Ixekizumab 

Taltz Autoinjector PFS

Taltz Autoinjector PFS is an FDA-approved medication used to treat plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It contains ixekizumab, a monoclonal antibody that works by targeting and neutralizing interleukin-17A, thereby reducing symptoms associated with these autoimmune conditions. The autoinjector, designed for easy use and consistent delivery of medication, delivers a single dose of 80 mg. The medication dosage depends on the condition being treated and the patient’s response. You should consult a medical professional for personalized advice and guidance related to usage, dosage, storage, and more. You can order Taltz prefilled syringe from Canada using a doctor’s prescription at affordable prices.  

Product Overview

Taltz Autoinjector PFS contains ixekizumab, a monoclonal antibody used to treat conditions such as moderate to severe psoriatic arthritis, plaque psoriasis & ankylosing spondylitis. Ixekizumab targets and neutralizes interleukin-17A, a protein involved in the inflammatory response, thereby reducing the symptoms associated with these autoimmune conditions.

Each Taltz Autoinjector delivers 80 mg of ixekizumab. It is administered subcutaneously, typically in the abdomen, thigh, or upper arm. The frequency and duration of use depend on the medical condition & the patient’s response to treatment. Taltz is suitable for adults and should only be used under the guidance of a healthcare professional. The autoinjector is designed for easy use and consistent medication delivery.

Common side effects of Taltz Autoinjector PFS include injection site reactions, upper respiratory infections, and headaches. Individuals should be closely monitored for signs & symptoms of allergic reactions, such as trouble breathing or severe rash. To avoid potential interactions, informing your physician of any existing health conditions or medications is essential. If a dose is missed, take it as soon as possible, but skip it if the next dose is near. Do not double up doses. In case of a Taltz overdose, seek immediate medical attention. Store the autoinjector in a refrigerator between 2°C-8°C, away from light and heat. For additional guidance, consult your healthcare provider.

What Are the Uses of Taltz Autoinjector PFS?

It is used to treat:

• Plaque psoriasis 
• Psoriatic arthritis
• Axial spondyloarthritis
• Ankylosing spondylitis

What Are the Forms & Strengths of Taltz Autoinjector PFS?

It is available as a liquid solution that comes in the form and strength of:

Form: Single dose prefilled syringe 

Strength: 80 mg/ml 

Form: Single-dose autoinjector

Strength: 80 mg/ml 

What Is the Recommended Dosage for Taltz Autoinjector PFS?

The dosage of Taltz Autoinjector PFS varies from individual to individual and is often determined based on multiple factors, including the patient’s needs, age, and the disease being managed. The dosage listed below is generalized, and if your doctor has suggested that you use a different dosage, do as directed and do not change your dosage without first speaking with them. Do not inject it more or less than recommended, in large doses, or more frequently than prescribed. Doing so will not cure your condition faster, but cause unwanted side effects. 

For Plaque Psoriasis

For Adult Patients with Moderate to Serious Plaque Psoriasis

• To be administered subcutaneously is 160 mg at week 0, followed by 80 mg at even weeks such as 2, 4, 6, 8, 10 & 12, then 80 mg every four weeks. 

For Children with Moderate to Serious Plaque Psoriasis

• The medication dosage for children is based on their weight. It is to be administered subcutaneously every four weeks. 
  • For children weighing more than 50 kg: The initial dose is 160 mg, followed by an 80 mg dose every four weeks. 
  • For children weighing 25-50 kg: 80 mg will be administered subcutaneously initially, followed by 40 mg every four weeks. 
  • For children weighing less than 25 kg: 40 mg initially followed by 20 mg every four weeks. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Taltz Autoinjector PFS? 

Before you begin using the Taltz Autoinjector, and each time you get a refill, carefully read and follow the Medication Guide and Instructions for Use provided by your pharmacist. If you have any questions or concerns, consult your doctor or pharmacist.

