Insulin Glargine-Yfgn 

Semglee Pre-Filled Pen

Semglee is a long-acting synthetic insulin that the FDA has approved for controlling high blood sugar levels in adults & children with diabetes mellitus. This medication can be used for type 1 and type 2 diabetes. It is available in various forms, including pre-filled pens and multiple-dose vials, each having distinct strengths. While this medication can be used by both adults & children, their dosages may differ based on various factors. Therefore, patients are advised to follow the dosage recommendations exactly as their doctor prescribes. Semglee is not indicated for the treatment of diabetic ketoacidosis. So, before considering treatment with this medication, consult a medical expert to determine whether the drug is safe for use or not.

Product Overview

Semglee pre-filled pen is a long-acting insulin glargine injection designed to help manage blood sugar levels in individuals with diabetes. This prescription medication contains insulin glargine, a synthetic hormone that copies natural insulin’s function in the body, helping to regulate blood glucose levels. Insulin glargine is known for its long-lasting effect, making it an effective choice for maintaining stable blood sugar levels throughout the day. The Semglee pen is FDA-approved, ensuring it meets safety and efficacy standards for diabetes management. It offers a convenient and precise way to administer insulin, making it easier for patients to follow their treatment plan.

Semglee is available as a pre-filled pen with 100 units/mL strength. The pen is designed for subcutaneous injection, providing a convenient and user-friendly method for administering the drug. Semglee is suitable for adults and children (above 6 years of age) with diabetes who require long-acting insulin. The pen delivers a steady release of insulin over 24 hours, helping to maintain consistent blood glucose levels throughout the day and night.

Common side effects of Semglee may include hypoglycemia, injection site reactions, and weight gain. Users should be cautious of hypoglycemia symptoms such as dizziness, sweating, and confusion. To minimize risks, follow your healthcare provider’s instructions on dosage and administration. If you miss a dose of Semglee, take it as soon as you remember, but do not double the dose. In case of an overdose, get immediate medical attention. Store Semglee pens in the refrigerator until the first use and at room temperature afterward, away from direct heat and light. Dispose of used needles safely to prevent injury.

What Are the Uses of Semglee Pre-Filled Pen?

Semglee pre-filled pen has various uses:

• It improves blood sugar control in patients with diabetes mellitus.
• It can be used for type 1 or type 2 diabetes. For type 1 diabetes, these pre-filled pens are used in combination with short-acting insulin.
• These injections keep working evenly for 24 hours.

What Are the Forms & Strengths of Semglee Pre-Filled Pen?

Semglee is available in the following strengths and forms:

• Single Patient Use Pre-Filled Pen: 3mL (U-100)
• Multiple-Dose Vial: 10 mL (U-100)

What Is the recommended dosage for Semglee Pre-Filled Pen?

The dosage recommendations for Semglee pre-filled pen depend on several factors, including the type/severity of your medical condition, your medication dose, your metabolic needs, blood glucose, and prior insulin use. Generally, medical professionals prescribe a starting dose and gradually adjust the drug doses as needed. It is important to note that the dosage recommendations below are only for the average dose. So, if you have been prescribed a different dose, do not change it without consulting your medical practitioner.

Dosage for Type 1 Diabetes

• Patients with this type of diabetes should administer Semglee in combination with a short-acting insulin.
• The starting dose of this medication is one-third of the total daily insulin needs.
• Use short-acting insulin before meals to cover the rest of your daily insulin needs.

Dosage for Type 2 Diabetes

• The recommended initial dose of Semglee for patients who have not used insulin before is 0.2 units per kg or 10 units once a day. 
• You might need to adjust the dose and timing of short- or rapid-acting insulins and any oral diabetes medications.

Switching from Other Insulin Therapies to Semglee 

When switching to Semglee from other insulin therapies, dose adjustments are essential. Doing so may lower the risk of developing hypoglycemia. Below are the recommended starting dose when switching from:

• Once-daily insulin glargine to once-daily Semglee, start with 80% of your previous insulin glargine dose.   
• Once daily NPH insulin to once-daily Semglee, the recommended Semglee dose is the same as the NPH dose that is being discontinued.
• Twice-daily NPH insulin to once-daily Semglee, the starting Semglee dose is 80% of the NPH dose that is being stopped.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Semglee Pre-Filled Pen?

