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Estradot is an FDA-approved hormone replacement therapy containing estradiol, used to alleviate menopausal symptoms like hot flashes and vaginal dryness. The patches, available in 25 mcg, 50 mcg, 75 mcg, and 100 mcg strengths, are applied to the lower stomach or upper buttocks. Dosage varies; follow your doctor’s instructions. Common side effects include skin irritation and breast tenderness. Serious risks include blood clots and heart issues. Store patches in a cool, dry place and dispose of them safely. Estradot supplements estrogen levels in the body, reducing menopausal symptoms. Consult a licensed medical practitioner for proper use and precautions. You can buy Estradot online at the best prices from reputable sources. 

Product Overview

Estradot contains estradiol, a form of estrogen identical to what the ovaries produce naturally. Estradot is used in hormone replacement therapy to relieve symptoms of menopause, including hot flashes, vaginal dryness, and night sweats. By supplementing the body with estrogen, it alleviates symptoms caused by decreased hormone levels during menopause. Estradot patches come in four strengths: 25 mcg, 50 mcg, 75 mcg, and 100 mcg. 

The patches are rectangular with rounded corners and are applied to the skin. The dosage varies per individual, so follow your doctor’s instructions precisely. This medication is not suitable for children. Apply the Estradot patch to a clean, dry, hairless area of the lower stomach or upper buttocks. Avoid applying to the breasts or irritated skin. Replace the patch twice weekly, alternating the application site to avoid skin irritation. Common side effects include skin irritation, breast tenderness, nausea, headache, and mood changes. 

Severe side effects, including blood clots, heart issues, and certain cancers, require immediate medical attention. Discuss your complete medical history with your doctor before using Estradot. Regular checkups are crucial to monitor your response to the treatment. If you miss a dose, you should apply a new patch as soon as you remember but do not double up on patches. Store Estradot in a cool, dry place away from children and pets. Dispose of used patches properly to avoid accidental exposure. Always consult a licensed healthcare provider with any concerns or questions about using Estradot.

What Are the Uses of Estradot?

Estradot is a hormone replacement therapy used for: 

  • The short-term relief of symptoms of menopause

What Are the Forms & Strengths of Estradot?

Estradot is available in the form of rectangular patches with rounded corners, which come in four strengths: 

  • 25 mcg
  • 50 mcg
  • 75 mcg
  • 100 mcg

What Are the Recommended Dosage of Estradot?

The dosage of Estradot varies from person to person. You should follow your doctor’s instructions or the instructions that come with your prescription label. If your dosage is different, do not change it unless instructed otherwise by your doctor. The amount of medicine you take depends on the medication’s strength. Also, the dose frequency, the gap between two doses, and the duration of your medication dose are based on the medical problem you are receiving treatment for. This medication is not indicated for use in children. 

For Hot Flashes & Other Symptoms Caused by Menopause
  • Climara: The initial recommended dose is one patch of 0.025 mg applied to the lower stomach or upper buttocks once weekly. Your doctor may make dosage adjustments if necessary. 
  • Minivelle and Vivelle-Dot: First, you should apply Estradot transdermal system 0.0375 mg daily to the skin of the lower stomach or upper buttocks twice weekly (every three to four days). Your doctor may make dosage adjustments if necessary.
For Prevention of Osteoporosis After Menopause
  • Climara: Initially, one patch of 0.025 mg should be applied to the lower stomach or upper buttocks once weekly. Your doctor may make dosage adjustments if necessary. 
  • Minivelle and Vivelle-Dot: The initial recommended dose is 0.025 mg daily, applied to the skin of the lower stomach or upper buttocks twice weekly (every three to four days). Your doctor may make dosage adjustments if necessary.
For the Treatment of Low Estrogen Levels
  • Once weekly, apply one patch of 0.025 mg to the lower stomach or upper buttocks. Your doctor may make dosage adjustments if necessary.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Estradot?

  • You should use Estradot patches exactly as your doctor directed. You should not use them more or less than prescribed, more frequently, in large quantities, or longer than prescribed. Doing so may cause unwanted side effects. 
  • This medication is for transdermal use only. You should not get it in your eyes, mouth, nose, vagina or breasts. Do not apply it to damaged skin. Do not use it on torn, cut, burned, or scraped areas. If it does get on such areas, you should rinse it off immediately with plenty of water. 
  • Before using this medication, you should carefully read and follow the instructions for use and patient information leaflet that came along with your prescription. 
  • Ask your doctor, healthcare provider, or pharmacist if you have any questions or if you need help understanding any part of the information insert. 
  • You should properly wash your hands using soap and water before and after applying Estradot patches. 

