Empagliflozin and Linagliptin
The Food and Drug Administration (FDA) has approved Glyxambi for managing blood sugar in patients with type 2 diabetes combined with a proper diet and exercise routine. This medicine contains two different drugs – empagliflozin and linagliptin. Glyxambi tablets come in two different strengths: 10 mg and 25 mg empagliflozin with 5 mg linagliptin for both. Empagliflozin is in a group of medicines called sodium-glucose cotransporter 2 inhibitors, while linagliptin is a dipeptidyl peptidase-4 inhibitor. Right now, there isn’t a generic version of Glyxambi available. So, if you want to buy Glyxambi online from a Canadian Pharmacy, get the prescription from your doctor first.
This medicine is a combination of two drugs, empagliflozin and linagliptin. This FDA-approved medication is used, along with a healthy diet and exercise, to manage high blood sugar in people with type 2 diabetes. By controlling high blood sugar, it helps prevent kidney damage, vision problems, nerve issues, limb loss, and sexual function issues.
Glyxambi tablets have two strengths: one with 10 mg of empagliflozin and 5 mg of linagliptin and another with 25 mg of empagliflozin and 5 mg of linagliptin. Dosage varies based on age, health conditions, and other medications. It comes in two strengths, and your doctor determines the recommended dosage.
To use Glyxambi, take it orally once a day, with or without food. However, you can consult your doctor if you experience severe side effects. Glyxambi comes with important warnings that include monitoring for pancreatitis, heart failure, ketoacidosis, and kidney function. It’s essential to discuss any allergies or skin reactions with your doctor before starting Glyxambi.
Additionally, if you miss a dose, take it as soon as you remember unless it’s close to the next dose. Don’t double up to compensate for a missed dose. You can also store it in a cool, dry place, away from moisture, and out of reach of children and pets. Glyxambi may interact with certain drugs and alcohol, so it’s crucial to inform your doctor of all medications and alcohol consumption. Alternatives to Glyxambi are available, but you must consult your doctor before making any changes.
Uses of Glyxambi Tablets
- To control blood sugar levels in patients with type 2 diabetes.
- To reduce the risk of heart attack and death.
- Prevent you from vision problems, limb loss, nerve & sexual function issues.
How to Use Glyxambi Tablets?
Glyxambi (empagliflozin & linagliptin) comes as oral tablets. It is available in two different strengths:
- 10 milligrams empagliflozin with 5 mg linagliptin
- 25 mg empagliflozin with 5 mg linagliptin
Your doctor will decide how much Glyxambi you need based on the following:
- The kind of health issue that Glyxambi is treating.
- Your age.
- Any other health conditions you have.
- The other medications you are taking.
Recommended Dosage for All Age Groups
Age More Than 60 Years
- Empagliflozin- 10 mg to 25 mg
- Linagliptin- 5 mg
Age Between 45 to 60 Years
- Empagliflozin- 10 mg
- Linagliptin- 5 mg
Age Between 30 to 45 Years
- Empagliflozin- 10 mg
- Linagliptin- 5 mg
Less Than 30 Years
- Not recommended
[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- Your pharmacist gives you a guide. Read it before you start the medicine and each time you get more. If you have questions, ask your doctor or pharmacist.
- Take it by mouth, with or without food, usually once a day in the morning.
- The amount you take depends on your health and how you respond to the medication.
- Take the medicine regularly to get the best results. Remember to take it at the same time every day.
- Don’t crush or chew it with your teeth.
- If your condition doesn’t improve or worsen, let your doctor know. For example, tell your doctor if your blood sugar is too high or too low.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Glyxambi Work?
Glyxambi is a medicine that combines two drugs. One of the drugs, empagliflozin, helps your kidneys prevent sugar from being reabsorbed into your body, lowering blood sugar by getting rid of extra sugar through urine. The other drug, linagliptin, works by blocking a protein called DPP-4 (Dipeptidyl Peptidase 4). This usually breaks down hormones that tell your body to make more insulin and produce less sugar. By blocking DPP-4, linagliptin helps your body produce more insulin and less sugar, lowering your blood sugar levels.
