Umeclidinium

Incruse Ellipta Inhaler

Incruse Ellipta (Umeclidinium) is a prescription medication approved by the FDA to treat chronic obstructive pulmonary disease (COPD) in adults. As an anticholinergic, it works by relaxing the muscles around the airways, making it easier to breathe. It is a maintenance medication meant to be used daily, not for sudden breathing problems. Common side effects include throat pain, tooth pain, and muscle pain. It is important to use the medication as directed and discuss any existing health conditions, such as glaucoma or heart disease, with your doctor. Incruse Ellipta is not approved for use by individuals under 18 years old.

Product Overview

Incruse Ellipta (Umeclidinium) is a long-term maintenance medication specifically designed to treat chronic obstructive pulmonary disease (COPD) in adults. This condition includes diseases such as chronic bronchitis and emphysema, which progressively worsen over time, causing the airways to tighten and making breathing increasingly difficult. Incruse Ellipta belongs to a class of drugs called anticholinergics, which work by relaxing the muscles around the airways, thereby easing breathing and reducing COPD symptoms like wheezing, coughing, and trouble breathing.

The medication is administered through an inhaler, with each inhalation providing 62.5 micrograms of the active ingredient, umeclidinium. It is crucial to use Incruse Ellipta exactly as prescribed, typically one inhalation per day, to maintain consistent medication levels in the body. It is not a rescue inhaler and should not be used for sudden breathing issues; a rescue inhaler like albuterol should be used instead.

Common side effects include throat pain, tooth pain, muscle pain, and upper respiratory tract infections. Serious side effects may involve eye problems, urinary retention, and severe allergic reactions. Patients should inform their doctor of any existing conditions, such as glaucoma, heart disease, or allergies, before starting Incruse Ellipta. It is also essential to consult a healthcare provider about the safety of using this medication during pregnancy or breastfeeding. Incruse Ellipta should be stored properly and disposed of safely after use. Regular consultations with a doctor will ensure the medication’s effectiveness and address any potential interactions with other drugs or supplements.

Uses of Incruse Ellipta

• It is used to treat COPD (chronic obstructive pulmonary disease) in adults.
• It is also used for the long-term treatment of Asthma.

[Important Warning: Incruse Ellipta is not a rescue inhaler. Do not use it for sudden breathing problems.]

How to Use Incruse Ellipta?

Dosage

Incruse Ellipta is a powder medication that you use with an inhaler. To take it, you inhale the medicine through your mouth so it goes into your lungs. Each inhalation (or puff) of Incruse Ellipta provides 62.5 micrograms (mcg) of the active ingredient, umeclidinium.

Recommended Dosage for Different Patients

Dosage for COPD

• Typical Dosage: For chronic obstructive pulmonary disease (COPD), the usual dosage of Incruse Ellipta is one inhalation (puff) once daily.
• Timing: It is recommended to take this medication at the same time each day. This helps ensure that you have a consistent level of Incruse Ellipta in your body, allowing the drug to effectively manage your COPD symptoms.
• Dosage Limit: Do not take more than one dose of this medication within 24 hours.

Long-term Use

• Consistent Use: Incruse Ellipta is intended for long-term treatment of COPD. It should be used regularly to help reduce COPD symptoms over time.
• Chronic Condition: COPD is a chronic (long-lasting) disease with no known cure, but Incruse Ellipta can help manage and lessen its severity.
• Long-term Treatment: If you and your doctor find that Incruse Ellipta is safe and effective for you, you will likely use it as a long-term treatment.
• Not for Sudden Symptoms: Incruse Ellipta is not meant for sudden breathing problems. Use a rescue inhaler for immediate relief of sudden breathing symptoms.

[Note: These above-mentioned recommendations may vary from person to person. You can discuss it with your doctor or healthcare giver, and they’ll customize your Incruse Ellipta dosage accordingly.]

How to Take It?