To use the patch properly, follow the instructions given below:

  • When ready to apply the patch to your skin, carefully tear open the pouch.
  • Do not cut it. 
  • Once the patch has been safely opened, remove the backing and apply it to a dry, clean, dry, and hairless area of the skin’s lower stomach or upper buttock area. This skin area should be free of oil, powder, and lotion for the patch to stick. 
  • Firmly press the patch in place with your hand for about ten seconds. 
  • You should not apply the patch to your breasts, vagina, or over any other skin folds. You should not apply the patch on oily, burned, broken, irritated skin or areas with skin conditions such as tattoos or birthmarks. 
  • Avoid applying the Estradot patch on your waistline or places where tight clothes may rub it off. 
  • Always wear the patch until it is time to put on a new one. Do not expose it to the sun for an extended period. 
  • While replacing the patch, you should apply the new patch to a different area of your lower stomach.
  • Wait at least one week before applying the patch to the same skin area. 
  • While changing an old patch for a new one, you should carefully and slowly peel the old patch. Let any remaining patch adhesive on your skin dry for fifteen minutes, then gently rub the sticky patch area with lotion or oil to remove it. Changing your patch on the same days of the week works best to help you remember it. 
  • While using the Estradot patch, you may take a bath, shower, or swim. Doing so will not affect your Estradot patch. 
  • Each Estradot patch contains enough estradiol for three to four days, so change it twice weekly on the same days. 
  • If your patch falls off, you should put it back in a different area. If the patch does not completely stick, you should put on a new patch but continue to follow your original schedule for replacing the patch. 
  • To dispose of the used patch, fold it in half with the sticky side together and place it in a child-proof container made of hard plastic with a tightly fitting lid. Throw this container in the garbage bin, away from the reach of children and pets. 
  • You should not flush the patch down the toilet. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Estradot Work?

Estradot patches are a type of HRT or hormone replacement therapy that contain estradiol, an identical form of estrogen to what the ovaries naturally produce. These patches work by adding back the estrogen that the ovaries no longer produce during perimenopause and menopause. This allows it to travel throughout the entire body, relieving a wide range of symptoms associated with falling estrogen levels. Most people start with the 50mcg dose, but adjustments may be necessary based on symptom improvement. 

Important Safety Information for Using Estradot

What Are the Side Effects of Estradot?

Like every other medication, Estradot may cause some side effects. These side effects do not require medical attention and can be managed by themselves within a few days. The side effects given below are not experienced by everyone who applies Estradot patches. If you are concerned about the side effects of this medication, discuss the risks & benefits of this medication with your healthcare provider. If these symptoms persist or have become bothersome, you should discontinue this medication and call your doctor immediately. Common side effects of Estradot may include:

  • Breast tenderness or pain
  • Nausea
  • Headache
  • Abdominal pain or bloating
  • Mood changes, including irritability or depression
  • Skin irritation: Itching, redness, or rashes at the application site
  • Fluid retention causing swelling in the feet, hands, or ankles
  • Vaginal discharge or spotting
  • Changes in libido
  • Hair changes (thinning or increased growth)

In rare cases, Estradot can cause serious side effects, which may be severe or fatal if you do not seek immediate medical attention. If you experience any of the following side effects, you should check with your doctor as soon as possible. It’s important to note that the benefits of Estradot may outweigh the risks for many women, particularly those with severe menopausal symptoms. Serious side effects that could result from Estradot include:

  • Blood clots: Patients are more likely to develop pulmonary embolism & deep vein thrombosis (DVT). Symptoms may include sudden chest pain, shortness of breath, leg pain, or swelling.
  • Cardiovascular issues: Increased risk of heart attack or stroke. Its symptoms may include chest pain, weakness on one side of the body, difficulty speaking, and sudden severe headache.
  • Breast cancer: Slightly increased risk, especially with long-term use. Its symptoms may include breast lumps, nipple discharge, and changes in breast appearance.
  • Endometrial cancer: Increased risk in women with an intact uterus who use estrogen-only therapy. Its symptoms may include abnormal vaginal bleeding, pelvic pain.
  • Gallbladder disease: Increased risk of gallstones. Its symptoms may include nausea, severe abdominal pain, and vomiting.
  • Liver problems are rare, but they can occur. Symptoms may include yellowing of skin or eyes, dark urine, and abdominal pain.
  • Severe allergic reactions to Estradot patches are rare but can be lethal if not properly treated. Its symptoms may include difficulty breathing and swelling of the face, lips, tongue, or throat.
  • Women over 65 starting hormone therapy have a possible increased risk of dementia. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Estradot? 

