Buy Pradaxa Capsule (Dabigatran Etexilate) Online from Canada
What Is a Pradaxa Capsule (Dabigatran Etexilate)?
Pradaxa capsule (Dabigatran Etexilate Mesylate) is a prescription medication used to prevent blood clots and reduce the risk of stroke in individuals with certain types of heart conditions, such as atrial fibrillation (irregular heart rhythm). It belongs to a class of medications known as direct oral anticoagulants (DOACs) or non-vitamin K antagonist oral anticoagulants (NOACs).
Pradaxa works by inhibiting the activity of thrombin, an enzyme in blood clot formation. This helps to prevent the formation of harmful blood clots in the circulatory system. It is essential to take Pradaxa precisely as a healthcare provider prescribes and follow all recommended monitoring and safety guidelines.
What Is Pradaxa Used For?
Pradaxa (Dabigatran Etexilate Mesylate) is primarily used for the following purposes:
- Preventing Stroke and Blood Clots in Atrial Fibrillation: Pradaxa is prescribed to individuals with atrial fibrillation, a type of irregular heartbeat. It helps prevent blood clots from forming, which can lead to strokes.
- Treating and Preventing Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE): Pradaxa may be used to treat and prevent DVT, a blood clot that forms in a deep vein, and PE, a potentially life-threatening condition where a blood clot travels to the lungs.
- Reducing the Risk of Recurrent Blood Clots: For patients who have already experienced a DVT or PE, Pradaxa may be prescribed to lower the risk of further blood clot formation.
- Preventing Blood Clots After Orthopedic Surgery: In some cases, Pradaxa may be used following hip replacement surgery to reduce the risk of postoperative blood clots.
It’s important to note that Pradaxa is an anticoagulant, which means it helps prevent blood clots. It should be taken precisely as a healthcare provider prescribes, and any dosage adjustments or changes should be made under their guidance. It’s crucial to follow all recommended safety measures and inform healthcare providers of other medications or medical conditions.
Dosage and Storage of Pradaxa
Here is the proper dosage and storage of Pradaxa (Dabigatran Etexilate Mesylate) for its effectiveness:
The dosage of Pradaxa (Dabigatran Etexilate) varies based on the specific medical condition it’s being used to treat. Here are the standard dosages:
- Preventing Stroke and Blood Clots in Atrial Fibrillation: Pradaxa 150 mg twice daily, taken with food.
- Treating and Preventing Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE): Pradaxa 150 mg twice daily after treatment with a parenteral anticoagulant for at least five days.
- Reducing the Risk of Recurrent Blood Clots: Pradaxa 150 mg twice daily after six months of initial DVT/PE treatment.
- Preventing Blood Clots After Orthopedic Surgery: Pradaxa 110 mg on the day of surgery, then Pradaxa 220 mg once daily for 28-35 days.
It’s crucial to follow the prescribed dosage provided by your healthcare provider, whether Pradaxa 150 mg or Pradaxa 110 mg. Please do not alter the dosage without their guidance. Additionally, your healthcare provider may recommend a different dosage for specific medical conditions or exceptional circumstances. Always consult them for personalized advice.
How to Store?
To maintain the effectiveness of Pradaxa capsules:
- Store the medication in a cool, dry place.
- Keep the capsules away from direct sunlight, as excessive exposure may affect their potency.
- Store Pradaxa out of reach of children and pets to prevent accidental ingestion.
- Adhere to additional storage instructions provided on the medication’s label or by your healthcare provider.
- Always ensure that you’re storing and using Pradaxa as directed by your healthcare provider or according to the manufacturer’s guidelines.
How Do Pradaxa Capsules Work?
Pradaxa 150 mg and Pradaxa 110 mg work by inhibiting the activity of an enzyme called thrombin. Thrombin plays a crucial role in the blood clotting process. When a blood vessel is injured, a series of reactions occur to form a blood clot and prevent excessive bleeding.
Thrombin is a critical enzyme in this process, as it converts a soluble protein called fibrinogen into insoluble strands of fibrin, forming a clot’s meshwork. By inhibiting thrombin, Pradaxa interferes with this clotting process. This helps prevent the formation of harmful blood clots within the circulatory system, reducing the risk of conditions such as stroke, deep vein thrombosis (DVT), and pulmonary embolism (PE).
It’s important to note that Pradaxa specifically targets thrombin, which distinguishes it from older anticoagulants like warfarin that target vitamin K in the clotting process. This makes Pradaxa a more direct and specific anticoagulant, classifying it as a direct thrombin inhibitor.
Warnings and Precautions for Pradaxa
- Pradaxa 150 mg and Pradaxa 110 mg increase the risk of severe and potentially fatal bleeding. This risk is higher in individuals with certain conditions or those taking specific medications. Seek immediate medical attention for signs of unusual bleeding.
- Discontinuing Pradaxa prematurely increases the risk of thrombotic events. If surgery is planned, healthcare providers should be informed to determine appropriate management.
- Pradaxa is excreted primarily via the kidneys. Dosage adjustments are required for individuals with renal impairment to prevent accumulation and reduce bleeding risk.
- Limited data is available for Pradaxa use in patients with severe hepatic impairment. Exercise caution and monitor closely.
- Pradaxa should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding.
- Elderly patients may be more susceptible to bleeding events. Monitor them closely.
- Pradaxa may interact with other medications. Inform healthcare providers of all current medications, including over-the-counter and herbal supplements.
- Pradaxa may cause dyspepsia and gastritis-like symptoms. If severe, seek medical attention.
