increasing levels of incretins (a natural substance) in the body, which helps control blood sugar levels by increasing insulin release, especially after eating. Linagliptin also works by blocking a protein called DPP-4 (Dipeptidyl Peptidase 4) in the body. When combined, the two medications also reduce glucose production by the liver. 

Important Safety Information of Glyxambi

What Are the Side Effects of Glyxambi?

Common Side Effects of Glyxambi

Like any medication, Glyxambi may cause side effects as your body adapts to its use. While most are mild and manageable, it’s important to understand their causes and how to address them. Below, we’ve outlined common side effects of Glyxambi, along with helpful tips for managing them and when to seek medical advice.

• Bladder Infection: Also known as urinary tract infections (UTIs), can occur due to increased glucose levels in the urine, which create a favorable environment for bacteria. Symptoms may include frequent urination, burning sensations, cloudy urine, or pelvic discomfort. Staying hydrated and maintaining good hygiene can help, but severe cases may require antibiotics prescribed by a doctor. 

• Depression: It can occasionally arise as a side effect, potentially due to hormonal imbalances or changes in glucose regulation. It may present as feelings of sadness, hopelessness, or a lack of energy. If you notice prolonged depressive symptoms, it’s essential to discuss them with your healthcare provider to explore support options, including therapy or medication adjustments.

• Nausea: It may occur as your body adjusts to the medication. It is often mild and temporary but can cause discomfort after taking Glyxambi. Eating smaller meals, avoiding fatty or greasy foods, and taking the medication with or without food (as directed) may help alleviate nausea. If symptoms persist, consult your doctor.

• Headache: This side effect can result from changes in blood sugar levels or the body’s adjustment to the medication. Although usually mild, it can disrupt daily activities. Drinking water, ensuring proper blood sugar control, and using over-the-counter pain relief (if your doctor recommends it) can help manage this.

• Sweating: Excessive sweating, particularly at night, can occur due to fluctuations in blood sugar levels. This may be linked to hypoglycemia (low blood sugar), which causes the body to activate stress responses. If excessive sweating persists, monitor your blood sugar levels and discuss potential adjustments to your treatment plan with your healthcare provider.

• Chills: These may result from hypoglycemia, dehydration, or the body’s response to infection. They are often accompanied by fatigue or shivering. Keeping track of your blood sugar levels and staying hydrated can reduce the likelihood of chills. If chills persist or worsen, seek medical advice to rule out underlying conditions.

• Dry mouth: It can occur due to dehydration or the way the medication affects fluid levels in the body. This can lead to discomfort, bad breath, or an increased risk of cavities. Drinking water regularly, chewing sugar-free gum, or using oral moisturizing products can help alleviate symptoms. Persistent dryness should be reported to a doctor.

• Nightmares: It may occur due to changes in blood sugar levels or medication effects on the central nervous system. While typically not harmful, frequent nightmares can disturb sleep. Maintaining consistent blood sugar levels and good sleep hygiene may help reduce this side effect.

• Dizziness: It may be caused by fluctuations in blood sugar levels, dehydration, or a drop in blood pressure. It may occur when standing up too quickly or during physical activity. Staying hydrated, monitoring blood sugar, and avoiding sudden movements can help. If dizziness persists, contact your healthcare provider for evaluation.

• Vomiting: This may occur as a side effect during the body’s adjustment to Glyxambi. It can lead to dehydration and disrupt blood sugar levels. Drinking fluids in small sips and eating bland foods can help manage mild symptoms. However, persistent or severe vomiting should be reported to a doctor to prevent complications.

Mild side effects of Glyxambi

As your body adjusts to Glyxambi, you may encounter mild side effects that are usually not cause for concern. Understanding these symptoms and managing them can help ensure a smoother experience with the medication. Below is a closer look at these mild side effects and what steps you can take to address them.

• Yellow eyes or skin: It is also known as jaundice, and may indicate liver dysfunction or a rare allergic reaction to Glyxambi. It occurs due to an accumulation of bilirubin, a yellow pigment produced during the breakdown of red blood cells. If this symptom appears, seek immediate medical attention, as it may signal a serious condition.

• Unexplained weight loss: It can occur due to Glyxambi’s effect on glucose elimination, leading to calorie loss through urine. While minor weight changes might be expected, significant or rapid weight loss should be discussed with your doctor, as it may indicate dehydration, underlying health issues, or the need for treatment adjustments.

