Rexulti

Rexulti (brexpiprazole) is a prescription medicine used to treat schizophrenia in adults. It is also approved as an add-on therapy for major depressive disorder (MDD) in adults. Rexulti is an atypical antipsychotic that helps balance dopamine and serotonin levels in the brain. This helps improve mood, thinking, and behavior. Rexulti comes as oral tablets in strengths ranging from 0.25 mg to 4 mg. It is usually taken once daily, with or without food. A Rexulti prescription is required, and treatment should be monitored by a doctor.

Rexulti is FDA-approved for:

• Treatment of schizophrenia in adults
• Adjunctive therapy with antidepressants for MDD (adults)

You must follow these Rexulti administration guidelines to ensure safe use:

• Take Rexulti once daily by mouth, with or without food.
• Swallow the Rexulti tablet whole with a glass of water. Do not crush, chew, or split it.
• Follow your doctor’s Rexulti dosing schedule carefully. Rexulti doses are usually started low and adjusted gradually.
• Take it at the same time each day to maintain steady levels in your body.
• Do not stop suddenly taking Rexulti tablets without medical advice. This may cause symptoms to return or worsen.

Consider the following Rexulti dosing schedule for effective use to treat your condition:

Patient Safety Notes

• Do not exceed the maximum Rexulti daily dose unless specifically directed by your doctor.
• Titration (gradual increase) helps reduce side effects such as restlessness or sleepiness.
• Rexulti dosage for dementia‑related psychosis is not approved and carries a boxed warning for increased risk of death.

Rexulti (brexpiprazole) works by modulating the activity of two key brain neurotransmitters, dopamine and serotonin. These chemicals influence mood, thoughts, and behaviour. Rexulti does not completely block them. However, it helps bring their signals into better balance. This balance helps reduce schizophrenia symptoms like hallucinations and disorganized thinking. As a result, it can improve mood when combined with antidepressants.

If you miss a dose of Rexulti, take it as soon as you remember. If it is almost time for your next scheduled dose of Rexulti, skip the missed one and continue with your regular schedule. Do not double up to make up for a missed Rexulti dose. Missing doses may reduce the medicine’s effectiveness and could allow symptoms to return or worsen. If you are worried about Rexulti missed dose side effects or have missed several doses, contact your doctor for guidance.

Taking more than the prescribed amount of Rexulti can increase the risk of very serious side effects. This includes extreme sleepiness, irregular heartbeat, dizziness, or movement problems. If you suspect a Rexulti overdose, contact the poison control center or your healthcare provider immediately.

When considering Rexulti for depression and schizophrenia, be aware of the following side effects:

• This medicine can cause weight gain, raise blood sugar levels, and alter cholesterol or triglyceride levels.
• It can cause sleepiness and impair judgment, potentially interfering with driving or operating machinery.
• Rexulti may lower blood pressure when standing, which can cause dizziness or fainting.
• Allergic reactions are possible, including rash, swelling, or difficulty breathing.

What Is the Black Box Warning on Rexulti?

Follow these Rexulti precautions if you are considering this medication for schizophrenia and MDD:

• Patients with liver problems or those taking certain interacting medicines may need dose adjustments for Rexulti.
• Avoid alcohol and be cautious with activities requiring alertness, as Rexulti may cause sleepiness or impaired judgment.
• Dose adjustments may be needed if you have liver impairment or are taking medicines that interact with Rexulti (such as CYP2D6 or CYP3A4 inhibitors).
• It is not known whether Rexulti passes into human breast milk. Avoid Rexulti while breastfeeding or consider alternative treatments.
• Always talk to your doctor about your medical history, current medications, and any concerns before starting Rexulti.
• Rexulti tablets should only be used during pregnancy if the benefit outweighs the possible risks. There are limited data in humans, so the exact safety profile is not known.

Rexulti should be stored properly to maintain its effectiveness. The guidelines include:

• Keep Rexulti tablets at room temperature between 20°C-25°C.
• Store Rexulti tablets in their original container.
• Protect these tablets from moisture, heat, and direct light.
• Do not keep Rexulti in bathrooms or other humid places.
• Always keep Rexulti tablets out of reach of children and pets.
• Do not use Rexulti after the expiration date printed on the package.
• Dispose of unused or expired Rexulti tablets safely, following pharmacy or local disposal guidelines.

• Paroxetine
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• Terbinafine
• Ketoconazole
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• Clarithromycin
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• Ciprofloxacin
• Diltiazem
• Rifampin
• Phenytoin
• Carbamazepine
• Phenobarbital

If Rexulti does not work well or causes side effects, doctors may consider other medications. Rexulti alternatives depend on the condition being treated:

• Rexulti alternatives for depression (adjunct or primary):
  • Trintellix (vortioxetine)
  • Auvelity (bupropion/dextromethorphan)
• Rexulti Alternatives for schizophrenia or related conditions:
  • Abilify (aripiprazole)
  • Risperdal (risperidone)
  • Vraylar (cariprazine)
  • Zyprexa (olanzapine)
  • Seroquel (quetiapine)

The high cost of Rexulti in the U.S. often forces patients to delay or forgo depression and schizophrenia treatment. This is particularly true when insurance coverage is unavailable. At Polar Bear Meds, we reduce this burden by providing a safe way to buy Rexulti online from Canada.

Through our partnership with licensed Canadian pharmacies, we offer Rexulti at prices up to 80% lower than those of typical U.S. pharmacies. New customers can save an additional 10% using the Rexulti coupon code “WELCOMEPB10.” Plus, our Rexulti orders are delivered reliably within 3-5 business days via Xpress Post.

• https://www.rexulti.com/
• https://www.drugs.com/rexulti.html
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/205422s009lbl.pdf
• https://reference.medscape.com/drug/rexulti-brexpiprazole-1000003
• https://www.webmd.com/depression/rexulti-major-depressive-disorder
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/205422s007lbl.pdf