• Before starting treatment, your doctor will ensure you have received all necessary vaccinations and will test you for tuberculosis (TB). Your doctor will also monitor you for TB symptoms during and after treatment. If required, treatment for TB or other infections will be initiated before starting this medication.
• Ixekizumab is administered by injection subcutaneously, following your doctor’s instructions. The injection is usually given in the upper arms, front thighs, or abdomen, at least one inch away from your navel. The medication dosage and schedule depend on your medical condition and how your body responds to treatment. For children, the dose is based on weight. Follow your doctor’s instructions closely.
• If you are administering this medication at home, ensure you understand all preparation and usage instructions from your healthcare professional and the product guide. 
• Wash your hands before handling the medication. Let the medication sit at room temperature for thirty minutes after removing it from the refrigerator. 
• Do not warm it in any other way, such as using a microwave, hot water, or sunlight. You should not shake the medication. 
• Check the injection before using it. It should appear clear or slightly yellow; if it looks cloudy, has particles in it, or is discolored, do not use it. Before each injection, clean the injection spot with rubbing alcohol. 
• Rotate injection sites to avoid skin injury. Do not inject into irritated, sore, bruised, red, hard, or psoriasis-affected skin. Avoid rubbing the injection site after administering the shot to reduce bruising. Learn how to properly store & dispose of medical supplies, and do not reuse syringes.
• For the best results, use this medication consistently. Mark your calendar as a reminder if necessary.
• Notify your doctor if your condition does not improve or worsen.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Taltz Autoinjector PFS Work?

The Taltz Autoinjector, containing the medication ixekizumab, is designed to treat conditions like plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. It works by targeting and neutralizing a protein called interleukin-17A, which plays a key role in the body’s inflammatory response. By blocking IL-17A, Taltz helps reduce inflammation and alleviate symptoms associated with these autoimmune conditions.

Important Safety Information for Using Taltz Autoinjector PFS

What Are the Side Effects of Taltz Autoinjector PFS?

Common Side Effects of Taltz Autoinjector PFS: Your doctor has prescribed this medication as they have determined its benefits outweigh the side effects. Most of these side effects are not serious and do not require any medical attention. These side effects disappear within a few days as your body adjusts to this medication. The list below does not cover all possible serious side effects of the medication. Some side effects caused by Taltz Autoinjector PFS may include: 

• Injection site reactions (redness, itching, pain): Injection site reactions are a common side effect of injectable medications like Taltz. These reactions occur because the body may perceive that the drug or the needle is a foreign substance, further causing localized inflammation. To manage injection site reactions, you should apply a cold compress to the area where you have injected the medication and rotate the injection spot each time you administer the dose. Get in touch with your doctor or medical provider if these reactions persist or worsen.
• Upper respiratory infections: They are a known side effect of Taltz and can include symptoms like nasal congestion, sore throat, Cough, and mild fever. The exact mechanism behind what causes this is not completely understood, but it is said to occur due to the medication’s effect as an immunosuppressant, which makes the upper respiratory tract more susceptible to bacteria and viruses. To prevent this, you should follow good hygiene practices and avoid coming into close contact with people who are sick. If you experience any signs & symptoms of a respiratory tract infection, you can use over-the-counter drugs to alleviate symptoms after consulting your healthcare provider. In severe bacterial infections, your doctor may prescribe you to use antibiotics. You should closely monitor your symptoms and let a medical professional know if you develop a URI symptom. 
• Nausea: This can typically affect those who have more sensitivity to the drug or those who have a pre-existing digestive condition. The cause of nausea in this context may be relayed to the body’s reaction to the drug. If you experience nausea after using Taltz on an empty stomach, you can start using it with food to prevent this. You can also manage nausea by staying hydrated and avoiding greasy or spicy food. 
• Fungal infections (such as athlete’s foot): The immunosuppressive action of Taltz can weaken the body’s natural defenses, which may make it easier for your body to develop symptoms of a fungal infection. Its symptoms include itching, redness, and peeling skin in areas that are warm and moist. You should maintain good hygiene and wear breathable footwear to prevent fungal infections. If an infection occurs, use antifungal creams or oral medications as a healthcare professional prescribes. It is important to complete the entire course of treatment, even if symptoms improve before the medicine is finished, to fully eradicate the infection. 
• Headache: This is a relatively common side effect of Taltz. The headache may vary from mild to moderate in intensity and can be related to the immunosuppressive action of this medication. To prevent this, you can stay hydrated, take adequate rest, and use over-the-counter medications if the pain becomes bothersome. If it is severe, talk to your doctor. In some cases, they may advise you to take additional medications or adjust your dosage accordingly.