Common Side Effects of Pradaxa
Common side effects of Pradaxa (Dabigatran Etexilate Mesylate) may include:
- Bleeding can manifest as nosebleeds, bruising, or blood in the urine or stools.
- Gastrointestinal Disturbances may include indigestion, upset stomach, or abdominal pain.
- Mild to moderate headaches may occur.
- Some individuals may experience musculoskeletal pain in the back.
- Dyspepsia (indigestion or upset stomach).
It’s important to note that not everyone will experience these side effects, and some individuals may experience effects not listed here. If you notice any unusual or severe symptoms while taking Pradaxa 150 mg or Pradaxa 110 mg, it’s essential to inform your healthcare provider promptly. They can provide personalized advice and guidance based on your specific situation. This list is not exhaustive, and individual experiences may vary.
What Are the Drugs That Interact with Pradaxa?
Drugs that interact with Pradaxa (Dabigatran Etexilate) may either increase the risk of bleeding or reduce its effectiveness. Some of these interactions include:
- Antiplatelet Agents: Drugs like aspirin, clopidogrel, and nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the risk of bleeding when used with Pradaxa.
- Anticoagulants: Combining Pradaxa with other anticoagulants, such as warfarin or heparin, can increase bleeding risk. It’s generally not recommended to use Pradaxa with other anticoagulants.
- Thrombolytic Agents: These drugs, used to dissolve blood clots, can increase the risk of bleeding when taken with Pradaxa.
- Certain Antiarrhythmic Drugs: Some medications used to treat irregular heart rhythms, like amiodarone and verapamil (dabigatran plasma concentration), may interact with Pradaxa. Adjustments in dosage or careful monitoring may be necessary.
- Certain Antifungal Drugs: Azole antifungal medications like ketoconazole and itraconazole may interact with Pradaxa.
- Rifampin: This antibiotic can decrease the effectiveness of Pradaxa.
- St. John’s Wort: This herbal supplement may reduce the levels of Pradaxa in the body, potentially making it less effective.
- Specific Protease Inhibitors: Some HIV medications, like ritonavir, may interact with Pradaxa.
It’s crucial to inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are taking. They can provide guidance on the appropriate use of Pradaxa and make any necessary adjustments to your treatment plan.
Alternative to Buy Pradaxa
Alternative medications to Pradaxa (Dabigatran Etexilate) in the class of direct oral anticoagulants (DOACs) include:
Rivaroxaban (Brand name, Xarelto): Another DOAC used for similar indications, including prevention of blood clots in patients with atrial fibrillation and treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
Apixaban (Brand name, Eliquis): Another DOAC commonly prescribed for atrial fibrillation and prevention and treatment of DVT and PE.
Edoxaban (Brand name, Savaysa): Edoxaban is also a DOAC used for similar indications as Pradaxa, including stroke prevention in atrial fibrillation and treatment of DVT and PE.
Warfarin (Coumadin): Warfarin is an older anticoagulant that works differently than DOACs. It requires regular monitoring of INR levels and dose adjustments. It is often considered an alternative for patients who may not be suitable candidates for DOACs.
It’s important to note that the choice of anticoagulant depends on individual patient factors, including medical history, kidney function, other medications being taken, and personal preferences. The decision should be made in consultation with a healthcare provider. Always follow their recommendations and instructions regarding anticoagulant therapy.
Frequently Asked Questions
How Quickly Does Pradaxa Start Working?
Pradaxa (Dabigatran Etexilate) starts working relatively quickly, typically within 1-2 hours of taking the first dose. It reaches its peak blood-thinning effect within about 2-3 hours. This rapid onset makes it effective in preventing and treating blood clots and reducing the risk of stroke in patients with atrial fibrillation. It’s essential to follow the prescribed dosing schedule and take Pradaxa as directed by your healthcare provider to ensure its continuous effectiveness in preventing blood clots. If there are specific concerns or questions, it’s advisable to consult with a healthcare professional.
Are There Any Food Or Drink Restrictions While Taking Pradaxa?
While taking Pradaxa (Dabigatran Etexilate), no specific food or drink restrictions exist. However, taking Pradaxa with food is essential to improve its absorption and reduce the risk of stomach upset. Avoiding alcohol in excessive amounts is generally advisable, as it can increase the risk of bleeding. Additionally, it’s essential to maintain a balanced diet and avoid making significant changes to your diet without consulting your healthcare provider, as some foods can interact with medications. Always follow your healthcare provider’s guidance regarding diet and medication.
Can Pradaxa Be Used With Other Medications?
Pradaxa (Dabigatran Etexilate) can interact with other medications, potentially affecting its effectiveness or increasing the risk of bleeding. It’s crucial to inform your healthcare provider about all your medications, including prescription, over-the-counter, herbal supplements, and vitamins.
Specifically, medications that may interact with Pradaxa include:
- Other anticoagulants or antiplatelet drugs.
- Certain antiarrhythmics like amiodarone and verapamil.
- Thrombolytic agents.
- Some antifungal drugs like ketoconazole and itraconazole.
- Rifampin (an antibiotic).
- St. John’s Wort (an herbal supplement).
- Specific protease inhibitors are used for HIV.
How Long Does Pradaxa Stay In The System?
Pradaxa (Dabigatran Etexilate) has a relatively short half-life of about 12 to 17 hours in individuals with normal kidney function. This means it takes roughly this amount of time for half of the medication to be eliminated from the body. However, it’s important to note that the effects of Pradaxa on blood clotting can last beyond its half-life.
Therefore, dosing should be consistent and follow healthcare provider instructions. For individuals with impaired kidney function, the elimination half-life may be longer. Always consult a healthcare provider for specific information regarding medication duration in your case.
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