  • Before taking estrogen replacement therapy, share your complete medical history with your doctor, especially if you have any allergies or medical conditions or are taking other medications. Let your doctor know if you are pregnant, planning to become pregnant, or breastfeeding. Here are key details:
  • WHI study findings: Postmenopausal individuals taking 0.625 mg conjugated equine estrogens and 2.5 mg medroxyprogesterone for five years had increased risks of heart attack, stroke, breast cancer, and blood clots compared to those on a placebo. Similar risks are assumed for other hormone replacement products.
  • Dosage and duration: Use the lowest dose for the shortest duration to manage menopausal symptoms, as directed by your doctor. Do not use it to prevent heart disease, heart attacks, or strokes.
  • Allergy: Rare skin reactions can occur. Discontinue use and call your doctor if you experience itching or redness.
  • Blood clotting disorders: There is a higher risk of blood clots in the lungs & legs. Avoid if you have had heart disease, stroke, or conditions increasing clot risk. Stop medication four weeks before major surgery.
  • Blood pressure: This can raise blood pressure. Regular monitoring is recommended.
  • Bone disease: If you have bone disease, discuss monitoring with your doctor.
  • Cancer risks: Long-term use increases breast and ovarian cancer risks. Regular breast examinations are advised. Avoid if you have a history of breast cancer.
  • Dementia: Increased risk over age 65. Discuss with your doctor.
  • Diabetes: Can affect blood glucose control. Monitor levels closely.
  • Endometrial cancer: Increased risk with estrogen therapy. Taking progestin reduces this risk.
  • Endometriosis: Can worsen the condition. Discuss with your doctor.
  • Fibroids: May cause enlargement and pain. Contact your doctor if symptoms worsen.
  • Fluid retention: This can be dangerous for those with heart or kidney issues. Discuss with your doctor.
  • Follow-up examinations: Regular checkups are necessary.
  • Gallbladder disease: May increase risk. Discuss with your doctor.
  • Heart disease and stroke: Increased risk. Seek immediate medical attention if symptoms occur.
  • High cholesterol or triglycerides: Monitor levels regularly.
  • Kidney function: This can affect calcium and phosphorus use. Discuss with your doctor.
  • Liver function: Special monitoring may be needed. Avoid if you have active liver disease.
  • Migraines: Avoid if you have migraines with aura. Discuss changes with your doctor.
  • Seizures: May increase risk. Discuss monitoring with your doctor.
  • Thyroid disease: This can affect thyroid hormone use. Discuss with your doctor.
  • Pregnancy & breastfeeding: Avoid use during pregnancy and breastfeeding. Contact your doctor if you become pregnant.
  • Children: Safety and efficacy not established for children.

What Are the Estradot Precautions?

  • Before using Estradot, share your complete medical and family history with your doctor, especially if you have the following conditions:
    • Endometriosis
    • Family history of breast cancer
    • Nodules, cysts, or lumps in your breasts or any other benign condition of the breasts
    • Fibroids or other benign tumors of the uterus
    • High blood pressure
    • Previous pregnancy loss
    • Kidney, heart, or liver problems
    • Asthma
    • Epilepsy
    • Hearing loss due to otosclerosis
    • Diabetes
    • Migraine or severe headaches
    • Gall bladder problems
    • High triglycerides
    • Systemic lupus erythematosus
    • Low calcium levels
    • Bone disease causing high calcium levels
    • History of jaundice or itchy skin
    • Skin condition worsened by patches
    • Hypothyroidism
    • Severe allergic reactions
    • Hereditary angioedema
  • Visit your doctor regularly (every 3-6 months) for checkups, including breast exams, pelvic exams, and mammograms.
  • Using Estradot during pregnancy can harm the fetus. Call your doctor immediately if you think you may be pregnant.
  • Estradot may increase the risk of strokes, blood clots, heart attacks, and cancers (breast, uterine, endometrial). Do not use it if you’ve had a hysterectomy. Contact your doctor or healthcare provider at once if you develop abnormal vaginal bleeding or symptoms like double vision, severe headache, confusion, difficulty speaking, or inability to move.
  • Estradot may increase the risk of dementia and gallbladder disease. Discuss potential risks with your doctor.
  • Inform your doctor about all the medications you are using, including prescription, non-prescription, over-the-counter drugs, and herbal supplements, especially if you are planning surgery. Estradot may affect medical test results.
  • Seek medical attention immediately if you have serious headaches, vision changes, or severe allergic reactions (itching, rash, hoarseness, difficulty breathing, swelling).
  • If your child develops breast swelling or tenderness, contact a doctor immediately.
  • Avoid allowing pets to lick or touch the application area; contact a veterinarian if they show signs of illness.
  • Do not take other medications or drink grapefruit juice without consulting your doctor.

