Prucalopride 

Resotran

Resotran is an FDA-approved medication for chronic constipation in adults. Its active ingredient is prucalopride, which works by stimulating 5-HT4 receptors in the gastrointestinal tract. The prescription medication is available as a tablet in two strengths: 1 mg & 2 mg, to be taken orally once daily, with or without food. It is not approved for children and adolescents under 18 years of age. Patients should take precautions, especially if they have pre-existing heart conditions, liver or kidney issues, or a history of depression. For a safe and efficient use of the medication, consult your doctor or healthcare provider. You can buy Resotran (prucalopride) online from trusted and reputable sources to treat chronic constipation. 

Product Overview

Resotran is a prescription medication containing the active ingredient prucalopride. It is used to treat chronic constipation in adults. Prucalopride works by stimulating 5-HT4 receptors in the gastrointestinal tract, which enhances muscle contractions necessary for bowel movements, effectively relieving symptoms of constipation. This targeted action is beneficial for individuals who have not found relief from other laxatives.

Resotran is available in tablet form with strengths of 1 mg and 2 mg. The recommended medication dosage for adults is 2 mg once every day, taken orally with or without food. For geriatric patients, an initial dose of 1 mg is recommended, with a possible increase to 2 mg as needed. The medication is not recommended for children or adolescents under 18 years of age. It is essential to take Resotran as directed by a healthcare provider, without altering the dosage unless advised.

Common side effects of Resotran may include headaches, nausea, abdominal pain, and diarrhea. Patients should take precautions, especially if they have pre-existing heart conditions, liver or kidney issues, or a history of depression. If a dose is missed, it should be taken as soon as possible, but not if it is close to the next scheduled dose. In case of an overdose, seek prompt medical assistance. Store Resotran in a cool, dry place away from children and pets. Always consult your medical provider for customized advice and guidance.

What Are the Uses of Resotran?

It is used to:

• Treat chronic constipation in adults 

What Are the Forms & Strengths of Resotran?

It comes in the form of a tablet with the following strengths:

• 1 mg 
• 2 mg 

What Are the Recommended Dosage of Resotran?

For Chronic Constipation 

For Adults 

• Recommended Dose: 2 mg once daily orally, by mouth with or without food, any time of the day. 
• Maximum Dose: 2 mg  

For Geriatric Patients 

• • Initial Dose: 1 mg once daily orally by mouth. 

• Maximum Dose: 2 mg 

Pediatric Patients

• Usage is not recommended for children and adolescents under 18 years of age. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your physician, and they will customize your dosage accordingly.]

How to Use Resotran? 

For a safe and efficient use of the medication, you should follow the instructions for use given below. 

• Before using this medication for the first time and each time you get a refill, you should carefully read and follow the instructions given in the patient information leaflet. If you have any queries or concerns or if you do not understand any part of the leaflet, you should consult a licensed healthcare provider. 
• You should use this medication exactly as your doctor or healthcare provider instructs. Do not take more or less of it, in large doses or more frequently than prescribed. 
• The recommended medication dosage for adults is 2 mg, taken once daily orally with or without food. Your doctor may increase the dose to 2 mg orally daily if necessary. 
• If you have severe kidney or liver conditions, your doctor may suggest a reduced dose of 1 mg once daily. 
• The medication dosage is based on the patient’s condition, needs, body weight, other medical conditions, medications they may be taking or plan to take, and response to treatment. If your doctor has recommended a dose different from the one given above, you should not change how you use the medication without consulting your doctor. 
• If you haven’t had a bowel movement after taking prucalopride for three or four days, contact your doctor. They may recommend that you take a rescue laxative occasionally while you are receiving treatment with Resotran. 
• You can take Resotran with or without food. Swallow the Resotran tablet whole with a glass of water. You should not crush, chew, or break the Resotran tablet.
• To get the most benefit from your medication, you should maintain consistency in dosage and take it around the same time every day to help you remember. 
• If the dose is too strong for you, you can consider taking it every few days.  

[Note: Your doctor will decide the most suitable amount of Resotran for you based on your medical condition, following guidelines & studies on the drug. They’ll adjust it as required over time.]

How Does Resotran Work?