Important Safety Information
Glyxambi Side Effects
Common side effects of Glyxambi include:
- Yellow eyes or skin
- Dry mouth
- Unexplained weight loss
- Chest pain or tightness
- Trouble breathing
- Cold sweats
Less common side effects of Glyxambi include:
- Body aches or pain
- Ear congestion
- Difficulty with breathing
- Loss of voice
- Runny or stuffy nose
- Sore throat
Serious side effects of Glyxambi include:
- Severe joint pain
- Allergic reaction
- Burning sensation while urinating
- Increased frequency of urination
- Blood in urine
- Pelvic pain
- Swelling in ankles, feet, or legs
[Note: If you experience severe side effects, immediately contact your doctor. In cases where the side effects appear life-threatening, or you believe you are facing a medical emergency, call 911 or your local emergency services without delay.]
Pancreatitis: Postmarketing reports of acute pancreatitis, including fatal cases, have been observed. This is a serious condition, and if suspected, prompt discontinuation of Glyxambi and appropriate management is advised.
Heart Failure: An association between DPP-4 inhibitor treatment and heart failure has been observed. Patients at risk for heart failure should be carefully evaluated, monitored during therapy, and advised to report symptoms immediately. Management according to current standards of care should be considered, and discontinuation of Glyxambi may be necessary.
Ketoacidosis: It is crucial to consult your doctor for treatment if you are experiencing diabetic ketoacidosis. Glyxambi should not be used in such cases, and prompt medical attention is necessary for managing this condition effectively. Glyxambi is associated with reports of ketoacidosis, a serious and life-threatening condition. Factors predisposing to ketoacidosis should be considered before initiating treatment, and monitoring for ketoacidosis is recommended.
Acute Kidney Injury and Impairment in Renal Function: Glyxambi is not suitable for individuals with severe kidney disease or those undergoing dialysis. It is essential to discuss your kidney health with your doctor before considering this medication. Consideration of factors predisposing to acute kidney injury is necessary before starting Glyxambi. Monitoring renal function periodically is recommended, with more frequent monitoring for patients with an eGFR below 60 mL/min/1.73 m2. The use of Glyxambi is not recommended in certain cases.
Necrotizing Fasciitis of the Perineum: Reports of necrotizing fasciitis have been identified, and patients presenting with certain symptoms should be assessed for this condition. Immediate discontinuation of Glyxambi is recommended if suspected.
Previous Reactions: If you have a history of severe allergic or skin reactions to empagliflozin or linagliptin, Glyxambi may not be the right choice for you. Your past experiences with these substances are significant factors in determining your suitability for this medication. Allergic reactions can be serious, and avoiding the medication is crucial if you are sensitive to any of its components.
Lifestyle Factors: Discuss with your doctor if you consume large amounts of alcohol or if you have experienced genital infections (penis or vagina). Additionally, disclose if you are 65 years or older, follow a low-salt diet, have high cholesterol or triglycerides, or if you have any planned surgeries. These factors can influence the suitability and effectiveness of Glyxambi for your specific health condition.
If you forget to take Glyxambi, take it as soon as you remember, unless it’s the next day. In that case, skip the missed dose and take your next dose as usual. Don’t take two doses at once, as it may increase the chance of side effects like low blood sugar. To avoid missing doses, use a reminder like setting an alarm, using a timer, or using a reminder app on your phone.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Only take the prescribed amount of Glyxambi as advised by your doctor. If you believe you have exceeded the recommended dose, promptly reach out to your healthcare provider or the nearest hospital emergency department or contact your regional Poison Control Centre, even in the absence of symptoms.
[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Store Glyxambi tablets in a cool place (68°F to 77°F / 20°C to 25°C) and make sure to keep them in a tightly closed container. Don’t keep them in places like bathrooms where they might get damp or wet. Keep it away from the children and pets while storing.
