Trulicity

Trulicity (dulaglutide) is a prescription-only injectable medication used with diet and regular exercise to help control A1C levels in adults and pediatric patients aged 10 years & older with type 2 diabetes. This once-weekly medication also helps reduce the risk of major cardiovascular events. These include heart attack, stroke, and cardiovascular-related death in patients with existing heart issues or risk factors.

Quick Facts About Trulicity

When you consider the Trulicity dose for type 2 diabetes, follow this table:

Trulicity vs. Other GLP-1 Medications: What Are The Differences?

In a clinical study, 94% of adults with type 2 diabetes reported that the Trulicity pen was easy to use. This ready-to-use injection pen is designed for ease and consistent weekly administration. Follow these Trulicity administration guidelines:

• Before taking, choose your weekly Trulicity day and try to stick to it each week.
• Wash your hands completely before handling the Trulicity pre-filled pen.
• Remove the Trulicity pre-filled pen from the refrigerator and check the label, dose strength, and expiration date.
• Inspect the medicine through the pen window to ensure the solution is clear and free of particles.
• Keep the base cap on until you are ready to inject.
• Select an injection site such as the thigh, abdomen, or upper arm.
• Rotate Trulicity injection sites each week and avoid injecting into the same exact spot.
• Remove the base cap and do not touch the hidden needle.
• Place the Trulicity (dulaglutide) pen flat and firmly against your skin at the injection site.
• Unlock the Trulicity pen by turning the lock ring.
• Press and hold the green button of the Trulicity (dulaglutide) injection.
• Continue holding the Trulicity pen in place until you hear two clicks, indicating the full dose has been delivered.
• Remove the pen from your skin after the second click.
• Do not reuse or share the Trulicity pen.
• Trulicity can be taken at any time of day, with or without food.
• If needed, the Trulicity pen may be stored at room temperature for a limited period as directed.
  • Keep Trulicity pens and disposal containers out of reach of children and pets.

Trulicity Pen Disposal Instructions After Usage

• Throw away used pens right after use in an FDA-approved sharps container.
• Do not place used pens in regular household garbage.
• If a sharps container is not available, use a strong household container that:
  • is made of thick, durable plastic
  • has a tight lid that cannot be punctured
  • stays upright and does not tip over
  • does not leak
  • is clearly marked as containing hazardous waste
• When the puncture-resistant sharps container is almost full, follow local or community rules for safe disposal.
• Dispose of used needles and syringes according to your state or local regulations.

Trulicity works by acting like GLP-1, a hormone your body releases after meals. This hormone plays a very important role in regulating your blood sugar levels in people with type 2 diabetes. It helps your pancreas release insulin when blood sugar rises, limits excess glucose production by the liver, slows the movement of food through the stomach, and reduces hunger. While natural GLP-1 breaks down within minutes, Trulicity remains active in the body for an entire week. This dosing allows it to be administered just once weekly.

Trulicity Warning: Risk of Thyroid C-Cell Tumors

Dulaglutide, the active ingredient of Trulicity, has been shown to increase the occurrence of thyroid C-cell tumors in both male and female rats when given over long periods and at higher doses. These tumors included both benign and malignant growths. However, it is not yet known whether this effect occurs in humans, as the relevance of these animal findings to people remains unclear. As a result, the potential risk of medullary thyroid carcinoma associated with Trulicity use in humans remains uncertain.

• Trulicity has been linked to thyroid C-cell tumors in animal studies. Seek medical advice if you notice neck swelling, a lump, voice changes, difficulty swallowing, or breathing issues.
• Avoid Trulicity if you or a close family member has a history of MTC.
• Trulicity should not be used by patients diagnosed with MEN 2.
• Do not take Trulicity if you have had a serious hypersensitivity reaction to dulaglutide or any of its components.
• Trulicity is approved for adults and pediatric patients aged 10 years and older with type 2 diabetes. Cardiovascular risk reduction applies to adults only.
• The risk of hypoglycemia increases when Trulicity is combined with insulin or insulin secretagogues.
• Worsening vision or new visual disturbances should be quickly reported while on Trulicity, especially in patients with diabetic retinopathy.
• Trulicity is not an FDA-approved medication for weight loss, type 1 diabetes, or diabetic ketoacidosis.
• Inform your doctor about Trulicity use prior to procedures, as it may increase aspiration risk during sedation.
• The safety of Trulicity during pregnancy has not been well established in humans. Trulicity should be used in pregnancy only if the advantage justifies the possible risk to the unborn baby. Poorly controlled diabetes during pregnancy can increase risks for both the mother and fetus; treatment decisions should be individualized.
• It is not known whether dulaglutide passes into human breast milk. There may be potential risks to a nursing infant when Trulicity is used while breastfeeding. Mothers should discuss alternative diabetes treatments with their doctor before starting Trulicity.
• Always consult a doctor when considering Trulicity use during pregnancy or lactation. This is especially important when comparing options such as Trulicity vs Ozempic, Trulicity vs Mounjaro, or Trulicity vs Januvia for type 2 diabetes.

