Pradaxa

Pradaxa, or Dabigatran, is a medicine approved by the FDA. It is a prescription medication used to treat blood clots deep in the body and lungs for adults who get injections of blood thinners for 5 to 10 days. Dabigatran, the active ingredient, comes in a group of medicines called direct thrombin inhibitors. It is especially effective for those with atrial fibrillation, as it reduces the risk of stroke and blood clots. Pradaxa comes in capsule form and is taken orally, with dosages varying based on age, weight, and specific medical conditions. Common side effects include bruising, abdominal pain, and mild bleeding. It’s important to follow your healthcare provider’s instructions carefully when taking Pradaxa, as it can increase the risk of bleeding and interact with other medications.

Pradaxa, also known as Dabigatran, is a medicine approved by the FDA that stops blood clots from forming. It is a prescription medication used primarily to prevent and treat blood clots in individuals ranging from children as young as 3 months to adults. It is particularly useful for patients with atrial fibrillation, a heart rhythm issue not related to heart valve problems, as it significantly lowers the risk of stroke and blood clot formation. The medication comes in capsule form and is available in various strengths, including 75 mg, 110 mg, and 150 mg. The recommended dosage of Pradaxa varies based on the patient’s age, weight, and specific medical conditions.

For adults with nonvalvular atrial fibrillation, the usual dosage is 75-150 mg taken two times a day. In the case of preventing blood clots after hip replacement surgery, adults typically take 110 mg shortly after surgery, followed by 220 mg once daily for 28-35 days. Children’s dosages are determined by their healthcare provider and are based on their weight. Common side effects of Pradaxa include bruising more easily, upper abdominal pain, mild bleeding, upset stomach, and heartburn. More serious side effects can occur, such as significant bleeding, blood clots after stopping treatment, and severe allergic reactions.

It’s crucial to follow the prescribed dosage and schedule and consult your healthcare provider if you experience any unusual or severe side effects. Pradaxa can interact with other medications, so it’s important to inform your healthcare provider about all medicines, supplements, and herbal products you are taking. Regular check-ups are necessary to monitor your progress and adjust the treatment plan if needed. Pradaxa is a vital medication for many patients, but it requires careful management to ensure its effectiveness and safety.

Your doctor may prescribe you Pradaxa for the following conditions and may also recommend using blood thinner Pradaxa to treat conditions not mentioned below. Use it exactly as prescribed by your doctor.

• Pradaxa helps children (3 months to less than 18 years old) with blood clots, especially if they’ve been treated with another blood thinner for at least 5 days.
• It’s also used in adults and kids to prevent blood clots from coming back after earlier treatment.
• After hip replacement surgery, Pradaxa is used to avoid deep vein thrombosis (DVT) or pulmonary embolism (PE).
• In adults with atrial fibrillation (a heart rhythm issue not caused by a heart valve problem), Pradaxa lowers the risk of stroke and blood clots.

What Are the Forms & Strengths of Pradaxa?

Pradaxa capsules can be taken orally and available in the following strengths:

• Pradaxa 75 mg capsules
• Pradaxa 110 mg capsules
• Pradaxa 150 mg capsules

What Is the Recommended Dosage of Pradaxa?

To get the most benefit from your medication, you should use it exactly as directed by your doctor. The dosage mentioned below is an average dosage schedule; however, if your doctor has prescribed you a dose different from the one listed, you should take it exactly as your doctor has prescribed, and do not make changes to your dosage schedule without consulting your doctor or medical provider.

For Capsules

Preventing Stroke and Blood Clots in Nonvalvular Atrial Fibrillation:

• Adults: Take 75-150 mg two times a day.
• Children: Follow your doctor’s instructions.

Preventing Blood Clots After Hip Replacement Surgery:

• Adults: Take 110 mg 1-4 hours after surgery, followed by 220 mg once daily for 28-35 days.
• Children: Follow your doctor’s instructions.

