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Glyburide/Metformin HCL

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Product Details

Description

Order Glyburide/Metformin HCl Online from Licensed Canadian Pharmacies

Glyburide/Metformin HCl is a prescription medicine used to help manage type 2 diabetes. This combination is often used when Metformin alone is not enough to maintain good control of blood glucose levels. This medication is meant to be taken as part of an overall treatment plan that includes healthy eating and regular activity. Doctors often use it to support better blood sugar control throughout the day without switching to complex therapies. In addition to the 5/500 mg, this medication is available in other strengths, including 1.25/250 mg and 2.5/500 mg. Before you buy Glyburide/Metformin HCl online, speak with your doctor to confirm the correct strength of the medication.

Drug Summary

Generic NameGlyburide/Metformin HCl
Brand NameGlucovance
FormsTablets
Strengths Available5/500 mg
PackagingBlister Pack (100 Tablets)
Requires PrescriptionPrescription only (Rx)
Ships to the U.S.Yes
Uses and Benefits

What Is Glyburide/Metformin HCl Used For?

Glyburide/Metformin HCl is used for type 2 diabetes in adults.

What Are the Benefits of Glyburide/Metformin HCl?

  • This combination is widely prescribed when single therapy is not enough to manage blood sugar.
  • Glyburide/Metformin HCl tablets reduce high fasting and post-meal blood sugar levels.
  • The medication provides better results when combined with diet and exercise.
Dosage

Glyburide/Metformin HCl Dosage

Before you order Glyburide/Metformin HCl online for type 2 diabetes, speak with your doctor for accurate dosage recommendations. The average dosing schedule may include:

  • If you have never taken this combination diabetes medicine, your starting dose may be 1.25/250 mg once or two times daily with food.
  • If your glucose levels are not well controlled, the dose may be 2.5/500 mg or 5/500 mg twice daily with meals.
  • If you are already on both medicines separately, your starting dose should not exceed your current doses.
  • Do not exceed 20/2,000 mg/day.
  • If you take colesevelam, take your Glyburide/Metformin HCl tablets at least 4 hours before it.

Note: The Glyburide/Metformin HCl dosage for patients with kidney problems may vary.

Usage Guide

How To Take Glyburide/Metformin HCl for Type 2 Diabetes?

Here are a few important steps on how to take Glyburide/Metformin HCl tablets correctly:

  • Take the medicine with food and a glass of water.
  • Always follow the diet your doctor prescribed for better control over your blood glucose levels.
  • Include exercise in your daily routine.
  • Take the medication at the same time each day to get the best results.
How It Works

How Glyburide/Metformin HCl Works

Glyburide helps your pancreas release more insulin, which lowers blood sugar after meals. Metformin, on the other hand, improves how your body uses insulin and reduces the amount of sugar made by the liver. It also helps reduce glucose absorption from the stomach. Together, these actions help maintain steadier blood sugar levels throughout the day.

Side Effects

What Are the Side Effects of Taking Glyburide and Metformin HCl Combination?

Common Glyburide/Metformin HCl side effects may include:

  • Headache
  • Stomach pain
  • Nausea or vomiting
  • Diarrhea
  • Dizziness

Severe but rare Glyburide/Metformin HCl side effects may include:

  • Skin or allergic reactions
  • Hypoglycemia or low blood sugar
  • Buildup of lactic acid

Note: Contact your medical provider if you experience any severe symptoms or unexpected reactions.

Warnings

Glyburide/Metformin HCL Warnings

A combination diabetes medicine has a higher chance of adverse effects when not used as prescribed. Here are some Glyburide/Metformin HCL warnings that users must consider before starting their treatment:

  • While rare, Metformin can cause a serious buildup of lactic acid in the blood. The risk is higher in people with kidney problems, severe infections, dehydration, or poor oxygen supply. Seek urgent medical care if you feel weak, notice trouble breathing, or have severe stomach pain.
  • Low blood sugar can occur, especially if you skip meals, drink alcohol, or use other diabetes medications.
  • People with unstable or severe heart failure should use Glyburide and Metformin Hydrochloride carefully to avoid the risk of lactic acidosis. Check with your doctor before considering this treatment.
Safety Guide

Glyburide/Metformin HCl Precautions

Before you order Glyburide/Metformin HCl online, be mindful of the following safety guidelines:

  • Temporarily stop using Glyburide/Metformin HCl tablets before certain imaging tests with contrast dye. Restart the treatment only after your doctor confirms your kidneys are working normally.
  • Do not take this medicine if you are allergic to Glyburide, Metformin, or Sulfonylureas.
  • Generic Glyburide/Metformin HCl should only be used for type 2 diabetes. It is not meant for diabetic ketoacidosis or type 1 diabetes.
  • Drink enough fluids, especially during illness or hot weather. Dehydration can affect kidney function.
  • Check your blood sugar often. If your diet, activity, or stress levels change, adjustments may be needed.
  • Generic Glyburide/Metformin HCl is usually not recommended during pregnancy. Discuss treatment options with your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Click here to know what the normal blood glucose level is for pregnancy.
Missed Dose

Glyburide/Metformin HCl Missed Dose

If you miss your Glyburide/Metformin HCl dose, talk to your doctor. They may adjust your dosing schedule or advise you to take the medicine as soon as possible. Do not take two doses at once to make up for a missed dose.

