Evolocumab 

Repatha

Repatha (evolocumab) is a medication primarily used to lower the risk of cardiovascular events like heart attacks and strokes and to reduce levels of low-density lipoprotein cholesterol (LDL-C) in adults and children with certain types of high cholesterol, including genetic disorders like familial hypercholesterolemia. Administered via subcutaneous injection, Repatha is available in prefilled syringes, SureClick autoinjector, and the Pushtronex on-body infusor. It works by inhibiting the PCSK9 enzyme, enhancing the liver’s ability to remove LDL-C from the blood. Common side effects include flu-like symptoms, injection site reactions, and upper respiratory infections.

Product Overview

Repatha (evolocumab) is an injectable medication designed to significantly reduce the risk of cardiovascular events such as heart attacks and strokes, as well as to decrease high levels of LDL cholesterol (often referred to as “bad cholesterol”) in both adults and children aged 10 and over. It is particularly effective for individuals diagnosed with primary hyperlipidemia, including both heterozygous and homozygous familial hypercholesterolemia—genetic conditions that affect the body’s ability to regulate cholesterol levels. Repatha is administered through subcutaneous injection and comes in several forms: prefilled syringes, SureClick autoinjector, and the Pushtronex system, a wearable on-body infusor.

Repatha’s mechanism of action involves blocking the PCSK9 enzyme. This enzyme is responsible for degrading liver receptors that remove LDL cholesterol from the blood. By inhibiting PCSK9, Repatha allows these receptors to remain active longer, thereby increasing the liver’s capacity to clear LDL cholesterol and reduce overall blood levels.

Dosage varies based on individual needs and conditions, with common regimens including 140 mg bi-weekly or 420 mg monthly. Usage requires careful handling, with specific instructions for preparation and administration depending on the delivery system chosen. While generally well-tolerated, Repatha can cause side effects such as respiratory infections, flu-like symptoms, back pain, and reactions at the injection site. Serious side effects, although rare, include allergic reactions, breathing difficulties, and severe skin reactions. It is essential for patients to discuss their complete medical history with their healthcare provider before starting treatment with Repatha to ensure its safety and effectiveness.

What Are the Uses of Repatha?

Repatha is primarily used for managing and treating several cardiovascular-related conditions:

• Lowering Cholesterol Levels
• Reducing Cardiovascular Risks
• Treatment for Genetic Cholesterol Issues

What Are the Forms & Strengths of Repatha?

• Repatha is an injectable medication that is administered under the skin (subcutaneously). It is offered in three different delivery options:
  • Pushtronex System (this device is worn on the body and automatically administers the medication from a prefilled cartridge over time)
  • SureClick Autoinjector
  • Prefilled Syringes
• Repatha comes in these following strengths:
  • 140 mg/ml
  • 420 mg/3.5 ml

What Are the Recommended Dosage of Repatha?

Dosage for Reducing LDL Cholesterol in Adults with Primary Hyperlipidemia

Adults diagnosed with primary hyperlipidemia, including those with heterozygous familial hypercholesterolemia (HeFH), have two dosing options for lowering their LDL cholesterol levels:

1. 140 mg Dosage:

• Frequency: Once every two weeks.
• Administration Methods:
  • Prefilled Syringe: Manually inject the dose using a syringe that comes already filled with the medication.
  • SureClick Autoinjector: Use this device for a simpler, more automated injection.

2. 420 mg Dosage:

• Frequency: Once every month.
• Administration Methods:
  • Pushtronex System: This wearable device automatically infuses the medication from a prefilled cartridge within five minutes.
  • Prefilled Syringe or SureClick Autoinjector: For this dosage, you’ll need to administer three consecutive injections, each within a span of 30 minutes.

Dosage Options for Reducing Cardiovascular Risks in Adults

For adults with cardiovascular disease seeking to lower their risk of heart attacks, strokes, and certain heart surgeries, Repatha offers two dosing regimens:

1. 140 mg Dosage:

• Frequency: Administered once every two weeks.
• Administration Methods:
  • Prefilled Syringe: Inject the medication manually using a syringe preloaded with the dose.
  • SureClick Autoinjector: Utilize this device for a more automated and straightforward injection process.

2. 420 mg Dosage:

• Frequency: Administered once every month.
• Administration Methods:
  • Pushtronex System: This wearable device automatically infuses the medication from a prefilled cartridge in about five minutes.
  • Prefilled Syringe or SureClick Autoinjector: This higher dosage requires three sequential injections, each completed within a 30-minute timeframe.

Reducing LDL Cholesterol in Adults with Homozygous Familial Hypercholesterolemia (HoFH)

Initial Dosage:

• Strength: 420 mg
• Frequency: Once every month
• Methods of Administration:
  • Pushtronex System: This device automatically infuses Repatha from a prefilled cartridge over approximately 5 minutes.
  • Prefilled Syringe or SureClick Autoinjector: This dosage requires three consecutive injections, each administered within a 30-minute interval.

