Moclobemide

Moclobemide 

Moclobemide is an FDA-approved medication designed to treat certain types of mental depression, including social anxiety and major depressive disorder. This anti-depression medication contains moclobemide, a monoamine oxidase inhibitor that helps suppress the action of monoamine oxidase in the nervous system. Since it is a prescription drug, it is available with a doctor’s approval. Therefore, patients should avoid sharing their medicine with others even if they have the same condition. Doing so may cause unwanted reactions that can be life-threatening. Besides, moclobemide is suitable for adult use only, so do not give it to children under 18 years of age. While taking this drug, you need to avoid certain beverages and medicines. Talk to a medical professional for a detailed list of these items. 

Product Overview

Moclobemide is a prescription medication commonly used to treat depression and social anxiety disorders. It belongs to a class of drugs known as reversible inhibitors of monoamine oxidase A (RIMA). The active ingredient, moclobemide, works by increasing the levels of specific neurotransmitters, such as norepinephrine, serotonin & dopamine, which are essential for improving mood. Moclobemide is not a controlled substance and is approved by the FDA for its intended uses. It is a well-tolerated alternative to traditional antidepressants, particularly for individuals who may experience fewer side effects.

This medication is available in tablet form, typically in strengths of 150 mg & 300 mg. The medication is taken orally, usually daily after meals in divided doses, to ensure optimal absorption. It is suitable for adults but should not be used in children or adolescents without proper medical advice. It works by selectively restricting the enzyme monoamine oxidase A, which helps increase the availability of mood-enhancing neurotransmitters in the brain.

Common side effects of this medication may include dizziness, nausea, and insomnia. To minimize these reactions, avoid alcohol and certain foods high in tyramine. In case of a missed dose, take it as soon as possible, but skip it if it’s near the next scheduled dose. Do not double the dose to compensate. Overdose requires immediate medical attention. Store moclobemide at room temperature, away from moisture and direct sunlight, and keep it out of reach of children.

What Are the Uses of Moclobemide?

This medication is used for the following purposes:

• Treatment of Depression: It helps manage major depressive disorder by re-establishing the balance of neurotransmitters in the brain.
• Bipolar Disorder: Moclobemide can also be used to treat depressive episodes of bipolar disorder.
• Social Anxiety Disorder: Moclobemide aids in reducing the symptoms of social anxiety.
• Improves Mood and Well-Being: It helps uplift mood and overall well-being.    

What Are the Forms & Strengths of Moclobemide?

It is available in the form of tablets with the following strengths:

• 150 mg, and
• 300 mg

What Is the Recommended Dosage for Moclobemide?

The dosage recommendations for moclobemide depend on several factors, including the type and severity of your medical condition and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.

Dosage for Major Depression

• Adults: Take 300 mg of moclobemide once daily in divided doses after having a meal. Your doctor may increase the dosage up to 600 mg per day based on your depression severity. The dose may be reduced to 150 mg as per the individual’s response to the treatment.
• Children (Below 18 Years of Age): Talk to a medical professional; a professional must determine the use and dose.

Dosage for Social Phobia or Anxiety

• Adults: Start the treatment by taking 300 mg once daily, and on day 4, increase the dosage to 600 mg per day divided into two doses. Moreover, it is not recommended to keep taking 300 mg per day for more than three days because the effective dose is 600 mg per day. You should take 600 mg daily for 8 to 12 weeks to see if the medicine works. If it helps, you can keep taking it. The doctor will check you regularly to see if you need to continue the treatment. 
• Children (Below 18 Years of Age): Talk to a medical professional; a professional must determine the use and dose.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Moclobemide? 

• Read the medication guide or PIL (patient information leaflet) carefully to know the detailed medication administration steps. If you have any questions or concerns, ask a healthcare professional.
• Follow the dosage recommendations exactly as mentioned on the prescription label.
• Do not exceed or subceed the doses without consulting a medical expert. Doing so may increase the risk of side effects.
• Take the medication orally with a glass of water.
• Swallow the tablets as a whole.
• You can take the medication with food unless your doctor advises otherwise.
• Avoid chewing, crushing, splitting, or breaking the tablets. Doing so may release the drug at once. 
• If you are unable to swallow the medicine, consult your healthcare practitioner. They will suggest alternate options that suit your body’s needs.
• Take the medicines at the same time each day to get the most benefit out of it.
• Do not abruptly stop taking your medication without consulting a medical provider. This may cause serious complications in the future. So, complete your course of treatment till the days your doctor has advised.  

