Semglee PRE-FILLED PEN

Semglee Pre-Filled Pen is a prescription long-acting insulin used to help control high blood sugar. This medication is FDA-approved to improve glycemic control in pediatric patients (age 6 years and older) & adults with type 1 diabetes, and in adults with type 2 diabetes. It contains insulin glargine 100 units/mL, a basal insulin designed to provide steady blood sugar control throughout the day.

Semglee is administered as a once-daily subcutaneous injection and works by providing a long-term basal insulin effect to help control blood glucose. This helps manage blood glucose levels between meals and overnight, reducing fluctuations that can occur in people with diabetes.

The pre-filled pen format allows patients to dial an accurate dose and inject insulin more easily compared to traditional syringes. This can support treatment consistency and adherence when used as prescribed by a healthcare provider.

Semglee (insulin glargine) is FDA-approved as an interchangeable biosimilar to Lantus, meaning it has been shown to be highly similar in safety, quality, and effectiveness when used under medical supervision. With a valid prescription, you can buy Semglee Pre-Filled Pen online from trusted Canadian pharmacies.

Semglee Pre-Filled Pen Quick Fact Table

Semglee 100 units/mL offers several benefits for people managing type 1 or type 2 diabetes when used as prescribed by a healthcare provider.

• It provides 24-hour blood sugar control with once-daily dosing.
• Mimics natural basal insulin, helping keep glucose levels stable.
• For patients, it is an easy-to-use pre-filled pen for accurate, consistent dosing.
• Healthcare providers can adjust dosages based on a patient’s health status, enabling personalized diabetes management.

Below is a dosage guidelines table that you may consider while using Semglee Pre-Filled Pen 100 units/mL:

Semglee is injected once daily, usually at the same time each day, as directed by a healthcare provider. Here are the steps on how you can use the pre-filled pen:

1. Prepare the pen: Wash your hands, and allow the medication to reach room temperature if it has been refrigerated.
2. Attach a New Needle: Remove the pen cap, attach a new sterile needle, and remove both needle caps.
3. Check the Insulin: Make sure the solution is clear and colorless. Do not use the pen if the insulin is cloudy or discolored.
4. Prime the Pen: Dial in a small test dose, then press the injection button to remove air bubbles.
5. Set your dose: Select the required number of units your provider prescribed.
6. Choose an Injection Site: Inject under the skin in the abdomen, thigh, or upper arm. Rotate injection sites to reduce skin irritation.
7. Inject the Insulin: Insert the needle straight into the skin at a 90-degree angle and then press the Semglee injection button fully, as instructed by your healthcare professional.
8. Needle Disposal: Remove the pen needle and always dispose of it in a sharps container. Replace the pen cap after use.

Always follow the specific instructions from your healthcare provider, or refer to the patient information leaflet included with your pen for detailed instructions.

Semglee contains insulin glargine, which is designed to release slowly and evenly after injection. Once injected under the skin, it forms micro-precipitates that gradually release insulin into the bloodstream. This steady release:

• Helps control fasting blood glucose
• Reduces blood sugar spikes between meals
• Supports overnight glucose stability

As it is a basal insulin, Semglee is often used alongside rapid-acting insulin at meals, depending on individual treatment plans.

The following side effects may improve as your body adjusts to the Semglee long-acting insulin. Contact your healthcare provider if symptoms are severe, persist, or worsen.

• Before using Semglee Pre-Filled Pen (insulin glargine), tell your healthcare provider about your medical history, including if you have:
  • Frequent episodes of low blood sugar (hypoglycemia)
  • Liver disease
  • A known hypersensitivity to insulin glargine or any of its ingredients
  • Kidney disease or reduced kidney function
  • Changes in diet, physical activity, or weight
  • Are pregnant or breastfeeding
• Semglee should not be used to treat DKA (diabetic ketoacidosis). Short-acting insulin is required in that situation.
• Do not share your insulin pen or needles with others.
• Never mix Semglee with other insulins or injectable solutions.
• Regularly monitor your blood glucose while using Semglee.
• Follow your prescribed dosage regimen; dose adjustments may be needed during illness, stress, or changes in activity.
• It is approved for children ≥6 years with type 1 diabetes, but not for type 2 diabetes in children.
• If you miss a Semglee dose, take it as soon as possible unless it is almost time for your next dose.
• Taking too much insulin can cause dangerously low blood sugar. If you notice an overdose, immediately call your doctor or contact the poison control center.

Some medications may change how Semglee (insulin glargine) works, affecting blood sugar levels. Here are some of them:

Medications That Increase Risk of Hypoglycemia

• Other diabetes medications:
  • Sulfonylureas (glipizide, glyburide)
  • Meglitinides
  • SGLT2 inhibitors (dapagliflozin, empagliflozin)
  • GLP-1 agonists
• Beta-blockers (carvedilol, propranolol)
• ACE inhibitors (lisinopril, enalapril)
• Alcohol, especially when consumed without food

Medications That Reduce Insulin Effectiveness (Hyperglycemia Risk)

• Corticosteroids (prednisone, dexamethasone)
• Diuretics (furosemide, hydrochlorothiazide)
• Thyroid hormones (levothyroxine)
• Oral contraceptives and estrogen therapy
• Protease inhibitors (HIV medications)

Medications That May Cause Unpredictable Effects

• Antipsychotics (olanzapine, clozapine)
• Statins (atorvastatin, simvastatin)
• Antidepressants (bupropion, SSRIs)
• Blood thinners (apixaban, warfarin)

If Semglee long-acting insulin does not provide adequate blood sugar control or causes side effects, your doctor may recommend the following alternatives:

• Lantus (insulin glargine)
• Basaglar (insulin glargine)
• Toujeo (insulin glargine)
• Levemir (insulin detemir)
• Tresiba (insulin degludec)
• Humulin N (insulin NPH)
• Novolin N (insulin NPH)

Semglee is available as a pre‑filled injection pen, providing the same long‑acting insulin as Lantus with convenient dosing and lower cost. Here is an overview of how the two medications compare across key features:

When you order Semglee Pre-Filled Pen through Polar Bear Meds, you can take advantage of:

• Standard price: Each Semglee Pre-Filled Pen is priced at $100.53 (before discounts or shipping fees).
• Exclusive first‑order discount: Use the Semglee coupon code ‘WELCOMEPB10’ at checkout to save 10% off your first order from Canada.
• Transparent pricing: There are no hidden handling or processing fees; what you see is what you pay.
• Price-match guarantee: We offer a price‑match guarantee on Semglee if you find a lower price for the exact same product at another licensed Canadian online pharmacy, helping ensure you get the best value.
• Referral rewards program: You’ll receive $20 account credit for every verified referral, and your referral will also get $20 off their first order. Plus, after 10 successful referrals, you’ll receive an additional $100 account credit as a thank you.

Actual savings depend on strength, quantity, and current pricing at the time you order. Always review pricing and coupon details on Polar Bear Meds before checkout.

• Get Semglee Pre-Filled Pens at significantly lower prices compared to typical U.S. retail costs.
• All medications are dispensed through licensed Canadian pharmacies to ensure quality and authenticity.
• Fast, secure shipping to your home in the U.S. with tracking and proper packaging.
• Transparent pricing with easy online ordering and prescription upload.
• Savings can be even greater when ordering larger quantities or using available coupon codes.
• Our support team is available to assist with prescriptions, orders, and any questions, so you can order with confidence.

• https://www.ema.europa.eu/en/documents/product-information/semglee-epar-product-information_en.pdf
• https://www.drugs.com/mtm/semglee-prefilled-pen.html
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/761201s007lbl.pdf