Mild Side Effects of Taltz Autoinjector PFS: Most mild side effects caused by this medication are temporary and usually do not require medical attention. However, if they become bothersome or persist, tell your doctor. 

• Mild allergic reactions: These reactions are usually caused by the body’s reaction to the ingredients of the medicine. Its symptoms may include skin rash, swelling, or itching at the injection site. To manage mild side effects, apply a cool compress to the affected area or use antihistamine medicines as directed by your doctor or healthcare provider. If the reaction does not affect your daily life, it is not usually a cause of concern, but if it spreads to other parts of the body or if it involves other symptoms like trouble breathing, this could indicate a severe hypersensitivity reaction. 
• Fatigue: This can be due to how your body reacts to medication, stress, or an underlying condition. To manage fatigue, you should follow a consistent sleep schedule, eat a well-balanced diet, and engage in light physical activity during the day. If fatigue becomes persistent or interferes with daily life, talking to a healthcare practitioner is best. Ensuring good hydration and avoiding caffeine late in the day can also be helpful for maintaining energy.
• Joint pain: Taltz can occasionally lead to mild joint discomfort in some patients, which may be exacerbated by physical activity or weather changes. To prevent and manage joint pain, you should engage in regular low-impact exercises and apply compresses. If the pain is persistent or severe, get in touch with your doctor.
• Muscle pain: This is most likely to occur during the initial weeks of treatment, and it is typically caused by the medication’s effect on the immune system. This can lead to temporary inflammation & pain in the muscles. To manage this, you should do gentle stretching exercises and use ibuprofen or other pain relievers to alleviate mild muscle pain. 
• Diarrhea: The exact reason behind what causes diarrhea while using Taltz; it is said to be caused by immunosuppressive behavior. Managing diarrhea involves staying adequately hydrated to replace lost fluids and electrolytes, avoiding spicy and greasy foods, and eating a bland diet. You can also use over-the-counter medicines to control diarrhea. If diarrhea persists for over a few days, accompanied by fever or blood in the poop, you should consult a medical provider.  
• Mouth sores: These mouth sores can be painful and may be related to the medicine’s effect on the immune system or as a side effect of changes in the body’s ability to heal and regenerate cells. To prevent mouth sores or oral ulcers, you should maintain good oral hygiene, use a soft-bristled toothbrush, and avoid spicy or acidic foods that may irritate the sores. To reduce the discomfort of a sore, you should use saltwater rinses or over-the-counter oral gels. You should tell your doctor if the sores are persistent or causing significant pain. 

Serious Side Effects of Taltz Autoinjector PFS: In rare cases, some people using Taltz Autoinjector PFS may experience severe side effects of Taltz Autoinjector PFS. It is essential to mention that not everyone using this medication will experience these side effects. These symptoms require prompt medical attention and can be life-threatening if not treated promptly. Contact your doctor or call 911 or poison control helpline if you experience any of the following symptoms.

• • Severe allergic reactions, including anaphylaxis: While rare, it can cause serious side effects which require prompt medical intervention. Its symptoms may include severe dizziness, difficulty breathing, swelling of the face/throat, and rapid heartbeat. The exact reason why this happens is not known, but it is said to be due to hypersensitivity to one of the components of the product. To prevent this, you should avoid Taltz if you have ever had an allergic reaction to biologic medicines. You should monitor your symptoms closely for allergic reaction symptoms. If you have severe signs, you should discontinue using Taltz and consult your medical giver. 