What Are the Contraindications of Estradot?

Estradot has specific contraindications that you should be aware of. Consult your physician, pharmacist, or healthcare provider if you have any of the following conditions:

  • Breast or uterine cancer
  • Blood clots 
  • Estrogen-dependent neoplasia 
  • Active deep vein thrombosis or pulmonary embolism 
  • Active arterial thromboembolic disease 

What If You Missed a Dose of Estradot?

  • If you forget to apply or change a patch, you should put on a new one as soon as you remember. 
  • If it is almost time to wear a new patch, you should wait until the scheduled day to apply it and omit the one you missed. 
  • You should not apply extra patches to compensate for the missed dose.
  • You should try setting a reminder on your phone to prevent missing doses. Medication reminders work best for this purpose. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Estradot?

If you have taken Estradot more than the prescribed dose or if you suspect you may have had a medication overdose, you should seek immediate medical attention. However, due to the way this medication is used, an overdose is unlikely to occur. However, if you have accidentally used Estradot more than recommended, you should call your doctor or 911 immediately. You can also head to the nearest emergency room. Swallowing an Estradot patch may cause vomiting and nausea. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store an Estradot?

  • You should keep Estradot patches in their original packaging until you can use them. 
  • Keep it in a cool, dark, and dry place, away from direct sunlight, excess heat, and moisture. 
  • Do not allow it to freeze.
  • Do not keep Estradot or other medication in the bathroom or near the sink. 
  • Do not expose it to extreme temperatures, such as in the freezer, car window, or trunk. 
  • Keep the patches in a safe place, away from the sight and reach of children. 
  • Do not keep medications that are outdated or no longer needed. Discard them safely. 
  • To dispose of the used patch, fold it in half with the sticky side together and place it in a child-proof container made of hard plastic with a tightly fitting lid. Throw this container in the garbage bin, away from the reach of children and pets. 
  • Do not flush the patch, pour it down the drain, or throw it in wastewater, as these actions may pollute the water. 
  • If you have Estradot patches that have passed their expiration date or are no longer needed, you should consult your healthcare provider or physician about what to do with the leftover patches. 
  • You can also contact the local waste disposal company for instructions on properly discarding unwanted medications. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Estradot?

Although certain medications should not be used together, there are instances where two different medications might be used concurrently despite potential interactions. In such cases, your doctor may adjust the dosage or take other necessary precautions. When taking this medication, your healthcare provider should know whether you are using any of the following medicines: The interactions listed below are based on their potential significance and are not exhaustive.

Medications Not Recommended

Using this medication with the following is not recommended. Your doctor may choose not to treat you with this medication or may modify your other medications:

  • Tranexamic Acid
Medications Usually Not Recommended but May Be Required

Using this medication with the following is generally not recommended but might sometimes be necessary. If both medications are prescribed together, your doctor may adjust the dosage or frequency of one or both:

  • Abametapir
  • Amifampridine
  • Amoxicillin
  • Ampicillin
  • Amprenavir
  • Apalutamide
  • Aprepitant
  • Armodafinil
  • Artemether
  • Bacampicillin
  • Belzutifan
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Bupropion
  • Carbamazepine
  • Carbenicillin
  • Cefaclor
  • Cefadroxil
  • Cefdinir
  • Cefditoren
  • Cefixime
  • Cefpodoxime
  • Cefprozil
  • Ceftazidime
  • Ceftibuten
  • Cefuroxime
  • Cenobamate
  • Ceritinib
  • Clarithromycin
  • Clobazam
  • Cloxacillin
  • Colesevelam
  • Conivaptan
  • Cosyntropin
  • Cyclacillin
  • Cyclosporine
  • Dabrafenib
  • Darunavir
  • Dexamethasone
  • Dicloxacillin
  • Donepezil
  • Doxycycline
  • Efavirenz
  • Elagolix
  • Elvitegravir
  • Enasidenib
  • Encorafenib
  • Enzalutamide
  • Eslicarbazepine Acetate
  • Etravirine
  • Fedratinib
  • Fexinidazole
  • Fosamprenavir
  • Fosaprepitant
  • Fosnetupitant
  • Fosphenytoin
  • Griseofulvin
  • Guar Gum
  • Isotretinoin
  • Itraconazole
  • Ivosidenib
  • Lesinurad
  • Lixisenatide
  • Lorlatinib
  • Lumacaftor
  • Mavacamten
  • Meropenem
  • Minocycline
  • Mitapivat
  • Mitotane
  • Mobocertinib
  • Modafinil
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nafcillin
  • Nelfinavir
  • Netupitant
  • Nevirapine
  • Octreotide
  • Oxacillin
  • Oxcarbazepine
  • Oxytetracycline
  • Penicillin G
  • Penicillin G Procaine
  • Penicillin V
  • Phenobarbital
  • Phenylbutazone
  • Phenytoin
  • Pitolisant
  • Pixantrone
  • Prednisolone
  • Prednisone
  • Primidone
  • Repotrectinib
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rufinamide
  • Secobarbital
  • Somatrogon-ghla
  • St John’s Wort
  • Sugammadex
  • Sultamicillin
  • Tazemetostat
  • Telaprevir
  • Tetracycline
  • Theophylline
  • Ticarcillin
  • Tigecycline
  • Tirzepatide
  • Tizanidine
  • Topiramate
  • Ulipristal
  • Valproic Acid
Medications That May Cause Increased Side Effects

