Empagliflozin and Linagliptin

Glyxambi Tablets

The Food and Drug Administration (FDA) has approved Glyxambi for managing blood sugar in patients with type 2 diabetes combined with a proper diet and exercise routine. This medicine contains two different drugs – empagliflozin and linagliptin. Glyxambi tablets come in two different strengths: 10 mg and 25 mg empagliflozin with 5 mg linagliptin for both. Empagliflozin is in a group of medicines called sodium-glucose cotransporter 2 inhibitors, while linagliptin is a dipeptidyl peptidase-4 inhibitor. Right now, there isn’t a generic version of Glyxambi available. So, if you want to buy Glyxambi online from a Canadian Pharmacy, get the prescription from your doctor first.

Product Overview

This medicine is a combination of two drugs, empagliflozin and linagliptin. This FDA-approved medication is used, along with a healthy diet and exercise, to manage high blood sugar in people with type 2 diabetes. By controlling high blood sugar, it helps prevent kidney damage, vision problems, nerve issues, limb loss, and sexual function issues. Glyxambi tablets have two strengths: one with 10 mg of empagliflozin and 5 mg of linagliptin and another with 25 mg of empagliflozin and 5 mg of linagliptin. 

Dosage varies based on age, health conditions, and other medications. It comes in two strengths, and your doctor determines the recommended dosage. To use Glyxambi, take it orally once a day, with or without food. However, you can consult your doctor if you experience severe side effects. Glyxambi comes with important warnings that include monitoring for pancreatitis, heart failure, ketoacidosis, and kidney function. It’s essential to discuss any allergies or skin reactions with your doctor before starting Glyxambi.

Additionally, if you miss a dose, take it as soon as you remember unless it’s close to the next dose. Don’t double up to compensate for a missed dose. You can also store it in a cool, dry place, away from moisture, and out of reach of children and pets. Glyxambi may interact with certain drugs and alcohol, so it’s crucial to inform your doctor of all medications and alcohol consumption. Alternatives to this medication are available, but you must consult your doctor before making any changes or even before you buy Glyxambi online from Canada.

What Are the Uses of Glyxambi?

Glyxambi is used to:

• Control blood sugar levels in patients with type 2 diabetes.
• Reduce the risk of heart attack and death.
• Prevent you from vision problems, limb loss, nerve & sexual function issues.

What Dosages Does Glyxambi Come In?

Glyxambi (empagliflozin & linagliptin) comes as oral tablets. It is available in two different strengths:

• 10 milligrams empagliflozin with 5 mg linagliptin
• 25 mg empagliflozin with 5 mg linagliptin

What Are the Typical Dosages of Glyxambi?

Glyxambi is a combination medication used in the management of Type 2 diabetes, containing empagliflozin and linagliptin. Here’s a guide to the typical dosages used for this medication, but remember, always follow the dosage your doctor prescribes as it may differ based on your specific health needs.

Dosage for Type 2 Diabetes

• Starting Dosage: Typically, the initial dose is 10 mg of empagliflozin combined with 5 mg of linagliptin, taken once daily.
• Adjustment and Maximum Dosage: Depending on your response to the initial treatment, your doctor may increase your dosage. The maximum recommended dose is 25 mg of empagliflozin with 5 mg of linagliptin once daily.

Factors Influencing Dosage: 

• Efficacy and Tolerance: Your doctor will prescribe the smallest dosage that effectively manages your blood sugar levels while minimizing side effects.
• Kidney Function: Since empagliflozin is cleared through the kidneys, your kidney function will also play a crucial role in determining the appropriate dosage.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Glyxambi Tablets?

Here’s how to take Glyxambi tablets and you can also talk with your doctor or pharmacist if you have any questions or concerns regarding taking this medication:

• Your pharmacist gives you a guide. Read it before you start the medicine and each time you get more. If you have questions, ask your doctor or pharmacist.
• Take it by mouth, with or without food, usually once a day in the morning.
• The amount you take depends on your health and how you respond to the medication.
• Take the medicine regularly to get the best results. Remember to take it at the same time every day.
• Don’t crush or chew it with your teeth.
• If your condition doesn’t improve or worsen, let your doctor know. For example, tell your doctor if your blood sugar is too high or too low.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Glyxambi Work?

Glyxambi is a medicine that combines two drugs. One of the drugs, empagliflozin, helps your kidneys prevent sugar from being reabsorbed into your body, lowering blood sugar by getting rid of extra sugar through urine. The other drug, linagliptin, works by blocking a protein called DPP-4 (Dipeptidyl Peptidase 4). This usually breaks down hormones that tell your body to make more insulin and produce less sugar. By blocking DPP-4, linagliptin helps your body produce more insulin and less sugar, lowering your blood sugar levels.

What Are the Safety Guidelines for Using Glyxambi?

