Nurtec ODT

Nurtec ODT (rimegepant) is a prescription medication used for the treatment and prevention of migraine in adults. It belongs to a class of drugs known as CGRP receptor antagonists. This medication works by blocking calcitonin gene-related peptide (CGRP), a key substance involved in migraine attacks. Nurtec ODT is available only with a valid prescription and should be taken under the guidance of a licensed healthcare provider.

Nurtec ODT (rimegepant) is an FDA-approved medication used in adults for:

• Preventive treatment of episodic migraine
• Treatment of acute migraine attacks, with or without aura

Nurtec ODT has specific precautions and safety warnings that patients should review before starting their migraine treatment:

What to Avoid While Taking Nurtec ODT?

• Avoid using strong or moderate CYP3A4 inhibitors or inducers (such as certain antifungals, antibiotics, or seizure medications) unless your healthcare provider approves.
• Do not exceed the recommended dose (maximum 75 mg in 24 hours).
• Do not take more than 18 doses in a 30‑day period (safety not established).
• Do not use Nurtec ODT for conditions other than migraine.
• Avoid combining Nurtec ODT with P-gp or BCRP inhibitors, which may increase drug levels.

What Are the Warnings of Nurtec ODT?

• Hypersensitivity reactions, including rash, shortness of breath, and swelling of the face or throat, have been reported.
• The safety of these orally disintegrating tablets in pregnancy & breastfeeding has not been established; consult your healthcare provider.
• Discontinue Nurtec ODT and seek medical help if signs of an allergic reaction occur.
• Nurtec ODT is not recommended in patients with severe hepatic impairment (Child-Pugh C). Rimegepant does not require dose adjustment in mild-to-moderate renal impairment; consult your healthcare provider in cases of severe renal impairment.
• Elevated liver enzymes and rare skin reactions have been reported.

Who Cannot Take Nurtec ODT?

• You should not take Nurtec ODT if you:
  • Have a known hypersensitivity to rimegepant
  • Have severe hepatic impairment (Child-Pugh C)
  • Have end-stage renal disease (creatinine clearance <15 mL/min)
• Nurtec ODT is not approved for use in pediatric patients.

What Should You Do If You Miss a Dose of Nurtec ODT?

• For acute treatment: Nurtec ODT is taken as needed for migraine attacks. If a dose is missed, do not take an extra dose; wait until the next migraine.
• For preventive treatment: If you miss a scheduled dose, take it as soon as you remember. Then continue with your regular every‑other‑day schedule. Do not double up doses.

Nurtec ODT 75 mg (rimegepant) is well tolerated by most patients when taken as prescribed, but like all medications, it can cause side effects. Most Nurtec ODT side effects are mild and temporary.

Nurtec ODT (rimegepant) works by blocking the activity of calcitonin gene-related peptide (CGRP), a protein involved in migraine attacks. By inhibiting CGRP, Nurtec ODT can:

• Reduce inflammation and pain signals in the nervous system
• Relieve migraine pain and associated symptoms, such as nausea and sensitivity to light or sound
• Help prevent future migraine attacks when taken as prescribed for preventive therapy

• Follow your healthcare provider's exact instructions. Do not start, stop, or change your dose without guidance.
• Ensure hands are dry before removing the tablet from the blister to prevent premature dissolving; do not push through the foil.
• Place the tablet on or under your tongue; allow it to dissolve completely; no water is needed.
• You can take orally disintegrating tablets with or without food.
• Do not chew or swallow whole.
• Keep orally disintegrating tablets in their original blister pack until use.
• Nurtec ODT is for episodic migraine prevention only, not for chronic migraine.

The Nurtec ODT dose may vary based on the patient's condition. Here is the average dosing schedule:

Clinical studies have shown that Nurtec ODT (rimegepant) is effective for the acute treatment of migraine attacks. It is also effective for the prevention of episodic migraine in adults.

Acute Migraine Treatment (single attack)

In a pivotal Phase 3 trial, patients with moderate-to-severe migraine took a 75 mg dose of Nurtec ODT. They were significantly more likely to be pain-free and experience relief from their most bothersome symptom (MBS) two hours after dosing, compared with placebo.

• 21.2% of patients on Nurtec ODT became pain‑free at 2 hours versus 10.9% on placebo.
• 35.1% achieved freedom from their most bothersome symptom versus 26.8% on placebo.

Preventive Treatment (episodic migraine)

For migraine prevention, studies have found that regular dosing of Nurtec ODT (75 mg every other day) can reduce the number of monthly migraine days (MMDs) compared with placebo. During weeks 9 to 12 of treatment:

• Patients taking Nurtec experienced an average reduction of 4.3 monthly migraine days compared with 3.5 days in the placebo group.
• A higher percentage of patients taking Nurtec achieved at least a 50% reduction in moderate to severe migraine days compared with placebo.

Overall, these findings show that Nurtec ODT works for both acute migraine relief and prevention effectively.

Many people get confused between Nurtec and Nurtec ODT. Both contain the same active ingredient, rimegepant, and are FDA-approved for the treatment and prevention of migraine. The key difference lies in the dosage form, as outlined below.

Some medications may interact with Nurtec ODT (rimegepant). You should not take Nurtec ODT with the following drugs unless your doctor advises otherwise:

If Nurtec ODT 75 mg is not suitable, your doctor may recommend the following alternatives:

• Ubrelvy (ubrogepant)
• Qulipta (atogepant)
• Zavzpret (zavegepant)
• Aimovig (erenumab)
• Ajovy (fremanezumab)
• Emgality (galcanezumab)
• Vyepti (eptinezumab)

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• https://nurtec.pfizerpro.com/
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/212728s000lbl.pdf
• https://pubmed.ncbi.nlm.nih.gov/36739335/
• https://www.drugs.com/nurtec-odt.html
• https://www.webmd.com/drugs/nurtec-odt-rimegepant