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Moclobemide Work?

Moclobemide works by restricting an enzyme called monoamine oxidase A (MAO-A) in the brain. This enzyme typically breaks down neurotransmitters such as serotonin, norepinephrine & dopamine, which are chemicals that help control mood. By blocking MAO-A, the medication increases the levels of these neurotransmitters, leading to enhanced mood and reduced symptoms of depression and anxiety. Unlike some older antidepressants, moclobemide is selective and reversible, meaning it targets MAO-A specifically, and its effects can be quickly reversed if needed. This makes it a safer and more targeted option for treating mood disorders.

Important Safety Information for Using Moclobemide

What Are the Side Effects of Moclobemide?

Common Side Effects of Moclobemide: This medication may cause various side effects. However, there is no need to panic as these reactions are temporary and will go away within a few days or weeks. In case these reactions persist for a long time or get intense, talk to a medical professional. Common side effects of moclobemide may include:

• Mild headache
• Dizziness or lightheadedness, especially when getting up from a sitting or lying position
• Nervousness
• Restlessness
• Unusual tiredness/weakness
• Nausea
• Vomiting 
• Insomnia
• Mouth dryness
• Constipation
• Diarrhea
• Aggressive behavior
• Feeling sick

Serious Side Effects of Moclobemide: Besides the above common side effects, the medication can lead to several adverse reactions, which can cause life-threatening situations. If you notice any sign that may seem concerning, visit a medical professional. Serious side effects of moclobemide may include:

• Rapid or irregular heartbeats
• Neck stiffness
• Extreme headaches starting from the back to the front of the head
• Slow heartbeat
• Anxiety
• Blurred vision
• High blood pressure
• Chest pain
• Confusion
• Suicidal thoughts
• Loss of taste
• Swelling
• Not feeling hungry
• Low Sodium levels in the blood. Its signs may include:
  • Sleepiness
  • Confusion
  • Seizures
• Serotonin syndrome. Its symptoms are:
  • Involuntary or rhythmic muscle contractions 
  • Coma
  • Excessive sweating
  • Tremor
  • Increased muscle tension
  • Losing consciousness
• Skin reactions
• Delusion

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Moclobemide?

Moclobemide can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious as it has several warnings, which are as follows:

• Risk of Suicidal Thoughts: It is not clear if older antidepressants increase the risk of suicidal thoughts and behavioral problems in adults or children. However, recent studies have observed changes in the behavior and emotions of patients taking newer antidepressants. Therefore, it’s important to closely monitor anyone taking any antidepressant for signs of suicidal thoughts or other changes in behavior and emotions.
• Hepatic Impairment: Patients with severe liver problems should consult a medical practitioner before taking this medication. The doctor will decide the accurate dose suiting the patient’s body needs. These doses are usually lower than the actual adult dose.
• Angle-Closure Glaucoma: Moclobemide may cause an acute attack of glaucoma. Therefore, if you are experiencing vision changes, eye pain, swelling, or redness around the eye, seek medical attention.

What Are the FDA Boxed Warning for Moclobemide?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Moclobemide does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or noticed any unusual symptoms, it’s best to consult with an expert.

What Are the Moclobemide Precautions?

When considering treatment with moclobemide, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using moclobemide for depression problems:

