Pirfenidone

Buy Pirfenidone Online

Pirfenidone is a prescription medication used for treating conditions like idiopathic pulmonary fibrosis (IPF). It is a lung disease that causes lungs to get scarred and makes them stiff, thus making it harder for patients to breathe. To treat such a situation, doctors prescribe Pirfenidone to slow down the exacerbation of IPF. This medication is available in both tablets and capsules and is suitable for only adults. However, like every drug, Pirfenidone may also cause side effects if not taken as per the doctor’s instructions. Therefore, patients should always follow their medical provider’s guidance while taking any medication. Moreover, people are advised not to share their medication with another individual, even if they share the same condition. This can increase the risk of side effects. 

Product Overview

Pirfenidone is a medication primarily used to treat idiopathic pulmonary fibrosis (IPF), a condition that causes progressive scarring of the lungs. This drug contains the active ingredient Pirfenidone, which helps to reduce lung fibrosis, inflammation, and the progression of the disease. This medication is FDA-approved and is available only by prescription, highlighting its necessity for proper medical supervision.

Pirfenidone is available in tablet and capsule form, with common strengths being 267 mg and 801 mg. It should be taken orally with food for gastrointestinal side effects. This medication is usually prescribed for adults diagnosed with IPF. It works by restricting the production of transforming growth factor-beta and tumor necrosis factor-alpha, which are involved in the fibrotic process in the lungs.

Common side effects of Pirfenidone include nausea, rash, fatigue, diarrhea, and loss of appetite. Patients are advised to avoid direct sunlight & wear protective clothing due to the increased risk of photosensitivity. In case of a missed dose, it should be taken as soon as remembered unless it is close to the time for the next dose. Store Pirfenidone tablets at room temperature and keep them out of reach of children. Pirfenidone provides a targeted approach to managing IPF, offering patients an opportunity to slow disease progression with proper medical guidance & adherence to prescribed instructions.

What Are the Uses of Pirfenidone?

This drug is used to treat idiopathic pulmonary fibrosis, which is a lung disease.

What Are the Forms & Strengths of Pirfenidone?

It is available in the following form and strength:

• Capsule: 267 mg
• Tablet: 801 and 267 mg

What Are the Recommended Dosage of Pirfenidone?

The dosage recommendations for Pirfenidone depend on several factors, including the type and severity of your medical condition, body weight, and the form of medication you take. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner. 

Dosage for Idiopathic Pulmonary Fibrosis

For Adults

• On Days 1 to 7: Take 267 mg thrice daily
• On Days 8 to 14: Take 534 mg thrice a day. 
• On Day 15 and Later: 801 mg three times a day.

For Children

• Talk to a medical practitioner before starting treatment with this medication, as the safety and effectiveness of Pirfenidone have not been established yet.    

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Pirfenidone? 

• Read the medication guide thoroughly provided by your healthcare professional or pharmacist. This guide will offer detailed information on the administration steps.
• Follow the dosage recommendations exactly as your doctor prescribes.
• Do not take extra or less doses of your medication. Doing so will increase the risk of side effects.
• Take the medication by mouth with food, thrice daily or as your practitoner directed. Take this medication with food reduce dizziness and nausea. 
• Swallow the medication as a whole with a glass of water.
• Do not break, split, chew, or crush the tablets or capsules. Doing so may release the drug at once.
• If you are unable to swallow the medication, talk to a medical professional. They will suggest some alternate options that suit your body’s needs.
• During your treatment with Pirfenidone, you should take frequent blood tests and closely monitor your liver function. These tests are essential, as your next dose is based on your liver function.
• Do not take more than three doses in a day. It will increase the chances of side effects.
• If you have discontinued the medication, avoid restarting it unless your doctor recommends it.
• Do not abruptly stop taking this medication without discussing it with your medical practitioner. Doing so will result in adverse reactions.
• Do not stop taking this medicine even if your condition improves.
• If the condition does not improve or worsens over time, reach out to your medical provider.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Pirfenidone Work?

Pirfenidone is a medication indicated for the treatment of idiopathic pulmonary fibrosis (IPF), a condition where the lungs become scarred and stiff. It works by minimizing inflammation and slowing down the progression of lung fibrosis. Pirfenidone restricts the production of fibroblast growth factors and transforming growth factor-beta (TGF-β), which are involved in the scarring process. Targeting these pathways helps preserve lung function and improves the quality of life for patients with IPF. Regular monitoring and sticking to prescribed doses are essential to maximize its benefits and manage potential side effects. 

Important Safety Information for Using Pirfenidone

What Are the Side Effects of Pirfenidone?

