Clarithromycin

Clarithromycin, approved by the FDA, treats a broad range of bacterial infections. This drug is also combined with other medications to treat certain types of stomach ulcers and may be used to prevent some bacterial infections. Clarithromycin belongs to the class of drugs known as macrolide antibiotics. It is available in several forms and strengths: oral suspension (125mg and 250mg per 5mL), tablets (250mg and 500mg), and extended-release tablets (500mg). Clarithromycin works by stopping the growth of bacteria. This antibiotic is effective only against bacterial infections, not viral infections like the common cold or flu. So, if you want to buy Clarithromycin online for bacterial infection treatment, you must get a valid prescription from your doctor.

Clarithromycin is a widely recognized macrolide antibiotic approved by the FDA for treating numerous bacterial infections. It is often prescribed not only as a standalone treatment but also in combination with other medications to address specific stomach ulcers. The antibiotic comes in several formulations, including oral suspensions (125mg and 250mg per 5mL concentrations), tablets (250mg and 500mg strengths), and a 500mg extended-release tablet option. The mechanism behind Clarithromycin involves inhibiting the growth of bacteria. It is crucial as it ensures the medication is effective exclusively against bacterial infections, not illnesses caused by viruses such as the common cold or influenza.

It is also effective against uncomplicated skin and structure infections like wounds, abscesses, and burns. Additionally, Clarithromycin plays a vital role in treating and preventing infections caused by mycobacteria. One of its significant uses is in treating Helicobacter pylori infections, often associated with duodenal ulcers. The dosages vary depending on the specific infection being treated but typically range from 250mg to 500mg taken every 12 hours or 1000mg daily for the extended-release form, always under a healthcare provider’s guidance.

When taking Clarithromycin, it is important to adhere strictly to the prescribed dosage and duration of treatment to prevent the development of drug-resistant bacteria. The tablets should be consumed with food to enhance absorption and reduce stomach upset. In contrast, the extended-release tablets must be swallowed whole, not crushed or chewed, to maintain the integrity of the medication release mechanism. Common side effects include nausea, diarrhea, and headaches, which are usually manageable. However, more severe reactions, such as significant allergic responses or cardiac issues, require immediate medical attention.

The Food and Drug Administration (FDA) has approved the use of Clarithromycin immediate-release oral tablets for treating various conditions in adults, including:

• Sinusitis
• Acute exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Uncomplicated infections of the skin and skin structure, such as abscesses, wounds, ulcers, or burns
• Infections caused by mycobacteria
• Acute otitis media, a type of ear infection
• Helicobacter pylori (H. pylori) infection and duodenal ulcer disease
• Pharyngitis or tonsillitis, which are infections of the mouth

What Strengths & Forms Does Clarithromycin Come In?

Clarithromycin comes in the following forms & strengths:

• Oral Suspension
  • 125mg per 5mL
  • 250mg per 5mL
• Tablets
  • 250 mg
  • 500 mg
• Tablets ER (extended-release)
  • 500 mg

What Is the Recommended Clarithromycin Dosage?

The dosage of this medication varies for each patient, depending on their specific needs. Always follow the instructions given by your doctor or those listed on the medication label. The following information provides average dosage guidelines, but if your prescribed dose differs, do not alter it without consulting your doctor.

For Clarithromycin ER Tablets, dosage guidelines are:

For Bacterial Infections

• Adults: A Clarithromycin dose for adults is 1000 milligrams (mg) taken once daily for 7 to 14 days.
• Children: The dosage for children should be determined by a doctor.

For Community-Acquired Pneumonia

• Adults: A typical dosage is 1000 milligrams (mg) taken once daily for 7 days.
• Children: The dosage for children must be determined by a doctor.

