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Januvia
Januvia (sitagliptin) is an FDA-approved medication for adults with type 2 diabetes. It helps manage blood sugar levels in combination with diet and exercise. Available in 25 to 100 mg tablets, the typical dose is 100 mg daily. Januvia is not for type 1 diabetes or those with a history of pancreatitis. Potential side effects include pancreatitis and allergic reactions. It should be taken as prescribed, with dosage adjustments for kidney issues. Always consult a healthcare provider for guidance on use and storage.
Product Overview
Januvia (sitagliptin) is a prescription medication approved by the FDA for managing blood sugar levels in adults with type 2 diabetes. It is typically prescribed alongside dietary modifications and exercise regimens to regulate blood sugar levels effectively. By addressing elevated blood sugar levels commonly associated with type 2 diabetes, Januvia helps reduce the risk of serious complications such as kidney damage and vision impairment.
This medication is available in tablet form, with strengths ranging from 25 to 100 mg. The recommended dosage for treating type 2 diabetes is typically 100 mg once daily, although individuals with kidney issues may require adjustments to their dosage. Januvia tablets should always be swallowed whole and taken simultaneously each day, with or without food, as directed by a healthcare provider.
While Januvia is effective for type 2 diabetes management, it is not suitable for individuals with type 1 diabetes or a history of pancreatitis. Serious side effects may include pancreatitis, allergic reactions, and severe joint pain, among others. It’s crucial to follow healthcare provider instructions closely, promptly report adverse reactions, and only adjust the dosage with medical guidance. If you have any concerns or difficulties with Januvia, consult your doctor or pharmacist for assistance.
Uses of Januvia
- Used in the treatment of managing blood sugar levels in adults diagnosed with type 2 diabetes.
How to Use Januvia?
Dosage
Strengths and Forms
It comes in a tablet form that you swallow and is available in the following strengths:
- Januvia 25 mg tablet
- Januvia 50 mg tablet
- Januvia 100 mg tablet
The recommended dosage of Januvia for treating type 2 diabetes is 100 mg once daily. Januvia 100 mg tablet is the maximum dose, so your dosage won’t be increased.
Recommended Dosage for Different Patients
Kidney Impairment: For individuals with moderate kidney impairment, it is recommended to take a daily dose of 50 mg. For those with severe kidney impairment, the recommended daily dosage is 25 mg.
Type 2 Diabetes: For individuals with Type 2 diabetes, the standard dosage of Januvia is 100 mg, taken once daily.
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
Always follow your healthcare provider’s instructions.
- Take Januvia once every day.
- You can take it with or without food.
- Try to take Januvia at the same time each day.
- Your doctor may adjust your dosage to better control your diabetes.
- You mustn’t change the dosage on your own.
- Your doctor may conduct periodic blood tests to assess your kidney function.
- Your dose may be adjusted based on the test results.
- Continue taking Januvia even when you feel well.
- Do not stop taking this medication unless directed by a doctor.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Januvia Work?
Januvia assists individuals with type 2 diabetes in managing their blood sugar levels. In type 2 diabetes, there is insufficient insulin production to regulate blood sugar levels effectively. Januvia functions by inhibiting the activity of a specific protein in the body called dipeptidyl peptidase 4 (DPP-4). This inhibition facilitates the release of another type of hormone known as GLP-1 and GLP. These hormones aid the body in producing more insulin. By increasing insulin production, Januvia helps to reduce blood sugar levels.
Important Safety Information
Side Effects
Some of the most common side effects of Januvia include:
- Diarrhea, Upset stomach
- Headaches or joint pains
- Upper respiratory infection
- Increased urination
Adverse/Serious Side Effects
- Edema (swelling), particularly in the feet, ankles, or legs
- Heart failure
- Bullous pemphigoid (a condition causing skin blisters or sores)
- Pancreatitis (inflammation of the pancreas)*
- Severe hypoglycemia (very low blood sugar level),* especially when Januvia is used with other diabetes medications
- Severe and disabling joint pain*
- Allergic reaction*
[Note: This list doesn’t cover all possible side effects, and there may be others. Contact your doctor for advice on side effects. You can also report side effects to the FDA at 1-800-FDA-1088.]
Warnings
- Do not use Januvia if you have diabetic ketoacidosis; instead, contact your doctor for insulin treatment.
- Call your doctor if you experience signs of cardiac arrest, such as shortness of breath (even while lying down), swollen legs or feet, or spiked weight gain.
- Stop taking Januvia and contact your doctor if you have symptoms of pancreatitis, such as severe pain in your upper stomach spreading to your back, with or without vomiting.