• Chest pain or tightness: This could result from stress on the heart, dehydration, or an allergic reaction. This side effect should never be ignored, as it may signal a serious issue such as angina or a heart-related complication. Seek immediate medical evaluation if you experience chest pain while taking Glyxambi.

• Trouble breathing: Difficulty breathing may be caused by an allergic reaction, fluid retention, or heart issues. It can be alarming and should be taken seriously. If you experience persistent or severe trouble breathing, contact your doctor promptly to rule out potentially life-threatening complications.

• Indigestion: Often characterized by discomfort in the upper abdomen, it may occur as your body adjusts to Glyxambi. Symptoms may include a burning sensation, bloating, or nausea. Eating smaller meals, avoiding spicy or fatty foods, and taking medication with food (if recommended) can help alleviate this issue.

• Bloating: Changes in digestion or fluid retention can cause a feeling of fullness in the abdomen. This can lead to mild discomfort, but it is generally temporary. Staying hydrated, eating fiber-rich foods, and avoiding gas-producing foods like beans and carbonated drinks can help manage bloating.

Adverse side effects of Glyxambi

While Glyxambi is effective for blood sugar control, it’s important to be aware of the serious side effects that may arise. Though rare, these conditions can have significant health implications. Below is a detailed explanation of these potential risks and guidance on when to seek urgent medical care to ensure your safety.

• Bullous pemphigoid: This is a rare skin condition associated with painful, fluid-filled blisters that develop on the skin, often in response to an autoimmune reaction. It can occur as a side effect of certain medications, including Glyxambi. This condition requires immediate medical attention, and treatment may include corticosteroids or immunosuppressive drugs to manage symptoms effectively.

• Pancreatitis: Inflammation of the pancreas, which may manifest as severe abdominal pain, nausea, vomiting, and fever. This side effect can be life-threatening if not treated promptly. It may occur due to the medication’s impact on pancreatic enzymes. If you experience symptoms, stop taking the medication and contact your doctor immediately for evaluation and treatment.

• Fournier’s gangrene: Rare but serious bacterial infection that affects the genital and perineal regions. It may lead to severe pain, swelling, and tissue death if not treated immediately. This condition requires emergency medical attention, often involving antibiotics and surgical intervention. Early recognition and treatment are critical to preventing life-threatening complications.

• Heart failure: This occurs when the heart cannot pump blood efficiently, leading to symptoms like shortness of breath, swelling in the legs, and fatigue. Glyxambi may exacerbate or trigger this condition in susceptible individuals. Monitoring for these symptoms is essential, and you should consult a doctor immediately if you notice worsening signs of heart failure.

• Ketoacidosis: A life-threatening condition where the body produces excess ketones, leading to a dangerously acidic state in the blood. Symptoms include nausea, vomiting, abdominal pain, confusion, and rapid breathing. Glyxambi may increase the risk of ketoacidosis, especially during illness or stress. Immediate medical attention is necessary to treat this condition effectively.

• Severe urinary tract infection: Usually present as intense pain during urination, fever, back pain, or cloudy urine. Glyxambi may increase susceptibility to UTIs due to glucose elimination through urine. Prompt treatment with antibiotics is often required to prevent complications, such as kidney infections. Stay hydrated and monitor for early symptoms.

• Dehydration: This occurs when the body loses more fluids than it takes in, often leading to dizziness, dry mouth, dark urine, and fatigue. Glyxambi can contribute to dehydration through increased urination. Drinking plenty of fluids and monitoring for signs of dehydration are essential. Severe cases may require medical intervention with intravenous fluids.

• Severe joint pain: This occurs as an immune response or due to inflammation triggered by the medication. It may affect mobility and quality of life. Resting the affected joints, using over-the-counter pain relievers (if your doctor approves), or seeking physical therapy can help. A healthcare provider should evaluate persistent pain.

• Allergic reaction: An allergic reaction to Glyxambi can range from mild symptoms, such as itching or rashes, to severe reactions, such as difficulty breathing, swelling of the face or throat, or anaphylaxis. If you experience signs of an allergic reaction, stop taking the medication immediately and seek emergency medical attention to prevent potentially life-threatening complications.

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

What Are the Warnings of Glyxambi?

