Janumet Xr Cp

Janumet XR CP is a prescription medicine used along with proper exercise and diet to help lower blood glucose levels in adults with type 2 diabetes. It contains two active ingredients: Sitagliptin and Metformin Hydrochloride (Extended-Release). Janumet XR CP contains the same active ingredients and strengths as Janumet XR.

Based on FDA labeling, this combination is available in fixed-dose strengths of 50 mg/500 mg, 50 mg/1000 mg, and 100 mg/1000 mg. Available strength options are displayed on this page and depend on current inventory.

Below is a quick overview of important facts for patients and caregivers:

Janumet XR CP is indicated as an adjunct to exercise and diet to help improve glycemic (blood sugar) control in adults with type 2 diabetes mellitus.

Limitations of use:

• It is not for use in people with type 1 diabetes.
• It has not been studied in patients with a history of pancreatitis. It is unknown whether these patients have an increased risk of pancreatitis when using this medicine.

These conditions require different treatments, as Janumet XR CP is not effective in such cases.

The mechanism of action of Janumet XR CP involves the combined effects of sitagliptin and metformin hydrochloride extended-release.

Sitagliptin works by enhancing the levels of natural hormones called incretins. These hormones are released after meals and help the body respond better to rising blood sugar. By slowing the breakdown of incretins, Sitagliptin helps:

• Raising insulin levels when blood sugar is high
• Reduces glucagon levels
• Reduce excess glucose produced by the liver

Metformin (Extended-Release) helps improve the body’s response to insulin over time. It works by:

• Improving insulin sensitivity so cells can use glucose more effectively
• Decreasing absorption of glucose from the intestines
• Reducing glucose production in the liver

Together, these effects improve daily blood glucose control without overstimulating insulin secretion.

Janumet XR CP tablet should be taken once daily, preferably in the evening, with a meal or exactly as prescribed by your healthcare provider. Taking it with food helps reduce stomach-related side effects and improves tolerability. Always follow your healthcare provider’s instructions. General guidelines include:

• Swallow the tablet whole with water
• Do not crush, chew, or split the tablet, as this may affect the extended-release action
• Take the medicine at the same time each day to maintain consistent blood sugar control
• If you notice the tablet shell in your stool, this is normal and does not affect how the medicine works

The dosage of Janumet XR CP tablet is individualized by a healthcare provider based on a patient’s current diabetes treatment, effectiveness, tolerability, and kidney function.

Recommended dosing:

• Janumet XR CP tablet is taken once daily with a meal.
• If two tablets are prescribed, they should be taken together once daily.
• Tablets must be swallowed whole and should not be split, crushed, or chewed.

Maximum recommended daily dose:

• Sitagliptin: 100 mg per day
• Metformin hydrochloride (extended-release): 2000 mg per day

Starting dose considerations:

• For patients not previously treated with Metformin, treatment is generally initiated at a lower dose and adjusted gradually to reduce gastrointestinal side effects.
• For patients already taking Metformin, the dose is adjusted to maintain a constant total daily dose of Metformin when Sitagliptin is added.
• When switching from immediate-release Janumet to Janumet XR CP, the same total daily doses of Sitagliptin and Metformin are usually maintained.

Patients with kidney impairment:

• Kidney function should be assessed before starting treatment and monitored periodically.
• Janumet XR CP is not recommended for initiation in patients with an eGFR below 45 mL/min/1.73 m².
• This medication is contraindicated in patients with severe renal impairment (eGFR below 30 mL/min/1.73 m²).
• If kidney function declines during treatment, dose adjustment or discontinuation may be required.

Temporary discontinuation:

Janumet XR CP may need to be stopped temporarily in certain situations, such as before imaging procedures involving iodinated contrast agents. Treatment is typically restarted once kidney function is confirmed to be stable.

What Happens If You Take Too Much Janumet XR CP?

If too much Janumet XR CP is taken, seek immediate medical support or contact a poison control center for guidance. An overdose may require supportive medical care, depending on the amount taken and the person’s condition. Doctors may monitor heart function and provide treatment based on symptoms.

