Estradiol 

Buy Estrogel Online 

Estrogel is an FDA-approved topical gal used to alleviate menopausal symptoms such as irritation, hot flashes, vaginal dryness, and burning. It contains estradiol, which is absorbed into the bloodstream, helping to balance estrogen levels in the body, which can improve overall comfort and quality of life during menopause. It comes in the form of a metered-dose pump of Estrogel that dispenses 1.25 grams of gel containing 0.75 mg of estradiol. Consult a licensed medical professional for personalized advice and guidance on dosage, usage, storage, and more. 

Product Overview

Estrogel is a topical gel containing estradiol, a form of estrogen used to alleviate menopausal symptoms such as hot flashes, vaginal dryness, irritation, and burning. When applied to the skin, estrogen is absorbed into the bloodstream, helping to balance estrogen levels in the body, which can improve overall comfort and quality of life during menopause.

Each metered-dose pump of Estrogel dispenses 1.25 grams of gel containing 0.75 mg of estradiol. The recommended dosage for treating moderate to severe menopausal symptoms is typically 1.25 grams daily, but this may vary based on individual needs and should be customized by a healthcare provider. Estrogel is suitable for postmenopausal women experiencing estrogen deficiency symptoms and works by replenishing estrogen levels to alleviate these symptoms.

Common side effects of Estrogel include breast tenderness, nausea, headaches, and skin irritation at the application site. More severe side effects may include stroke, blood clots, and certain cancers. Users should follow their doctor’s instructions carefully, applying the gel to clean, dry skin, usually on the arms, and avoiding breasts. Washing hands thoroughly after application is essential to prevent accidental transfer to others. If a dose is missed, it should be applied as soon as remembered unless it is almost time for the next dose. Do not double the dose. Estrogel overdose symptoms may include nausea, vomiting, and vaginal bleeding. In such cases, seek immediate medical attention. Store Estrogel at a controlled room temperature, away from moisture, light, and heat, and out of reach of children and pets. Proper disposal of unused medication should be discussed with a healthcare provider. Regular medical check-ups are advised to monitor treatment effectiveness and safety. 

What Are the Uses of Estrogel?

It is used to:

• Provide relief from certain symptoms of menopause, such as hot flashes, vaginal dryness, irritation, and burning 

What Are the Forms & Strengths of Estrogel?

It is available in the form of estradiol gel supplied in a non-aerosol, metered-dose pump and comes in the following strengths:

• 1.25 g of gel containing 0.75 mg of estradiol

What Are the Recommended Dosage of Estrogel?

For Treating Moderate to Severe Menopausal Symptoms 

• The recommended dosage of Estrogel is 1.25 mg daily

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Estrogel? 

• Before using Estrogel, you should carefully read and follow the directions given in the patient information leaflet and medication guide that came with your prescription. If you have any queries or concerns or if you do not understand any part of the leaflet, ask your doctor. 
• Use this medication exactly as recommended by your physician. Do not use more of it, in large quantities, or more frequently. 
• Estradiol can increase your risk of uterine cancer. To reduce your risk of cancer of the uterus, your doctor may prescribe you to take progestin while you are using estradiol. If you experience vaginal bleeding, inform your doctor immediately. 
• Apply the gel to only the clean, dry, and unbroken part of your skin. Do not apply it to an irritated, damaged, or red area. You should not apply this medication to your breasts. 

To use Estrogel effectively, follow the instructions given below:

• Before using this metered pump, you should properly prime it first. Remove the cover of the large pump and fully depress it twice for the 93-gram pump or thrice for the 50-gram pump and 25-gram pump. Dispose of the unused estrogel by simply rinsing it under the sink or throwing it in the household garbage bin in such a way that prevents accidental exposure or ingestion by children, animals, and others. 
• After priming, the pump is ready for use. One complete depression of the pump will dispense the same amount of Estrogel every time. 
• Apply the gel around the same time each day. Apply your daily recommended dose of Estrogel to a dry, clean, and unbroken part of your skin. If you take a bath or use a sauna or shower, apply the gel after your bath, sauna, or shower. If you go swimming, try to leave as much time as possible between applying Estrogel and swimming. 
• Make sure that your skin is completely dry before applying the gel. 
• To apply the medication, collect the gel into your palm by firmly pressing the pump with one fluid motion without hesitating. 
• Use your hand to apply the Estrogel to one arm. Spread the gel as thinly as possible over the whole area on the inside and outside of your arm, from wrist to shoulder. 
• Do not apply Estrogel directly to your breast. 
• Always place a cap on the tip of the pump & the large pump cover over the top of the pump after every use. 
• Properly wash your hands with soap and water after applying the gel to decrease the chance that it will spread from your hands to other people. 
• It is not important to rub or massage in Estrogel. Simply allow estrogel to dry for up to 5 minutes before dressing. 
• This gel is flammable. Avoid smoking or exposing your skin to an open flame until the medication has completely dried on your skin. 
• Properly wash your hands with soap and water after applying this gel. Avoid allowing others, especially children, to touch or get the gel on your skin. If this happens, wash the area properly with soap and water. Cover the area where you applied the cream with clothing to prevent others from coming into contact with the gel. 
• Your doctor may check your progress regularly to determine whether this medication is working well for you and whether you should continue receiving treatment with Etrogel. 
• You may also be required to self-examine your breast every month to look for lumps and have mammograms on a regular basis while using estradiol. 
• Tell your doctor if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Estrogel Work?

Estrogel is primarily used to reduce certain menopausal symptoms. When applied to the skin, the estradiol in Estrogel is absorbed through the skin into the bloodstream. Once in the bloodstream, estradiol circulates throughout the body, binding to estrogen receptors in various tissues. By increasing estrogen levels, Estrogel can help alleviate symptoms associated with low estrogen, including hot flashes, vaginal dryness, and bone loss.

Important Safety Information for Using Estrogel

What Are the Side Effects of Estrogel?

Similar to other medications, Estrogel may also cause certain side effects in people using it. These side effects are not usually severe and disappear within a few days or weeks as your body starts adjusting to this medication. If you are concerned about side effects caused by this medication, you can consult your doctor or healthcare provider to learn how you can prevent or manage these side effects. Common side effects caused by Estrogel are given below: 

Common Side Effects of Estrogel: 

• Breast tenderness or pain
• Nausea
• Headache
• Bloating
• Fluid retention
• Vaginal discharge or spotting
• Mood swings
• Skin irritation at the application site

Mild Side Effects of Estrogel: Mild side effects caused by Estrogel don’t usually require medical attention and disappear within a few days or weeks. Report any new or worsening symptoms immediately to your doctor. The mild side effects caused by Estrogel are given below. 

• Weight changes
• Hair changes (thinning or increased growth)
• Changes in libido
• Mild dizziness
• Leg cramps
• Stomach upset or mild abdominal pain
• Mild acne or skin changes
• Fatigue
• Mild depression or anxiety
• Increased vaginal infections

Serious Side Effects of Estrogel: In rare cases, Estrogel may cause severe side effects in some people. These side effects require prompt medical attention & may become fatal if not treated properly. Regular check-ups & open communication with a healthcare provider are essential. If you experience any of the symptoms given below, you should immediately call your doctor, 911, or poison control helpline. You can also head to the nearest emergency room. 