Adjustment of Dosage:

• After 12 weeks of treatment, your doctor may reassess your cholesterol levels. If the initial monthly dosage does not sufficiently lower your LDL cholesterol, the doctor may recommend an increased frequency of dosage.
• New Frequency: 420 mg once every 2 weeks
• This adjusted dosage may also be recommended for patients undergoing lipid apheresis—a therapy that filters cholesterol from the blood.

Children’s Dosage for Lowering LDL Cholesterol with Repatha

1. Dosage for Children with Homozygous Familial Hypercholesterolemia (HoFH):

• Initial Dosage:
  • 420 mg Dosage:
    • Frequency: Once every month.
    • Administration Methods: Same as above for the 420 mg dose.
• Adjusted Dosage (if needed after 12 weeks):
  • New Dosage: 420 mg once every two weeks.
  • Reason for Adjustment: If the initial monthly dosage does not adequately lower LDL cholesterol levels or if the child is undergoing lipid apheresis (a therapy to filter cholesterol from the blood).
  • Administration Methods: Same as above for the 420 mg dose.

2. Dosage for Children with Heterozygous Familial Hypercholesterolemia (HeFH):

• 140 mg Dosage:
  • Frequency: Once every two weeks.
  • Administration Methods:
    • Prefilled Syringe: Manually inject using a syringe pre-filled with Repatha.
    • SureClick Autoinjector: Use the autoinjector for an easier and more controlled injection process.
• 420 mg Dosage:
  • Frequency: Once every month.
  • Administration Methods:
    • Pushtronex System: This device automatically administers the medication from a cartridge over approximately five minutes.
    • Prefilled Syringe or SureClick Autoinjector: This dosage involves three consecutive injections, each to be administered within a 30-minute period.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Repatha?

Repatha is administered as a subcutaneous injection, meaning it’s injected under the skin. A healthcare professional will initially guide you or a caregiver on how to properly inject the medication, and you can also find detailed instructions on the drug manufacturer’s website.

• Preparation for Injection:

• • • Remove Repatha from the refrigerator and allow it to reach room temperature before injecting. Let prefilled syringes and SureClick autoinjectors sit for 30 minutes and Pushtronex systems for 45 minutes. Avoid using any external heat sources to warm Repatha.
    • Before injecting, inspect the Repatha solution to ensure it is colorless or pale yellow. Do not use it if the solution is cloudy, discolored, or contains floating particles.

• Choosing an Injection Site:

• • You can inject Repatha into your abdomen or thigh. If someone else is administering the injection, they can also use your upper arm.
  • Always select an injection site that is free of bruising, soreness, redness, or discoloration. Avoid areas with scars or stretch marks.
  • Use a different site each time you inject to help minimize discomfort and potential skin reactions.
• Timing of Injection: Repatha doses can be injected at any time during the day that suits your schedule.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Repatha Work?

Repatha functions by targeting and blocking a specific enzyme in the body known as PCSK9. This enzyme is responsible for breaking down receptors in the liver that are crucial for removing LDL cholesterol (often referred to as “bad” cholesterol) from your bloodstream. By inhibiting the PCSK9 enzyme, Repatha allows these liver receptors to remain active longer, enabling them to remove more LDL cholesterol from your blood. This reduction in bad cholesterol levels can significantly lower your risk of developing heart disease, suffering a stroke, or experiencing a heart attack.

Important Safety Information for Using Repatha

What Are the Side Effects of Repatha?

Common Side Effects of Repatha: This medicine may cause side effects that are generally temporary, usually lasting only a few days to weeks. If these side effects persist, become bothersome, or intensify, it is important to consult your doctor or pharmacist. Some of the common side effects associated with Repatha include:

• Flu symptoms
• Pain, bruising, or redness near the injection site 
• Infection in the nose or sore throat, throat, or common cold symptoms
• High blood sugar
• Back pain

Serious Side Effects of Repatha: While serious side effects from Repatha are rare, they can occur. If you experience any serious side effects, it is crucial to contact your doctor immediately. In the event that these side effects seem life-threatening, or if you think you are having a medical emergency, call 911 or your local emergency number without delay. Some of the serious side effects that may be associated with Repatha include:

• Joint pain
• Trouble swallowing or throat tightness
• Swelling of the face, lips, mouth, tongue, or throat
• Dizziness, feeling lightheaded or fainting
• Stomach cramps
• Racing heart
• Swollen lymph nodes
• Nausea or vomiting
• Fever or general ill feeling
• Itching, skin rash, or pale red bumps on the skin called hives
• Breathing problems or wheezing

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Repatha? 