This is because Janumet XR CP contains Metformin; taking too much can increase the risk of lactic acidosis, a rare but serious condition that requires urgent medical attention. In severe cases of Metformin overdose, hemodialysis may be used to help remove the drug from the body.

Commonly reported Janumet XR CP side effects are listed below:

Common Side Effects

These are usually mild and may improve as the body adjusts to the medication:

• Nausea or vomiting
• Diarrhea
• Stomach upset, gas, or indigestion
• Headache
• Weakness or tiredness
• Stuffy or runny nose, sore throat, or other upper respiratory symptoms

Low blood sugar (hypoglycemia) may occur, especially when Janumet XR CP is taken with insulin or sulfonylureas.

Less Common Side Effects

• Dizziness
• Changes in appetite
• Joint pain
• Mild skin reactions

Rare or Serious Side Effects

• Lactic acidosis: A rare but serious condition linked to Metformin, with symptoms such as unusual muscle pain, trouble breathing, extreme tiredness, dizziness, slow or irregular heartbeat, or stomach pain with nausea or vomiting
• Pancreatitis: It may cause severe abdominal pain that can spread to the back, with or without vomiting
• Severe allergic reactions: These include rash, swelling of the face, lips, tongue, or throat, or difficulty breathing
• Bullous pemphigoid: A serious skin reaction with blisters or skin breakdown
• Kidney problems: Sometimes requiring medical treatment
• Vitamin B12 deficiency with long-term use

If any side effects bother you, last longer than expected, or worsen, contact your healthcare provider.

Some individuals may require additional monitoring when using Janumet XR CP. Always share your full medical history with your healthcare provider before starting treatment.

Precautions Before Using Janumet XR CP Tablet

Before starting Janumet XR CP tablets, inform your healthcare provider about your full medical history. Extra caution may be needed in the following situations:

• Kidney or liver problems: This medicine may not be suitable for people with reduced kidney or liver function
• Older adults (65 years or above): Kidney function should be monitored more closely
• Heart-related conditions: Including heart failure or conditions that reduce oxygen supply
• Dehydration: Ongoing vomiting, diarrhea, fever, or heavy sweating can increase risks
• Upcoming surgery or medical procedures: Janumet XR CP may need to be stopped temporarily
• Imaging tests using contrast dye: Temporary discontinuation may be required before certain scans
• Alcohol use: Excessive alcohol intake increases the risk of lactic acidosis

Pregnancy and Breastfeeding

Pregnancy:

Limited data are available regarding the use of Janumet XR CP during pregnancy. Poorly controlled diabetes during pregnancy increases maternal and fetal risks. This medication should be used during pregnancy only if clearly needed and under medical supervision.

Breastfeeding:

Metformin is present in human breast milk in small amounts, and sitagliptin may also pass into breast milk. The benefits of breastfeeding should be weighed against the mother's need for treatment. Consult a healthcare provider before use.

Janumet XR CP may interact with medications that affect blood glucose levels or metformin clearance. Patients should inform their healthcare provider of all medications and supplements they are taking. Medications that may interact include:

This is not a complete list of all possible drug interactions. Do not start, stop, or change any medication while taking Janumet XR CP without consulting your healthcare provider.

Prescription medications for managing type 2 diabetes can be costly at many local U.S. pharmacies. Ordering Janumet XR CP online from Polar Bear Meds helps reduce overall costs while maintaining safety, quality, and reliability.

• Lower prices than many U.S. pharmacies, depending on the prescription and supply.
• Medications sourced from licensed and reputable Canadian pharmacies.
• Fast and secure shipping across the United States, typically within 3-5 business days via Xpress Post.
• Discreet packaging with order tracking for added security.
• Simple online ordering with easy prescription upload.
• Transparent pricing with no hidden fees.
• Additional savings with coupon code WELCOMEPB10: 10% off your first order.
• Dedicated customer support team to assist with prescriptions, orders, and delivery questions.

All Janumet XR CP orders are processed through licensed Canadian pharmacies that follow strict quality and safety standards. A valid prescription is required for every purchase to ensure proper medical use and patient protection.

• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64beb3d2-3aeb-4cd5-ba11-dacf6c9a5b50
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/202270s026lbl.pdf