What Is the Side Effect of Glyxambi?

Common Glyxambi Side Effects: Medications often have side effects, many of which are common and typically temporary, lasting from a few days to a few weeks. If these side effects persist beyond this period, become bothersome, or intensify, it’s important to contact your doctor or pharmacist to ensure your safety. Below are some common side effects you might experience with Glyxambi:

• Depression: Feeling unusually sad, hopeless, or uninterested in daily activities.
• Nausea: Feeling queasy or like you might vomit.
• Sweating: Unusual or excessive sweating.
• Yellow Eyes or Skin: This can indicate liver issues; it’s important to seek medical advice.
• Chills: Feeling unusually cold without a clear reason.
• Dry Mouth: Less saliva than usual, making your mouth feel dry.
• Headache: Pain or a throbbing sensation in your head.
• Unexplained Weight Loss: Losing weight without trying through diet or exercise.
• Chest Pain or Tightness: Feeling pressure or discomfort in your chest.
• Trouble Breathing: Difficulty catching your breath.
• Indigestion: Discomfort or pain in the stomach associated with difficulty in digesting food.
• Bloating: Feeling uncomfortably full and swollen in the stomach area.
• Nightmares: Disturbing dreams that can disrupt your sleep.
• Dizziness: Feeling lightheaded or unsteady, like the room is spinning.
• Vomiting: Throwing up the contents of your stomach.
• Cold Sweats: Breaking out in sweats without physical exertion or high temperature.
• Anxiety: Feeling unusually nervous, anxious, or fearful.

Mild Glyxambi Side Effects: This medication can lead to some mild side effects that are usually temporary. Over time, your body may adjust to the drug. If these side effects do not go away or become bothersome, it’s important to speak with your primary caregiver. Here are some mild side effects you might experience while taking Glyxambi:

• Body Aches or Pain: You might feel general discomfort or aches throughout your body.
• Ear Congestion: Your ears might feel blocked or full, affecting your hearing.
• Difficulty with Breathing: You may experience mild trouble breathing, such as feeling short of breath.
• Loss of Voice: You might find your voice is hoarse or absent.
• Headache: Experiencing pain or a throbbing sensation in your head.
• Sneezing: More frequent sneezing than usual.
• Runny or Stuffy Nose: Your nose may be blocked or continuously running, making it hard to breathe through your nose.
• Sore Throat: Pain, irritation, or scratchiness in the throat.

Serious Glyxambi Side Effects: Glyxambi can cause some serious side effects. If you experience any of the following while taking this medication, contact your doctor immediately. In cases where the side effects seem life-threatening, or if you believe you are having a medical emergency, call your local emergency number or 911 right away. Here’s a detailed look at some serious side effects associated with Glyxambi:

• Severe Joint Pain: Intense pain in the joints that can significantly affect your mobility and comfort.
• Ketoacidosis: A serious condition where the body produces high levels of blood acids called ketones, which can lead to diabetic ketoacidosis if not treated promptly.
• Pancreatitis: Inflammation of the pancreas that causes severe pain in the abdomen which can sometimes be felt in the back.
• Allergic Reaction: Symptoms may include swelling of the face, lips, tongue, or throat, itching, rash, difficulty breathing, or severe dizziness.
• Dehydration: Symptoms include feeling very thirsty, dry mouth, not urinating much, and dark-colored urine.
• Burning Sensation While Urinating: A painful, burning feeling during urination, which may be a sign of infection.
• Increased Frequency of Urination: Needing to urinate more often than usual, which may disrupt daily activities.
• Blood in Urine: Presence of red blood cells in urine, which can appear pink, red, or cola-colored.
• Pelvic Pain: Pain in the lower abdomen below the belly button, which can be sharp or dull.
• Swelling in Ankles, Feet, or Legs: Noticeable increase in the size or puffiness in the lower extremities.

[Note: If you experience severe glyxambi side effects, immediately contact your doctor. In cases where the side effects appear life-threatening, or you believe you are facing a medical emergency, call 911 or your local emergency services without delay.]

Who Should Not Take Glyxambi?

Before starting Glyxambi, it’s essential to discuss your complete health history with your doctor, as certain medical conditions or factors may make this medication unsuitable for you. Here are some specific conditions and factors that might contraindicate the use of Glyxambi:

• Pancreatitis: Postmarketing reports of acute pancreatitis, including fatal cases, have been observed. This is a serious condition, and if suspected, prompt discontinuation of Glyxambi 25 mg 5 mg tablet and appropriate management is advised.
• Heart Failure: An association between DPP-4 inhibitor treatment and heart failure has been observed. Patients at risk for heart failure should be carefully evaluated, monitored during therapy, and advised to report symptoms immediately. Management according to current standards of care should be considered, and discontinuation of Glyxambi may be necessary.
• Ketoacidosis: It is crucial to consult your doctor for treatment if you are experiencing diabetic ketoacidosis. Glyxambi should not be used in such cases, and prompt medical attention is necessary for managing this condition effectively. Glyxambi is associated with reports of ketoacidosis, a serious and life-threatening condition. Factors predisposing to ketoacidosis should be considered before initiating treatment, and monitoring for ketoacidosis is recommended. 
• Acute Kidney Injury and Impairment in Renal Function: Glyxambi is not suitable for individuals with severe kidney disease or those undergoing dialysis. It is essential to discuss your kidney health with your doctor before considering this medication. Consideration of factors predisposing to acute kidney injury is necessary before starting Glyxambi. Monitoring renal function periodically is recommended, with more frequent monitoring for patients with an eGFR below 60 mL/min/1.73 m2. The use of Glyxambi is not recommended in certain cases.
• Necrotizing Fasciitis of the Perineum: Reports of necrotizing fasciitis have been identified, and patients presenting with certain symptoms should be assessed for this condition. Immediate discontinuation of Glyxambi is recommended if suspected.

What Are the Precautions for Glyxambi?

When considering treatment with Glyxambi for Type 2 diabetes, it’s important to discuss all aspects of your health with your doctor. Certain conditions and factors can impact how suitable Glyxambi is for you, and may require special monitoring or adjustment of treatment. Here are some key precautions to consider:

• Previous Reactions: If you have a history of severe allergic or skin reactions to empagliflozin or linagliptin, Glyxambi may not be the right choice for you. Your past experiences with these substances are significant factors in determining your suitability for this medication. Allergic reactions can be serious, and avoiding the medication is crucial if you are sensitive to any of its components.
• Lifestyle Factors: Discuss with your doctor if you consume large amounts of alcohol or if you have experienced genital infections (penis or vagina). Additionally, disclose if you are 65 years or older, follow a low-salt diet, have high cholesterol or triglycerides, or if you have any planned surgeries. These factors can influence the suitability and effectiveness of Glyxambi for your specific health condition.

What If I Miss a Dose of Glyxambi?

If you forget to take Glyxambi, take it as soon as you remember, unless it’s the next day. In that case, skip the missed dose and take your next dose as usual. Don’t take two doses at once, as it may increase the chance of side effects like low blood sugar. To avoid missing doses, use a reminder like setting an alarm, using a timer, or using a reminder app on your phone.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Glyxambi?

Only take the prescribed amount of Glyxambi as advised by your doctor. If you believe you have exceeded the recommended dose, promptly reach out to your healthcare provider or the nearest hospital emergency department or contact your regional Poison Control Centre, even in the absence of symptoms.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

How to Store Glyxambi?

Store Glyxambi 25 mg 5 mg tablets in a cool place (68°F to 77°F / 20°C to 25°C) and make sure to keep them in a tightly closed container. Don’t keep them in places like bathrooms where they might get damp or wet. Keep it away from the children and pets while storing.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Drug Interactions Does Glyxambi Have?

Glyxambi, which combines empagliflozin and linagliptin, can interact with other medications, affecting how well it works or increasing the likelihood of side effects. It’s essential to inform your healthcare provider about all the medications, supplements, and over-the-counter products you are taking. Here are some common drug interactions to be aware of:

• Diuretics (Water Pills): If you take water pills (diuretics) along with Glyxambi, it can raise your chances of experiencing Glyxambi’s side effects. These side effects may involve low blood pressure and dehydration. Some examples of diuretics are:
  • Chlorthalidone
  • Furosemide (Lasix)
  • Spironolactone (Aldactone, Carospir)
  • Hydrochlorothiazide (Microzide)
• Sulfonylureas (Diabetes Medications): If you take sulfonylureas along with Glyxambi, it could increase the chance of having low blood sugar as a side effect. Examples of sulfonylureas include:
  • Glyburide (Diabeta, Glynase)
  • Glimepiride (Amaryl)
  • Glipizide (Glucotrol)
• Insulins: If you use insulin medications along with Glyxambi, it might increase the likelihood of having low blood sugar as a side effect. Examples of insulins include:
  • Insulin Aspart (Novolog)
  • Premixed Insulins (Humalog 50/50 and Novolin 70/30)
  • Insulin Degludec (Tresiba)

What Are the Other Interactions of Glyxambi?