• Take Incruse Ellipta exactly as your doctor or healthcare provider tells you.
• Incruse Ellipta is an inhaled medication taken once a day. Use the inhaler to inhale the medicine through your mouth and into your lungs.
• Even if you don’t taste or feel the medication in your mouth, do not take another dose. Some people do not taste or feel anything when taking Incruse Ellipta, but taking more than one dose in a day can be dangerous.
• Your doctor or pharmacist can show you how to use Incruse Ellipta correctly before you take it for the first time.
• Take only one dose of Incruse Ellipta (Umeclidinium) once each day.
• Do not take the medication more than once within a 24-hour period.
• For the best results, take your doses at the same time each day.
• To avoid missing a dose, set a reminder on your phone or use a medication timer.
• Your doctor will typically have you start using Incruse Ellipta once each day.
• Over time, your doctor may adjust your dosage to find the amount that works best for you. They will prescribe the smallest effective dosage.
• The following information describes commonly used or recommended dosages. However, always take the dosage your doctor prescribes for you, as they will determine the best dosage to fit your needs.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Incruse Ellipta Work?

Incruse Ellipta is approved to treat chronic obstructive pulmonary disease (COPD) in adults. COPD is a lung condition that includes several diseases, such as chronic bronchitis and emphysema, which worsen over time. This condition causes your airways to tighten, making it increasingly difficult to breathe as time progresses. Incruse Ellipta is a type of medication called an anticholinergic. It works by relaxing the muscles around your airways, making it easier for you to breathe. This medication also helps decrease your COPD symptoms, such as wheezing, coughing, and trouble breathing.

Incruse Ellipta is a maintenance (long-term) medication intended to be used every day. It works overtime to relax your airways and help you breathe more easily. Although Incruse Ellipta can start working after your first dose, it may take several weeks for you to notice a significant decrease in your COPD symptoms. It is important to continue taking Incruse Ellipta every day, regardless of whether you are experiencing COPD symptoms. Be sure to use your rescue inhaler for any sudden breathing problems you may have. Regular use of Incruse Ellipta will help manage your symptoms and improve your breathing over the long term.

Important Safety Information

Side Effects

Common side effects of Incruse Ellipta may include:

• Throat pain
• Tooth pain
• Muscle pain
• Bruising on your skin
• Belly pain
• Joint pain
• Changes in taste
• Irregular heartbeat
• Upper respiratory tract infections
• Cough
• Stuffy or runny nose
• Increased heart rate

Serious side effects of Incruse Ellipta may include:

• Eye problems, like glaucoma (increased pressure in your eye). Signs may include:
  • Nausea
  • Seeing halos or bright colors around lights
  • Blurry vision
  • Vomiting
  • Eye pain
  • Redness in your eyes
• Paradoxical bronchospasm signs may include:
  • Chest tightness
  • Trouble breathing
  • Shortness of breath
• Urinary retention. Signs may include:
  • Painful urination
  • Having a weak stream or only drops of urine
  • Urinating more often than usual
  • Trouble urinating

Mild allergic reactions may include:

• Itchiness
• Flushing (warmth and redness in your skin)
• Skin rash

Severe allergic reactions may include:

• Swelling of your tongue, mouth, or throat
• Trouble breathing or speaking
• Swelling under your skin, typically in your eyelids, lips, hands, or feet

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Warnings

You should not use Incruse Ellipta if you are allergic to umeclidinium or if you have:

• A severe allergy to milk proteins.

To ensure Incruse Ellipta is safe for you, inform your doctor if you have:

• Glaucoma
• Heart disease
• An enlarged prostate
• Urination problems

Additionally, tell your doctor if you are pregnant or breastfeeding. Incruse Ellipta is not approved for use by anyone younger than 18 years old. Always consult with your healthcare provider before starting any new medication to ensure it is appropriate for your health condition.

