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Glyxambi

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Product Details

What Is Glyxambi?

What Is Glyxambi?

Glyxambi is a prescription tablet used to help manage type 2 diabetes along with a balanced diet and regular exercise. It combines two medicines - empagliflozin and linagliptin. Taken once daily, it helps control blood sugar. Empagliflozin, one of Glyxambi’s active ingredients, has shown cardiovascular benefits in certain patients with type 2 diabetes. However, Glyxambi is not approved for reducing cardiovascular risk. It is not suitable for people with type 1 diabetes or certain medical conditions.

Quick Facts About Glyxambi

Quick Facts About Glyxambi

Product NameGlyxambi
Active IngredientEmpagliflozin/Linagliptin
FDA Approval StatusFebruary 2, 2015
Drug ClassSGLT2 inhibitor (empagliflozin) and DPP-4 inhibitor (linagliptin)
Available FormsOral tablet
Strengths Available10 mg/5 mg and 25 mg/5 mg
Routes of AdministrationOral
Administration FrequencyOnce daily
Glyxambi UsesFor type 2 diabetes (with diet and regular exercise to improve glycemic control)
Elimination Half-LifeEmpagliflozin (12.4 hours) and linagliptin (terminal half-life ~200 hours)
Glyxambi StorageStore below 30°C
PregnancyConsult your doctor
Legal StatusRx-only
ManufacturerBoehringer Ingelheim

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What Is Glyxambi Used For?

What Is Glyxambi Used For?

Glyxambi is FDA-approved to treat:

  • Type 2 diabetes with diet and regular exercise
How Does Glyxambi Work?

How Does Glyxambi Work?

Glyxambi works by combining two medications, empagliflozin and linagliptin, to lower blood sugar in adults with type 2 diabetes. Empagliflozin is an SGLT2 inhibitor that helps the kidneys remove extra sugar from the body through urine. Linagliptin is a DPP-4 inhibitor that increases natural hormones called incretins. These hormones stimulate insulin release from the pancreas after meals and reduce sugar production in the liver.

Glyxambi Dosage Guide

Glyxambi Dosage Guide

Follow this Glyxambi dosing schedule for managing type 2 diabetes.

StrengthWhen to TakePurposeImportant Notes
10 mg/5 mg1 tablet in the morningStarting dose for sugar controlTake daily, with or without food
25 mg/5 mg1 tablet in the morningUsed if blood sugar is not adequately controlledThe doctor may increase the dose after checking your blood sugar levels

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Glyxambi vs. Other Type 2 Diabetes Medications

Glyxambi vs. Other Type 2 Diabetes Medications

MedicationDrug ClassHow It WorksMajor Benefits
Glyxambi (empagliflozin and linagliptin)SGLT2 inhibitor and DPP-4 inhibitorRemoves excess sugar via urine (empagliflozin),
Boosts insulin secretion (linagliptin)
Dual action - lowers blood sugar, reduces heart/kidney risks
MetforminBiguanideDecreases liver glucose production. Also, improves insulin sensitivity significantly.First-line therapy, weight-neutral, proven long-term safety
Jardiance (empagliflozin)SGLT2 inhibitorPromotes glucose excretion via urineLowers blood sugar, reduces heart failure, and reduces kidney risks
Januvia (sitagliptin)DPP-4 inhibitorIncreased incretin hormones lead to more insulin releaseWeight-neutral, low hypoglycemia risk
Sulfonylureas (e.g., glimepiride)Insulin secretagoguesStimulate the pancreas to release more insulinEffective at lowering sugar quickly
Insulin (various types)Hormone replacementDirectly lowers blood sugarMost effective for uncontrolled diabetes

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How to Use Glyxambi Tablets?

How to Use Glyxambi Tablets?

If you are prescribed Glyxambi for type 2 diabetes mellitus, follow these administration guidelines:

  • Always take Glyxambi at the same time each day. This helps maintain steady blood sugar control.
  • Food does not affect how the medicine works, so you may take it after breakfast or on an empty stomach.
  • Take this tablet with a glass of water.
  • Drink enough water while taking Glyxambi tablets to reduce the risk of dehydration, dizziness, or low blood pressure.
  • Glyxambi works best when combined with healthy eating and regular physical activity.
Important Safety Information About Glyxambi Tablets

Important Safety Information About Glyxambi Tablets

  • Do not take Glyxambi if you have had a serious allergic reaction to empagliflozin, linagliptin, or any of their ingredients.
  • Glyxambi (empagliflozin/linagliptin) tablets must not be used in patients with severe kidney problems or those on dialysis.
  • People with a history of pancreatitis should be cautious, as linagliptin may increase this risk.
  • There is a risk of ketoacidosis, which can be serious and requires immediate medical attention.
  • Inform your doctor if you have liver problems, since dose adjustments or closer monitoring may be necessary.
  • When combined with insulin or sulfonylureas, Glyxambi may increase the risk of hypoglycemia.
  • Glyxambi is not recommended during the second and third trimesters of pregnancy. This is due to the potential risk to the developing fetus.
  • Breastfeeding is not recommended because it is unknown if the medicine passes into breast milk. Consult your doctor for this.
What to Do If You Forget Your Glyxambi Dose?

What to Do If You Forget Your Glyxambi Dose?