Common Side Effects of Pirfenidone: This medication can cause various side effects. These reactions are usually temporary, lasting from a few days to weeks. However, if these effects stay for a long period or get intense over time, contact your medical provider. Common side effects of Pirfenidone may include:

• Fatigue
• Diarrhea
• Upper respiratory tract infection
• Nausea
• Skin rash
• Insomnia
• Dizziness
• Upset stomach
• Weight loss
• Headache
• Not feeling hungry
• Abdominal pain
• Gastroesophageal reflux disease
• Joint pain
• Mild allergic reaction
• Stuffy nose
• Sneezing
• Sore throat

Serious Side Effects of Pirfenidone: Besides common side effects, this drug can also lead to adverse reactions, which can be fatal for certain patients. If you notice any unusual effects that seem serious to you, immediately reach out to a healthcare professional. Serious side effects of Pirfenidone may include:

• Increased levels of liver enzyme (an indication of liver damage). Its signs may include:
  • Stomach pain
  • Dark urine
  • Jaundice
  • Fatigue
• Photosensitivity
• Severe allergic reactions
• Confusion
• Unusual bleeding
• Vomiting

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Pirfenidone? 

Pirfenidone can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious as it has several warnings, which are as follows:

• Liver Injury: Patients using this medication have reported cases of drug-induced liver injury. Clinical studies have observed that patients treated with 2403 mg/day had higher elevated ALT/AST rates. So, doctors usually advise taking monthly liver tests for six months before starting treatment with Pirfenidone. If symptoms of liver injury occur, such as fatigue, loss of appetite, upper right abdominal pain, dark urine, or jaundice, check liver function immediately.
• Skin Reactions: Severe skin reactions, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia & systemic symptoms (DRESS), have been reported with Pirfenidone. If you experience any symptoms of severe skin reactions, stop treatment until the cause is identified and consult a dermatologist. If a severe skin reaction is confirmed, discontinue the medication permanently.
• Drug Interactions: Pirfenidone is a CYP1A2 substrate. Patients are advised to avoid using moderate or strong CYP1A2 inhibitors before starting treatment with Pirfenidone. If you are unable to do so, talk to a medical professional; they will reduce your dosage. Moreover, if you are considering taking Pirfenidone, discontinue the use of strong CYP1A2 inducers, as they may reduce its effectiveness.
• Gastrointestinal Issues: Patients taking this medication have higher chances of experiencing gastrointestinal problems, and nausea, diarrhea, indigestion, vomiting, gastroesophageal reflux disease, and abdominal pain are more common among patients. The most frequent gastrointestinal issues causing dose changes were nausea, diarrhea, vomiting, and indigestion. These events were most common in the first 3 months of treatment and decreased over time. Dose adjustments may be required for managing gastrointestinal side effects.

What Are the FDA Boxed Warning for Pirfenidone?

Boxed warnings, sometimes referred to as black-boxed warnings, are said to be the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Pirfenidone does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this medication, follow the instructions provided by a medical professional. If you have any concerns or experience any unusual symptoms, it’s best to consult with an expert.

What Are the Pirfenidone Precautions?

When considering treatment with Pirfenidone, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using this medication for idiopathic pulmonary fibrosis:

• Before starting your treatment with this medication, make sure to tell your practitioner about your allergies or if you are allergic to any of Pirfenidone’s ingredients. The product may contain certain inactive components that can cause severe allergic reactions.
• If you are undergoing surgery or any medical procedure, inform your healthcare provider about the products you use. This includes all prescription medications, over-the-counter drugs, and herbal products. 
• When considering using this medication, let your doctor know about your or your family’s medical history, especially for kidney problems like dialysis or liver diseases.
• Pirfenidone usage may make your skin more sensitive to the sun. Therefore, patients are advised to limit their time in the sun & avoid tanning booths or sunlamps. To prevent any skin sensitivity issues, use sunscreen and wear protective clothes when going outside during the daytime. Moreover, if you get sunburned or develop skin redness/blisters, reach out to a medical practitioner immediately.
• Consuming alcohol while taking this medication may increase the effects of alcohol and make you dizzy. So, it is recommended to limit alcoholic beverages or marijuana during your treatment. Also, do not drive or operate any heavy machinery just after taking this medication.
• If you are pregnant or planning to have a baby, avoid using Pirfenidone unless it is clearly needed, as the drug may harm the developing baby. Talk to a medical expert before making any decision and discuss every risk and benefit associated with it.
• It is unclear whether the drug enters into the breastmilk or not. So, if you are a nursing mother, consult a healthcare professional before breastfeeding your child. They will tell you if the drug is safe for the feeding baby or not.
• Avoid smoking when using this medication, as it may result in adverse reactions.
• Take your medication with food to avoid nausea and dizziness.

What If You Missed a Dose of Pirfenidone?