• Blood clots (pulmonary embolism (PE) or deep vein thrombosis (DVT)). Its symptoms may include swelling, warmth, redness, pain in one leg (DVT), shortness of breath, chest pain, and coughing blood. (pulmonary embolism)
• Stroke. Its symptoms may include sudden numbness or weakness in the face, leg, or arms, confusion, difficulty speaking or understanding, vision problems, severe headache, dizziness, and loss of balance or coordination.
• Heart attack. Its symptoms may include chest pain or pressure, shortness of breath, nausea, cold sweat, lightheadedness, and pain spreading to the arm, jaw, or back. 
• Breast cancer. Its symptoms may include changes in breast size or shape, breast pain, a lump in the breast or underarms, nipple discharge, and skin changes on the breast. 
• Endometrial cancer. Its symptoms may include abnormal vaginal bleeding or discharge, pelvic pain, and pain during intercourse. 
•  Gallbladder disease. Symptoms may include nausea, severe abdominal pain, fever, vomiting, and jaundice.
• Severe liver problems. Symptoms may include dark urine, jaundice, abdominal pain, nausea, and loss of appetite. 
• Dementia is a common condition in elderly women. Symptoms may include memory loss, difficulty solving problems, confusion, and changes in mood or behavior. 
• A severe allergic reaction may occur. Symptoms may include a rash, itching, swelling in the face, tongue, throat, ankles, and legs, severe dizziness, and difficulty breathing. 
• Vision changes or loss. Symptoms may include sudden vision loss, double vision, and bulging eyes. 
• Severe abdominal pain 
• Unusual vaginal bleeding
• Severe depression. Symptoms may include persistent sadness, changes in sleep or appetite, loss of interest in activities, or thoughts of self-harm or suicide. 
• Hypertension. Symptoms may include nosebleeds, chest pain, severe headaches, and difficulty breathing. 

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]

Are There Any Warnings for Estrogel?

• You should not use this medication if you have a history of stroke, heart attack, abnormal vaginal bleeding, blood clot, liver disease, bleeding or blood-clotting disorder, history of allergic reaction to estradiol, or hormone-related cancer such as breast cancer or cancer of the uterus. 
• You should not use this medication if you are pregnant. 
• This medication may increase your risk of developing certain conditions that can lead to cancer of the uterus. Immediately call your doctor if you experience any usual vaginal bleeding while using this medication. 
• You should not allow children to come into contact with skin areas where you have applied the gel. This medication is absorbed through the skin and may cause unwanted side effects in the child who comes into contact with this medication or with the skin where this medication was applied. 
• Estrogel should not be used to prevent heart disease, stroke, or dementia, as it may increase your risk of developing these conditions. Long-term use of this medication may increase your risk of developing blood clots or breast cancer. 
• The risk of severe side effects may depend on the Estrogel dose and duration of use. Estrogel should be used at the lowest dose possible and for the shortest time possible. Discuss the use of this medication with your physician regularly to determine if you still need to use it. If you have been using Estrogel for a long time, you should make regular visits to your doctor and have regular physical exams as directed by your doctor. 

What Are the FDA Boxed Warning for Estrogel?

A boxed warning for Estrogel has been issued by the FDA due to the following risks:

Endometrial Cancer

• If you have unusual, ongoing, or recurring abnormal vaginal bleeding, doctors should conduct proper tests, including a sample of the endometrial lining, to rule out cancer.
• Cardiovascular and Other Risks: Preventing dementia or cardiovascular disease with estrogens- with or without progestins is not advised.
• The Women’s Health Initiative (WHI) study found that using estrogen alone increased the risks of stroke and blood clots (DVT) in women aged 50-79 over about 7 years of treatment with daily oral conjugated estrogens (0.625 mg), compared to those taking a placebo.
• The WHI study also found that using estrogen plus progestin increased the risks of heart attack, stroke, breast cancer, pulmonary embolism (blood clot in the lungs), and DVT in women aged 50-79 over about 5.6 years of treatment with daily oral conjugated estrogens combined with medroxyprogesterone acetate, compared to a placebo.

Dementia

• The Women’s Health Initiative Memory Study (WHIMS), part of the WHI, found an increased risk of developing probable dementia in women aged 65 or older during about 5 years of treatment with daily oral conjugated estrogens (0.625 mg), alone or combined with 2.5 mg of medroxyprogesterone acetate, compared to a placebo. It is not known if this applies to younger postmenopausal women.

What Are the Estrogel Precautions?

