Zepbound Kwikpen

Zepbound is an injection used to help with chronic weight management in adults with obesity (BMI ≥30) and overweight (BMI ≥27) with health-related conditions. It should be used in conjunction with a diet and increased physical activity. This medication contains tirzepatide and should not be taken with other GLP-1 receptor agonist medications. Zepbound is also used for moderate-to-severe OSA (Obstructive Sleep Apnea). Consult your doctor before using this medication.

Quick Facts About Zepbound

Below is a quick overview for patients and caregivers about Zepbound.

The Zepbound KwikPen is approved for use in adults for:

• Chronic weight management
• The treatment of moderate-to-severe OSA (obstructive sleep apnea)

Zepbound Weight Loss Results by Dosage

The data shown are based on findings from the 72-week SURMOUNT-1 clinical study, which evaluated weight-loss outcomes in individuals using varying maintenance doses of Zepbound (tirzepatide). Participants followed a calorie-reduced eating plan and increased their physical activity throughout the trial. After 72 weeks of treatment, the average tirzepatide weight loss outcomes observed are:

Zepbound vs. Wegovy: Which Is Right for You?

When you consider Zepbound for chronic weight management & obstructive sleep apnea, follow these administration guidelines:

• Zepbound KwikPen is injected once weekly under the skin (subcutaneous injection).
• The injection can be taken at any time of day, with or without food.
• Start with the recommended dose and increase only as directed.
• Before use, inspect the medicine and ensure the solution is clear to slightly yellow and free of particles.
• Wash both hands and clean the injection site properly with alcohol before injecting Zepbound KwikPen.
• Attach a new pen needle to the KwikPen for each injection.
• Inject into the abdomen, thigh, or upper arm (upper arm only if someone else gives the injection).
• Rotate injection sites each week and avoid injecting into the same spot repeatedly.
• Insert the Zepbound pen needle fully into the skin and press the dose knob until it stops.
• Hold the dose knob down for at least 5 seconds to make sure the full dose is delivered.
• Confirm that the dose window shows zero before removing the needle.
• Remove the needle after injection and dispose of it immediately in an FDA-approved sharps container.
• Do not reuse needles or share the Zepbound KwikPen with anyone else.
• Do not transfer medicine from the KwikPen into a syringe.
• Discard the Zepbound KwikPen even if some medicine remains.
• If a dose of Zepbound is missed and it has been 4 days or less since the missed dose, take the dose as soon as possible. If more than 4 days (96 hours) have passed since the missed Zepbound dose, skip it. Take the next dose on the regularly scheduled day. Do not take two doses within the same week to make up for a missed dose.
• If the dosing day needs to be changed, allow at least 3 days (72 hours) between doses.

In the event of a Zepbound overdose, contact a healthcare provider or the poison control center immediately.

Zepbound KwikPen delivers tirzepatide via a once-weekly subcutaneous injection and works by activating two natural hormone receptors, GIP and GLP-1. These hormone receptors regulate appetite and metabolism. These hormones help regulate hunger signals in the brain. As a result, people tend to feel full sooner and eat less. Tirzepatide also improves insulin response and blood glucose control, supporting long-term weight management.

The side effects of Zepbound are:

Zepbound Warning: Risk of Thyroid C-Cell Tumors

Zepbound carries an FDA boxed warning because it may increase the risk of having thyroid C-cell tumors based on animal studies. It should not be used by anyone who has a family history of MEN 2 (Multiple Endocrine Neoplasia type 2) & medullary thyroid carcinoma. Patients should watch for symptoms such as a lump in the neck, hoarseness, difficulty swallowing, or shortness of breath and report them to a physician immediately. This warning highlights the most serious potential risk associated with the medication.

• Before using Zepbound Kwikpen, talk to your doctor about:
  • All medications, including prescription, over-the-counter, and supplements
  • Any allergies you have
  • Your current and past medical conditions
  • Pregnancy or breastfeeding status
• Zepbound is not recommended for individuals with severe gastrointestinal disorders.
• This medication can cause acute kidney injury, especially if dehydration occurs.
• Zepbound is associated with an increased risk of gallstones or gallbladder inflammation.
• Seek medical help for severe upper abdominal pain after using Zepbound.
• Using Zepbound with insulin may increase hypoglycemia risk. Be careful about that.
• Zepbound may worsen diabetic retinopathy in people with type 2 diabetes.
• Suicidal thoughts or behavior may occur. Stop Zepbound in that case and contact your doctor immediately.
• Zepbound may harm an unborn baby. Women on oral contraceptives should switch to non-oral methods or use a barrier method for 4 weeks after starting or increasing the dose.
• After taking Zepbound pens out of the refrigerator, they can be kept at room temperature for up to21 days, but only if they are unopened.

Zepbound (tirzepatide) is known to interact with 426 medications, as well as 5 medical conditions. Among these drug interactions, 16 are considered major, 402 are moderate, and 8 are minor, meaning some interactions may require close monitoring or dose adjustments. Some of them are listed below:

• Zepbound interacts with any oral prescription or over-the-counter drugs, including:
  • Ibuprofen
  • Antidepressants like Bupropion
  • Omeprazole
  • Antibiotics like Doxycycline
  • Warfarin
  • Cyclosporine
  • Theophylline
• Zepbound interacts with oral birth control medications:
  • Sprintec
  • Yasmin
  • Yaz
  • Aurovela
  • Junel
• Zepbound interacts with Sulfonylureas:
  • Diabeta (glyburide)
  • Glynase (glyburide)
  • Amaryl (glimepiride)
  • Glucotrol XL (glipizide)
• Zepbound interacts with insulin:
  • Levemir
  • Humalog
  • Lyumjev
  • Lantus
  • Toujeo
• Zepbound interacts with Meglitinides:
  • Nateglinide
  • Repaglinide
• Zepbound disease interactions are:
  • Thyroid cancer
  • Acute kidney injury
  • Pancreatitis
  • Retinopathy
  • Severe GI disease

• Wegovy (semaglutide)
• Saxenda (liraglutide)
• Contrave (naltrexone/bupropion)
• Qsymia (phentermine/topiramate)
• Xenical (orlistat)

When you buy Zepbound online through Polar Bear Meds, you can lower your medication costs and avoid high U.S. pharmacy prices. Without insurance, the average cost of Zepbound Kwikpen in the U.S. is around $1,500. We offer the same medication for approximately $500, resulting in savings of more than $1,080 per pen. Plus, most Zepbound orders are delivered within 3-5 business days.

First-time customers can use the Zepbound coupon code “WELCOMEPB10” during checkout for an additional 10% off. All orders require a valid Zepbound prescription, and medications are sourced from licensed Canadian pharmacies. This ensures access to Zepbound at a lower cost while meeting standard prescription requirements.

• https://zepbound.lilly.com/
• https://www.drugs.com/zepbound.html
• https://www.webmd.com/drugs/2/drug-187794/zepbound-subcutaneous/details
• https://www.healthline.com/health/drugs/zepbound
• https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management
• https://pi.lilly.com/us/zepbound-uspi.pdf
• https://www.drugs.com/medical-answers/how-weight-lose-zepbound-3575539/#:~:text=5mg/week%20Zepbound:%2016%25,%2C%20and%20COVID%2D19%20infection
• https://www.nejm.org/doi/full/10.1056/NEJMoa2206038#:~:text=The%20mean%20percentage%20change%20in,tirzepatide%20doses%20and%20placebo%2C%20respectively.