Glyxambi can effectively control type 2 diabetes, but certain safety precautions must be observed to avoid complications. Being aware of these warnings can help ensure proper medication use and recognition of signs requiring medical intervention. 

• Glyxambi may affect your vision and thinking abilities. Do not drive, operate heavy machinery, or engage in activities that require your attention until you have determined how this medication affects you. 
• Glyxambi should be used with caution in patients who have problems related to their kidneys or liver. Such patients may require a dosage adjustment. 
• You should not use Glyxambi if you are on dialysis due to a severe kidney disease. 
• Call your doctor immediately if you experience signs and symptoms of adverse glyxambi side effects such as nausea, severe pain in your upper stomach spreading to your back, rapid heart rate, drowsiness, increased thirst or urination, or excess sweating. 
• Rarely, Glyxambi may cause infection in your genital area. Get immediate medical assistance if you notice itching, burning sensation, pain, tenderness, redness, odor, discharge or swelling in the genital or rectal area or if you have a fever or a feeling of unwellness. 
• If you notice symptoms such as joint pain, stomach ache, nausea, and vomiting, discontinue taking Glyxambi and inform your doctor immediately. 
• Empagliflozin can cause life-threatening diabetic ketoacidosis. You may need to regularly check your level of ketones in the urine and carefully monitor your blood sugar levels. 

What Are the Precautions of Glyxambi?

Before starting Glyxambi, taking certain precautions is important to ensure safe and effective use. Your medical history, current health conditions, and lifestyle choices can all influence how this medication affects you. Below is a brief overview of key precautions to consider while taking Glyxambi.

• Before taking Glyxambi, let your doctor know: 
  • If you are aged 65 years or more.
  • If you are currently facing alcoholism.
  • If you have a planned surgery
  • If you are on a low-sodium diet. 
• If you have triglycerides or high cholesterol. 
• Do not take Glyxambi if you are allergic to empagliflozin, linagliptin, or other ingredients.
• It is considered unsafe to consume alcohol while taking Glyxambi. Avoid taking medications that contain alcohol. Discuss with your doctor the potential risks of Glxambi if you drink alcohol. 
• Glyxambi may cause harm to the unborn fetus and may pass into the breast milk. Tell your doctor if you think you may be pregnant, planning to become pregnant, or if you are breastfeeding a baby. Your doctor may suggest you stop the medication in this condition. 
• Keep your genital area clean and hygienic to reduce the chances of yeast or urinary tract infection. 
• Do not take Glyxambi if you have or have ever had a urination problem, bladder infection, heart failure, pancreas disorder, or genital infection. 

What Are the Contraindications of Glyxambi?

Glyxambi isn’t suitable for everyone, and understanding its contraindications is essential for safe use. If you have specific allergies or medical conditions, it’s important to review these details with your healthcare provider.

• If you are allergic to empagliflozin, linagliptin or any other ingredients in Glyxambi.
• If you are allergic to any other sodium-glucose-cotransporter 2/SGLT2, dipeptidyl-peptidase-4/DPP4. 
• Patients on dialysis.

What If You Missed a Dose of Glyxambi?

• If you missed a dose of Glyxambi, take it as soon as you remember. 
• If it is almost time for your next dose, you may skip the missed dose and take the next dose according to your dosing schedule. 
• Do not take two doses or an extra dose of the same medication to compensate for the missed dose, as it may cause adverse side effects. 
• You can try setting a reminder on your phone to avoid missing your dose. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Glyxambi?

You should not take Glyxambi more than your doctor prescribed. If you think you may have taken the medication more than the recommended dose, seek immediate medical assistance, even in the absence of symptoms. If someone has overdosed on Glyxambi and is having severe symptoms such as trouble breathing, unconsciousness and seizures, immediately call 911 or head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately, or call the Poison Help line at 1-800-222-1222.]

How to Store Glyxambi?

Proper storage of Glyxambi is essential to maintaining its effectiveness and ensuring safety. A few simple precautions can help preserve the medication’s quality and prevent accidental misuse. Below are key guidelines for storing Glyxambi correctly.

• Store Glyxambi in its original container at room temperature, away from direct sunlight, excess heat, and moisture. 
• Do not keep it at room temperature above 30°C. Do not keep it in the bathroom; keep it in a dark, cool, dry place. 
• Keep all medications away from the sight and reach of children and pets.
• Do not keep medicines that are outdated or no longer needed. 
• Do not throw the medicine in wastewater or your household garbage bin. 
• Do not flush the medicine or pour it into the drain unless instructed. 
• Properly discard Glyxambi if it has expired or is no longer needed. 
• For more information on the proper disposal of the medication, consult your pharmacist or local waste disposal company.

