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Apixaban is an FDA-approved anticoagulant that is used to treat or prevent severe blood clots or strokes in individuals who suffer from atrial fibrillation. It contains the active ingredient Apixaban, which reduces the clotting ability of blood. It comes in the form of a tablet that is to be taken orally, typically twice daily, with or without food. The strength of the tablet is 2.5 mg and 5 mg. The dosage depends on various factors like the patient’s medical condition, age, weight, and more. Consult your doctor to learn more about side effects, storage, and precautions. 

Product Overview

Apixaban is a prescriptive medication that contains the active ingredient Apixaban, an FDA-approved anticoagulant used to prevent severe blood clots or strokes in individuals with atrial fibrillation. It works by reducing the clotting ability of the blood, reducing the risk of harmful clots forming in the blood vessels. Apixaban comes in tablet form and is taken orally, typically twice daily, with or without food. The strength of Apixaban tablets is available in 2.5 mg and 5 mg. The dosage is based on various factors, including medical conditions, age, weight, kidney function, and response to treatment. 

It is essential to take Apixaban precisely as prescribed by your doctor to ensure optimal results. Common side effects of Apixaban may include fatigue, lack of energy, drowsiness, mild rash, nausea, and bruising or bleeding more quickly than usual. Serious side effects such as heavy bleeding, bleeding in the brain, severe allergic reactions, and others may also occur. Before taking Apixaban, inform your doctor about any allergies you may have and provide your medical history, especially if you currently have or have ever had liver or kidney disease, bleeding problems, or have had recent major surgery or injury. 

You should follow your doctor’s instructions carefully, including any advice regarding alcohol consumption and precautions to avoid injuries. Store Apixaban at room temperature, away from direct light, excess heat, and moisture, and keep it out of reach of children. Do not stop taking Apixaban without consulting your doctor, as this may increase the risk of certain conditions. If you miss a dose, take it as soon as you remember, but do not take two doses at once. If you suspect you may have taken more than the recommended dose, seek immediate medical attention.

Uses of Apixaban 

  • Apixaban is used to help prevent severe blood clots or strokes in individuals who suffer from atrial fibrillation, which is a condition where the heart beats irregularly, increasing the chances of clots and strokes. 
  • The medication also helps in preventing deep vein thrombosis (a blood clot usually found in the leg) and pulmonary embolism (a blood clot found inside the lung) in people who are undergoing knee or hip replacement surgery. 
  • It is also used to treat DVT and PE, and it may be continued as a preventive measure even after the initial treatment process is complete. 

How to Use Apixaban?


Apixaban comes in the form of a tablet that is taken orally. It comes in two strengths:

  • 2.5 mg
  • 5 mg

Recommended Dosage for Different Patients 

Recommended Dosage to Reduce Blood Clots and Strokes in Patients with Atrial Fibrillation: 

  • Adult dosage: The usual dosage for adults is 5 mg, which is to be taken twice daily.
  • Pediatric dosage: Apixaban should be used with caution in individuals below 18 years of age. The dosage decisions should be made carefully in consultation with a healthcare professional.
  • Geriatric dosage: If you have severe kidney issues or weigh 60 kg or less, your doctor might reduce your dosage. Impaired kidney function can lead to higher drug concentrations in your body, increasing the risk of side effects.

Recommended Dosage to Reduce Blood Clots in People Who Have Just Had a Hip or Knee Replacement Surgery:

  • Adult dosage: You should take your first dose of Apixaban 12 to 24 hours after the surgery. The usual dosage is taking 2.5 mg orally twice daily. For hip replacement surgery, your treatment with Apixaban will last around 35 days. While for knee replacement surgery, your treatment with Apixaban will last about 12 days.

Recommended Dosage for Patients with Deep Vein Thrombosis and Pulmonary Embolism:

  • Adult dosage: the usual dosage is 10 mg twice a day for one week. After that, you may have to take 5 mg twice daily for at least six months. 
  • Pediatric dosage: Apixaban should be used with caution in individuals below 18 years of age. The dosage decisions should be made carefully in consultation with a healthcare professional.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take It?

  • You are typically required to take this medicine orally twice daily, with or without food. 
  • If you are not able to swallow the tablet as a whole, you may crush the tablet mix into a solution and take it within four hours. 
  • Use Apixaban regularly to get the most benefit from it. 
  • To maintain consistency, it is essential to take it at the same time every day. 
  • Do not stop taking Apixaban without consulting your doctor. 
  • Conditions like atrial fibrillation may become worse when you suddenly stop taking this medication.
  • To avoid running out of this prescription, order your refills early. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Apixaban Work?

Apixaban is a blood thinner that prevents blood clots from forming in the body as quickly or as effectively as usual. It works by stopping a specific clotting factor known as Xa, which reduces the amount of enzyme thrombin in your bloodstream.