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Interactions with Certain Drugs
Diuretics (Water Pills): If you take water pills (diuretics) along with Glyxambi, it can raise your chances of experiencing Glyxambi’s side effects. These side effects may involve low blood pressure and dehydration. Some examples of diuretics are:
- Furosemide (Lasix)
- Spironolactone (Aldactone, Carospir)
- Hydrochlorothiazide (Microzide)
Sulfonylureas (Diabetes Medications): If you take sulfonylureas along with Glyxambi, it could increase the chance of having low blood sugar as a side effect. Examples of sulfonylureas include:
- Glyburide (Diabeta, Glynase)
- Glimepiride (Amaryl)
- Glipizide (Glucotrol)
Insulins: If you use insulin medications along with Glyxambi, it might increase the likelihood of having low blood sugar as a side effect. Examples of insulins include:
- Insulin Aspart (Novolog)
- Premixed Insulins (Humalog 50/50 and Novolin 70/30)
- Insulin Degludec (Tresiba)
Interactions with Herbs & Supplements
No herbs or supplements have been specifically reported to interact with Glyxambi. Still, it’s important to consult your doctor or pharmacist before using any of these products while taking Glyxambi.
Glyxambi & Foods
No specific foods are known to interact with Glyxambi. If you’re unsure about what foods are okay to eat with Glyxambi, just ask your doctor.
Glyxambi & Alcohol
Drinking a lot of alcohol, especially regularly, can increase the chances of experiencing side effects from Glyxambi. In particular, consuming large amounts of alcohol may heighten the risk of ketoacidosis, a rare but potentially life-threatening side effect of Glyxambi that results in a high level of acid in your blood. This risk is higher if you frequently consume alcohol.
Moreover, it’s crucial to be aware that alcohol can lower your blood sugar, and Glyxambi also has a similar effect. Combining alcohol with the medication may increase the risk of dangerously low blood sugar levels, which, in rare cases, can be life-threatening. If you drink alcohol, discuss with your doctor the amount that is safe for you while taking Glyxambi.
[Note: This isn’t a complete list, and there could be other drugs that interact with Glyxambi. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
- Xigduo XR (dapagliflozin & extended-release metformin)
- Jardiance (empagliflozin)
- Invokamet (canagliflozin and metformin)
- Jentadueto (linagliptin and metformin)
- Janumet (sitagliptin phosphate and metformin hydrochloride)
- Victoza (liraglutide )
- Repaglinide (meglitinides)
- Oseni (alogliptin and pioglitazone)
- Rybelsus (semaglutide)
- Qtern (dapagliflozin and saxagliptin)
- Ozempic (semaglutide)
- Trulicity (dulaglutide)
- Januvia (sitagliptin)
- Nesina (alogliptin)
- Byetta (exenatide)
- Farxiga (dapagliflozin)
- Nateglinide (meglitinides)
- Onglyza (saxagliptin )
- Steglatro (ertugliflozin)
- Steglujan (ertugliflozin and sitagliptin)
- Tradjenta (linagliptin)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
Frequently Asked Questions
Is Glyxambi safe for pregnancy?
If you’re pregnant or planning to be, follow your doctor’s advice on using Glyxambi. It’s crucial to manage diabetes well during pregnancy. Avoid using Glyxambi in the second or third trimester, and refrain from breastfeeding while using it.
When should I stop taking Glyxambi?
If you notice any signs of an allergic reaction, like a rash, peeling skin, hives, or swelling of the skin, face, lips, tongue, or throat that makes it hard to breathe or swallow, stop taking Glyxambi and get medical help right away.
Does Glyxambi make you lose weight?
Glyxambi’s clinical trials didn’t show weight loss as a side effect. But, Glyxambi can have some side effects like dehydration and ketoacidosis, which might cause temporary weight loss. Contact your healthcare professional for more information.
Is Glyxambi good for the heart?
Glyxambi helps lower blood sugar in adults with type 2 diabetes when used with a healthy diet and exercise. It can also be used in adults with type 2 diabetes who have heart problems, especially when empagliflozin (a medicine in Glyxambi) is necessary to lower the risk of heart-related death.
What is the mode of action of empagliflozin and linagliptin?
Empagliflozin helps eliminate sugar through urine by stopping the kidneys from reabsorbing blood sugar. On the other hand, linagliptin lowers sugar levels by making the pancreas produce more insulin and reducing the amount of glucagon in the bloodstream.
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