Resotran functions by stimulating the 5-HT4 receptors in the gastrointestinal tract, enhancing the muscle contractions necessary for bowel movements. This action helps to increase peristalsis, the rhythmic, wave-like contractions of the muscles that push food through the digestive system. By promoting these contractions, Resotran effectively increases the frequency of bowel movements, providing relief from chronic constipation. This mechanism is especially beneficial for people who have not found sufficient relief from other laxatives.

Important Safety Information for Using Resotran

What Are the Side Effects of Resotran?

Common Side Effects of Resotran: Like other medications, Resotran may cause side effects in certain individuals. It is noteworthy to mention that not everyone taking this medication will experience these side effects. Most of the side effects are not severe and do not require medical attention.  

• Headache
• Nausea
• Abdominal pain
• Diarrhea

Mild Side Effects of Resotran: This medication may cause mild side effects in some people. These side effects are not usually serious and do not require any medical attention. They will disappear within a few days as your body adjusts to the medication. However, if they are persistent or bothersome, tell your doctor immediately. 

• Dizziness
• Fatigue
• Flatulence
• Loss of appetite
• Vomiting
• Rectal bleeding

Serious Side Effects of Resotran: Your doctor has prescribed Resotran to you because they have determined that the benefits of Resotran will outweigh the risks associated with its use. Rarely, Resotran may cause serious side effects for some people using it. Get medical help immediately if you experience any of the side effects given below. They may be life-threatening if not treated promptly. 

• Severe allergic reactions, including anaphylaxis. Its symptoms may include difficulty breathing, rapid onset of hives, swelling of the face/mouth/tongue or throat, dizziness, and a rapid or weak pulse.
• Suicidal ideation and behavior. Its symptoms may include persistent thoughts of self-harm, planning suicide, or attempting suicide. This may be accompanied by depression, anxiety, or mood changes.
• Cardiovascular conditions (in patients with pre-existing heart disease), including myocardial infarction, stroke, or worsening of existing heart conditions. Its symptoms may include chest pain (angina), sudden weakness or numbness on one side of the body, shortness of breath, difficulty speaking, or severe headache.
• Ischemic colitis. Its symptoms may include sudden onset of severe abdominal pain, bloody diarrhea, and fever.
• Severe dehydration due to persistent or severe diarrhea. Its symptoms may include extreme thirst, dry mouth and skin, decreased urine output, dark-colored urine, fatigue, dizziness, and confusion.
• Serotonin syndrome. Its symptoms may include agitation, hallucinations, rapid heart rate, fluctuating blood pressure, elevated body temperature, overactive reflexes, and coordination problems.
• Severe abdominal pain or cramping which may be a sign of bowel obstruction or other serious gastrointestinal issues. Its symptoms may include intense, persistent abdominal pain, bloating, vomiting, and inability to pass stool or gas.

[Note: The list given above may not cover all potential side effects. Always consult with your medical giver for medical advice about side effects.]

Are There Any Warnings for Resotran? 

There are some warnings that you should consider while using this medication. 

• Abnormal Heart Rate: This medication may cause an increased heart rate and irregular heartbeat. If you have a history of ischemic heart disease or irregular heartbeat, you should talk to your doctor to determine how this medication may affect your medical condition, how it may affect your dosage and effectiveness, and whether any special monitoring is required. 
• Ischemic Colitis: Resotran may cause ischemic colitis, a potentially dangerous condition that occurs when an insufficient amount of blood reaches the colon walls. Its symptoms may include abdominal pain, bleeding from the rectum, and severe watery diarrhea that may be bloody. If you notice any of these symptoms, you should discontinue using this medication and immediately call your doctor. 
• Decreased Alertness/drowsiness: Resotran may cause fatigue or dizziness during the initial period of use. You should not drive, operate heavy machinery, or engage in tasks that require alertness and clear vision. 
• Liver Function: Not much is known about how this medication is affected by reduced liver function. If someone has reduced liver function or liver problems, they should discuss with their doctor how this medication may affect their condition, how their condition may affect the medication dosing & effectiveness of Resotran, and whether special monitoring is required. You may require a reduced dose if you have severely decreased liver function. 
• Kidney Disease: Reduced kidney function or renal disease may cause Resotran to build up in the body, causing unwanted side effects. If you have renal disease or decreased kidney function, discuss with your doctor how Resotran may affect your medication dosage and the effectiveness of this medication. A reduced dose is recommended for people with low kidney function. If you have a severe kidney disease that requires dialysis, do not take this medication. 
• Mental Health: People taking Resotran may experience worsening depression, changes in mood or behavior, or an urge to hurt themselves or others. If you experience any of these side effects or notice them in anyone else taking this medication, get in touch with your doctor at once. 
• Pregnancy: There is not enough information to establish the safety and efficacy of Resotran in pregnant people. People of childbearing potential should use an effective method of contraception while receiving treatment with Resotran, as certain birth control methods may not be as effective as usual if you are experiencing severe diarrhea. 
• Not Recommended for People Under 18: The safety & efficacy of this medication has not been established for use in children and adolescents under 18 years of age. 