Precautions

Before taking Incruse Ellipta, discuss your health history with your doctor. Incruse Ellipta may not be suitable for you if you have certain medical conditions or other factors affecting your health. These include:

• Sudden Trouble Breathing: You shouldn’t use Incruse Ellipta to treat sudden breathing problems. Incruse Ellipta is intended to be used consistently as a maintenance (long-term) treatment to reduce symptoms of COPD. This medication will not help you treat sudden flare-up signs or symptoms. To manage sudden breathing problems, you’ll need to utilize a rescue inhaler like albuterol (Proair, Ventolin HFA) or levalbuterol (Xopenex). Always keep your rescue inhaler on hand for immediate relief during sudden breathing difficulties.
• Allergic Reactions, Including Allergies to Milk Proteins: Allergic reactions have occurred in people taking Incruse Ellipta. Sometimes, these reactions can be severe (called anaphylaxis) and may cause symptoms such as swelling of the tongue or mouth, itching, or rash. Because Incruse Ellipta has lactose, you should not use this medication if you have a severe allergy to milk proteins. Additionally, if you are allergic to umeclidinium (the active ingredient in Incruse Ellipta) or any other ingredients in the medication, you should avoid taking it. Using this drug can increase your chances of having a severe allergic reaction. Always inform your doctor about any known allergies before starting Incruse Ellipta.
• Worsening of Narrow-Angle Glaucoma: This medication can cause you new or worsening narrow-angle glaucoma. Symptoms of glaucoma (increased pressure in your eye) include eye pain and blurry vision. If you are suffering from glaucoma, it’s essential to talk with your doctor or healthcare provider before starting the Incruse Ellipta dose. Your doctor or healthcare giver can suggest that you should take a different medicine to avoid exacerbating your glaucoma symptoms. Always discuss your eye health and any concerns with your healthcare provider before beginning treatment with Incruse Ellipta.
• Worsening of Urinary Retention: Incruse Ellipta might cause you to experience new or worsening urinary retention, making urination difficult or even painful. You may be at higher risk of urinary retention if you have certain prostate or bladder problems. It is important to talk with your doctor about your risk of urinary retention before starting Incruse Ellipta treatment. Your doctor can help determine if this medication is suitable for you and discuss alternative options if necessary.

Other Important Precautions

• Alcohol: There are no known interactions between Incruse Ellipta & alcohol. However, consuming alcohol over a long period may potentially worsen your chronic obstructive pulmonary disease (COPD) symptoms. Prolonged alcohol consumption can also weaken your immune system, making your COPD symptoms more severe. If you have COPD and consume alcohol, it’s important to discuss with your doctor how much alcohol is safe for you to drink. Your doctor can provide guidance tailored to your specific health needs to help manage your COPD effectively.
• Pregnancy: It’s not known whether Incruse Ellipta is safe to take during pregnancy because there haven’t been enough studies conducted on pregnant women using the drug. However, animal studies have shown that there is no increased risk of birth defects in fetuses exposed to the drug during pregnancy. In these studies, pregnant animals were given doses between 50 and 200 times the maximum recommended dose for humans. It’s important to remember that animal studies don’t always predict what will happen in humans using the drug. If you are pregnant or planning to become pregnant, you can talk with your healthcare provider or doctor prior to using Incruse Ellipta. They can provide personalized advice based on your health and pregnancy.
• Birth Control: It’s not known for sure if Incruse Ellipta is safe to take during pregnancy. If you are sexually active and you or your partner can become pregnant, it is important to discuss your birth control needs with your doctor while using Incruse Ellipta. Your doctor can provide guidance on effective birth control methods to use while taking this medication to ensure safety and avoid any potential risks.
• Breastfeeding: It’s not known whether Incruse Ellipta is safe to take while breastfeeding. There haven’t been any studies done in humans to determine if Incruse Ellipta passes into breast milk or if it would have any effects on a breastfed child. In animal studies, the drug was found in the offspring of females who were injected with an Incruse Ellipta solution. However, it’s important to note that Incruse Ellipta is not given by injection in humans; it is inhaled into the lungs. The results of animal studies do not always predict what will happen in people. If you are breastfeeding, talk with your doctor before using Incruse Ellipta. They can provide guidance based on your specific situation and help you make an informed decision.

Contraindications

• Incruse Ellipta is contraindicated for use in people who are allergic to umeclidinium or any of its components, including magnesium stearate and lactose monohydrate.
• It is also contraindicated in people with severe allergies to milk protein, as the medication contains lactose. Severe allergic reactions have occurred due to lactose exposure. If you have any known allergies to these ingredients, you should not use Incruse Ellipta. Always inform your healthcare provider about any allergies before starting this medication.

