Estradiol and Norethindrone Acetate

Activella

Activella is an FDA-approved hormone replacement therapy designed to ease the symptoms of menopause and support long-term health. Combining estradiol (a form of estrogen) and norethindrone acetate (a progestin), it provides effective relief from hot flashes, night sweats, mood swings, and vaginal dryness. Activella also helps reduce the risk of osteoporosis, promoting stronger bones in postmenopausal women. Available in two strengths (1 mg/0.5 mg and 0.5 mg/0.1 mg), Activella ensures tailored treatment to suit individual needs. Its once-daily, easy-to-swallow tablet makes it a convenient solution for managing menopause symptoms and improving overall well-being. Buy Activella online from Canada to enjoy trusted, FDA-approved relief at your convenience. Always consult your healthcare provider to determine the right dosage for your needs and ensure safe, effective use. Reclaim your comfort and confidence during menopause with this reliable therapy.

Product Overview

Navigating menopause can be challenging, but Activella is here to help. This hormone replacement therapy combines estradiol (a form of estrogen) and norethindrone acetate (a progestin) to provide comprehensive relief from common menopausal symptoms like hot flashes, night sweats, and mood swings. Activella also addresses vaginal dryness and discomfort, ensuring you feel at ease and confident during this transitional phase. Additionally, it offers protection against osteoporosis, helping maintain bone strength for postmenopausal women at higher risk.

Activella has two strengths that suit your unique requirements: 1 mg/0.5 mg and 0.5 mg/0.1 mg. Each dosage is carefully formulated to provide effective symptom relief while minimizing risks associated with hormone therapy. The once-daily tablet is film-coated for easy swallowing, making it a convenient addition to your daily routine. Whether you’re looking for short-term relief from vasomotor symptoms or long-term bone health benefits, Activella’s balanced composition ensures reliable support for your health goals.

Take control of your menopause management by choosing Activella as a trusted solution. Buy Activella online to conveniently access this essential therapy and enjoy the benefits of reliable symptom relief and enhanced well-being. Always consult your healthcare provider to determine the right dosage for your needs and ensure safe, effective use. With Activella, you can confidently embrace this new chapter of life with comfort and peace of mind.

What Are the Uses of Activella? 

• Hormone Replacement Therapy (HRT)
• Menopausal Symptom Relief
• Prevention of Osteoporosis
• Treatment of Vaginal Atrophy

What Are the Forms & Strengths of Activella?

Activella comes in different strengths to suit individual treatment needs. Here’s a quick overview of the available options.

• 1 mg/0.5 mg: Contains 1 mg of estradiol and 0.5 mg of norethindrone acetate.
• 0.5 mg/0.1 mg: Contains 0.5 mg of estradiol and 0.1 mg of norethindrone acetate.

Each tablet is white, round, biconvex, and film-coated. The 1 mg/0.5 mg tablets are debossed with “ALH” on one side and plain on the other. 

What Is the Recommended Dosage of Activella?

Understanding the recommended dosage of Activella is crucial for safe and effective treatment. The dosage varies depending on the specific condition being treated, and it’s important to follow your healthcare provider’s guidance. Below is a breakdown of the standard dosages for different treatment purposes, ensuring you can align your medication plan with your health needs. 

For Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause:

• Activella 1 mg/0.5 mg: One tablet taken orally once daily.
• Activella 0.5 mg/0.1 mg: One tablet taken orally once daily.
• Use the lowest effective dose for the shortest duration, consistent with treatment goals and individual risks.

Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause:

• Activella 1 mg/0.5 mg: One tablet taken orally once daily.
• Consider topical vaginal products when prescribing solely for the treatment of vulvar and vaginal atrophy.

For Prevention of Postmenopausal Osteoporosis:

• Activella 1 mg/0.5 mg: One tablet taken orally once daily.
• Activella 0.5 mg/0.1 mg: One tablet taken orally once daily.
• Therapy should only be considered for women at significant risk of osteoporosis, and non-estrogen medications should be carefully considered. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Activella?