Treatment and Prevention of Blood Clots:

• Adults: Take 150 mg two times a day.
• For children 8 years and older, the dose depends on weight, so follow your doctor’s guidance.

Weight-based Dosage for Children:

• Over 81 kg: 260 mg two times a day.
• 61-80 kg: 220 mg two times a day.
• 41-60 kg: 185 mg two times a day.
• 26-40 kg: 150 mg two times a day.
• 16-25 kg: 110 mg two times a day.
• 11-15 kg: 75 mg two times a day.

For Pellets

Treatment and Prevention of Blood Clots:

• Children 2-12 years: Dosage based on weight; follow your doctor’s guidance.

Weight-based Dosage for Children:

• Over 41 kg: 260 mg two times a day.
• 21-40 kg: 220 mg two times a day.
• 16-20 kg: 170 mg two times a day.
• 13-15 kg: 140 mg two times a day.
• 11-12 kg: 110 mg two times a day.
• 9-11 kg: 90 mg two times a day.
• 7-9 kg: 70 mg two times a day.

Specific Dosages for Age and Weight:

• 18-24 months, 21-25 kg: 180 mg two times a day.
• 12-24 months, 16-20 kg: 140 mg two times a day.
• 11-24 months, 13-15 kg: 140 mg two times a day.
• 10-11 months, 11-13 kg: 100 mg two times a day.
• 18-24 months, 11-12 kg: 110 mg two times a day.
• 8-18 months, 9-11 kg: 100 mg two times a day.
• 11-24 months, 9-11 kg: 90 mg two times a day.
• 6-11 months, 8-11 kg: 80 mg two times a day.
• 5-6 months, 7-9 kg: 60 mg two times a day.
• 9-24 months, 7-9 kg: 70 mg two times a day.
• 4-9 months, 7-9 kg: 60 mg two times a day.
• 3-4 months, 5-7 kg: 50 mg two times a day.
• 5-24 months, 5-7 kg: 50 mg two times a day.
• 3-5 months, 3-4 kg: 40 mg two times a day.
• 3-10 months, 4-5 kg: 40 mg two times a day.
• 3-6 months, 3-4 kg: 30 mg two times a day.

[Note: Remember, these recommended doses may vary from person to person. Discuss it with your doctor or pharmacist, and they’ll customize your Pradaxa dosage accordingly.]

Before using Pradaxa 75 mg tablet, each time you get a refill, you should carefully read & follow the directions for use given in the prescription label and medication guide provided by your pharmacist and healthcare provider. If you have any questions or concerns or if you have difficulty understanding any part of the leaflet, ask your doctor or medical giver.

• Follow the prescribed dosage and schedule for Pradaxa Capsules. Take this capsule orally by mouth, usually twice daily, exactly as instructed by your healthcare provider. Do not use more or less than prescribed, in large quantities, or more frequently. 
• The medication dosage is based on your age, medical condition being treated, response to treatment, and other medications you may be taking. Tell your doctor about all the medications you are using or plan to use, including all prescription, non-prescription, and over-the-counter drugs and herbal or vitamin supplements. For pediatric patients, the medication dosage is also based on weight and age.
• Pediatric patients should take the first dose of Pradaxa in the morning and the second dose in the evening. You should keep a gap of about 12 hours between both doses.
• To prevent blood clots after knee/hip replacement surgery, you should take Pradaxa exactly as your doctor prescribes, usually once daily. Avoid taking antacids within twenty-four hours after surgery, or Pradaxa may not work as well as it should. If you experience an upset stomach while taking Dabigatran, you may take it with a meal.
• Swallow Pradaxa capsules whole with a glass of water; do not break, open, crush, chew, or empty the pellets from the capsule. Doing so may release all the medication at once, increasing the risk of unwanted side effects. 
• Take Pradaxa Capsules with or without food, as directed by your healthcare professional.
• If you miss a dose of Pradaxa Capsules, take it as soon as you remember unless it’s close to the next scheduled dose. In such cases, skip the missed dose and resume your regular dosing schedule.
• Do not alter your Pradaxa Capsules dosage without consulting your healthcare provider.
• Keep track of your Pradaxa capsule supply and refill your prescription in a timely manner to avoid interruptions in treatment.
• If you experience any unusual or severe side effects from Pradaxa Capsules, contact your healthcare provider promptly.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking with Pradaxa Capsules, as they may interact with the prescribed medication.
• Attend regular check-ups with your healthcare provider to monitor your progress on Pradaxa Capsules and adjust the treatment plan if necessary.
• Ensure you take Pradaxa Capsules with a full glass of water to facilitate proper absorption.
• To avoid running out of Pradaxa Capsules, remember to refill your prescription before running out to maintain consistent and effective treatment.
• Do not discontinue using Pradaxa capsules without consulting your doctor, as it can increase the risk of having a stroke or formation of blood clots. If you plan to discontinue using the medication, talk to your doctor, and they will help you taper off.
• Tell your doctor if your condition does not get better or if it worsens.
• Do not share your medications with other people, even if they have the same condition as you.