Overdose

Glyburide/Metformin HCl Overdose

An overdose may lead to severe hypoglycemia or lactic acidosis, which requires immediate medical care. Both drugs have different overdose symptoms. If you notice any unusual reactions after exceeding your daily recommended dose, get immediate medical attention or contact the poison control helpline.

Symptoms of Severe Hypoglycemia (from Glyburide):

  • Extreme weakness
  • Feeling hungry
  • Irritation
  • Anxiety
  • Confusion
  • Excessive sweating
  • Slurred speech
  • Loss of consciousness
  • Nausea or vomiting

Symptoms of Lactic Acidosis (from Metformin):

  • Diarrhea
  • Muscle pain
  • Feeling cold
  • Troubled breathing
  • Extreme sleepiness
  • Hypotension
  • Stomach pain
Storage Guide

What Are the Glyburide/Metformin HCl Storage Requirements?

Store the tablets:

  • At temperatures up to 25°C.
  • Always keep the medicine in its blister pack to protect it from light.
  • Avoid exposure to hot or moist conditions.
  • Keep out of the reach and sight of children.
  • Once you order Glyburide/Metformin HCl online, verify its expiration date.
  • Dispose of the used packaging in accordance with local disposal guidelines.
Interactions

Glyburide/Metformin HCl Interactions

Use caution when taking Glyburide/Metformin HCl with the following medications:

  • Tracleer (bosentan)
  • Acetazolamide
  • Topiramate
  • Zonisamide
  • Cimetidine
  • Colesevelam
  • Aspirin
  • Patiromer

Note: Caution is also advised when used with thiazide diuretics, corticosteroids, NSAIDs, sulfonamides, cationic drugs, and other diabetes medications.

Alternatives

Glyburide/Metformin HCl Alternatives

If you are not achieving stable blood glucose levels, your doctor may prescribe the following Glyburide/Metformin HCl alternatives:

Combination Oral Medicines:

  • Janumet (sitagliptin/metformin)
  • Duetact (glimepiride/pioglitazone)
  • Kombiglyze XR (saxagliptin/metformin ER)
  • Synjardy (empagliflozin/metformin)

Single-Agent Oral Medicines:

  • Invokana (canagliflozin)
  • Januvia (sitagliptin)
  • Actos (pioglitazone)
  • Glipizide (Glucotrol XL)

Injectable Medications:

  • Ozempic (semaglutide)
  • Victoza (liraglutide)
  • Mounjaro (tirzepatide)
Cost & Coupons

Why Buy Glyburide/Metformin HCl from Polar Bear Meds?

At Polar Bear Meds, we’re committed to making prescription medications like Glyburide/Metformin HCl 5/500 mg more accessible and affordable for patients in the U.S. Our prices are significantly lower than typical U.S. pharmacy retail rates without compromising on safety or quality. Each order is sourced exclusively from licensed, trusted pharmacies and undergoes comprehensive prescription verification to ensure compliance and authenticity. We offer discreet, trackable shipping to all U.S. states, along with refill support for ongoing treatment. Our friendly customer service team is here to help you.

Glyburide/Metformin HCl Cost & Coupons

Buy Glyburide/Metformin HCl from Canada and have it delivered to your doorstep in the U.S. You can also save more with the coupon code “WELCOMEPB10” for 10% off your first order. There are no hidden handling or processing fees, as we believe in complete transparency. If the Glyburide/Metformin HCl cost is a concern for you, we make it easy to manage your overall medical expenses. Join our referral program and get a $20 credit every time you refer a friend or a family member. Your referral will also receive a $20 credit, so everyone wins. Additionally, after every 10 verified customers' referrals, you'll receive a $100 credit in your account as a thank-you for spreading the word.

FAQ

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AtPolar Bear Meds,yoursafetyisourpriority.EveryorderisdispensedfromafullylicensedCanadianpharmacyfollowingstrictstandardsforquality,security,andpatientcare.ToconvenientlybuyGlyburide/MetforminHClfromCanadaatasubstantialdiscount,callusat1-888-779-2193toll-free.

Important Notice

The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller

Medically Reviewed by "Dr. Jackson Miller (M.D)"

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

Find Dr. Jackson Miller on:LinkedIn
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