Using Activella correctly is essential to ensure its effectiveness and minimize potential risks. This guide will walk you through the key steps for proper administration, storage, and medication handling, helping you stay on track with your treatment plan. Always follow your healthcare provider’s instructions and consult them with questions or concerns.

• Take one tablet orally once daily, at the same time each day.
• Swallow the tablet whole; do not crush or chew.
• If you miss a dose, take it as soon as you remember. If it’s near the time for your next dose, skip the missed dose. Do not double up to compensate.
• Store at room temperature (15-30°C or 59-86°F) in the original container, away from moisture, heat, and direct light. Keep out of reach of children and pets.
• Unused or expired medication should be disposed of through a drug take-back program or by consulting your pharmacist for proper disposal methods. Do not flush or throw it in the trash. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Activella Work?

Activella combines two hormones, estradiol (a form of estrogen) and norethindrone acetate (a progestin). Estradiol helps alleviate symptoms of menopause, such as hot flashes and vaginal dryness, by replacing the estrogen that the body no longer produces naturally after menopause. Norethindrone acetate is added to counteract the potential increase in the risk of endometrial cancer that can arise from estrogen alone. This combination helps maintain a hormonal balance, thus easing menopausal symptoms and preventing post-menopausal bone loss.

Important Safety Information for Using Activella

What Are the Side Effects of Activella?

Common Side Effects of Activella
Common side effects of Activella include a range of symptoms that vary in severity and frequency. These side effects are generally more common during the initial stages of treatment and may diminish as the body adjusts to the medication.

• Headache: Often experienced by users, headaches can be a reaction to hormone changes caused by Activella. They typically resolve as the body adjusts to the medication.
• Breast Pain: This symptom is related to the hormonal fluctuations caused by the therapy. Breast pain or tenderness can occur as the body adapts to different estrogen and progestin levels.
• Irregular Vaginal Bleeding or Spotting: Common in hormone replacement therapy, this side effect occurs due to changes in the hormonal balance affecting the menstrual cycle or vaginal lining.
• Stomach or Abdominal Cramps and Bloating: These gastrointestinal symptoms can result from the body’s reaction to the hormones in Activella, which impacts digestive processes and causes discomfort.
• Nausea and Vomiting: These are common gastrointestinal reactions to many medications, including hormone therapies like Activella, often related to how the hormones interact with your digestive system.
• Hair Loss: A less common but concerning effect, hair loss may occur due to hormonal changes impacting hair growth cycles.
• Fluid Retention: Hormonal changes can lead to fluid retention, resulting in swelling or puffiness in various body parts.
• Vaginal Yeast Infection: The change in hormone levels can affect the natural balance of bacteria and yeast in the vaginal area, leading to yeast infections.

Serious Side Effects of Activella

While Activella is used to manage menopause symptoms and prevent osteoporosis, it carries potential risks for serious side effects. Understanding these risks is crucial for those considering or currently using this hormone replacement therapy. Below, we explore several serious side effects, detailing their mechanisms, potential impacts on health, and the importance of monitoring and preventive care during treatment. Each side effect discussed highlights the importance of personalized medical advice and careful management in the context of individual health profiles.