• Read the medication guide or PIL (patient information leaflet) carefully to understand the administration steps. If you have any questions, you can ask your practitioner.
• Follow the dosage recommendations as it is prescribed on your prescription label. Do not exceed or subceed the doses without consulting your medical professional.
• Before using the medication, make sure to check insulin labels.
• Visually inspect your vials and pre-filled pens. Discard the product if you notice any discoloration, thickened or clumped particles. Your medication or solution should be clear and colorless.
• When administering the medication, clean the area where you want to inject the drug.
• Avoid shaking the container.
• Once you have prepped the injection site, administer Semglee subcutaneously into the thigh, abdominal area, or upper arms.
• Do not rub the injected areas, and avoid injecting into red, swollen, injured, or itchy skin.
• Inject the medication in different areas each time to lower the risk of damaged skin, like pits, lumps, or thickened skin.  
• If you are changing your insulin regimen, closely monitor your blood glucose levels.
• Do not take the medication intravenously or through an insulin pump.
• Avoid mixing Semglee with other solutions or insulin.
• Do not use cold insulin under your skin, as it can be painful. Let the insulin container rest at room temperature for a bit.  
• To get the most benefit from the medication, take it once daily at the same time before breakfast or at bedtime. 
• Do not change brands or insulin types without consulting your doctor. If you are changing, read the directions carefully.
• If you are using vials for administering the medication, avoid reusing needles and syringes. 
• Do not share your medication pen with other individuals, even if the needle is new. Doing so may cause serious infection.
• If your condition does not improve or worsen over time, contact a medical professional immediately.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Semglee Pre-Filled Pen Work?

The Semglee pre-filled pen works by delivering insulin glargine, a long-acting insulin that helps manage blood sugar levels. Once injected under the skin, insulin glargine is slowly absorbed into the bloodstream, providing a steady release of insulin over 24 hours. This helps keep blood sugar levels controlled throughout the day and night. By mimicking the body’s natural insulin, Semglee helps cells absorb glucose for energy and reduces the amount of sugar produced by the liver. This combination helps maintain balanced blood glucose levels in people with diabetes.

Important Safety Information for Using Semglee Pre-Filled Pen

What Are the Side Effects of Semglee Pre-Filled Pen?

Common Side Effects of Semglee: This medication may lead to various side effects, which are usually not permanent. These temporary reactions may stay for a few days to weeks. However, if these side effects persist for a long time and get intense over time, visit the nearest clinic and get immediate medical assistance. Common side effects of Semglee may include:

• Hypoglycemia or low blood sugar. Its signs may include:
  • Sweating
  • Headache
  • Confusion
  • Dizziness
  • Blurred vision
  • Shakiness
  • Rapid heartbeats
  • Anxiety
  • Irritability
  • Hunger
  • Slurred speech
• Skin thickening at the injection site (lipodystrophy)
• Itching
• Rash
• Fluid retention (edema)

Serious Side Effects of Semglee: Besides common reactions, Semglee may lead to various adverse effects, which can be life-threatening to certain patients. If you are noticing any such signs that seem concerning, reach out to a healthcare professional. Serious side effects of Semglee may include:

• Severe allergic reactions. Its symptoms may include:
  • Difficulty breathing
  • Extreme drowsiness
  • Rashes all over the body
  • Breath shortness
  • Swelling on the face, throat, or tongue
• Low potassium levels in the blood (hypokalemia)
• Heart failure. Its signs are:
  • Swelling on the feet or ankles
  • Weight gain
  • Chest fluttering
  • Sudden dizziness
  • Breath shortness
• Eye problems. Symptoms are:
  • Tunnel vision 
  • Sudden vision loss
  • Eye pain or swelling
  • Seeing halos around lights
• Arm or leg weakness
• Loss of coordination
• Muscle stiffness
• High fever

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Semglee Pre-Filled Pen? 