In addition to medications, Glyxambi can interact with certain vitamins, herbs, and dietary substances. Sharing all your supplements and dietary habits with your doctor can help avoid any unintended interactions and ensure that the treatment is safe and effective. Here are some potential non-drug interactions to consider:

• Interactions with Herbs & Supplements: No herbs or supplements have been specifically reported to interact with Glyxambi. Still, it’s important to consult your doctor or pharmacist before using any of these products while taking Glyxambi.
• Glyxambi & Foods: No specific foods are known to interact with Glyxambi. If you’re unsure about what foods are okay to eat with Glyxambi, just ask your doctor.
• Glyxambi & Alcohol: Drinking a lot of alcohol, especially regularly, can increase the chances of experiencing side effects from Glyxambi. In particular, consuming large amounts of alcohol may heighten the risk of ketoacidosis, a rare but potentially life-threatening side effect of Glyxambi that results in a high level of acid in your blood. This risk is higher if you frequently consume alcohol. 

Moreover, it’s crucial to be aware that alcohol can lower your blood sugar, and Glyxambi also has a similar effect. Combining alcohol with the medication may increase the risk of dangerously low blood sugar levels, which, in rare cases, can be life-threatening. If you drink alcohol, discuss with your doctor the amount that is safe for you while taking Glyxambi.

[Note: This isn’t a complete list, and there could be other drugs that interact with Glyxambi. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Glyxambi Alternatives?

 If Glyxambi isn’t the right fit for you, there are several other medications available to manage Type 2 diabetes. Each medication has unique benefits, and your doctor can help you determine which might work best for your individual needs. Some of these alternatives may be used off-label, meaning they are prescribed for conditions other than those for which they are FDA-approved. Here are some alternatives:

• Xigduo XR (dapagliflozin & extended-release metformin)
• Jardiance (empagliflozin)
• Invokamet (canagliflozin and metformin)
• Jentadueto (linagliptin and metformin)
• Janumet (sitagliptin phosphate and metformin hydrochloride)
• Victoza (liraglutide )
• Repaglinide (meglitinides)
• Oseni (alogliptin and pioglitazone)
• Rybelsus (semaglutide)
• Qtern (dapagliflozin and saxagliptin)

• Ozempic (semaglutide)
• Trulicity (dulaglutide)
• Januvia (sitagliptin)
• Nesina (alogliptin)
• Byetta (exenatide)
• Farxiga (dapagliflozin)
• Nateglinide (meglitinides)
• Onglyza (saxagliptin )
• Steglatro (ertugliflozin)
• Steglujan (ertugliflozin and sitagliptin)
• Tradjenta (linagliptin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Glyxambi Coupons & Cost

Glyxambi, often prescribed for managing type 2 diabetes, can be expensive in the U.S., with monthly costs climbing without insurance. To mitigate these high expenses, consider buying Glyxambi online from Canada through Polar Bear Meds, where we provide it at remarkably reduced prices. We also provide a coupon for Glyxambi on our website. This initiative aids U.S. residents in accessing more affordable healthcare options. When you purchase Glyxambi for the first time, make sure to use the coupon code “WELCOMEPB10” for an additional 10% discount. Furthermore, our referral program could help you save up to $200 on your healthcare expenditures, making your treatment journey both cost-effective and efficient.

Frequently Asked Questions

Is Glyxambi hard on the kidneys?

Glyxambi can potentially affect your kidneys, especially if you become dehydrated. Dehydration can lead to serious kidney damage while taking this medication. To prevent this, it’s important to drink plenty of fluids. If you are unable to keep up with your normal fluid intake or if you lose fluids through vomiting, diarrhea, or heavy sweating, contact your doctor or pharmacist right away. Maintaining hydration is key to reducing the risk of kidney-related issues while on Glyxambi. Always follow your healthcare provider’s guidance to stay safe while using this medication.

Is Glyxambi safe for pregnancy?

If you’re pregnant or planning to be, follow your doctor’s advice on using Glyxambi. It’s crucial to manage diabetes well during pregnancy. Avoid using Glyxambi in the second or third trimester, and refrain from breastfeeding while using it.

When should I stop taking Glyxambi?

If you notice any signs of an allergic reaction, like a rash, peeling skin, hives, or swelling of the skin, face, lips, tongue, or throat that makes it hard to breathe or swallow, stop taking Glyxambi and get medical help right away.

Does Glyxambi make you lose weight?

Glyxambi 25 mg 5 mg tablet’s clinical trials didn’t show weight loss as a side effect. But, Glyxambi can have some side effects like dehydration and ketoacidosis, which might cause temporary weight loss. Contact your healthcare professional for more information.

Is Glyxambi good for the heart?

Glyxambi helps lower blood sugar in adults with type 2 diabetes when used with a healthy diet and exercise. It can also be used in adults with type 2 diabetes who have heart problems, especially when empagliflozin (a medicine in Glyxambi) is necessary to lower the risk of heart-related death.

What is the mode of action of empagliflozin and linagliptin?

Empagliflozin helps eliminate sugar through urine by stopping the kidneys from reabsorbing blood sugar. On the other hand, linagliptin lowers sugar levels by making the pancreas produce more insulin and reducing the amount of glucagon in the bloodstream.

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