• Before using this medication, tell your doctor if you have any allergies or are even allergic to moclobemide or any of the ingredients used in its formulation. The product may contain certain inactive components that can cause allergic reactions. 
• When considering treatment with moclobemide, tell your doctor about your or your family’s medical history.
• Taking this medicine with certain drinks or other drugs can cause serious reactions like high blood pressure. To avoid this life-threatening reaction, avoid drinking excessive alcohol. 
• If you are undergoing surgery or any medical procedure, inform your healthcare provider about the products you are taking. This includes all prescription medications, over-the-counter drugs, and herbal products. Some of the examples are:
  • Dextromethorphan (found in cough medicines)
  • Buprenorphine
  • Fluoxetine
  • Bupropion
  • Paroxetine
  • Clomipramine
  • Pethidine (for pain relief)
  • Selegiline (for Parkinson’s disease)
  • Linezolid (for the treatment of infections)
  • St John’s Wort (for anxiety)
  • Triptans (for migraines)
  • Tramadol (for pain relief)
• It is advised not to eat large amounts of tyramine during your treatment with moclobemide. Ask your medical practitioner about any diet changes that you should take. Some of the foods containing tyramine are:
  • Yeast extract
  • Mature cheese
  • Fermented soya bean products 
• Sometimes, you may feel better, but you must continue taking the medicine for several weeks or as your doctor advises. 
• Make frequent doctor visits, as they will monitor your progress reports, especially during the initial stages of treatment. This will prevent you from any serious effects and ensure that the medicine is working properly.
• Moclobemide may cause blurred vision or make you drowsy, so avoid driving or using any heavy machinery that requires alertness. 
• If your course is completed or you have stopped using this medication, you must exercise caution for at least two weeks while taking any food, drink, or other medicines.
• If you have suicidal thoughts or thoughts of killing someone, get medical assistance right away.
• If you are pregnant or planning to have a baby, avoid using this medication unless advised by your doctor. Discuss every risk and benefit with your medical provider before making any decision.
• If you are intolerant to some sugars, talk to a medical expert to avoid any serious side effects. 
• This medicine is not intended for use in children under 18 years of age.
• If you are experiencing psychotic symptoms or any antipsychotic medications, talk to your medical professional.

What Are the Contraindications of Moclobemide?

It is contraindicated in the following conditions:

• Patients with hypersensitivity reactions to moclobemide or any of the ingredients present in its formulation.
• Patients who have an acute confusional state.
• Co-administration with bupropion, tramadol, and triptans.
• Using moclobemide in combination with thioridazine and dextromethorphan.
• Patients with phaeochromocytoma (tumor on one of the adrenal glands).
• Taking pethidine or selegiline.

What If You Missed a Dose of Moclobemide?

Generally, it is advisable not to miss any doses of moclobemide, but if someone forgets, they should:

• Take the tablets as soon as possible or whenever they remember.
• If it is almost time for the next dose, omit the missed dose and follow the regular dosing schedule as a medical professional instructed.
• Remember not to take double doses of the prescribed medication just for the sake of making up for the missed dose. This may cause adverse side effects.
• Use medication apps or set reminders on your mobile phone to avoid skipping any doses.
• Take each dose at the same time every day to get the most benefit out of it.
• If patients are still unsure about the missed doses, talk to an expert physician. They will guide each patient and suggest alternate options suiting their body needs.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Moclobemide?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly take an excessive amount of moclobemide tablets. In such cases, patients are advised not to panic and instead look for unusual signs like:

• Vomiting
• Nausea
• Disorientation
• Slurred speech
• Drowsiness
• Reduced reflexes
• Hypertension
• Agitation
• Amnesia
• Convulsions

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Moclobemide?

• Store the medication at a room temperature of 15-30°C.
• Keep the tablets in a closed container and place a safety lock to avoid poisoning your child. There are many products in the market that are not child-resistant. 
• Keep the medicine protected from heat, direct light, and moisture. 
• Ensure that tablets are kept somewhere safe, away from the reach and sight of children and pets.
• Do not flush the medication down the toilet. 
• Avoid keeping them in moist or damp areas like the bathroom or near the sink.
• Discard the product when not in use.
• Keep the tablets in a dry place.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• Ask a medical professional how to dispose of the product properly without damaging the environment.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Moclobemide?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their moclobemide medication. Below are some of the drugs that can interact with moclobemide:

• Brimonidine
• Carbidopa
• Carbinoxamine
• Amitriptyline
• Amoxapine
• Apraclonidine
• Benzphetamine
• Codeine
• Cyclobenzaprine
• Cyproheptadine
• Desipramine
• Clomipramine
• Deutetrabenazine
• Dexfenfluramine
• Dextromethorphan
• Diethylpropion
• Tetrabenazine
• Tramadol
• Tranylcypromine
• Trazodone
• Trimipramine
• Tryptophan
• Viloxazine
• Pseudoephedrine
• Reserpine
• Safinamide
• Selegiline
• Sibutramine
• Solriamfetol
• Sumatriptan
• Nefopam
• Nortriptyline
• Opipramol
• Ozanimod
• Phendimetrazine
• Phenmetrazine
• Phentermine
• Phenylalanine
• Protriptyline
• Isometheptene
• Levodopa
• Levomethadyl
• Lofepramine
• Maprotiline
• Mavacamten
• Mazindol
• Methamphetamine
• Methotrimeprazine
• Methyldopa

What Are the Other Moclobemide Interactions?