• Heart Attack: Estrogens, when combined with progestogens like in Activella, can increase the risk of a heart attack. This is especially significant for women who have existing heart disease risk factors such as high blood pressure or high cholesterol. Hormonal fluctuations can affect heart and blood vessel function, potentially leading to cardiovascular events.
• Stroke: The risk of strokes increases with the use of hormone replacement therapies like Activella. This risk is compounded by estrogen’s effect on blood clotting factors and arterial health, which can lead to blockages or ruptures in cerebral vessels.
• Blood Clots: Activella can increase the likelihood of developing blood clots in the veins (venous thromboembolism), including deep vein thrombosis and pulmonary embolism. Estrogens can cause changes in the coagulation system, which can lead to these dangerous clots forming and traveling to vital organs.
• Breast Cancer: Long-term use of combined estrogen and progestin therapy has been linked to an increased risk of breast cancer. The hormones can stimulate breast tissue growth, potentially leading to malignant transformations.
• Cancer of the Lining of the Uterus (Endometrial Cancer): When used without a progestin, estrogen increases the risk of endometrial cancer. Activella, which contains progestin, is less likely to pose this risk, but it’s still a concern, especially if not appropriately balanced or monitored.
• Ovarian Cancer: Hormone replacement therapy has been associated with a slightly increased risk of ovarian cancer. The mechanisms are not fully understood but may involve the hormonal regulation of ovarian cells.
• Dementia: Studies suggest an increased risk of developing probable dementia in postmenopausal women over the age of 65 who use estrogen therapy. Hormonal changes can affect brain function and structure, although the exact relationship between hormones and dementia is complex and not fully delineated.
• High Blood Pressure: Hormone replacement therapy can lead to high blood pressure as estrogen affects the regulation of blood vessels and sodium and fluid retention, which can increase blood pressure.
• Gallbladder Disease: Using estrogens may increase the risk of gallstones and gallbladder disease, as hormones can affect the metabolism of cholesterol, a component of gallstones.
• Liver Problems: Estrogens can negatively impact liver function, leading to conditions such as gallstones, liver enzyme elevation, and, in rare cases, serious liver diseases.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Activella? 

While Activella can be helpful for certain health conditions, it can also pose serious health risks, which may be higher for some individuals. If any of these concerns worry you, please discuss alternative options with your doctor or pharmacist.

• Blood Clots, Heart Attacks, and Strokes: Estrogen/progestin therapies like Activella can increase your risk of blood clots, which can travel through your body and block blood flow. This may cause deep vein thrombosis (DVT), pulmonary embolism (PE), heart attacks, or strokes. If you or your family have a history of blood clots, if you smoke, or if you have certain health conditions like high blood pressure or cholesterol, you’re at a higher risk.
  • Before surgery or in a less mobile situation, you may need to stop using Activella. Your doctor will guide you on the timing. To reduce the risk of clots, you may need to wear compression stockings or move around frequently during long trips.
  • If you experience pain or swelling in your limbs, difficulty breathing, chest pain, or sudden neurological symptoms like facial drooping, weakness, severe headaches, or changes in speech or vision, seek emergency medical help immediately.