Generally, doctors recommend not to miss a dose of Pirfenidone, but if you have forgotten a dose of your medication:

• Take the medication as soon as possible or whenever you remember.
• If it is almost time for the next dose, you may omit the missed dose and continue your regular dosing schedule.
• Remember not to take double doses of Pirfenidone simultaneously, as it can increase the risk of side effects.
• Use medication apps or set reminders on your phone to avoid skipping any doses.
• You can use a pill box for timely medication administration. These boxes have separate compartments for each week. You can organize your doses weekly. 
• However, if you have missed the doses for 14 straight days, you have to restart the treatment.
• If you are still unsure about the missed dose, consult a healthcare professional. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Pirfenidone?

Doctors usually advise not to take extra doses of Pirfenidone as this medication can cause adverse reactions if overdosed. However, if you have mistakenly overdosed and are experiencing unusual symptoms like fainting and difficulty breathing, visit the nearest clinic or seek medical assistance by calling 911.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Pirfenidone?

• Store your tablets and capsules at room temperature of 25°C or 77°F.
• Keep your medication in its original container and store it in a tightly closed container.
• Place safety locks on the container to avoid poisoning your child or pet.
• Do not flush the medication down the toilet.
• Avoid storing the tablets in damp or moist places like the bathroom or near the sink.
• Do not keep the medication under direct sunlight or heat.
• Store your medications somewhere safe and away from the reach and sight of children and pets.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Pirfenidone?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Pirfenidone medication. Below are some of the drugs that can interact with Pirfenidone:

• Aminolevulinic acid
• Amiodarone
• Capmatinib
• Ciprofloxacin
• Enoxacin
• Fluvoxamine
• Givosiran
• Ketoconazole
• Leflunomide
• Levoketoconazole
• Lomitapide
• Mibefradil
• Mipomersen
• Osilodrostat
• Pexidartinib
• Ritlecitinib
• Rucaparib
• Teriflunomide
• Vemurafenib
• Viloxazine

What Are the Other Pirfenidone Interactions?

Besides drug interactions, there are several other disease interactions, which are as follows:

• Hepatic impairment
• Renal impairment
• Smoking

[Note: This isn’t a complete list, and there could be other drugs that interact with Pirfenidone. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Pirfenidone Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives to Pirfenidone are as follows:

• Ofev (nintedanib)
• Nintedanib
• Actimmune
• Interferon gamma-1b

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Pirfenidone Cost & Coupons

It is important to note that the cost of Pirfenidone is not the same everywhere. The actual price of these tablets depends on several factors, including your insurance plan, location, and the pharmacies you use. Pirfenidone, with its effective therapeutic qualities, can be a bit expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here you can buy Pirfenidone online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Pirfenidone coupon code WELCOMEPB10 to receive a 10% discount on their first order.   

Frequently Asked Questions

What foods should I avoid during my treatment with Pirfenidone?

While taking Pirfenidone, it’s advised to avoid foods and beverages that can increase side effects, particularly those that cause photosensitivity, such as grapefruit and grapefruit juice. These can interfere with the metabolism of the medication, increasing its concentration in your bloodstream and potentially leading to more severe side effects. Additionally, it’s recommended to avoid excessive alcohol consumption, as it can further strain your liver, which is already processing the medication.

For how long do I have to take Pirfenidone?

The duration of treatment with Pirfenidone depends on your specific condition & response to the medication. Typically, it takes a long time to manage idiopathic pulmonary fibrosis (IPF). Your doctor will closely monitor your progress & determine the appropriate length of treatment. It’s essential to follow your doctor’s instructions and not to stop taking the medication without medical guidance, even if you feel better, to ensure the best possible management of your condition.

Is Pirfenidone a steroid medication?

No, Pirfenidone is not a steroid medication. It is an antifibrotic agent designed to treat idiopathic pulmonary fibrosis (IPF). Pirfenidone works by reducing lung fibrosis and inflammation, thereby slowing the progression of the disease. Unlike steroids, which suppress the immune system, this medication targets specific pathways involved in fibrosis and inflammation.

What happens if I suddenly stop taking Pirfenidone?

Suddenly stopping Pirfenidone can lead to exacerbation of idiopathic pulmonary fibrosis (IPF) symptoms, as the medication helps manage and slow the disease. It’s crucial to follow your doctor’s instructions regarding any changes in medication. If you need to stop taking Pirfenidone, your doctor will likely advise a gradual reduction in dosage to minimize any potential adverse effects and ensure a smooth transition, avoiding any sudden exacerbation of your condition.

Does Pirfenidone affect the liver?

Yes, Pirfenidone can affect the liver. That’s why liver function tests are recommended before starting treatment & periodically during treatment to monitor for potential liver toxicity. Elevated liver enzymes can indicate liver stress or damage, and your doctor may adjust your dosage or discontinue the medication if significant liver issues are detected. It’s important to report any symptoms of liver problems, such as yellowing of the skin or eyes, dark urine, or persistent nausea, to your doctor immediately.

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