• Allergy Precautions: Be aware that the needle covers on the syringes and autoinjectors contain latex, which might cause an allergic reaction if you are sensitive to latex. Discuss any latex or rubber allergies with your healthcare provider.

What Are the Repatha Precautions?

• Prescription and Usage: Only use Repatha if it has been prescribed to you by a healthcare provider and follow the specified instructions. Repatha is an injectable medication that goes under the skin. If you or someone helping you has any questions about how to prepare or administer Repatha, contact your healthcare provider for guidance.
• Injection Site: Avoid using the same spot for each injection. Do not inject into areas where the skin is painful, thickened, bruised, red, or swollen.
• Sharing the Medication: Do not share Repatha with others, even if they have the same medical condition. It could be harmful to them.
• Health Conditions and Medications: Inform your healthcare provider about all your health conditions and any medications you take, including over-the-counter drugs, vitamins, minerals, herbal products, and supplements. This helps determine if Repatha is safe for you.
• Pregnancy: The effects of Repatha on pregnancy are not fully understood. If you are pregnant or planning to become pregnant, inform your healthcare provider. If you do become pregnant while on Repatha, you are encouraged to report your pregnancy to the manufacturer.
• Breastfeeding: It is unknown if Repatha passes into breast milk. If you are breastfeeding or planning to breastfeed, discuss with your healthcare provider whether you should use Repatha during this time.

What If You Missed a Dose of Repatha?

If you forget to take a dose of Repatha and realize it within 7 days, go ahead and take the missed dose. After that, continue with your regular dosing schedule and take the next dose at its normal time.

If more than 7 days have passed since the missed dose, what you should do next depends on your regular dosing frequency:

• If you take Repatha every 2 weeks: Skip the missed dose and simply take your next scheduled dose at the regular time.
• If you take Repatha once a month: Take the missed dose as soon as you remember. Then, adjust your monthly schedule to start from the new date you took the missed dose.

If you’re unsure about whether to take a missed dose, contact your doctor or pharmacist for guidance.

To prevent missing doses in the future, consider using a medication reminder. This could involve setting an alarm, using a timer, or downloading a reminder app on your phone.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Repatha?

It is crucial not to administer more Repatha than your doctor has prescribed. Overdosing on any medication can cause serious side effects. If you accidentally use too much Repatha, contact your doctor immediately. Alternatively, you can call America’s Poison Centers at 800-222-1222 or utilize their online tool. If you experience severe symptoms, dial 911 or your local emergency number, or head to the nearest emergency room for immediate assistance.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Repatha?

Repatha should ideally be kept in the refrigerator between 36°F and 46°F. However, if necessary, Repatha can be stored at room temperature, not exceeding 77°F, for up to 30 days as long as it remains in its original packaging. Make sure it is kept away from direct light and heat.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Repatha?

Currently, Repatha is not known to have interactions with other medications. However, as it is a relatively new drug, future interactions might be identified based on reports from users. Before you start using Repatha, it’s essential to inform your doctor and pharmacist about all the medications you are taking, including prescription drugs, over-the-counter medicines, and any supplements. This will help them identify and prevent potential drug interactions. If you have any concerns or questions about how other medications might interact with Repatha, don’t hesitate to ask your healthcare provider for advice.

What Are the Other Repatha Interactions?

Repatha may interact with various substances such as supplements, foods, vaccines, and even lab tests. Below is a detailed breakdown, though it’s important to note that this does not cover every possible interaction.

• Repatha and Supplements: While there are no specific reports of interactions with supplements, it is possible for interactions to occur. Always consult your doctor or pharmacist before taking any vitamins or herbal supplements with Repatha.
• Repatha and Herbs: No specific interactions between Repatha and herbal products have been reported. However, this does not rule out the possibility of future interactions, so it’s wise to discuss any herbal products you plan to take with your healthcare provider.
• Repatha and Vitamins: Similarly, no specific vitamin interactions have been reported, but unexpected interactions could be recognized later. Always talk to your healthcare provider before combining vitamins with Repatha.
• Repatha and Food: There are no known food interactions with Repatha. If you have dietary concerns or questions about specific foods during your treatment, it’s best to consult your doctor.
• Repatha and Vaccines: There are no known interactions between Repatha and vaccines. Discuss your vaccination schedule with your healthcare provider to ensure you are up-to-date.
• Repatha and Lab Tests: Repatha does not typically interfere with lab tests, but if you have concerns, discuss them with your doctor.
• Repatha and Alcohol: There are no known interactions between Repatha and alcohol. However, drinking alcohol might exacerbate some side effects of Repatha, such as dizziness or headaches. Discuss any concerns about alcohol consumption during your treatment with Repatha with your doctor.

[Note: This isn’t a complete list, and there could be other drugs that interact with Repatha. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Repatha Alternatives?