• Breast Cancer Risk: Combination hormone therapies, such as Activella, may increase the risk of breast cancer, particularly if used for long periods. Do not use Activella if you currently have or have had breast cancer. To minimize risks, your doctor will prescribe the lowest effective dose for the shortest time possible. Regular breast checks and mammograms are important.
• Uterine or Endometrial Cancer: Activella can change the lining of your uterus, raising the risk of uterine or endometrial cancer. This risk is higher with estrogen-only therapy, but you should still be aware of the symptoms of uterine cancer, such as irregular vaginal bleeding. If you notice any unusual bleeding, contact your healthcare provider immediately.
• Dementia Risk: Hormone therapies like Activella may increase the risk of dementia, especially for women who start treatment after age 65. These therapies should not be used to prevent dementia. If you’re concerned about dementia, discuss it with your doctor.
• Ovarian Cancer: Hormone therapy might increase the risk of ovarian cancer. Report any unusual vaginal bleeding, discharge, or pelvic pain to your doctor, as these can be signs of ovarian cancer.
• Liver or Gallbladder Problems: Estrogen therapy can increase the risk of gallbladder disease. If you have a history of jaundice (yellowing of the skin or eyes), notify your doctor. If jaundice reoccurs while on Activella, stop the medication and consult your doctor.
• Calcium Imbalances: Estrogen can affect calcium levels, which could be problematic if you have certain conditions, such as breast cancer that has spread to your bones. High calcium levels can cause fatigue, muscle weakness, nausea, or constipation, while low calcium can lead to muscle spasms or numbness. Regular blood tests may be necessary to monitor calcium levels.
• Vision Problems: In rare cases, estrogen therapy can cause vision problems due to eye clot formation. If you experience sudden vision loss, bulging eyes, double vision, or severe migraines, stop the medication and contact your doctor immediately.
• High Triglyceride Levels: Estrogen therapy may elevate triglyceride levels in your blood, increasing the risk of pancreatitis. Notify your healthcare provider if you experience symptoms like stomach pain that radiates to your back, fever, nausea, or vomiting.
• Thyroid Hormone Imbalances: Estrogen can alter thyroid hormone levels. If you have a thyroid condition and are taking thyroid hormone replacement, you may need a higher dose of medication. Regular blood tests may be required to ensure thyroid levels stay balanced.
• Fluid Retention: Estrogen/progestin therapies can lead to fluid retention, causing swelling in the hands and ankles. If you have heart or kidney issues, be especially cautious and monitor for any signs of worsening fluid retention.
• Worsening of Pre-Existing Conditions: Estrogen-containing medications like Activella can aggravate certain conditions, including high blood pressure, asthma, diabetes, and migraines. Before starting Activella, inform your healthcare provider about any medical conditions so they can help assess the potential risks and benefits for your health.

What Are the FDA Boxed Warning for Activella?

Activella carries several FDA-boxed warnings due to significant risks associated with its use. These warnings are particularly critical to consider before starting treatment:

• Cardiovascular Disorders: Activella is associated with an increased risk of stroke and deep vein thrombosis (DVT) in postmenopausal women, which is a serious concern that necessitates caution in prescribing and monitoring.
• Probable Dementia: There is an increased risk of probable dementia in postmenopausal women aged 65 and older who use estrogen-alone therapy, such as in the formulation of Activella. This risk does not necessarily apply to younger women but is a significant consideration for the elderly.
• Breast and Endometrial Cancer: Using estrogen-alone or in combination with a progestin, as in Activella, can increase the risk of breast cancer and, in the absence of progestin, the risk of endometrial cancer. This necessitates careful screening and monitoring of women using these therapies.
• Endometrial Hyperplasia: Activella can cause an increase in the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Progestins added to estrogen therapy reduce this risk, but it requires that healthcare providers undertake adequate diagnostic measures to rule out malignancy, especially in women with undiagnosed persistent or recurring abnormal genital bleeding.

What Are the Activella Precautions?

Before starting a new medication, discussing any allergies, medical history, and lifestyle factors with your healthcare provider to ensure safety and effectiveness is important. Special considerations may be needed for surgery, immobility, or exposure to sunlight. Here are key precautions to consider with your doctor.

• Allergies: Inform your doctor if you have allergies to Activella or any of its components. Inactive ingredients may also trigger allergic reactions.
• Medical History: Discuss your medical history, especially if you have:
  • Unexplained vaginal bleeding
  • Cancers such as breast, uterine, or ovarian
  • Blood clots or history of clotting disorders like protein C or S deficiency
  • Stroke or heart disease
  • Liver or kidney disease
  • High blood pressure or cholesterol
  • Diabetes, obesity, or lupus
  • Thyroid disorders
  • Calcium imbalances or hypoparathyroidism
  • Uterine issues like fibroids or endometriosis
  • Gallbladder disease, asthma, seizures, migraine headaches
  • Blood disorders such as porphyria
  • Mental/mood conditions like dementia or depression
• Smoking: Avoid smoking as it increases the risks of stroke, blood clots, and heart attack when combined with estrogen, especially in women over 35.
• Surgery or Immobility: If you are planning surgery or will be immobilized (e.g., on long flights), discuss with your doctor, as you may need to stop this medication temporarily to reduce clotting risks.
• Sun Exposure: This medication may cause melasma, which can worsen with sun exposure. Limit time in the sun, avoid tanning booths, use sunscreen, and wear protective clothing.
• Vision Changes: If you are nearsighted or wear contact lenses, monitor for vision problems or difficulties with contact lenses.
• Pregnancy: Do not use this medication during pregnancy. Inform your doctor immediately if you become pregnant.
• Breastfeeding: The medication can pass into breast milk. Consult your doctor before breastfeeding.