If you miss a dose of a Glyxambi tablet, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed Glyxambi dose and continue with your regular dosing schedule. Do not double dose or take extra medication to make up for a missed dose, as this may increase the risk of side effects. You should maintain a consistent routine to avoid missing a dose of Glyxambi.

What Happens If You Take Too Much Glyxambi?

What Happens If You Take Too Much Glyxambi?

Overdosing on Glyxambi tablets may cause dehydration and acute kidney injury. You may experience Glyxambi overdose symptoms, which may include fainting, dizziness, rapid heartbeat, confusion, severe nausea or vomiting, abdominal pain, and fruity-smelling breath. If you suspect a Glyxambi overdose, contact the poison control center or your healthcare provider immediately.

What Are the Possible Glyxambi Side Effects?

What Are the Possible Glyxambi Side Effects?

Glyxambi (empagliflozin/linagliptin) can cause both common and serious side effects. These include:

Common Side Effects of GlyxambiRare or Serious Side Effects of Glyxambi
Genital yeast infectionsKetoacidosis
Urinary tract infectionsKidney problems
Upper respiratory tract infectionSevere hypoglycemia (mainly when used with insulin or sulfonylureas)
Increased urination & thirstAllergic reactions
HeadacheFournier's gangrene
CoughJoint pain
Gastrointestinal issues (diarrhea, constipation, and nausea)Pancreatitis

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Glyxambi Storage Guidelines

Glyxambi Storage Guidelines

If you are considering Glyxambi for type 2 diabetes mellitus, proper storage ensures the medicine remains effective. These Glyxambi storage guidelines are:

  • Glyxambi should be stored at room temperature, ideally between 20°C-25°C (68°F-77°F).
  • The tablets may be stored between 15°C-30°C (59°F-86°F) without losing effectiveness.
  • Glyxambi should not be stored in bathrooms or other damp places because humidity can affect the tablets.
  • The medication should be kept away from direct sunlight and heat sources like stoves or car dashboards.
  • Expired Glyxambi tablets should not be used. Any unused or expired tablets should be discarded safely.
  • The Glyxambi tablets should always be stored out of reach of children. This is to prevent accidental ingestion.
Glyxambi Interactions

Glyxambi Interactions

Glyxambi (empagliflozin/linagliptin) is known to interact with 497 different medications, along with 4 disease-related conditions. Out of all the drug interactions, 4 are considered major, 484 are moderate, and 9 are minor. Some of the Glyxambi interactions are listed below:

  • Major Glyxambi Interactions
    • Bexarotene
    • Capivasertib
    • Gatifloxacin
    • Lithium
  • Minor Glyxambi Interactions
    • Dexamethasone ophthalmic
    • Difluprednate ophthalmic
    • Fluocinolone ophthalmic
    • Fluorometholone ophthalmic
    • Loteprednol ophthalmic
    • Medrysone ophthalmic
    • Menthol topical
    • Prednisolone ophthalmic
    • Rimexolone ophthalmic
  • Some Moderate Interactions with Glyxambi
    • Abametapir topical
    • Belzutifan
    • Capmatinib
    • Dabrafenib
    • Daclatasvir
    • Estradiol topical
    • Estramustine
  • Glyxambi Disease Interactions
    • Renal dysfunction
    • Pancreatitis
    • Hypotension
    • Infections
What Are Alternatives to Glyxambi?

What Are Alternatives to Glyxambi?

Common Glyxambi alternatives include:

  • Jardiance (empagliflozin)
  • Tradjenta (linagliptin)
  • Synjardy (empagliflozin and metformin)
  • Farxiga (dapagliflozin)
  • Invokana (canagliflozin)
  • Steglatro (ertugliflozin)
  • Fortamet (metformin)
  • Glumetza (metformin)
Why Buy Glyxambi Online from Polar Bear Meds?

Why Buy Glyxambi Online from Polar Bear Meds?

The Glyxambi cost in the U.S. can feel overwhelming. Insurance often does not cover it, leaving many people struggling. Some even delay or skip treatment, despite knowing their health matters. No one should have to choose between relief and their budget. At Polar Bear Meds, we understand this worry. That’s why we make it possible to buy Glyxambi online at a price that feels manageable. We source from licensed Canadian pharmacies and offer Glyxambi at up to 80% less than U.S. pharmacies. You can expect Glyxambi delivery within 3-5 business days via our Xpress Post.

Glyxambi Coupons

Glyxambi Coupons

New customers can also use our Glyxambi coupon code “WELCOMEPB10” for an extra 10% discount. Your discount is applied instantly so that you can see the updated total at checkout. No insurance is required, and there are no hidden conditions, unlike the Glyxambi savings card. All you need is a valid Glyxambi prescription from your doctor to use this coupon while purchasing.

Important Disclaimer

Important Disclaimer

The information provided about Glyxambi is for general educational purposes only and is not a substitute for any diagnosis, medical advice, or treatment. Glyxambi is a prescription medication used for type 2 diabetes and should be used only under the guidance of a licensed healthcare provider. Always consult your healthcare provider, pharmacist, or doctor before starting, stopping, or changing the Glyxambi dose. This is especially true if you already have medical issues or are taking other medications.

Glyxambi FAQs

Glyxambi FAQs

Learn more about Glyxambi and related topics

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