[Note: Your doctor will decide the suitable amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Pradaxa works by sticking to thrombin, which is a key part of how blood clots form. This helps to slow down thrombin’s ability to create clots in the blood. So, using Pradaxa helps prevent clots from forming inside the blood vessels.

What Are the Side Effects of Pradaxa?

Common side effects of Pradaxa: Similar to other medications, blood thinner Pradaxa may also cause certain side effects in people using it. Most of these side effects do not require medical attention and disappear by themselves within a few days or weeks as your body starts to adjust to the medication. If you are concerned about the unwanted side effects caused by Pradaxa, consult your doctor and discuss with them how to prevent and manage them. Common side effects of Pradaxa may include: 

• Bruising More Easily: Pradaxa 75 mg tablet reduces the body’s ability to form clots, which may make it harder for wounds to heal and cause increased bruising. To reduce the risk of increased bruising, avoid engaging in activities that could cause injury or cuts, wear gloves while using sharp objects, use electric razors, and take out retainers or dentures for a few hours daily to allow your gums to rest. 
• Upper Abdominal Pain: Pradaxa users experience gastrointestinal issues, including upper abdominal pain, dyspepsia, epigastric discomfort, and abdominal discomfort. Symptoms of upper abdominal pain include a burning feeling in the stomach.
• Mild Bleeding: It is one of the most commonly occurring side effects of Pradaxa, a blood thinner that prevents blood clotting. You should immediately contact your doctor if you experience any of the following symptoms. 
• • • Unusual fatigue
    • Frequent nosebleeds
    • Unusual pain or discomfort
    • Prolonged bleeding from cuts or gums
    • Abnormal or prolonged heavy menstrual flow
    • Vomiting blood
    • Vomit that looks like coffee grounds
• Upset Stomach: This is one of the most common side effects of this medication. To avoid stomach upset, you should take this medication with food. If it is consistent, get in touch with your doctor at once.
• Heartburn: This can occur in Pradaxa users. It may manifest itself as a pain or burning sensation in your chest. This may occur due to acid from your stomach moving into your esophagus. 

Mild side effects of Pradaxa: In some cases, this medication may also cause certain mild side effects in some users. Usually, these side effects are not serious and go away within a couple of days. However, if they persist or become bothersome, you should get in touch with your doctor and report any new or worsening side effects to your medical team immediately. This list is not exhaustive; you may experience other side effects from Padaxa. Talk to your doctor or medical giver for more details. Mild side effects of Pradaxa may include:

• Nausea: Some users of Pradaxa have reported mild side effects such as nausea. But if it becomes troublesome, you should take it with food.
• Diarrhea: If you experience an upset stomach while receiving treatment with this medication, you should take it with food. You should use this medication exactly as prescribed by your doctor and do not skip medication doses. 
• Gastroesophageal Reflux Disease (GERD): Patients who complain of onset symptoms of GERD after starting treatment with Pradaxa should be monitored on a regular basis to ensure that they are using the medication correctly. Patients with swallowing difficulties may require an alternative anticoagulant medication. 
• Esophagus Mild Bleeding: This drug makes blood clotting more difficult, so it is no surprise that one of the most common side effects is bleeding. Your risk of bleeding increases in certain situations, such as if you are above 75 years of age, have a mechanical heart, have kidney problems, or have a history of ulcers or stomach bleeds. 
• Mild Allergic Reaction: You may have a mild allergic reaction to Pradaxa or any of its excipients. Its symptoms may include hives, itching, and rashes. You should not use Pradaxa if you have ever had an allergic reaction to Dabigatran or any other ingredient present in the medication. This product also contains certain inactive ingredients that can cause allergic reactions or similar problems in some users. Ask your medical giver to provide you with the complete list of the ingredients present in the medication. 

Serious side effects of Pradaxa: Rarely, this medication can cause adverse side effects in people belonging to certain groups. It is important to mention that not everyone using Pradaxa will experience these side effects. Adverse side effects caused by this medication require prompt medical attention and can become fatal if not treated promptly. Your doctor has prescribed you this medication because they have decided that the benefits of this medication outweigh the undesirable risks associated with its use. However, if you are concerned about any of the risks associated with the use of Pradaxa 75 mg tablet, consult your doctor. Serious side effects caused by Pradaxa may include: 

• Serious Bleeding: The prescription label contains an important warning highlighting the risk of significant and, in some cases, fatal bleeding. While receiving treatment with this medication, your doctor should closely monitor you for signs and symptoms of serious bleeding. If you notice symptoms of serious bleeding, you should seek prompt medical attention, as this can be dangerous. 
• Blood Clots After Stopping Pradaxa Treatment: Pradaxa belongs to a class of drugs known as anticoagulants that help prevent the formation of blood clots. When you discontinue using it, your blood’s ability to clot returns to its normal state, which can lead to the building of clots in the blood vessel, which can further lead to severe conditions such as pulmonary embolism and deep vein thrombosis. If you plan to discontinue using this medication, your doctor may recommend that you take another blood thinner to decrease your risk of blood clotting and to taper off the medication safely. 
• Blood Clot in or near Your Spinal Column: This medication carries a boxed warning for the risk of the building of blood clots in or near your spinal column. While using this medication, there is an increased risk of hematoma after spinal procedures such as spinal taps. This risk is also increased if you receive an injection of medication, such as an epidural injection into your spinal column or spinal area, while using Pradaxa. A hematoma in your spinal column may be severe and can cause paralysis. 
• Severe Allergic Reaction: This medication may cause adverse allergic reactions in some people. These can include anaphylaxis, which requires immediate medical attention and can become fatal if not treated properly. Symptoms may include a skin rash, swelling under the skin, difficulty breathing, chest tightness, hives, dizziness, or fainting. 

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

• Pradaxa 75 mg tablet can increase your risk of bleeding more frequently and easily. Call your doctor immediately if you experience abnormal bleeding from gums, nose, vagina, blood in urine and stool.
• It can increase the risk of the formation of blood clots in and around your spinal column, especially if you underwent a spinal tap or received an epidural. This kind of blood clot may result in long-term or permanent paralysis.
• Do not stop taking Pradaxa without consulting your doctor, as it may lead to adverse, life-threatening side effects such as blood clots and stroke. You may be required to discontinue using this medication, if possible, before a medical procedure, including a dental procedure or surgery. Make sure to inform your surgeon, dentist, and medical team treating you beforehand that you are using blood thinner Pradaxa. If you need to stop taking Pradaxa, your healthcare provider will recommend you on when you should discontinue using this medication and when you can start using it again. 
• You may have an increased risk of bleeding if you:
  • Are aged 75 or more
  • Have renal issues
  • Have stomach or intestinal bleeding that is recent or recurrent, or if you have stomach ulcers.
  • Take other medicines that can increase the risk of bleeding, such as NSAIDs, blood thinners, and aspirin or aspirin-containing medicines.
  • Have renal disease and use medications such as dronedarone and ketoconazole.
• If you plan to receive spinal anesthesia or have a spinal puncture while using this medication, your doctor or healthcare provider shall monitor your symptoms closely to check for risks of spinal or epidural blood clots. Contact your physician or medical provider immediately if you have a tingling sensation, numbness, muscle weakness, loss of bowel control, urinary incontinence, or back pain.
• This medication can cause stomach upset or burning, stomach pain, or indigestion.