Missed Dose

• If you forget to take a dose of Incruse Ellipta (Umeclidinium), take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Never take more than a single dose of Incruse Ellipta at once, and do not take more than one dose in 24 hours. To avoid missing a dose, set a reminder on your phone or use a medication timer.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdose

In clinical studies, no one has overdosed on Incruse Ellipta. However, it is possible to overdose on the drug by using more than the recommended dosage, which can lead to serious side effects. Symptoms of overdose that have occurred with drugs similar to Incruse Ellipta include:

• Increased blood pressure
• Dry mouth and eyes
• Hallucinations
• Blurry vision
• Increased heart rate
• Flushing or redness
• Fever
• Decreased sweating
• Seizures

If you think you have taken too much of this drug, call your doctor immediately. You can also contact the American Association of Poison Control Centers at 800-222-1222 or use their online tool. If your symptoms are severe, call 911 or go to the nearest emergency room right away.

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Storage

• Incruse Ellipta should be stored at room temperature, between 68°F and 77°F (20°C to 25°C). The lowest temperature at which it should be stored is 59°F (15°C), and the maximum temperature should be 86°F (30°C).
• Keep Incruse Ellipta in a foil tray it comes until you are ready to use it. Once the foil tray is opened, the medication is only good for 6 weeks.
• Incruse Ellipta is not a refillable inhaler. Each time you pick up a new prescription from your pharmacy, you will receive a new inhaler filled with 30 doses of the drug.
• Incruse Ellipta inhalers should be discarded after they have been out of their foil packaging for 6 weeks or when the dose counter on the inhaler reads “0.” A reading of “0” indicates that there are no doses remaining in the inhaler.
• If you no longer need to take Incruse Ellipta (Umeclidinium) and have leftover medication, it’s essential to dispose of this medication safely. This helps prevent others, including children and pets, from accidentally taking the drug and helps protect the environment.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Incruse Ellipta Interactions

Incruse Ellipta can interact with other medications, so it’s important to inform your healthcare provider about all the medicines you are taking. However, there are no known interactions between Incruse Ellipta and supplements or foods.

Different interactions can lead to different effects. For example, some interactions may reduce the effectiveness of the medication, meaning it might not work as well as it should. Other interactions can increase the risk of side effects or make existing side effects more severe. Always consult with your doctor or pharmacist to understand how to safely use Incruse Ellipta with other medications you might be taking.

Incruse Ellipta and Other Medications

Below is a list of medications that can interact with Incruse Ellipta. This list does not include all the drugs that may interact with Incruse Ellipta. Before starting Incruse Ellipta, it is important to talk with your doctor and pharmacist. Inform them about all the prescription medications, over-the-counter drugs, and any other substances you are taking. Sharing this information can help you avoid potential interactions. If you have any questions about drug interactions that may affect you, do not hesitate to ask your doctor or pharmacist. They can provide you with the necessary guidance to ensure the safe and effective use of Incruse Ellipta alongside your other medications.

Incruse Ellipta and Other Anticholinergic Medications: Incruse Ellipta belongs to a class of drugs called anticholinergics. (A medication class is a group of drugs that work in the same way.) You should not take Incruse Ellipta if you are already taking another anticholinergic medication. Anticholinergic medications work by relaxing the muscles in your airway, making it easier for you to breathe. However, taking more than one anticholinergic medication at the same time can increase your risk of side effects. These side effects can sometimes be serious, causing you to overheat or experience hallucinations. Examples of anticholinergic medications to avoid when taking this drug include:

• Aclidinium bromide (Tudorza Pressair)
• Formoterol/glycopyrrolate (Bevespi Aerosphere)
• Glycopyrrolate (Seebri Neohaler)
• Olodaterol/tiotropium (Stiolto Respimat)
• Tiotropium bromide (Spiriva)
• Vilanterol/umeclidinium (Anoro Ellipta)
• Ipratropium bromide (Atrovent HFA)

There are many other anticholinergic medications not listed above. Before starting Incruse Ellipta, discuss all the medications you are taking with your doctor. They will help you determine if it is safe for you to take Incruse Ellipta. Your doctor can provide personalized advice to ensure that you manage your health effectively and avoid any harmful interactions.