What Are the Contraindications of Activella?

It is contraindicated in several specific situations due to the potential risks associated with its use. Here are the main contraindications for Activella:

• Undiagnosed Abnormal Genital Bleeding: Activella should not be used until the cause of abnormal genital bleeding is determined.
• History of Breast Cancer or Current Breast Cancer: Due to its estrogen component, Activella is contraindicated in women with a known, suspected, or past history of breast cancer.
• Estrogen-Dependent Neoplasia: It should not be used in cases of confirmed or suspected estrogen-dependent tumors.
• Active or Recent Blood Clots: This includes conditions like deep vein thrombosis (DVT), pulmonary embolism (PE), and a history of these conditions.
• Active or Recent Arterial Thromboembolic Disease: Such as stroke or myocardial infarction.
• Liver Dysfunction or Disease: Activella is contraindicated in women with liver impairment or disease.
• Known Protein C, Protein S, or Antithrombin Deficiency, or Other Thrombophilic Disorders: These conditions increase the risk of thrombotic diseases.
• Pregnancy: It should not be used during pregnancy as it can harm the fetus.

What If You Miss a Dose of Activella?

If you miss a dose of Activella, the general guidance is to take it as soon as you remember. However, if it’s almost time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. This approach helps to maintain a consistent level of medication in your body and avoids the risks associated with over-dosage.

Correctly managing missed doses is crucial for maintaining the medication’s effectiveness and minimizing potential side effects. Always follow the specific instructions your healthcare provider provides or refer to the patient information that comes with your medication.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Activella?

Taking too much Activella can lead to several serious health complications. It’s important to follow your healthcare provider’s instructions regarding dosage to avoid these risks. Some potential consequences of an overdose include:

• Symptoms resembling blood clots: These could manifest as sudden pain in the chest, groin, or leg, particularly in the calves, along with coughing up blood.
• Heart-related issues: Symptoms might include chest pain, tightness, sweating, and nausea, indicative of a potential heart attack.
• Stroke symptoms: Watch for sudden severe headaches, loss of coordination, sudden shortness of breath, slurred speech, or unexpected changes in vision.
• Liver problems: Indicators can include nausea, vomiting, loss of appetite, weight loss, yellowing of the skin or eyes, and unusually dark urine.
• Pancreatitis: This might present as severe abdominal pain on the upper left side, back pain, nausea, fever, chills, a rapid heartbeat, or a swollen abdomen.
• Severe allergic reactions: Symptoms can include abdominal cramps, difficulty breathing, nausea, vomiting, and swelling of the face and throat.

If you experience any of these symptoms or suspect an overdose, it’s crucial to seek immediate medical attention. Continued monitoring and regular check-ups are recommended for anyone taking hormone replacement therapies to manage potential side effects and ensure the treatment’s effectiveness and safety.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store Activella?

Proper storage of Activella is essential to maintain its effectiveness and ensure safety. Here are the recommended storage guidelines:

• Temperature: Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F). Short-term variations are acceptable between 15°C to 30°C (59°F to 86°F).
• Protection from Light: Keep the medication in its original packaging to shield it from light exposure.
• Moisture Control: Store in a dry environment; avoid areas with high humidity, such as bathrooms.
  Container Security: Ensure the container is tightly sealed to prevent contamination and maintain the medication’s integrity.
• Child Safety: Keep children and pets out of reach to prevent accidental ingestion.
• Disposal of Unused Medication: Dispose of any unused or expired Activella properly, following local regulations or pharmacy guidelines. Do not flush medications down the toilet or throw them into household trash. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Activella?