• Before using estrogel, tell your doctor or pharmacist if you have an allergy to any other medication or to any of its ingredients. Ask your pharmacist or medical provider for the complete list of ingredients. 
• Before using this medication, share your complete medical and family history, especially if you have the following conditions: 
  • Abnormal vaginal bleeding
  • Breast cancer, uterine cancer, cancer of the ovaries
  • Blood clots 
  • Stroke
  • Heart disease 
  • Liver disease
  • Kidney disease
  • Angioedema 
  • High blood pressure 
  • Diabetes
  • High cholesterol/triglyceride levels
  • Obesity 
  • Hypothyroidism 
  • Hypoparathyroidism 
  • Gallbladder disease
  • Asthma
  • Seizures
  • Migraine 
  • mental/mood disorders
  • Porphyria 
• Do not smoke or consume tobacco products while using this medication. Estrogen combined with smoking may further increase your risk of blood clots, stroke, hypertension, and heart attack, especially in women aged more than 35. 
• Inform your doctor if you are planning to have surgery or if you will be on bed rest or confined to a chair for a long time. This increases your risk of developing certain blood clots, especially if you are using estrogen. You may be required to stop using this medication or take special precautions. 
• This medication may cause blotchy, dark areas on your skin and face. Exposure to sunlight may worsen this effect. To prevent this, limit your time in the sun. Avoid sunlamps and tanning booths, and protect your protective clothing when you are outdoors. Consult your doctor or healthcare provider about using sunscreen with Estrogel, as it may affect the absorption of this gel if applied on the same skin area where the medication was used. 
• If you are shortsighted or wear contact lenses, you may develop vision problems or difficulty wearing them. Contact your ophthalmologist if any vision problems occur. 
• This medication is not indicated for use in children. If a child is accidentally exposed to it, they may experience unwanted side effects, including early puberty. Call your doctor at once if you notice any signs and symptoms of unexpected puberty, such as an increase in nipple size or nipples. To reduce this risk, use this medication carefully. 
• Do not use this medication if you are pregnant. If you get pregnant or if you suspect a pregnancy while using this medication, inform your doctor immediately. 
• Estrogel may pass into breast milk, further decreasing the quality & amount of breast milk produced. Consult a physician before breastfeeding while using this drug. 

What Are the Contraindications of Estrogel? 

Estrogel is contraindicated for use in;

• Known or suspected breast cancer
• Known or suspected estrogen-dependent neoplasia
• Undiagnosed abnormal genital bleeding
• Untreated endometrial hyperplasia
• Previous or current venous thromboembolism 
• Active or recent arterial thromboembolic disease 
• Liver dysfunction or disease
• Known hypersensitivity to estradiol or any ingredients in Estrogel
• Porphyria cutanea tarda 
• Pregnancy or suspected pregnancy
• Lactation
• History of idiopathic jaundice of pregnancy
• History of herpes gestationis

What If You Missed a Dose of Estrogel?

• If you have missed a dose of Estrogel, you should apply it as soon as possible. 
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• Do not take double or extra doses of the same medication to compensate for the missed dose, as it can cause undesirable side effects. 
• You can set a medication reminder on your phone to prevent further missed doses. 

[Note: If you have missed a medication dose and are unsure when to take the next one, consult your doctor or pharmacist immediately.]

What Happens If You Take Too Much of Estrogel?

An overdose of Estrogel can lead to various complications due to excessive estrogen in the body. Symptoms of an estrogen overdose may include nausea, vomiting, breast tenderness or pain, vaginal bleeding or spotting, severe headache, dizziness, leg pain or swelling. If you suspect an overdose of Estrogel, you should immediately discontinue using this medication and seek immediate medical attention. You should immediately call your doctor, 911, or the poison control helpline. If someone is having severe symptoms such as passing out, seizures, or loss of consciousness, you may head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store an Estrogel?

• You should keep this medication in its original container or packaging at a controlled room temperature between 15°C-30°C or 59°F to 86°F. 
• Store Estrogel away from moisture, direct sunlight, and excess heat. 
• Do not keep it in the bathroom or near the sink. 
• Keep all medications, including Estrogel, away from the sight and reach of children and pets. 
• Do not refrigerate or allow the medication to freeze. 
• Do not use medications that are outdated or no longer needed. Discard them safely. 
• Do not pour them down the drain, flush them down the toilet, or throw them in the household garbage bin.
• Dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• To learn more about properly disposing of unwanted medications, consult your doctor, healthcare provider, or local waste disposal company.  