Precautions
- Before taking Januvia, inform your doctor about all your medical conditions. Januvia can cause serious side effects, including severe pancreatitis that may lead to death. Tell your doctor if you’ve had pancreatitis before starting Januvia. Stop taking Januvia and call your doctor immediately if you experience severe, persistent abdominal pain that may radiate to your back and is accompanied by vomiting, as these could be symptoms of pancreatitis.
- Don’t take Januvia if you’re allergic to it. Seek immediate medical help if you experience rash, hives, or swelling of the face, lips, tongue, or throat, which may indicate a serious allergic reaction.
- Some people may develop joint pain or a skin reaction called bullous pemphigoid while taking Januvia. Contact your doctor if you notice blisters or skin erosion.
- Taking Januvia with certain medications may increase the risk of low blood sugar. Watch for symptoms like headache, drowsiness, hunger, dizziness, sweating, weakness, and fast heartbeat.
- Your doctor will monitor your kidney function before and during Januvia treatment. Common side effects include upper respiratory tract infections, stuffy or runny nose, sore throat, and headache.
Missed Dose
If you forget to take a dose of Januvia, take it as soon as you remember. But if it’s almost time for your next dose, skip the missed one and take the next scheduled dose.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
If you suspect an overdose of Januvia, seek immediate assistance from the Poison Control Center. Supportive measures may include removing unabsorbed material from the gastrointestinal tract, conducting clinical monitoring such as electrocardiogram assessment, and providing supportive therapy tailored to the patient’s clinical condition.
[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Storage
- Store the medication in a sealed container at ambient temperature, shielded from heat, humidity, and direct illumination. Prevent freezing.
- Ensure the medication is inaccessible to children.
- Avoid retaining expired or unnecessary medication.
- Consult your healthcare provider regarding proper disposal methods for unused medication.
[Note: If you have questions about medicine overdose, storage, or disposal, it’s important to consult with a qualified medical professional.]
Januvia Interactions
Here are the interactions of Januvia that everyone should be aware of:
- Sulfonylureas
- Oral Birth Control
- Insulin
Other Health-Related Interactions
- Kidney problems
- Heart failure
- Pancreatitis
- Allergic reaction
- Pregnancy
- Breastfeeding
[Note: This is not the complete interactions list. Contact a qualified doctor or pharmacist for more information regarding the Januvia interactions.]
Januvia Alternatives
- Tradjenta (linagliptin)
- Fortamet (metformin)
- Glumetza (metformin)
- Jardiance (empagliflozin)
- Invokana (canagliflozin)
- Saxagliptin
- Nesina (alogliptin)
- Glucotrol XL (glipizide)
- Janumet (sitagliptin/metformin)
- Janumet XR (sitagliptin/metformin)
- Actos (pioglitazone)
- Amaryl (glimepiride)
- Victoza (liraglutide)
- Trulicity (dulaglutide)
- Forxiga (dapagliflozin)
- Ozempic (semaglutide)
[Note: This is not the complete list of medicine alternatives. For more information, refer to a certified medical professional.]
Frequently Asked Questions
Can Januvia be used to treat type 1 diabetes?
No, Januvia is not intended for the treatment of type 1 diabetes. It is particularly indicated for type 2 diabetes management. This limitation of use means it should not be prescribed for type 1 diabetes. For more information on Januvia’s uses, please refer to the “What is Januvia used for?” section above.
Is long-term use of Januvia necessary?
Type 2 diabetes, treated by Januvia, is a chronic condition without a cure, necessitating long-term medication. Consult your doctor to determine the duration of Januvia usage suitable for your condition. Depending on the progression of your diabetes, your doctor may adjust your dosage or suggest alternative medications.
Can I Take Januvia while Pregnant?
The safety and use of Januvia during pregnancy have not been studied extensively in humans. However, it is important to note that animal studies have not shown any harmful effects on pregnant women or their babies. However, animal research is not always a reliable indicator of a drug’s safety for humans. If you got pregnant while taking this medicine, it is crucial to inform your medical expert immediately. Your doctor may describe alternatives of Januvia as part of the treatment.
Can you stop taking Januvia suddenly?
It is important to let any doctor or pharmacist know that you are taking Januvia. If you become pregnant while taking this medication, it is important to call your doctor right away. This medication has not been observed to result in withdrawal symptoms, but discontinuing suddenly can spike your blood sugar levels again. It is important to talk to your doctor if you plan to stop taking Januvia. Your doctor can recommend alternative methods to manage your high blood sugar.
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