What Are the FDA Boxed Warning for Pradaxa?

• A boxed warning is the most severe warning given by the FDA. Pradaxa has a boxed warning for blood clots coming back if the medication is stopped abruptly and also for blood clots forming in and around your spinal column.

• You should not take Pradaxa if you are allergic to any of its ingredients.
• Do not take the medication if you have a prosthetic heart valve or active bleeding from an injury, surgery, or due to some other cause.
• Pradaxa may cause you to bleed even due to a minor injury. Call your doctor immediately if you are experiencing any of the following signs and symptoms of abnormal or severe bleeding: 
  • Unexpected or unusual bruising
  • Severe, uncontrollable bleeding or bleeding that lasts for a long time
  • Coughing up or vomiting blood
  • Pink or brown urine
  • Red, black, or tarry stools
  • Swelling or pain
  • Unexpected joint pain
  • Headaches and dizziness
  • A vomit that looks like coffee grounds
  • Weakness
• Tell your doctor about your medical history, especially if you had or currently have any of the following conditions: a genetic spinal defect;
  • a thin tube (catheter) placed in your back to give you certain medicine
  • a history of problems with your spine or a spinal surgery
  • a history of difficult or repeated spinal taps
  • bleeding problems
  • a stomach ulcer or bleeding in your stomach or intestines
  • Take certain other medicines that can increase bleeding risk.
  • Antiphospholipid syndrome is an immune system disorder that increases the risk of blood clots.
  • plan for surgery, a medical or dental procedure, or kidney disease
• Before using Pradaxa 75 mg tablet, you should tell your doctor about all medications you are taking or plan to take, including all prescription, non-prescription medicines, over-the-counter drugs, or herbal and vitamin supplements. Some medications can reduce the effectiveness of Pradaxa or cause unwanted side effects. Some medications may increase the risk of abnormal bleeding, including:
  • Aspirin or aspirin-containing medications
  • Long-term use of non-steroidal anti-inflammatory drugs
  • Warfarin
  • Heparin
  • Prasugrel
  • Clopidogrel bisulfate
  • If you have renal problems and you are taking medications such as dronedarone or ketoconazole
• It is not known if Pradaxa passes into your breastmilk and affects the nursing baby. If you are breastfeeding or plan to breastfeed while using this medication, consult your doctor. Get in touch with your medical team to discuss the risks & benefits associated with its use.
• If you think you are pregnant or planning to get pregnant, let your doctor know, as taking Pradaxa during pregnancy may cause bleeding in the mother or baby. Consult with an expert medical practitioner regarding the risk of having severe abnormal uterine bleeding if you are treated with blood thinner medications. 

This medication is contraindicated for use in patients who:

• Currently have abnormal bleeding
• Have an allergic reaction to Pradaxa or any of its excipients
• Have had or want to have a prosthetic valve replacement in the heart

• If you forget to take your medicine, take it as soon as you remember.
• But if it’s almost time for your next dose, don’t take the missed one; just continue with your regular schedule. Don’t take two doses together.
• If you have less than 6 hours before your next dose, skip the missed one and stick to your usual schedule.
• If you’ve only taken part of your oral pellet dose, wait at least 12 hours before taking the next dose. Don’t take another dose right away.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