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Estrogel?

Certain medications may interact with Estrogel and affect how it works. Before using this medication, tell your doctor or pharmacist about all the medications you are taking or plan to take, including all prescription, non-prescription, over-the-counter drugs, or herbal and vitamin supplements. This information helps identify and avoid potential drug interactions. Below are some possible drug interactions of Estrogel. This list is not complete, and there may be other drugs that interact with this medication. Consult your healthcare provider for more information. 

• Aromatase inhibitors (e.g., anastrozole, letrozole, exemestane)
• Tamoxifen
• Fulvestrant
• Raloxifene
• Carbamazepine
• Phenytoin
• Rifampicin
• St. John’s Wort
• Ritonavir
• Erythromycin
• Ketoconazole
• Itraconazole
• Cimetidine
• Warfarin
• Thyroid hormones
• Corticosteroids
• Insulin
• Phenobarbital
• Primidone
• Oxcarbazepine
• Topiramate
• Felbamate
• Nevirapine
• Efavirenz
• Nelfinavir
• Bosentan
• Modafinil

What Are the Other Estrogel Interactions?

Estrogel, like other estrogen products, can interact with various substances, including herbs, supplements, foods, and beverages. The significance and extent of these interactions can vary among individuals. Also, this list is not exhaustive. Here’s an overview of some potential interactions:

• St. John’s Wort
• Black cohosh
• Red clover
• Grapefruit juice
• Caffeine
• Alcohol
• Cruciferous vegetables 

[Note: This isn’t a complete list, and there could be other drugs that interact with Estrogel. Tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Estrogel Alternatives?

People look for alternatives to Estrogel when this medication does not suit their needs, or they do not get desired results. Many effective alternatives to Estrogel are present in the market. Some of these alternatives are mentioned below. However, you should not use any alternative without consulting your doctor, as it may cause unwanted side effects. Consult a licensed healthcare provider before changing your prescription or starting a new one. 

• Estradiol topical (estradiol)
• Premarin Vaginal (Conjugated estrogens)
• Estring (estradiol) 
• Yuvafem
• Estrace (estradiol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Estrogel Cost & Coupons

The cost of Estrogel can be a significant concern for many, particularly as it may not be covered by health insurance, leading to high out-of-pocket expenses. To help manage these costs, some Americans turn to services like Polar Bear Meds, which allows them to purchase Estrogel from Canada at a reduced price. By utilizing this option, patients can access the medication they need without the financial strain. Additionally, customers can benefit from the Estrogel coupon code WELCOMEPB10, which offers a 10% discount on their first order, further easing the financial burden. Exploring these avenues can provide substantial savings and make Estrogel more accessible. 

Frequently Asked Questions

How does Estrogel impact bone density in postmenopausal women?

Estrogel helps maintain bone density by supplying estrogen, which reduces bone resorption and increases bone formation. This is crucial for postmenopausal women, as the decline in estrogen levels can lead to osteoporosis and an increased risk of fractures.

Can Estrogel be used in conjunction with other hormone replacement therapies?

Yes, Estrogel can be used with other hormone replacement therapies (HRT) under medical supervision. Combining Estrogel with progestin is often recommended to decrease the risk of endometrial hyperplasia in women who still have an intact uterus.

What are the effects of Estrogel on cardiovascular health?

Estrogel has been shown to improve lipid profiles and reduce arterial stiffness, which may benefit cardiovascular health. However, it is essential to monitor and discuss cardiovascular risks with a medical provider before starting treatment, especially for women with pre-existing heart conditions.

Are there any long-term side effects associated with Estrogel?

Long-term use of Estrogel may increase the risk of breast cancer, blood clots, and stroke. Regular medical check-ups and discussions with a healthcare provider are important to evaluate the benefits and risks of prolonged Estrogel use, ensuring it is the best option for your health needs.

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