In the event of a missed Trulicity dose, administer it quickly if at least 3 days remain before the next scheduled dose. If fewer than 3 days remain, skip the missed Trulicity dose and take your next dose on your regular weekly day. Do not take two doses at the same time or extra doses to make up for a missed Trulicity injection, as this can increase the risk of side effects.

Taking more Trulicity than prescribed may increase the chance of side effects. This includes especially nausea, vomiting, diarrhea, stomach pain, or low blood sugar, particularly if you also use insulin or other diabetes medicines. If you suspect a Trulicity overdose, contact the poison control center or your healthcare provider immediately.

• Store Trulicity pre-filled pen at 36°F-46°F (2°C-8°C).
• Keep Trulicity Pens refrigerated and protected from light.
• Do not use them after the expiration date on the label.
• Do not freeze.
• Trulicity pens may also be stored at room temperature for up to 14 days before use.

As of 2026, Trulicity (dulaglutide) has documented interactions with 284 medications and 4 disease-related interactions. Among these drug interactions, 16 are classified as major, 259 as moderate, and 9 as minor. These include:
Major Interactions with Trulicity (dulaglutide)

• Capivasertib
• Sevoflurane
• Ketamine
• Methoxyflurane
• Bexarotene
• Thiopental
• Isoflurane
• Fospropofol
• Halothane
• Gatifloxacin
• Propofol
• Desflurane
• Nitrous oxide
• Methohexital
• Etomidate
• Enflurane

• Minor Interactions with Trulicity (dulaglutide)
  • Fluorometholone ophthalmic
  • Sitagliptin
  • Prednisolone ophthalmic
  • Loteprednol ophthalmic
  • Dexamethasone ophthalmic
  • Rimexolone ophthalmic
  • Difluprednate ophthalmic
  • Medrysone ophthalmic
  • Fluocinolone ophthalmic
• Some Moderate interactions with Trulicity (dulaglutide)
  • Acetazolamide
  • Benzphetamine
  • Cariprazine
  • Cinoxacin
  • Dexfenfluramine
  • Everolimus
  • Insulin Aspart
  • Methazolamide
• Trulicity Disease Interactions
  • Gastroparesis
  • Pancreatitis
  • Thyroid Carcinoma
  • Renal Dysfunction

If Trulicity is unsuitable or unavailable for the management of type 2 diabetes, the following alternatives may be considered:

• Actos (pioglitazone)
• Mounjaro (tirzepatide)
• Januvia (sitagliptin)
• Lantus Solostar (insulin glargine)
• Farxiga (dapagliflozin)
• Victoza (liraglutide)
• Amaryl (glimepiride)
• Ozempic (semaglutide)
• Invokana (canagliflozin)
• Jardiance (empagliflozin)
• Rybelsus (semaglutide)

In the U.S., the cost of Trulicity pens for type 2 diabetes can be overwhelming, often ranging from $987 to $1,000 per month without insurance. Because of this high price, many people delay or skip their medication, which can negatively affect their health. Polar Bear Meds offers a more affordable alternative by sourcing Trulicity from licensed Canadian pharmacies. This helps customers save more than approximately $450 compared to U.S. prices.

To make savings even easier, new customers can receive an extra 10% off by just using the Trulicity coupon code “WELCOMEPB10” at checkout. This coupon requires no insurance, has no eligibility restrictions, and won’t expire unexpectedly. Trusted by many people managing type 2 diabetes, Polar Bear Meds delivers Trulicity within 3-5 days through Xpress Post for added convenience.

• https://trulicity.lilly.com/
• https://www.drugs.com/trulicity.html
• https://pmc.ncbi.nlm.nih.gov/articles/PMC4665063/
• https://reference.medscape.com/drug/trulicity-dulaglutide-999965
• http://www.webmd.com/drugs/2/drug-167025/trulicity-subcutaneous/details
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/125469s061s062lbl.pdf
• https://pi.lilly.com/us/trulicity-mg.pdf