Important Safety Information

Side Effects

Common Side Effects of Apixaban may include:

  • Fatigue
  • Lack of energy
  • Drowsiness
  • A mild rash
  • Nausea
  • Bruising and bleeding more quickly than usual

Serious Side Effects of Apixaban may include:

  • Heavy bleeding 
  • Bleeding in the brain 
  • Serious allergic reaction 
  • Tightness in the chest 
  • Blood in the eyes, urine, or stool
  • Vomiting of blood 
  • Shortness of breath 

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]


  • Do not abruptly stop taking Apixaban without consulting your doctor, as it may increase your risk of having a heart attack or stroke.
  • Apixaban may cause a severe kind of allergic reaction known as anaphylaxis, which can sometimes be fatal. You should seek immediate medical attention if you notice any symptoms of allergy, such as itching, rash, trouble breathing, and swelling on your hands, mouth, or face. 
  • This medicine may cause fatal bleeding, so you should keep monitoring for signs of blood loss. 
  • Do not take other medicines along with Apixaban without consulting your doctor. This includes prescription medication, over-the-counter drugs, and herbal supplements. 

Boxed Warning

If you abruptly stop taking Apixaban without consulting your doctor, it may increase your risk of blood clots in the spine or epidural area. While on treatment with Apixaban, regular monitoring of the patient is necessary for signs of neurological impairment. If such signs and symptoms are noticed in the patient, urgent treatment is required. 


  • Apixaban is not usually recommended for use in pregnant or breastfeeding women. 
  • If you cannot swallow Apixaban as a whole, you can crush it, mix it with a liquid, and consume it by mouth. Make sure to take it within four hours of crushing it. 
  • It is crucial to visit your doctor to check your progress regularly, ensure that this medication is working correctly, and determine if you should continue taking it. Your doctor or healthcare provider may suggest some blood tests to check for unwanted side effects. 
  • If you are planning to have surgery, including dental surgery, you may need to stop taking Apixaban and tell your doctor that you are taking this medication. 
  •  Call your doctor immediately if you have any unusual bruising or abnormal bleeding, headache, drowsiness, black, red, or tarry stools, blood in stools, or urine. 
  • You may bruise and bleed more easily while on treatment with this medication. Try your best to avoid injuries. 

Apixaban Contraindications 

Apixaban is contraindicated in patients who have:

  • Active pathological bleeding
  • Severe hypersensitivity to Apixaban 

Missed Dose

  • If you missed your dose of Apixaban, take it as soon as you remember. 
  • However, if it is time for you to take the next dose, you may skip the missed dose of Apixaban and take the next dose at the same time. 
  • Do not take two doses of the same medicine together to make up for the missed dose, as it may cause side effects. 

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]


If you think that you may have consumed more than the recommended dose, you may have an increased risk of bleeding, which can be severe and, in some conditions, fatal. If someone you know has taken this medication more than prescribed and is having seizures, has passed out and can’t be awakened, or is having difficulty breathing, call 911 immediately or head to the nearest emergency room. Symptoms of an overdose may include:

  • Unusual prolonged bleeding or bruising
  • Pink, red, or brown urine
  • Red or black, tarry stools
  • Coughing or vomiting blood

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Store Apixaban tightly closed in the original container at room temperature, away from the sight and reach of children. 
  • You should keep this medication away from direct sunlight, excess heat, and moisture. Do not keep it in the refrigerator or bathroom, as humidity may reduce the effectiveness of the medication.
  • Unwanted and expired medicines should be disposed of safely so that no one consumes them. Do not flush the medication unless instructed. 
  • The best way to dispose of the medicine is through the medicine take-back program. Talk to your pharmacist or check online to learn more about the medicine take-back programs. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Apixaban Interactions

Do not use Apixaban with the following medications:

  • Mifepristone
  • Clopidogrel
  • Ibuprofen
  • Fluoxetine
  • Itraconazole
  • Ketoconazole
  • Conivaptan
  • HIV protease inhibitors
  • Rifamycins
  • St. John’s wort
  • Carbamazepine
  • Phenytoin
  • Aspirin 

[Note: This isn’t a complete list, and there could be other drugs that interact with Apixaban. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Apixaban Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

What is Apixaban used for? 

Apixaban is used to prevent severe blood clots or strokes in individuals who suffer from atrial fibrillation. It is also used in order to avoid pulmonary embolism and deep vein thrombosis and in people who have just had a knee or hip replacement surgery.

What will happen if I stop taking Apixaban? 

If you stop taking Apixaban, the rate at which your blood clots will return to as they were before taking the medication. This means that you may be at higher risk of severe and, in some cases, life-threatening problems like stroke, heart attack, deep vein thrombosis, or pulmonary embolism. 

Is Apixaban safe for use during pregnancy? 

Apixaban is not recommended for use in pregnant and breastfeeding women. If you think you are pregnant or are planning to get pregnant, let your doctor know as soon as possible. They will tell you about the risks and benefits of using this medication in your condition. They may suggest you change to a different medication.

What are the side effects of Apixaban?

Common side effects of Apixaban are fatigue, lack of energy, dizziness, rash, nausea, and bleeding or bruising more quickly than normal. Rare but adverse side effects of taking the medication are abnormal bleeding, difficulty in breathing, severe allergic reactions, blood in the eyes, urine, and stool. It is important to note that Apixaban may cause other symptoms, too. Contact your doctor or healthcare provider to know in detail about the potential side effects of using this medicine and ways to overcome them. 

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