Semglee can cause severe side effects in certain patients, or it may not be an ideal treatment option for specific populations due to their medical conditions. So, if you are using this medication, you should remain cautious. Its warnings are as follows:

• Blood-Borne Pathogens: Semglee pre-filled pens should not be shared with other patients, even if the needle is changed. Patients are strictly advised against reusing the same needles/syringes, as doing so may increase the risk of transmission of blood-borne pathogens.
• Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen: Any alteration in your insulin regimen, including brand, strength, type, injection site, or method, may impact blood sugar control and cause hypoglycemia or hyperglycemia.  Moreover, administering medication into the same area has resulted in hyperglycemia. If you are making any changes to your insulin regimen, do so under medical supervision.
• Hypoglycemia: Insulins, including insulin glargine medications, can cause adverse reactions like very low blood sugar, causing seizures, which may require hospitalizations or cause death. This effect can also impair your ability to concentrate and react, which can be dangerous when driving or operating machinery. So, when taking this medication, talk to a medical practitioner.
• Medication Errors: Sometimes, people mix up different types of insulin, like long-acting and rapid-acting insulins, which may cause severe side effects. To avoid mistakes with Semglee and other insulins, patients should always check the insulin label before each injection.
• Allergic Reactions: Patients using insulin glargine products like Semglee pre-filled products can experience severe life-threatening allergies such as anaphylaxis. Stop using Semglee and contact your medical professional if you notice such reactions.
• Fluid Retention & Heart Failure with Concomitant Use of PPAR-Gamma Agonists: Thiazolidinediones, one of the peroxisome proliferator-activated receptor-gamma agonists, can cause water retention in the body, especially when used in combination with insulin. This retention may result in heart failure or exacerbate the condition. Patients using Semglee, along with PPAR-gamma agonists, should be monitored closely for any signs of heart failure.   

What Are the FDA Boxed Warning for Semglee Pre-Filled Pen?

Boxed warnings, also called black-boxed warnings, are among the most stringent guidelines issued by the FDA. These warnings alert doctors and patients about the harmful effects of a particular drug, which can be life-threatening if overlooked. Semglee does not have any boxed warnings, meaning it is safe to use. However, its safety is based on the precautions you take. Therefore, if you are taking this drug, follow the instructions provided by your medical practitioner. If you have any concerns or noticed any unusual symptoms, it’s best to consult with an expert.

What Are the Semglee Pre-Filled Pen Precautions?

When considering treatment with Semglee, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Semglee to control blood pressure:

• Before using this medication, inform your medical provider if you are allergic to other types of insulin or to any of Semglee’s ingredients. The product may contain certain inactive components that can cause severe allergic reactions. 
• Avoid using Semglee pre-filled pens if you have low blood sugar.
• When considering treatment with Semglee, inform your doctor about your or your family’s medical history, especially of kidney and liver diseases.
• If you are undergoing surgery or any medical procedure, tell your surgeon or practitioner about the products you use. This includes all prescription drugs, over-the-counter medications, and herbal products.
• When taking Semglee, you can experience extremely low or high blood sugar levels, which can cause blurred vision, dizziness, or drowsiness. Therefore, avoid driving or operating machinery that requires alertness. 
• If you are habitual in consuming alcohol, limit your consumption during your treatment with Semglee, as it can raise the chances of developing hypoglycemia.
• When doing exercise, make sure to check your blood sugar levels before & after the workout. 
• Older patients should exercise caution while taking this medication as they have higher chances of experiencing side effects, especially low blood sugar levels.
• If you are pregnant or planning to have a baby, consult a medical professional, as pregnancy can worsen diabetes. Discuss every risk and benefit with your practitioner and make a suitable plan for managing your sugar levels during pregnancy. 
• Semglee may pass into the breast milk, but it is not sure if the drug harms the child. Therefore, if you are a nursing mother, talk to your healthcare provider about whether breastfeeding is safe for the child or not. 

What Are the Contraindications of Semglee Pre-Filled Pen?

Semglee is contraindicated:

• When the patient is having episodes of hypoglycemia or low blood sugar.
• If the patient has hypersensitive reactions to Semglee or any of the ingredients present in its formulation. 

What If You Missed a Dose of Semglee Pre-Filled Pen?

Patients are usually advised not to miss their doses of any medication, and when it comes to controlling blood glucose levels, taking medication on time becomes more important. However, if somehow you forget to take a dose of Semglee:

• Take the missed dose as soon as possible unless your doctor advises otherwise.
• Call your doctor for specific instructions on what to do next.
• Remember not to take double doses. Do not use more than one dose in a 24-hour period unless your practitioner tells you to.
• In rare cases, a missed dose may fluctuate your sugar levels. So, keep a track on your blood glucose levels to ensure they remain stable.
• Use medication apps or set phone reminders to avoid missing doses.
• Take your medication at the same time every day to get the most benefit from it.
• Make sure to get your prescription refilled before you run out of medicine. This will ensure that you do not miss any doses.
• If you have any questions or concerns about it, ask your medical practitioner. They will suggest alternate options that suit your body’s needs.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Semglee Pre-Filled Pen?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly take an excessive amount of Semglee. In such cases, patients can experience hypoglycemia. Its symptoms may include:

• Trouble speaking
• Numbness or tingling in the mouth
• Blurred vision
• Confusion
• Drowsiness
• Jerky movements
• Seizures
• Muscle weakness

If you are experiencing such overdose symptoms, visit the nearest clinic or get medical assistance immediately by calling 911.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Semglee Pre-Filled Pen?