What Are the Resotran Precautions?

• Before using this medication, you should tell your doctor if you have an allergic reaction to Resotran, prucalopride, or any of the ingredients listed in the medication. Also, tell them if you have an allergic reaction to any other medicines, dyes, food items, preservatives, or animals. Carefully read the medication guide before using this product, as it may contain certain inactive ingredients that can cause severe hypersensitivity reactions or other problems. Talk to your pharmacist, doctor, or healthcare provider for the complete list of ingredients.  
• If you become pregnant, suspect a pregnancy, or plan to become pregnant while using this medication, you should tell your doctor before using Resotran.
• Resotran may pass into breast milk and cause harm to the nursing baby. You should consult a licensed medical professional before breastfeeding a baby while using this medication. 
• Elderly patients using this medication may have an increased risk of developing age-related kidney problems, which may require dosage adjustment and cautious use for geriatric patients using Resotran. 
• Before using this medication, tell your doctor about all the medications you are taking or plan to take alongside Resotran, including all prescription and nonprescription medications, vitamins, and herbal supplements. 
• You should not share this medication with others, even if they have the same condition as you, as it may cause undesirable side effects.  

What Are the Contraindications of Resotran?

It is contraindicated for use in patients who have:

• Hypersensitivity to Resotran, prucalopride, or any of the ingredients present in the medication. 
• Renal impairment requiring dialysis 
• Galactose intolerance or glucose malabsorption
• Intestinal perforation or obstruction because of a structural or functional disorder of the wall of the stomach
• Intestinal blockage 
• Severe inflammatory bowel disease 
• Ulcerative colitis 
• Crohn’s disease 
• Toxic megacolon/megarectum 

What If You Missed a Dose of Resotran?

• If you have missed a dose of Resotran, you should take it as soon as possible. 
• However, if it is almost time to take your next dose, you may omit the missed dose and continue taking your medication according to the regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose, as it may increase your risk of unwanted side effects.  
• You can set a reminder on your phone to prevent missing doses further. 

[Note: If you have missed a dose of your medication and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Resotran?

Symptoms of a Resotran overdose may include diarrhea, nausea, or headache. If you have taken Resotran more than recommended and are experiencing diarrhea, you should drink plenty of water. If someone is experiencing severe side effects such as difficulty breathing and passing out, you should immediately seek medical assistance. You can call a medic, 911, or poison control helpline. You can also head to the nearest emergency room. 

[Note: If you have taken the medication more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

How to Store a Resotran?

• Resotran should be Kept in its original blister pack in a dark and dry place until you are ready to use it. 
• You should store it at room temperature below 30°C, away from direct sunlight, moisture, and excess heat. 
• Do not keep it in the bathroom, near the sink, or in places with high humidity, as moisture can harm some medications. 
• You should keep all medications, including Resotran, in a safe place, away from the sight and reach of children and pets. 
• Do not keep medications that are no longer needed or have passed their expiration date, which is the last day of the month mentioned on the back of the blister pack or carton. Discard them safely. 
• With that said, do not pour them into the drain, throw them into the household garbage bin, or flush them down into the toilet unless instructed to do so. 
• You should dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• The best way to eliminate unwanted medications is to give them in a medicine take-back program. 
• For more information on how to safely dispose of unwanted medications, consult your pharmacist, healthcare provider, or local waste disposal company. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Resotran?