When taking Activella, it’s important to be aware of potential interactions with other medications. These interactions can impact the effectiveness of your treatment or increase the risk of side effects. Some medications may alter how Activella works, while others may be affected by its presence in your system. Below is a list of key drug interactions to consider when using Activella.

• Anticoagulants (Blood Thinners): Estrogen-containing medications like Activella can affect blood clotting mechanisms. This may necessitate adjustments in the dosage of anticoagulants to maintain their therapeutic effect and prevent complications.
• Aromatase Inhibitors (e.g., Anastrozole, Exemestane, Letrozole): These medications are used to treat hormone-sensitive breast cancer by inhibiting estrogen production. Concurrently, using Activella with aromatase inhibitors may reduce the effectiveness of the cancer treatment due to opposing actions on estrogen levels.
• Selective Estrogen Receptor Modulators (SERMs) (e.g., Raloxifene, Tamoxifen): SERMs are used for osteoporosis and breast cancer prevention. Combining them with Activella may lead to conflicting effects on estrogen receptors, potentially diminishing the benefits of either medication.
• Anticonvulsants (e.g., Phenytoin, Carbamazepine): These drugs can induce liver enzymes that metabolize estrogens, potentially decreasing the effectiveness of Activella. This interaction may increase the risk of breakthrough bleeding or unintended pregnancy.
• Antibiotics (e.g., Rifampin, Rifabutin): Certain antibiotics can induce liver enzymes that metabolize estrogens, potentially decreasing the effectiveness of Activella. This interaction may increase the risk of breakthrough bleeding or unintended pregnancy.
• Antifungals (e.g., Itraconazole and Ketoconazole): These medications inhibit liver enzymes responsible for metabolizing estrogens, potentially increasing the body’s levels of Activella. This may heighten the risk of estrogen-related side effects.
• Antidepressants (e.g., Amitriptyline, Clomipramine): Some antidepressants can interact with hormonal therapies, potentially affecting their metabolism and efficacy. It’s important to monitor for any changes in mood or side effects when these medications are used together.
• Antidiabetic Medications (e.g., Metformin, Insulin): Estrogen therapy can influence glucose metabolism. Women with diabetes should monitor their blood sugar levels closely when starting or stopping Activella, as adjustments to their diabetes medication may be necessary.
• Antihypertensive Drugs (e.g., Lisinopril, Amlodipine): Estrogen can affect blood pressure regulation. To ensure optimal control, blood pressure should be regularly monitored when using Activella alongside antihypertensive medications.
• Herbal Supplements (e.g., St. John’s Wort): Some herbal supplements can induce liver enzymes that metabolize estrogens, potentially decreasing the effectiveness of Activella. It’s advisable to consult with a healthcare provider before combining herbal supplements with hormonal therapies. 

What Are the Other Activella Interactions?

• Grapefruit and Grapefruit Juice: Grapefruit can increase the blood levels of norethindrone, a component of Activella, potentially enhancing its effects and side effects. Therefore, it’s advisable to limit grapefruit consumption while taking this medication. 
• Tobacco Use: Smoking while taking Activella can elevate the risk of serious cardiovascular events, such as heart attacks and strokes. It’s recommended to avoid smoking during treatment. 
• Sunlight Exposure: Activella may increase sensitivity to sunlight, leading to skin reactions like melasma (dark, blotchy skin). Limiting sun exposure and using sunscreen is advisable. 
• Alcohol Consumption: While no specific interactions between alcohol and Activella are noted, excessive alcohol intake can exacerbate certain side effects, such as liver issues. Moderation is recommended.

[Note: This isn’t a complete list, and there could be other drugs that interact with Activella. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Activella Alternatives?

