Myrbetriq

Myrbetriq is a prescription medication containing mirabegron, a beta-3 adrenergic agonist used to treat overactive bladder (OAB) symptoms such as frequent urination, urinary urgency, and urge urinary incontinence. It is typically prescribed when patients need medication to help improve bladder control and reduce sudden urges to urinate.

Key information about Myrbetriq is summarized below:

Myrbetriq tablets are prescribed to treat overactive bladder (OAB) in adults. This condition causes symptoms such as urinary urgency, frequent urination, and urge urinary incontinence. Doctors may prescribe this medication:

• As a single therapy for overactive bladder symptoms
• Together with solifenacin succinate for additional symptom control

In pediatric patients aged 3 years and older, Myrbetriq may be used to treat neurogenic detrusor overactivity (NDO). Tablets are generally used in patients weighing 35 kg or more, while granules may be used in lower-weight pediatric patients.

Myrbetriq (mirabegron) works by activating beta-3 adrenergic receptors in the bladder. This action relaxes the detrusor smooth muscle during the bladder’s storage phase, allowing the bladder to hold more urine and increasing bladder capacity. The mechanism of action includes:

• Acts as a beta-3 adrenergic receptor agonist
• Relaxes detrusor smooth muscle in the bladder
• Improves bladder storage capacity

Myrbetriq is available in two formulations designed for different dosing needs and patient populations.

These two formulations are not interchangeable on a milligram-per-milligram basis. The appropriate product should be selected based on the patient’s condition, age, and body weight.

Follow your healthcare provider’s instructions when taking this medication. General guidelines include:

• Take 1 tablet once daily at the same time each day
• Swallow the tablet whole with water
• Do not break the tablet, chew, or crush it
• Adults may take Myrbetriq with or without food
• Children should take Myrbetriq with food

If you miss a dose, take it as soon as you remember. If more than 12 hours have passed, skip the missed dose and take the next dose at the usual time. Do not take two doses at the same time.

The appropriate dose of Myrbetriq depends on the patient’s condition, age, and response to treatment. The typical adult starting dose is 25 mg once daily, which may be increased to 50 mg once daily after 4 to 8 weeks if needed. Doctors typically start with a lower dose and adjust it if needed.

Adult dosage for overactive bladder (OAB):

Pediatric dosage for neurogenic detrusor overactivity (NDO):

Dosage in kidney or liver impairment:

Important dosage information:

• The correct product should be selected based on patient weight and medical condition.
• Do not combine the tablet and granule forms to reach a total dose.

In clinical studies, high doses of mirabegron were associated with palpitations, increased pulse rate, and elevated blood pressure. If an overdose occurs, treatment is usually supportive and symptomatic. Healthcare providers may monitor:

• Heart rate
• Blood pressure
• ECG (heart rhythm)

Patients who may have taken too many Myrbetriq tablets should seek immediate emergency medical help or contact a poison control center.

Like all medications, Myrbetriq tablets may cause side effects in some patients. Many side effects are mild and may improve as the body adjusts to treatment. However, some reactions may require medical attention.

Common Side Effects

Commonly reported Myrbetriq side effects include:

• High blood pressure (hypertension)
• Nasopharyngitis (cold-like symptoms)
• Urinary tract infection (UTI)
• Headache
• Constipation
• Upper respiratory tract infection
• Diarrhea
• Dizziness

Rare or Serious Side Effects

Although uncommon, Myrbetriq may cause serious side effects. Patients should seek medical attention immediately if they experience:

• Angioedema, a severe allergic reaction causing swelling of the face, lips, tongue, or throat
• Urinary retention, which means difficulty emptying the bladder
• Severely increased blood pressure or worsening hypertension

This is not a complete list of side effects. Contact your healthcare provider for medical advice about adverse reactions. You may report side effects to the FDA at 1-800-FDA-1088 or visit MedWatch.

Myrbetriq may increase blood pressure in some patients. Healthcare providers may recommend periodic blood pressure monitoring during treatment, particularly in individuals with a history of hypertension. This medication is not recommended in patients with serious uncontrolled high blood pressure (systolic blood pressure of 180 mm Hg or higher and/or diastolic blood pressure of 110 mm Hg or higher).

What Are the Warnings for Myrbetriq?

Myrbetriq should be used with caution in certain patients due to potential safety risks. Important warnings include:

• Increased blood pressure during treatment
• Urinary retention, particularly in patients with bladder outlet obstruction or those taking certain medications for an overactive bladder
• Angioedema, a rare but serious allergic reaction involving swelling of the tongue, lips, throat, or face

If any of these symptoms occur, stop taking the medication and seek emergency medical care immediately.

What Are the Precautions for Myrbetriq?

Before starting this medication, inform your healthcare provider if you have:

• High blood pressure
• Kidney disease
• Liver disease
• Bladder outlet obstruction or issues with bladder emptying
• Allergies to mirabegron or any components of the medication

Pregnancy and Breastfeeding

There are no adequate studies of Myrbetriq in pregnant women to determine drug-related risks. Animal studies have shown developmental effects at very high exposure levels. It is not known whether mirabegron passes into human breast milk. Patients who are pregnant, planning to become pregnant, or breastfeeding should consult a healthcare provider before using this medication.

Myrbetriq may interact with certain medications that affect how the drugs work or increase the risk of side effects.

Patients should inform their healthcare provider about all supplements, over-the-counter drugs, and prescription medications they use before starting Myrbetriq tablets.

Several medications may be used as alternatives to treat overactive bladder (OAB). The most appropriate option depends on the patient’s condition and response to treatment.

Brand availability may vary depending on location and pharmacy supply. A healthcare provider will determine the most appropriate option based on the patient’s symptoms and treatment response.

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All Myrbetriq orders require a valid prescription. Medications are dispensed by licensed pharmacies that comply with applicable pharmacy regulations and safety standards.