
Vortioxetine



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Trintellix is an antidepressant medication containing the active ingredient Vortioxetine. It is approved by the FDA to treat adults with major depressive disorder (MDD), also known as depression, which is a serious mental health condition. Trintellix increases serotonin activity in the brain and has unique effects on specific serotonin receptors. It comes as immediate-release tablets with strengths of 5mg, 10mg, and 20mg. Common side effects include nausea, constipation, and vomiting. It’s essential to consult a doctor for personalized dosage and to monitor for any serious side effects or interactions with other medications.
Trintellix (vortioxetine) is a prescription medication primarily used to treat major depressive disorder (MDD). It works by enhancing serotonin activity in the brain, which is thought to have a positive effect on mood and emotional well-being. It is unique among antidepressants because it not only inhibits the reuptake of serotonin but also directly affects certain serotonin receptors in the brain. It is available in the form of immediate-release tablets in three strengths: 5mg, 10mg, and 20mg. The usual starting dose for adults with depression or MDD is 10mg once daily, which can be adjusted based on individual response and tolerability, with a maintenance dose ranging from 5mg to 20mg once daily.
There can be some common side effects of Trintellix, including vomiting, nausea, and constipation which typically improve as the body adjusts to the medication. However, it can also cause more serious side effects such as increased risk of bleeding, discontinuation syndrome, serotonin syndrome, manic episodes, and low sodium levels in the blood. Therefore, it is crucial to follow the doctor’s instructions and report any adverse reactions.
Before starting Trintellix, patients should be screened for bipolar disorder, mania, and hypomania. It is also essential to discuss any other medications being taken to avoid potential interactions. Trintellix should not be abruptly discontinued without consulting a healthcare provider to prevent withdrawal symptoms. It is an effective treatment for depression and MDD, but it requires careful monitoring and adherence to the prescribed regimen to ensure safety and efficacy.
Trintellix is used to treat:
It comes in the form of immediate-release tablets and has three following strengths:
Adults with Depression & Major Depressive Disorder (MDD)
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your Trintellix dosage accordingly.]
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
Trintellix is a type of antidepressant medication known for its unique way of working. It works by increasing the activity of serotonin in the brain. It does this by stopping the reabsorption of serotonin, which can help balance the levels of brain chemicals and improve symptoms of depression. Trintellix is different from other antidepressants as it targets and blocks specific serotonin receptors in the brain. These receptors are like docking stations for serotonin. By blocking these receptors, serotonin cannot attach to them. Although it’s not entirely clear how this action contributes to relieving depression, it is an important aspect of how Trintellix works.
Common side effects of Trintellix may include:
These Trintellix side effects are common and may go away as your body adjusts to the medication. However, if they worsen, inform your doctor or healthcare provider.
Serious side effects of Trintellix include:
Serotonin Syndrome: It is a serious health condition that can be life-threatening when Trintellix is combined with certain other medications. Signs and symptoms of this syndrome:
Increased Risk of Bleeding: Combining Trintellix with non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, warfarin, or blood thinners can increase the risk of bleeding. Inform your healthcare provider immediately if you notice any unusual bleeding or bruising.
Manic Episodes: Symptoms may include:
Discontinuation Syndrome: Abruptly stopping Trintellix can cause serious side effects. Your healthcare provider may decrease the amount of your dose slowly. Symptoms may include:
Eye Problems (Angle-closure Glaucoma): Trintellix can lead to angle-closure glaucoma (an eye problem) in individuals with specific pre-existing eye conditions. If you experience any changes in your vision, eye pain, redness, or swelling in or around the eye, contact your doctor promptly for evaluation and guidance.
Low Levels of Sodium in Your Blood (Hyponatremia). Low levels of sodium in the blood can occur during treatment with Trintellix, and this can be severe and potentially fatal. Older adults and individuals taking certain medications may be at higher risk for developing this condition. Signs and symptoms may include:
Sexual Problems (Dysfunction): Symptoms in males and females may include:
If you experience severe side effects, immediately contact your doctor. In cases where the side effects appear life-threatening, or you believe you are facing a medical emergency, call 911 or your local emergency services without delay.
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Trintellix comes with a special warning, known as a “boxed warning,” the most serious type of warning issued by the Food and Drug Administration (FDA). This warning is to let doctors and patients know that this drug can be associated with severe risks.
One of the risks of Trintellix is that it can increase the chances of having suicidal thoughts and behaviors in children and young adults. However, this increased risk does not seem to affect older adults. Because of this, Trintellix is not recommended for use in children. If you are a family member or caregiver of a child or young adult who is taking Trintellix, it’s essential to keep an eye out for any signs that their depression is getting worse or if they are having suicidal thoughts. You should contact a doctor immediately if you notice any of these signs.
Here are some precautions you need to be aware of when using Trintellix:
This medication is not recommended for individuals who are allergic to Trintellix or any of its ingredients. It should not be taken by individuals who are currently using monoamine oxidase inhibitors (MAOIs) or have used them in the last 14 days. Similarly, MAOIs should not be used within 21 days of stopping Trintellix. Also, Trintellix should not be taken by individuals who are receiving linezolid or intravenous methylene blue.
In case of a missing dose of Trintellix. Take it as soon as you possibly can. If the next dose is almost due, skip the missed dose. Take your next dose at its usual time. Do not take two doses to make up for the one you missed.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Taking an overdose of Trintellix may increase your chances of getting serious side effects. Don’t use Trintellix more than your doctor prescribed.
[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Keep Trintellix at room temperature and protect it from moisture and heat. Remember, this is a general guide. Always consult with your doctor or healthcare professional for personalized advice and adjustments to your treatment plan.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Always tell your doctor and pharmacist about all the medicines and supplements you’re taking. This includes everything from prescription drugs to over-the-counter items, vitamins, and even herbal supplements. Trintellix can react with some medications. These reactions might not be safe, so it’s crucial to be aware.
Your doctor will decide the best course of action, which might mean not using Trintellix or adjusting other medications you’re taking. Here’s a list of specific drugs that can interact with Trintellix. Remember, this isn’t a complete list, but it covers some of the major ones:
[Note: This isn’t a complete list, and there could be other drugs that interact with Trintellix. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

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