If you take Pradaxa more than recommended, it can lead to excessive bleeding. If you think you may have overdosed on the Pradaxa medication, seek immediate medical assistance by calling 911 or heading to the nearest emergency room.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

• Store Pradaxa at room temperature (68° F to 77° F or 20° C to 25° C).
• Use Pradaxa Capsules within 4 months after opening the bottle.
• Dispose of any Pradaxa Capsules you haven’t used after 4 months.
• Keep Pradaxa Capsules in the original bottle or blister package to prevent moisture exposure.
• Do not store Pradaxa Capsules in pill boxes or organizers.
• Immediately close the bottle tightly after taking your dose.
• Ensure Pradaxa Capsules and all medicines are kept out of the reach of children.
• Check expiration dates regularly and discard expired medication.
• Avoid exposure to extreme temperatures and direct sunlight.
• Store Pradaxa away from sources of humidity.
• Do not transfer Pradaxa Capsules to other containers without consulting your healthcare provider.
• Keep out of the reach of pets and children.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Certain medications may interact with Pradaxa and reduce its effectiveness or cause unwanted side effects. Before using this medication, you should tell your doctor about all the medications you are using, including all prescription, non-prescription medicines, over-the-counter drugs, and herbal and vitamin supplements. This information helps you and your doctor identify and prevent potential drug interactions. Some of the most important drug interactions of Pradaxa may include:

• Enoxaparin
• Warfarin
• Apixaban
• Rifampin
• Clopidogrel
• Heparin
• Prasugrel
• Dronedarone
• Ibuprofen
• Dalteparin
• Naproxen
• Defibrotide
• Aspirin
• Ketoconazole
• Rivaroxaban

[Note: This isn’t a complete list, and there could be other drugs that interact with (drug name). Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Other Pradaxa Interactions?

Apart from medications, certain food items, beverages, herbs, and supplements may interact with the Pradaxa 75 mg tablet. To prevent and manage such interactions, your doctor may advise you to make certain dietary and lifestyle changes. They may also recommend you change your dosage of one or two medications or avoid using certain medications alongside Pradaxa. Pradaxa also has certain disease interactions which you should take into consideration:

• Kidney disease
• Liver disease
• Heart valve disease
• Recent surgery
• Bleeding disorders
• Stomach ulcers
• Esophageal varices
• Spinal or epidural blood clots
• Antiphospholipid syndrome
• Uncontrolled hypertension
• Stroke
• Gastrointestinal bleeding
• Intracranial hemorrhage
• Thrombocytopenia
• Hemophilia
• Von Willebrand disease
• Lupus anticoagulant syndrome
• Endocarditis

While Pradaxa is an effective anticoagulant, it may not be suitable for everyone. In such cases, people look for alternatives that are more effective and do not cause any unwanted side effects. There are many substitutes for Pradaxa available on the market, but you should consult your doctor before changing your prescription or starting a new medication. Based on the medical condition being treated, age, and other factors, they will help you determine the medication that works best for you. Some of the most popular Pradaxa alternatives include:

• Eliquis (apixaban) 
• Xarelto (rivaroxaban) 
• Plavix (clopidogrel) 
• Warfarin (warfarin sodium) 
• Coumadin (warfarin sodium) 
• Apixaban (apixaban) 
• Dabigatran (dabigatran etexilate) 
• Rivaroxaban (rivaroxaban)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Pradaxa 75 mg tablet is a prescription medication used to reduce the chance of stroke & blood clots in individuals with Atrial Fibrillation along with treat Deep Vein Thrombosis & Pulmonary Embolism. As part of the thrombin inhibitors drug class, it works by preventing the formation of harmful blood clots. For patients looking to reduce the cost of Pradaxa with Medicare, options such as using Pradaxa discount coupon or exploring savings programs from online pharmacies may be available. Some patients opt for international options, such as Polar Bear Meds, which helps you buy Pradaxa online from Canada at more affordable rates, along with a coupon code WELCOMEPB10 for additional savings on their first order.

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