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Are the Interactions of Glyxambi?

When using Glyxambi, it’s essential to understand how it may interact with other substances, including medications and alcohol. These interactions can impact the effectiveness of Glyxambi or increase the risk of side effects. Here’s a detailed explanation of some key interactions:

• Alcohol: Consuming alcohol while taking Glyxambi can raise the risk of low blood sugar (hypoglycemia) and dehydration. Alcohol may also increase the likelihood of serious complications like ketoacidosis or kidney issues, making it vital to limit alcohol intake during treatment.
• Diuretics: It can cause excessive fluid loss. When combined with Glyxambi, they may increase the risk of dehydration, low blood pressure, and electrolyte imbalances. This combination could strain kidney function, requiring regular monitoring of hydration and kidney health.
• Sulfonylureas: These medications, like Glyxambi, lower blood sugar. Taking them together can lead to severe hypoglycemia, which may cause symptoms like dizziness, sweating, or fainting. To avoid these risks, regular blood sugar checks and potential dosage adjustments are necessary.
• Rifampin: A medication used to treat tuberculosis, can reduce the effectiveness of Glyxambi. It accelerates the breakdown of Glyxambi in the liver, making it less effective in controlling blood sugar levels. Your doctor may adjust your medication if you need rifampin.
• Insulins: When Glyxambi is taken with insulin, the risk of hypoglycemia increases significantly. While the combination can improve blood sugar control, it must be carefully managed to avoid dangerously low blood sugar levels. Your healthcare provider may modify insulin doses to balance this interaction effectively.

[Note: This isn’t a complete list, and there could be other drugs that interact with Glyxambi. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

What Are the Alternatives of Glyxambi?

If Glyxambi isn’t the right fit for your treatment plan, there are several alternative medications available to help manage your diabetes. Each option works differently, targeting various aspects of blood sugar control. Below is a list of potential alternatives to discuss with your healthcare provider based on your needs and health profile.

• Metformin
• Ozempic (semaglutide)
• Onglyza (saxagliptin)
• Januvia (sitagliptin)
• Levemir (insulin detemir)
• Lantus (insulin glargine)
• Toujeo (insulin glargine)
• Starlix (nateglinide)
• Prandin (repaglinide)
• Jardiance (empagliflozin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Glyxambi Cost & Coupons

The cost of Glyxambi, a medication used to manage type 2 diabetes, can vary depending on factors like your health insurance coverage and the pharmacy you choose. For individuals whose insurance does not cover diabetes medications, out-of-pocket costs can be significant. However, online platforms like Polar Bear Meds provide an affordable solution. You can buy Glyxambi from Canada through Polar Bear Meds, ensuring authentic medication at a fraction of the price found in the USA. Plus, first-time buyers can save even more when they buy Glyxambi with coupon WELCOMEPB10, which offers a 10% discount on their first purchase.

Frequently Asked Questions

What is Glyxambi and how does it help in managing type 2 diabetes?

Glyxambi is a combination medication containing empagliflozin and linagliptin, used to improve blood sugar control in adults with type 2 diabetes mellitus. It works by increasing insulin levels after meals and helping the kidneys eliminate glucose from the bloodstream, thereby regulating blood sugar levels.

Can Glyxambi be taken with other diabetes medications?

While Glyxambi can be used in combination with other diabetes medications, it is essential to consult with your healthcare provider before adding any new medication to your treatment regimen. Glyxambi may interact with certain drugs, such as diuretics, sulfonylureas, and insulins, potentially affecting blood sugar control.

What are the common side effects of Glyxambi?

Common side effects of Glyxambi include bladder infection, depression, nausea, headache, sweating, chills, dry mouth, nightmares, dizziness, and vomiting. Contact your healthcare provider immediately if you experience any severe side effects or signs of an allergic reaction.

How should Glyxambi be stored and disposed of?

Glyxambi should be stored at room temperature, away from direct sunlight, excess heat, and moisture. Keep the medication in its original container and out of reach of children and pets. Dispose of unused or expired medication properly, following local regulations or consulting your pharmacist or waste disposal company for guidance.

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