Exploring alternatives to Activella for hormone replacement therapy can provide various options tailored to individual health needs and preferences. Below is a detailed list of alternative medications, including combination therapies, estrogen—or progestin-only treatments, and non-hormonal options for symptom relief. 

• Combination of Estrogen and Progestin Therapies:

• • Climara Pro (estradiol/levonorgestrel)
  • FemHRT, Lopreeza, CombiPatch (estradiol/norethindrone)
  • Prempro, Premphase (conjugated estrogens/medroxyprogesterone)
  • Angeliq (estradiol/drospirenone)

• Estrogen-Only Therapies:

• Estrace (estradiol – oral)
• Vivelle-Dot, Alora, Minivelle, Menostar (estradiol – transdermal patch)
• Premarin (conjugated estrogens – oral and vaginal cream)
• Ogen (estropipate)
• Delestrogen (estradiol valerate)
• Vagifem, Estring (estradiol – vaginal tablet or ring)

• Progestin-Only Therapies (if needed to pair with estrogen):

• Provera (medroxyprogesterone acetate)
• Aygestin (norethindrone acetate)
• Prometrium (micronized progesterone)

• Bioidentical Hormone Therapies (Compounded or FDA-Approved):

• Bijuva (17β-estradiol/micronized progesterone)

• Non-Hormonal Alternatives (for symptom relief):
• Brisdelle (paroxetine – low-dose for hot flashes)
• Neurontin (gabapentin)
• Catapres (clonidine)
• Osphena (ospemifene – for vaginal symptoms)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Activella Cost & Coupons

Activella tablets are a trusted hormonal therapy for treating menopause symptoms such as hot flashes and osteoporosis prevention. They provide a combination of estrogen and progestin to help restore hormonal balance. However, the high retail cost of Activella in the US often strains monthly healthcare budgets. At Polar Bear Meds, we address this concern by offering Activella at significantly more affordable prices. Our pharmacy provides special discounts, including a first-order coupon for new customers, to make your purchase even more cost-effective. If you’re in the USA, buy Activella at coupon offer using code “WELCOMEPB10” during checkout.

Frequently Asked Questions

Can Activella be used as birth control?

No, Activella is not a birth control medication. It is a hormone replacement therapy (HRT) designed to relieve menopausal symptoms and help prevent osteoporosis in postmenopausal women. While it contains a combination of estrogen and progestin, similar to some birth control pills, it is not intended to prevent pregnancy. If you’re looking for birth control options, there are combined oral contraceptives (COCs) that contain estrogen and progestin combinations, like ethinyl estradiol and norethindrone, found in products such as Junel 1.5/30. Always consult your healthcare provider to find the right option for your needs.

Does Activella contain estrogen?

Yes, Activella contains estradiol, a type of estrogen. Estradiol helps relieve menopausal symptoms caused by decreased estrogen levels, such as hot flashes, night sweats, and vaginal dryness or irritation. Additionally, it supports bone health by helping to prevent bone loss associated with menopause.

Can Activella cause weight gain?

Some people have reported weight gain in clinical studies by taking Activella, though the exact cause is unclear. Research suggests that hormone replacement therapy (HRT), like Activella, is unlikely to cause weight gain due to increased body fat but may lead to temporary bloating from fluid retention. Menopause-related changes in the body are more commonly linked to weight gain than HRT itself. If you’re concerned about weight changes while using Activella, discuss your concerns with your healthcare provider.

Can Activella cause hair loss?

Some people have reported hair loss on the scalp after starting Activella, though it’s unclear if this is directly caused by the medication or related to menopause itself. Hormonal changes during menopause can often lead to hair thinning and slower growth. If you’re concerned about hair loss while using Activella, consult your healthcare provider for guidance and potential solutions.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Activella online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Activella online at a substantial cost, call us at 1-888-779-2193 toll-free.