Some medications are usually not recommended with moclobemide, but your doctor may prescribe them in certain situations. In such cases, the medical professional may change the dose and how often you should use both medicines. These drugs are as follows:

• Oxymetazoline
• Palonosetron
• Pentazocine
• Phenobarbital
• Primidone
• Reboxetine
• St John’s Wort
• Tamoxifen
• Tyrosine
• Ziprasidone
• Alfentanil
• Atropine
• Belzutifan
• Benzhydrocodone
• Buspirone
• Butorphanol
• Cilostazol
• Clovoxamine
• Clozapine
• Difenoxin
• Dihydrocodeine
• Diphenoxylate
• Dolasetron
• Droperidol
• Ethchlorvynol
• Femoxetine
• Frovatriptan
• Granisetron
• Guarana
• Hydrocodone
• Lasmiditan
• Levorphanol
• Licorice
• Lithium
• Metaxalone
• Methadone
• Methylene Blue
• Metoclopramide
• Midodrine
• Nalbuphine
• Naratriptan
• Nebivolol
• Nefazodone
• Norepinephrine
• Ondansetron

[Note: This isn’t a complete list, and there could be other drugs that interact with moclobemide. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Moclobemide Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to moclobemide are as follows:

• Selective Serotonin Reuptake Inhibitors. Examples are:
  • Fluoxetine (Prozac)
  • Sertraline (Zoloft)
  • Citalopram (Celexa)
• Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs). For example:
  • Venlafaxine (Effexor)
  • Duloxetine (Cymbalta)
• Tricyclic Antidepressants. Some of its examples are:
  • Amitriptyline
  • Nortriptyline (Pamelor)
• Atypical Antidepressants. Examples are:
  • Bupropion (Wellbutrin)
  • Mirtazapine (Remeron)
• Monoamine Oxidase Inhibitors (MAOIs). For example:
  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Moclobemide Cost & Coupons

It is important to note that the cost of moclobemide is not the same everywhere. The actual price of these tablets depends on several factors, including your insurance plan, location, and the pharmacies you use. Moclobemide, with its anti-depressant qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here, you can buy moclobemide online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the moclobemide coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

How fast does moclobemide work?

Moclobemide typically starts to show effects within 1 to 2 weeks of consistent use, but it may take up to 4 weeks for the full therapeutic benefits to become noticeable. The time it takes to work can vary based on the individual & the severity of symptoms. It’s important to continue taking the medication as directed, even if you don’t feel immediate improvement, and to discuss any concerns, consult your medical provider.

Does moclobemide make you sleepy?

Moclobemide is generally not known to cause drowsiness or sleepiness, which is a common side effect of many other antidepressants. In fact, some individuals may experience increased alertness or insomnia, particularly when first starting the medication. However, as with any medication, reactions can vary, so it’s important to monitor how you feel and discuss any sleep-related issues with your healthcare provider to ensure proper management.

Is moclobemide an addictive drug?

Moclobemide is not considered an addictive drug. It does not have the potential for abuse or physical dependence that some other medications, particularly certain types of antidepressants or anxiolytics, may have. This makes it a safer option for long-term use in treating depression and anxiety disorders. However, it should still be used under the guidance of a healthcare provider, and any discontinuation should be done gradually to avoid potential withdrawal symptoms.

Does moclobemide affect dopamine levels?

Yes, moclobemide affects dopamine levels by suppressing the enzyme monoamine oxidase A (MAO-A), which breaks down dopamine in the brain. By preventing this breakdown, moclobemide increases the availability of dopamine, along with other neurotransmitters like serotonin and norepinephrine. This action helps improve mood and alleviate symptoms of depression and anxiety. The selective nature of moclobemide means it specifically targets MAO-A, leading to a more balanced increase in neurotransmitter levels.

Is moclobemide a sedative?

Moclobemide is not a sedative. It is an antidepressant that works by raising the levels of specific neurotransmitters present in the brain, such as serotonin, norepinephrine, and dopamine. Unlike sedatives, which are designed to calm or induce sleep, moclobemide is intended to improve mood & reduce symptoms of depression and anxiety without causing sedation. Most patients do not experience drowsiness, making it suitable for daytime use, although individual reactions can vary.

Our Guarantee

At PolarBearMeds.com, we assure you the most affordable price to buy Moclobemide online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently buy Moclobemide online to treat mental depression at a substantial cost, call us at 1-888-779-2193 toll-free.