Incruse Ellipta and Herbs and Supplements: No specific herbs or supplements have been reported to interact with Incruse Ellipta. However, it is still important to check with your doctor or pharmacist before using any vitamins, herbs, or supplements while taking Incruse Ellipta. They can provide you with the best advice to ensure that your treatments do not interfere with each other and that you can safely manage your health. Always inform your healthcare provider about all the supplements you are taking to avoid any potential issues.

Incruse Ellipta and Foods: No specific foods have been reported to interact with Incruse Ellipta. However, if you have questions about whether eating certain foods when using Incruse Ellipta (Umeclidinium) is safe, it is best to talk with your doctor. They can provide personalized advice based on your overall health and treatment plan. Always consult your healthcare provider to ensure your diet does not interfere with your medication.

[Note: This isn’t a complete list, and there could be other drugs that interact with Incruse Ellipta. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Incruse Ellipta Alternatives

• Breo Ellipta
• Spiriva Handihaler (tiotropium bromide)
• Spiriva Respimat (tiotropium bromide)
• Trelegy Ellipta (fluticasone-umeclidinium-vilanterol)
• Stiolto Respimat (olodaterol-tiotropium)
• Tudorza Pressair (aclidinium)
• Anoro Ellipta (umeclidinium-vilanterol)
• Combivent Respimat (ipratropium-albuterol)
• Symbicort (budesonide-formoterol)
• Duaklir Pressair (aclidinium-formoterol)
• Zithromax (azithromycin)
• Daliresp (roflumilast)
• Advair Diskus (fluticasone-salmeterol)
• N-acetylcysteine
• Yuperli (revefenacin)
• Theophylline ER
• Bevespi Aerosphere (formoterol–glycopyrrolate)
• Breztri Aerosphere (budesonide–formoterol–glycopyrrolate)
• Lonhala Magnair (glycopyrrolate)
• Atrovent HFA (ipratropium)
• Proair HFA (albuterol)
• Ventolin HFA (albuterol)
• Albuterol nebulizer solution
• Ipratropium–albuterol nebulizer solution
• Serevent Diskus (salmeterol)
• Perforomist (formoterol)
• Prednisone
• Brovana nebulizer solution (arformoterol)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Should I utilize Incruse Ellipta for sudden breathing problems?

No, you should avoid using Incruse Ellipta (Umeclidinium) to treat issues related to sudden breathing. Incruse Ellipta works overtime to provide relaxation to the muscles present in your airway & make it easier for you to breathe, but it doesn’t act quickly enough to help with sudden breathing issues. If you experience sudden breathing problems, you must use a rescue inhaler to treat your symptoms quickly. Examples of rescue inhalers include albuterol & levalbuterol (Xopenex). If you have questions about using a rescue inhaler, consult your doctor for guidance.

Can I use Incruse Ellipta if I have heart problems?

Yes, you’ll probably be able to use Incruse Ellipta if you have heart problems. However, it’s important to note that Incruse Ellipta can increase your heart rate. In clinical trials, about 1% of people taking Incruse Ellipta experienced an increased heart rate, compared to less than 1% of people taking a placebo (no active drug). If you already have an increased heart rate or other heart-related conditions, this medication may increase your heart rate too much. It is crucial to talk with your doctor before starting Incruse Ellipta. They can determine whether this medication is safe for you to use and recommend appropriate alternatives if necessary.

Can I stop taking Incruse?

Do not stop using Incruse Ellipta without consulting your doctor. Stopping the medication suddenly may increase the risk of side effects and worsen your symptoms. Inhaled umeclidinium comes with a patient information leaflet and instructions. Be sure to read the directions carefully before using this medication, and follow your doctor’s advice on how to use it properly. If you have any questions or concerns about stopping the medication, discuss them with your healthcare provider.

Can you take Incruse twice a day?

No, you should not take Incruse Ellipta twice a day. The usual dose is one inhalation per day. Use the medicine at the same time each day, and do not use it more than once in a 24-hour period. Incruse Ellipta is not a rescue medicine and will not work fast enough to treat a bronchospasm attack. Always follow your doctor’s instructions and the prescribed dosage to ensure safe and effective use of the medication.

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