Certain medications may interact with Resotran and decrease its effectiveness or cause unwanted side effects. Before using this medication, you should tell your doctor about all the medications you are using or plan to use alongside Resotran, including all prescription, non-prescription, over-the-counter, and herbal or vitamin supplements. Some potential drug interactions of Resotran are as follows:

• Aclidinium 
• Atropine 
• Benztropine 
• Birth control pills
• Buprenorphine 
• Butorphanol 
• Clidinium 
• Darifenacin 
• Disopyramide 
• Conjugated estrogen
• Estradiol
• Ethinyl estradiol
• Glycopyrrolate 
• Ipratropium 
• Methadone 
• Monoamine oxidase inhibitors 
• Muscle relaxants 
• Narcotic pain relievers 
• Oxybutynin 
• Pizotifen 
• Propiverine 
• Progestins 
• Scopolamine 
• Sirolimus 
• Solifenacin 
• Tiotropium 
• Tolterodine 
• Tricyclic antidepressants
• Trospium 
• Umeclidinium 

What Are the Other Resotran Interactions?

Apart from medications, certain herbs, supplements, food items, and beverages may interact with Resotran and affect its effectiveness. To prevent interactions, your doctor may recommend making certain dietary changes. There are also certain disease interactions which you should take into consideration before using this medication, such as:

• Depression or other mood disorders
• Severe or end-stage kidney disease 
• Stomach or bowel perforation, blockage, or swelling 

[Note: This isn’t a complete list, and there could be other drugs that interact with Resotran. Tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Resotran Alternatives?

People look for alternative medications to Resotran when it does not suit them, or they do not get the desired results from using it. There are many effective alternative medications to Resotran available in the market. You should consult with your physician or medical provider before using them. Based on your medical condition, age, needs, and other medications, they will help you decide the medication that will work best for you. Some of the popular alternative medicines of Resotran are as follows:

• Linzess (linaclotide)
• Trulance (plecanatide)
• Lubiprostone
• Amitiza
• Lactitol

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Resotran Cost & Coupons

The cost of Resotran can vary depending on factors such as pharmacy pricing, location, and whether you have health insurance coverage. Many insurance plans may not cover Resotran, leading to higher out-of-pocket expenses. To help manage these costs, some individuals in the U.S. purchase Resotran from Canadian pharmacies, which may offer the medicine at a reduced price. Services like Polar Bear Meds provide an option to buy Resotran from Canada and deliver it to the U.S. For additional savings, first-time customers can use the coupon code WELCOMEPB10 to receive a 10% discount on their initial order.

Frequently Asked Questions

How long does it take for Resotran to work?

Resotran typically begins to work within 24 hours of the first dose. However, depending on the individual’s response to the medication, the full effect may take a few days to develop. Patients should continue taking the medication as specified, even if they do not notice immediate results. If there is no bowel movement after several days, it is recommended to consult a healthcare provider for further advice.

Is prucalopride safe for long-term use?

Prucalopride, the active ingredient in Resotran, has been evaluated for long-term treatment of chronic constipation. Clinical studies have shown it to be effective and well-tolerated for up to one year. However, a healthcare provider should assess long-term safety beyond this period, who will consider individual patient factors & monitor for any potential side effects or complications.

Is Resotran a laxative?

Resotran is not a traditional laxative. It is a prokinetic agent that specifically targets 5-HT4 receptors in the gastrointestinal tract to enhance bowel motility. Unlike laxatives, which work by softening stools or directly stimulating bowel movement, Resotran increases the natural contractions in the muscles of the intestines, promoting regular bowel movements in those with chronic constipation.

What precautions should be taken when taking prucalopride?

When taking prucalopride, patients should inform their healthcare provider about any pre-existing heart conditions, liver or kidney issues, or mental health concerns. It is essential to monitor for symptoms such as irregular heartbeat, severe abdominal pain, or mood changes. Prucalopride should not be used by individuals with severe kidney disease requiring dialysis, and its use should be closely monitored in elderly patients.

When is the best time to take Resotran?

Resotran can be taken at any time of day, with or without food, depending on personal preference and daily routine. Consistency is key; taking it at the same time each day helps maintain its effectiveness. Patients should follow their healthcare provider’s instructions regarding the timing of the dose, particularly if they experience any side effects that might be managed by adjusting the timing of the medication.

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