• Lovastatin
• Juxtapid (lomitapide)
• Vascepa (icosapent ethyl)
• Zetia (ezetimibe)
• Lescol XL (fluvastatin)
• Advicor (lovastatin)
• Pravastatin
• Welchol (colestipol)
• Lovaza (omega-3-acid esters)
• Crestor (rosuvastatin)
• Lopid (gemfibrozil)
• Leqvio (inclisiran)
• Nexletol (bempedoic acid)
• Lipitor (atorvastatin)
• Niaspan (niacin ER)
• Tricor (fenofibrate)
• Questran (cholestyramine)
• Zocor (simvastatin)
• Repatha (evolocumab)
• Praluent (alirocumab)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Repatha Cost & Coupons

The price of Repatha can be substantial, often exceeding $1,000 per month, especially if it is not covered by health insurance for conditions like high cholesterol. To alleviate the financial burden, many Americans opt to buy Repatha online from Canada, where it is available at a more affordable rate. Purchasing in the USA from Canada through vendors like Polar Bear Meds offers significant savings. Additionally, first-time customers can benefit from further reductions by using the Repatha coupon code WELCOMEPB10, which provides a 10% discount on their initial purchase. This approach makes managing health costs more feasible for many individuals.

Frequently Asked Questions

Is Repatha the same as a statin?

Repatha is not the same as a statin. It belongs to a class of medications known as PCSK9 inhibitors, which function differently from statins. While statins primarily work by reducing the production of cholesterol in the liver, Repatha targets and inhibits a specific protein, helping the liver remove more LDL cholesterol (“bad” cholesterol) from the blood. Additionally, it’s important to note that Repatha is not used to treat high triglycerides.

Are there any reviews about Repatha and its side effects from people who used the medication?

Reviews about Repatha and its side effects are available from various sources. The manufacturer of Repatha provides testimonials from individuals who have used the medication. Additionally, your doctor can share insights on how Repatha has impacted patients they have treated and discuss the outcomes observed in clinical trials. It’s crucial to consult your doctor about whether Repatha is suitable for you. They will make this decision based on your medical history and the evidence from clinical studies, which is typically more reliable than personal reviews found online. Your doctor’s guidance is essential in ensuring the treatment is safe and effective for your specific health needs.

Does Repatha cause any liver-related side effects?

Repatha is not typically associated with liver-related side effects. Clinical trials have shown that Repatha does not lead to an increase in liver enzyme levels or cause hepatitis, which is inflammation of the liver. Furthermore, there have been no reports of liver-related side effects since the medication was approved for use.

It’s important to contrast this with statins, another type of cholesterol-lowering medication, which can cause liver issues. Sometimes, doctors prescribe statins alongside Repatha. If you have concerns about liver health or questions about Repatha, it’s best to discuss them with your doctor to ensure your treatment plan is safe and appropriate for your health needs.

What are the dangers of taking Repatha?

Repatha is generally safe for most people, and serious side effects are uncommon. However, it is possible for serious side effects to occur, though they are rare. It’s important to note that certain medical conditions might increase the likelihood of experiencing side effects from Repatha. If you have any concerns about using Repatha or if you’re wondering how it might interact with your existing health conditions, it’s essential to discuss these with your doctor. Your doctor can provide personalized advice and help you weigh the benefits and risks of using this medication.

Should I expect dizziness when using Repatha?

Dizziness can occur as a side effect when using Repatha, though it is generally mild and not very common. This symptom was reported by a few individuals during clinical trials of the medication. If you experience dizziness while taking Repatha, it’s essential to consult your doctor. They can offer advice on how to manage this side effect and may consider adjusting your treatment plan, which could include discontinuing the medication if necessary. Always discuss any side effects with your healthcare provider to ensure your treatment is safe and effective.

Does Repatha cause hair loss?

No, based on clinical trial data, hair loss is not a side effect associated with Repatha. While there have been some sporadic reports of hair loss among individuals taking statin medications, extensive studies have not established a link between statins and hair loss. Sometimes, doctors may prescribe a statin along with Repatha. If you have concerns about hair loss, it’s best to discuss them with your doctor or pharmacist for personalized advice.

Are weight gain and weight loss side effects of Repatha?

No, weight gain and weight loss were not reported as side effects by people who participated in Repatha clinical trials. However, Repatha has been linked to high blood sugar in rare cases, which, if not managed, could potentially lead to weight gain over time. Additionally, Repatha can cause swelling in your intestines or stomach, which might result in symptoms like diarrhea, vomiting, and abdominal cramping. These symptoms can lead to dehydration and loss of appetite, possibly causing weight loss. If you experience any significant weight changes that concern you, consult your doctor. They can provide guidance on maintaining a healthy weight while on treatment.

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