• Serious infections, which may include bacterial, fungal, or viral infections: Due to the immunosuppressive effects of Taltz autoinjector PFS, some people may have an increased risk of certain infections. To reduce the risk, you should be screened for infections, especially TB, before starting treatment with Taltz. You should avoid close contact with people who have active infections. You should also practice good hygiene and immediately get in touch with your doctor if you have any signs and symptoms of a serious infection, including fever, fatigue, or rashes. If you experience an infection, you should discontinue using Taltz Autoinjector PFS and contact your healthcare provider. 

• • Inflammatory bowel disease: This side effect is said to occur because this medication affects the immune system, potentially leading to abnormal inflammation in the gastrointestinal tract. Although IBD is rare, it can cause severe complications if left untreated. Symptoms may include diarrhea, weight loss, and abdominal pain. To prevent and manage inflammatory bowel disease, you should tell your doctor. They are most likely to conduct certain tests to determine the cause. In some cases, patients may be advised to discontinue using the medicine and use an alternative therapy. 

• Changes in laboratory test results: This medicine can cause changes in certain laboratory test results, which may indicate potential side effects of Taltz or a more serious underlying cause. Before taking certain tests, such as liver function, blood cell counts, and kidney function, tell your doctor that you are using Taltz. If abnormal results are detected, the provider may adjust the treatment or conduct further investigations to rule out complications. 

• • Severe skin reactions like Stevens-Johnson syndrome: While extremely rare, severe skin reactions can occur in patients using Taltz. Its symptoms may include blisters, widespread rash, or peeling skin. This reaction can be life-threatening & requires immediate medical intervention. If SJS is confirmed, Taltz should be discontinued, and the patient may require hospitalization to manage the symptoms, which may include pain control, fluid management, and antibiotics to prevent secondary infections.

• Reactivation of tuberculosis in patients with a history of TB or those at high risk: In patients with latent TB, the bacteria remain dormant and cause no symptoms. However, immunosuppressive drugs like Taltz can trigger the reactivation of dormant bacteria, leading to active TB. Symptoms of active TB may include persistent cough, chest pain (angina), fatigue, weight loss  & night sweats. Before starting Taltz, patients are usually screened for TB, and if they have latent TB, they may need to undergo a course of TB treatment to prevent reactivation. During treatment with Taltz, healthcare providers may continue to monitor for signs of TB. If TB reactivation occurs, Taltz should be stopped, and the patient will be treated for TB with antibiotics.

• • Liver problems: These include hepatitis or liver enzyme abnormalities. Symptoms may include dark urine, abdominal pain, and yellowing of the skin or eyes. These symptoms may indicate liver damage or a more severe liver condition. To prevent liver problems, you should have regular liver function tests before & during treatment with Taltz to monitor for any signs & symptoms of liver damage. If hepatic issues are detected, you should discontinue using this medicine and explore alternative treatments for the underlying condition. 

• Increased risk of certain cancers: While Taltz effectively treats autoimmune conditions by suppressing parts of the immune system, it can also increase the risk of developing certain types of cancers, typically skin cancers and lymphomas. To prevent the risk of cancer, you should regularly visit your doctor to get yourself checked and report any changes in your health status. If a patient develops cancer during treatment, the healthcare provider may discontinue Taltz and consider alternative treatments.

• Central nervous system effects: Although rare, Taltz can cause CNS effects. Symptoms may include weakness, numbness, or vision changes. Taltz’s influence on the immune system might trigger CNS reactions. Depending on the severity of the symptoms, the healthcare provider may need to adjust the Taltz treatment plan or perform additional testing to rule out severe conditions affecting the central nervous system (CNS).

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Taltz Autoinjector PFS? 

There are certain warnings that you should keep into consideration when you are using Taltz Autoinjector PFS. The key points of the warnings include: 

• You should not receive a live vaccine while using Taltz Autoinjector PFS, as the vaccine may not work as well as it should during this time and may not fully protect against disease. Live vaccines mag include mumps, rubella, polio, measles, rotavirus, yellow fever, typhoid, nasal flue, zoster, and varicella vaccine. 
• Do not share this medication with others, even if they have the same symptoms as you. 
• During treatment with Taltz, watch for signs of worsening or beginning of inflammatory bowel disease (IBD). In clinical trials involving patients with plaque psoriasis, conditions like Crohn’s disease and ulcerative colitis were reported more frequently in those treated with this medication over a 12-week period compared to those in the placebo group.