Using this medication with the following may increase the risk of certain side effects. However, using both drugs might be the best treatment option. If both are prescribed together, your doctor may adjust the dosage or frequency of one or both:

  • Atazanavir
  • Diazepam
  • Ginseng
  • Lamotrigine
  • Levothyroxine
  • Licorice
  • Lorazepam
  • Selegiline
  • Tacrine
  • Temazepam
  • Tipranavir
  • Triazolam
  • Troleandomycin
  • Voriconazole
  • Warfarin

What Are the Other Estradot Interactions?

Certain medications should not be taken with food or specific types of food due to potential interactions. Similarly, using alcohol or tobacco with certain medications can also cause interactions. The following interactions are listed due to their potential importance and are not exhaustive.

Food, Alcohol, and Tobacco Interactions
  • Using this medication with the following substances may increase the risk of certain side effects, but in some cases, it might be necessary. If they are used together, your doctor may adjust the dosage or frequency of this medication or provide specific instructions regarding the use of food, alcohol, or tobacco:
    • Caffeine

[Note: This isn’t a complete list, and there could be other drugs that interact with Estradot. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Estradot Alternatives?

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Estradot Cost & Coupons

The cost of Estradot and ways to obtain it at a lower price can vary significantly based on several factors, including insurance coverage. Many individuals find that their insurance does not cover Estradot for hormone replacement therapy, leading to substantial out-of-pocket expenses. To reduce these costs, some people opt for services like Polar Bear Meds, which allow them to purchase Estradot from Canadian pharmacies at a lower price. Additionally, new customers can benefit from a 10% discount on their first order by using the coupon code WELCOMEPB10. Exploring these options can help manage Estradot’s financial burden.

Frequently Asked Questions

How do I manage the side effects caused by Estradot?

Common side effects like skin irritation can often be managed by applying the patch to a different, clean, dry, and hairless area each time. Rotating application sites can help prevent irritation. If you experience breast tenderness, nausea, or mood changes, discuss these symptoms with your healthcare provider. They might adjust your dosage or suggest additional treatments to alleviate these side effects. For serious side effects such as severe headaches, chest pain, or sudden vision changes, seek immediate medical attention.

What are the long-term effects of using Estradot?

Long-term use of Estradot can lead to an increased risk of serious health conditions, including blood clots, stroke, heart attack, breast cancer, and endometrial cancer. It is crucial to make regular follow-up appointments with your physician or healthcare provider to look out for these risks. Additionally, your doctor may recommend periodic mammograms, pelvic exams, and blood pressure checks. Always discuss any new or unusual symptoms with your doctor promptly.

Can Estradot be used in conjunction with other medications?

Estradot can interact with various medications, including antibiotics, anticonvulsants, and certain herbal supplements, such as St. John’s Wort. It is important to provide your healthcare provider with a complete list of all the medications and supplements you are currently taking. Your doctor might need to adjust the dosages or monitor your symptoms more closely for side effects. Alternative therapies may be recommended in some cases to avoid potential interactions.

What should I do if my Estradot patch falls off?

If your Estradot patch falls off, try reapplying it to a clean, dry, and free-of-hair skin area. If the patch does not stick, apply a new one. Do not use tape or other adhesives to reattach the patch. Continue to follow your original schedule for replacing patches, even if you have to apply a new one early. If you frequently have problems with patches falling off, discuss this with your healthcare provider, as they may have additional recommendations.

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