• Store the medication in your refrigerator at room temperature or below 86°F. 
• Do not freeze the product.
• If the solution freezes, discard the product.
• Keep the medication in its original container somewhere safe, away from the reach and sight of children and pets.
• Protect the medication from direct heat and light.
• Use the product within 28 days and discard it after that date, even if there is insulin in the pen. 
• Do not flush the medication down the toilet.
• Avoid storing the product in damp or moist places like the bathroom or near the sink,
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• Ask a medical professional or a pharmacist how to dispose of the product properly without damaging the environment.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Semglee Pre-Filled Pen?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Semglee medication. Below are some of the drugs that can interact with Semglee (insulin glargine):

• Cinoxacin
• Ciprofloxacin
• Delafloxacin
• Enoxacin
• Gatifloxacin
• Gemifloxacin
• Grepafloxacin
• Levofloxacin
• Lomefloxacin
• Moxifloxacin
• Nalidixic acid
• Norfloxacin
• Ofloxacin
• Sparfloxacin
• Trovafloxacin
• Alogliptin
• Alpelisib
• Betamethasone topical
• Betaxolol
• Captopril
• Cariprazine
• Disopyramide
• Dobutamine
• Ethanol
• Fluoxetine
• Glimepiride
• Glipizide
• Hydrocortisone
• Indapamide
• Indinavir
• Levonorgestrel
• Levothyroxine
• Metaproterenol
• Niacin
• Orlistat
• Pentamidine
• Quinapril
• Ritonavir
• Saxagliptin
• Terbutaline
• Vorinostat
• Ziprasidone

What Are the Other Semglee Pre-Filled Pen Interactions?

Besides drugs, Semglee also has several disease interactions, which are as follows:

• Renal/liver disease
• Hypokalemia
• Hypoglycemia

[Note: This isn’t a complete list, and there could be other drugs that interact with Semglee Pre-Filled Pen. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Semglee Pre-Filled Pen Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives of Semglee are as follows:

• Metformin
• Ozempic
• Rybelsus
• Victoza
• Januvia
• Mounjaro
• Apidra
• Humulin N 
• Lyumjev
• Novolog
• Tresiba
• Afrezza 

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Semglee Pre-Filled Pen Cost & Coupons

It is important to note that Semglee’s cost is not the same everywhere. The actual price of these pre-filled pens depends on several factors, including your insurance plan, location, and the pharmacies you use. Semglee, with its anti-diabetes qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here you can buy Semglee online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Semglee coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

How long does Semglee Pre-filled pen last?

A Semglee pre-filled pen, once in use, provides insulin glargine for up to 28 days when stored at room temperature. Each pen is designed to be used until empty, following your prescribed dosage. Ensure it is kept away from direct heat and light to maintain its effectiveness throughout its usage period.

How long does Senglee take to work?

Semglee starts working within a few hours after injection, providing a steady release of insulin glargine over 24 hours. It maintains consistent blood sugar levels throughout the day and night, helping to manage diabetes effectively. Always follow your healthcare provider’s instructions for optimal results.

When is the best time to use Semglee pre-filled pens?

The best time to use Semglee pre-filled pens is once daily, at the same time each day. This consistency helps maintain stable blood glucose levels. Your physician will guide you on the specific timing based on your individual treatment plan and lifestyle.

Why does Semglee cause weight gain?

Semglee may cause weight gain because insulin helps the body store glucose for energy. When blood sugar levels are controlled, the body uses glucose more efficiently, which can lead to an increase in fat storage. Monitoring diet and exercise can help manage this potential side effect.

What happens if I stop using Semglee pens?

If you stop using Semglee pens, your blood sugar levels may become uncontrolled, leading to hyperglycemia (high blood sugar). This can increase the risk of diabetes-related problems such as kidney damage, vision problems, and cardiovascular issues. Always consult your medical expert before making any changes to your medication regimen.

Our Guarantee

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