What Are the Taltz Autoinjector PFS Precautions?

• Before using ixekizumab, inform your doctor or pharmacist about any allergies you have. Taltz may contain ingredients that can trigger allergic reactions or other issues. Speak with your pharmacist for more information.
• Tell your healthcare provider about your medical history before starting this treatment, especially if you have had infections like tuberculosis or herpes or if you have ulcerative colitis or Crohn’s disease.
• Ixekizumab can increase your risk of infections or worsen existing ones. Avoid coming into contact with people who have infectious diseases like chickenpox, COVID-19, measles, or influenza. Discuss it with your doctor if you’ve been exposed to any infections.
• Inform your healthcare provider that you are taking ixekizumab before receiving any vaccines. Stay away from people who have recently received live vaccines, like the intranasal influenza vaccine.
• Before undergoing any surgery, tell your doctor, surgeon, or dentist about all the products you use, including prescribed and over-the-counter medications and herbal supplements.
• This medication should only be used during pregnancy if necessary. Talk about the potential risks & benefits with your doctor.
• It is not known if this medication transfers into breast milk. Talk to your doctor before breastfeeding.

What Are the Contraindications of Taltz Autoinjector PFS?

Taltz Autoinjector PFS is contraindicated for use in patients who have:

• Known hypersensitivity to ixekizumab or any of the excipients in Taltz 
• Clinically important active infections such as tuberculosis 
• Taken live vaccines
• Inflammatory bowel disease (caution is advised)
• Latex allergy (caution is advised)

What If You Missed a Dose of Taltz Autoinjector PFS?

To get the most benefit out of Taltz Autoinjector PFS, you should be consistent in dosage. To help you remember to take it, take it around the same time each day. If you have missed a dose of Taltz, you should call your doctor or follow the instructions given below. 

• If you have missed a dose of Taltz, you should take it as soon as possible. 
• However, if it is almost time to take your next dose, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• Do not use double or extra doses of the same medication to compensate for the missed dose. 
• You can set a reminder on your phone to prevent missing doses further. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Taltz Autoinjector PFS?

You should not use Taltz more than the prescribed dose, in large quantities, or more frequently, as it can cause an overdose. If you suspect an overdose, you should immediately seek medical attention. You can call a medical professional, 911, or poison control helpline. You can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Taltz Autoinjector PFS?

Following proper storage guidelines is essential to ensure the medicine’s potency. You should keep Taltz Autoinjector PFS should be kept in its original container, tightly closed, at a controlled room temperature, away from direct sunlight, moisture, and excess heat. 

• Keep all medications, including Taltz Autoinjector PFS, in a safe place away from the sight & reach of children and pets. 
• You should not keep medications that are outdated or no longer needed. Discard them safely. 
• You should not pour them into the drain, flush them down the toilet, or throw them in the garbage bin. 
• You should dispose of unwanted medications in such a way that prevents children, animals, and others from consuming them. 
• The best way to eliminate unwanted medications is to give them in the medicine take-back program. 
• To learn more about the proper ways to dispose of unwanted medications, consult your pharmacist, healthcare provider, or local waste disposal company. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Taltz Autoinjector PFS?

Certain medications may interact with Taltz Autoinjector PFS and affect how it may work. Before using this medication, tell your doctor about all the medications you are using, including all prescription, non-prescription, and over-the-counter drugs, as well as herbal or vitamin supplements you may be taking. This information will help them identify and manage drug interactions. Some potential drug interactions of Taltz are as follows:

• Typhoid Polysaccharide Vaccine
• Yellow Fever Vaccine
• Measles Mumps And Rubella Vaccine, Live
• Influenza Virus Vaccine Quadrivalent, Recombinant
• Smallpox (Vaccinia) Vaccine, Live
• Anthrax Vaccine Adsorbed
• Diphtheria & Tetanus Toxoids/Acellular Pertussis/Poliovirus, Inactivated Vaccine
• Meningococcal A C Y And W-135 Diphtheria Conjugate Vaccine
• Adenovirus Types 4 And 7 Live, Oral
• Zoster Vaccine Live
• Varicella Virus Vaccine Live
• Measles, Mumps, Rubella And Varicella Vaccine, Live
• Rotavirus Oral Vaccine, Live
• Pneumococcal Vaccine 13-Valent
• BCG Vaccine Live
• Diphtheria & Tetanus Toxoids
• Meningococcal Group B Vaccine
• Axicabtagene Ciloleucel
• Influenza Virus Vaccine Trivalent, Recombinant
• Ciltacabtagene Autoleucel
• Typhoid Vaccine Live
• Brexucabtagene Autoleucel
• Tetanus & Reduced Diphtheria Toxoids/ Acellular Pertussis Vaccine
• Influenza Virus Vaccine Quadrivalent, Intranasal
• Idecabtagene Vicleucel
• Meningococcal A C Y And W-135 Polysaccharide Vaccine Combined
• Lisocabtagene Maraleucel
• Tisagenlecleucel
• Pneumococcal Vaccine Polyvalent
• Upadacitinib
• Tetanus Toxoid Adsorbed Or Fluid

What Are the Other Taltz Autoinjector PFS Interactions?

Apart from medications, Taltz Autoinjector PFS may interact with certain herbs, supplements, foods, and beverages. Here are the important interactions you should take into consideration before using this medication. 

• St. John’s Wort 
• Excessive alcohol consumption
• Garlic supplements 
• Grapefruit juice 

[Note: This isn’t a complete list, and there could be other drugs that interact with Taltz Autoinjector PFS. Tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Taltz Autoinjector PFS Alternatives?

People look for alternative medicines to Taltz Autoinjector PFS when they do not suit them or do not get the desired results from it. There are many effective substitutes for Taltz Autoinjector available in the market. You should consult a medical professional before switching your medication or starting a new one. Some of the popular alternatives to Taltz are as follows:

• Skyrizi (risankizumab)
• Tremfya (guselkumab)
• Stelara (ustekinumab)
• Humira (adalimumab)
• Apremilast
• Zoryve (roflumilast)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Taltz Autoinjector PFS Cost & Coupons

The cost of Taltz Autoinjector PFS can be significant, especially when not covered by health insurance. Many individuals seeking this medication for its benefits often face challenges with affordability due to limited insurance support. To address these financial constraints, options like Polar Bear Meds offer a more budget-friendly solution. You should buy Taltz Autoinjector online from Canadian sources through Polar Bear Meds, which significantly reduces the expense. Additionally, new customers can benefit from further savings by using the coupon code WELCOMEPB10, which grants a 10% discount on their initial purchase. This approach provides a practical way to manage medication costs effectively.

Frequently Asked Questions

How do you inject ixekizumab with the Taltz Autoinjector?

To inject ixekizumab using the Taltz Autoinjector, clean the injection site, remove the cap, and place the autoinjector against the skin. Press the button to release the medication. Hold it in place until you hear a click, signaling the injection is complete. Follow your healthcare provider’s instructions for proper usage.

Where should Taltz shots be administered?

Taltz shots can be administered in the stomach, front thigh, or upper arm. Rotate the injection spot each time you inject the dose to minimize irritation. Avoid injecting into areas with scars, stretch marks, or skin conditions. It is advisable to consult with a healthcare provider for personalized guidance on choosing the best injection sites.

What conditions is Taltz FDA-approved to treat?

The FDA has approved Taltz for psoriasis treatment & ankylosing spondylitis. It is also approved for the treatment of non-radiographic axial spondyloarthritis in adults. The medication is specifically indicated for patients who are candidates for systemic therapy or phototherapy.

Can Taltz be used in combination with other medications?

Taltz can be used alongside other medications, but it is essential to tell your healthcare provider of all current treatments, including biologics and immunosuppressants. The combination should be closely monitored to avoid potential drug interactions or adverse effects. Always consult your doctor before starting a new medication or changing it.

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