Entresto

Entresto (sacubitril and valsartan) is a prescription medication used to treat long-term heart failure in adults and symptomatic heart failure in pediatric patients aged 1 year and older with left ventricular systolic dysfunction. It combines two blood pressure-lowering medicines, sacubitril and valsartan, that work together to help reduce the chances of cardiovascular death and hospitalization due to heart failure.

Quick Facts About Entresto

Entresto doses for heart failure depend on age, weight, and individual health factors. Here is a quick overview of the FDA dosage recommendations for adults and children.

Entresto Dosage for Adults

Entresto Dosage for Children

Pediatric doses can vary based on body weight. Take the recommended Entresto doses twice daily.

Entresto contains two medications, sacubitril and valsartan, that help the heart pump blood more effectively and reduce strain on the cardiovascular system.

• Sacubitril, a neprilysin inhibitor, increases beneficial peptides like ANP and BNP that relax blood vessels and remove excess sodium and fluid, helping the heart work more efficiently.
• Meanwhile, valsartan, an angiotensin II receptor blocker (ARB), blocks angiotensin II, a hormone that tightens blood vessels and raises heart workload.
• This combined action helps lower blood pressure, reduce fluid buildup, and help prevent heart failure complications, such as hospitalization and heart-related death.

• Using Entresto during the second and third trimesters of pregnancy can cause fetal harm.
• Valsartan, one of Entresto’s active ingredients, is an angiotensin II receptor blocker (ARB), which can impair fetal kidney function and development if used during pregnancy.
• Adverse fetal outcomes reported include fetal hypotension, renal failure, oligohydramnios (low amniotic fluid), skull hypoplasia, and neonatal death.
• Pregnant women or those who are planning a pregnancy should be informed about the potential Entresto pregnancy warning signs during treatment.

• Before taking Entresto for heart failure, tell your doctor if you have:
  • Low blood pressure
  • Kidney disease
  • Liver impairment
  • High potassium
• Black patients and anyone with a history of angioedema from ACE inhibitors/ARBs are at higher risk of angioedema.
• Low blood pressure may occur, especially in patients on diuretics or those with low blood volume.
• Take the medicine only as prescribed.
• Avoid potassium supplements and potassium-based salt substitutes unless your doctor instructed otherwise.
• Do not use Entresto for heart failure if you:
  • Take the medication with an ACE inhibitor, or within 36 hours after the last dose of an ACE inhibitor.
  • Had angioedema caused by ACE inhibitors or ARBs.
  • Have diabetes and take medicines that contain aliskiren.
• Keep a close check on your kidney function and potassium levels.
• If you missed a dose, take it as soon as possible unless the next dose is due soon.
• Stick to your dosing schedule. An overdose of Entresto may cause hypotension. If you notice overdose symptoms, such as dizziness, fainting, blurred vision, unusual weakness, or nausea, call a poison control center right away.

Entresto has several drug interactions, some of which are as follows:

• Angiotensin-Converting Enzyme (ACE) Inhibitors:
  • Zestril (lisinopril)
  • Vasotec (enalapril)
  • Altace (ramipril)
  • Lotensin (benazepril)
• Angiotensin II Receptor Blockers (ARBs):
  • Atacand (candesartan)
  • Avapro (irbesartan)
  • Benicar (olmesartan)
• Aliskiren

• Lisinopril
• Diovan (valsartan)
• Atacand (candesartan)
• Cozaar (losartan)
• Vasotec (enalapril)
• Prinivil or Zestril (lisinopril)
• Altace (ramipril)
• Monopril (fosinopril)

Entresto (sacubitril/valsartan) is often the first-line option for heart failure with reduced ejection fraction (HFrEF). In the PARADIGM-HF clinical trial, Entresto has shown to reduce the risk of cardiovascular death or first heart failure hospitalization by about 20% vs enalapril, and all-cause mortality by 16%

• Actual costs may vary by pharmacy, insurance coverage, coupons, and pharmacy network.
• Prices shown above are based on recent online pharmacy listings and do not guarantee availability or discounts.

• Our medications are supplied through a network of licensed Canadian pharmacies for safety and authenticity.
• Enjoy lower pricing than typical U.S. retail rates.
• We provide refill support and long-term treatment guidance for heart failure management.
• Use the Entresto coupon code ‘WELCOMEPB10’ to save up to 10%.
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