For oral suspension or regular tablets, the dosage guidelines are:

For Bacterial Infections

• Adults: The usual dosage is between 250 to 500 milligrams (mg) every 12 hours for 7 to 14 days.
• Children (6 months and older): The dosage is typically calculated based on the child’s body weight and determined by the doctor. Usually, it is 7.5 milligrams (mg) per kilogram (kg) of body weight every 12 hours for 10 days.
• Infants (under 6 months): The dosage for infants must be determined by a doctor.

For Community-Acquired Pneumonia

• Adults: The typical dosage is 250 milligrams (mg) every 12 hours for 7 to 14 days.
• Children (6 months and older): The doctor will determine the dosage based on the child’s weight.
• Infants (under 6 months): The dosage for infants must be determined by a doctor.

For Prevention or Treatment of Mycobacterium Avium Complex (Mac) Infection

• Adults: The usual dosage is 500 milligrams (mg) twice daily.
• Children (20 months and older): The dosage is based on the child’s weight, typically 7.5 milligrams (mg) per kilogram (kg) of body weight, with a maximum of 500 mg twice daily.
• Children (under 20 months): A doctor must determine the dosage.

For Treatment of Ulcers Associated with Helicobacter Pylori (H. Pylori) Infection

• Adults: A typical dosage is 500 milligrams (mg) every 8 hours for 14 days when combined with omeprazole, or 500 milligrams (mg) every 12 hours when combined with amoxicillin and lansoprazole for 10 to 14 days, or 500 milligrams (mg) every 12 hours in combination with amoxicillin and omeprazole for 10 days.
• Children: The dosage for children should be determined by a doctor.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

Only use this medication as prescribed by your healthcare provider. Avoid exceeding the recommended dosage, frequency, or duration of treatment as set by your doctor. You can take this medicine alongside meals, with milk, or on an empty stomach to suit your comfort.

• For Extended-Release Tablets
  • Swallow the extended-release tablet whole without breaking, crushing, or chewing it. Altering the tablet can affect the release and absorption of the medication into your system.
  • If you are taking Clarithromycin extended-release tablets, consuming them with food is important to ensure proper absorption.
  • It’s common to see parts of the extended-release tablet in your stools. This occurs because the body absorbs the medication and expels the indigestible components. This should not be a cause for concern.
• For Oral Liquid
  • Use a specially marked measuring spoon, syringe, or cup to ensure you administer the correct dose of the oral liquid. Household teaspoons vary in size and might not provide an accurate dose.
  • Always shake the bottle well before each use to evenly mix the medication.
  • If you are prescribed both Clarithromycin and zidovudine, take these medications at least two hours apart to avoid interference with their absorption and effectiveness.
  • Continue taking the medication for the entire prescribed period. Some people might feel better after just a few doses, but stopping early can lead to a resurgence of the infection as it may not be fully cleared.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Clarithromycin is classified as an antibiotic, specifically targeting and halting the growth of bacteria. It functions by obstructing the production of crucial proteins that bacteria need for performing essential life-sustaining tasks. Without these proteins, the bacteria cannot grow or replicate. This action effectively halts the spread of the bacterial infection, as it prevents the bacteria from continuing to proliferate and carry out the processes necessary for their survival and multiplication in the host body.

Common Side Effects of Clarithromycin: Common Clarithromycin side effects occur in more than 1 in 100 people. Understanding these side effects can help you manage them if prescribed this medication. Here are some of the most common side effects:

• Feeling Nauseous (Nausea): It’s not uncommon to feel nauseous while taking Clarithromycin. This sensation can generally be managed by taking the medication with food rather than on an empty stomach. Staying hydrated and eating light, bland meals can also help alleviate this discomfort.
• Vomiting: Some individuals may experience vomiting as a side effect of Clarithromycin. To help prevent this, eat small, frequent meals and avoid eating rich or fatty foods which can aggravate your stomach. If vomiting persists, it is important to stay hydrated by sipping water or an electrolyte-rich drink slowly.
• Diarrhea: Diarrhea is another possible side effect of taking Clarithromycin. Ensuring a good intake of fluids to prevent dehydration is crucial. Consider eating foods that can help firm up your stools, like bananas, rice, applesauce, and toast. If diarrhea is severe or continues for an extended period, consult your healthcare provider.
• Bloating and Indigestion: If you experience bloating or indigestion while on Clarithromycin, it may help to eat smaller, more frequent meals and avoid spicy and fatty foods. Over-the-counter antacids might relieve discomfort, but it’s a good idea to consult your doctor before taking additional medications.
• Headaches: Headaches can occur when taking Clarithromycin. Regular hydration and adequate rest can help, as well as over-the-counter pain relief medications, such as acetaminophen or ibuprofen, used according to the package directions or your doctor’s advice.
• Difficulty Sleeping (Insomnia): Insomnia may be a side effect of Clarithromycin. To combat this, try establishing a regular bedtime routine, avoiding caffeine in the late afternoon and evening, and creating a comfortable sleep environment that’s cool, dark, and quiet. If sleep issues persist, discuss them with your doctor, who may recommend additional strategies or alternative treatments.

Serious Side Effects of Clarithromycin: When you buy Clarithromycin online for bacterial infection treatment, you may experience the following serious side effects:

• Allergic Reactions: Some individuals may experience severe allergic reactions when taking Clarithromycin for bacterial infections. Symptoms can include skin rash, itching, or hives. More severe reactions involve swelling of the face, lips, or tongue, which could indicate a potentially life-threatening condition requiring immediate medical attention.
• Heart Issues: Clarithromycin can occasionally cause cardiac problems, such as an irregular heartbeat or chest pain. These symptoms are serious and could signal underlying heart issues exacerbated by the medication, warranting urgent medical consultation.
• Urinary Difficulties: Users of Clarithromycin may experience pain or difficulty when passing urine. This side effect can indicate a urinary tract issue or severe dehydration, which should be assessed by a healthcare provider.
• Skin and Lymph Node Reactions: This medication can lead to a severe condition marked by a rash accompanied by fever and swollen lymph nodes. This trio of symptoms could suggest a severe immune response known as a hypersensitivity syndrome and requires immediate medical evaluation.
• Dermatological Reactions: Some patients may develop serious skin reactions while on Clarithromycin, characterized by redness, blistering, peeling, or loosening of the skin, including inside the mouth. These symptoms can be signs of severe skin disorders like Stevens-Johnson syndrome or toxic epidermal necrolysis, both of which require emergency medical care.
• Liver Issues: One of the serious side effects of Clarithromycin includes the yellowing of the eyes or skin, which is indicative of liver problems such as jaundice. This condition can result from liver damage or dysfunction, potentially linked to the drug, and should be quickly addressed by a healthcare professional.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

When you buy Clarithromycin online for bacterial infection treatment, consider the following warnings associated with this medication:

• For People with Coronary Artery Disease: For individuals diagnosed with coronary artery disease, taking this medication could significantly increase the risk of death. This increased risk can persist for one to ten years after initiating treatment with the drug. The exact cause of this increased risk has not been determined.
• For People with Kidney Problems: This drug is processed and eliminated through the kidneys. If you have compromised kidney function, there is a risk that the drug could accumulate in your body, potentially intensifying side effects. This is especially critical for patients with severe kidney dysfunction, who may not be able to process the drug efficiently.
• For People with Clostridioides Difficile-Associated Diarrhea: Clarithromycin, like most antibacterial drugs, can cause Clostridioides difficile-associated diarrhea (CDAD), previously known as pseudomembranous colitis. This can range from mild diarrhea to life-threatening colitis. Antibacterial treatment disrupts the normal gut flora, potentially leading to an overgrowth of C. difficile. This bacterium produces toxins that can cause CDAD, and certain strains may be particularly harmful and resistant to treatment, possibly necessitating surgical intervention (colectomy). Symptoms might develop up to two months post-antibiotic treatment, necessitating a detailed medical history review. Patients with a history of gastrointestinal diseases, particularly colitis, are at increased risk of severe symptoms. In suspected or confirmed cases, stopping non-C. difficile-targeted antibiotics and initiating appropriate treatments, including fluid management, protein supplementation, specific antibacterial therapy, and possibly surgical evaluation, is crucial.
• For People with Hepatotoxicity: Clarithromycin has been linked to various forms of liver dysfunction, including increased liver enzymes & hepatocellular or cholestatic hepatitis, which may present with or without jaundice. While these conditions are generally reversible, they have been fatal in some cases, particularly among patients with severe underlying conditions or concurrent medications. It is crucial to monitor liver function closely in patients taking Clarithromycin, especially those with pre-existing liver disease. The medication should be discontinued immediately if symptoms of hepatitis such as anorexia, dark urine, jaundice, pruritus, or abdominal tenderness appear. Clarithromycin is contraindicated in patients with a history of cholestatic jaundice or hepatic dysfunction linked to previous use of the drug.
• For People with Myasthenia Gravis: The use of macrolide antibiotics, including Clarithromycin, has been associated with exacerbation of myasthenia gravis symptoms and new onset of myasthenic syndrome. Care should be taken when prescribing these antibiotics to patients with a history of myasthenia gravis, and symptoms should be closely monitored.
• For People with Renal Dysfunction: Clarithromycin is eliminated primarily through the kidneys and liver. In patients with severe renal impairment (creatinine clearance < 30 mL/min), dosage adjustments or extended dosing intervals are recommended to prevent drug accumulation, especially if there is concurrent liver disease. Patients with mild to moderate renal impairment generally do not require adjustments but should be monitored for potential drug accumulation.
• For People with QT Prolongation: Clarithromycin, along with other macrolides, may cause QT interval prolongation, leading to rare cases of arrhythmia. It is advised to avoid the use of Clarithromycin in patients with known QT prolongation, ventricular cardiac arrhythmia (including torsades de pointes), and other proarrhythmic conditions such as uncorrected hypokalemia, hypomagnesemia, significant bradycardia, or concurrent use of other drugs that prolong the QT interval.

Clarithromycin comes with specific safety measures to consider before use. Here are the main precautions:

• Allergy: Do not take Clarithromycin if you are allergic to it or to other macrolides such as erythromycin or azithromycin. Allergic reactions can be severe and potentially life-threatening.
• Breastfeeding: Clarithromycin can pass into breast milk and may affect a breastfed child. Discuss with your doctor whether you should continue breastfeeding or stop taking the medication.
• Use in Children: Clarithromycin is not safe or effective for children under 20 months old for treating mycobacterium avian complex (based on the use of Clarithromycin suspension). It has not been studied for other infections in children under 6 months old and should not be used in this age group.

If you realize that you’ve missed a dose and it hasn’t been too long since it was due, take it as soon as you remember. For example, if you usually take your medication at 8 AM and remember by 10 AM, you should take the missed dose immediately. If substantial time has passed—meaning it’s close to the time for your next dose—skip the missed dose altogether. For instance, if your next dose is due at 8 PM and it’s already 6 PM or later when you remember, it’s safer to wait and only take the next scheduled dose.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

If you accidentally take more than the recommended dose of Clarithromycin, you may experience significant adverse effects that require immediate medical intervention. The symptoms of an overdose typically include intense stomach pain, which can feel sharp or persistent, along with nausea that may lead to vomiting. Diarrhea is also a common symptom, which can further dehydrate the body and worsen the condition. In such situations, it’s critical to seek urgent medical help to manage these symptoms effectively.

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

When you buy Clarithromycin online from Canada, follow these essential storage guidelines to maintain its effectiveness:

• Always store Clarithromycin in a place inaccessible to children. High shelves or locked cabinets are ideal to prevent accidental ingestion by little ones.
• Do not keep Clarithromycin that has passed its expiration date. Expired medications can be ineffective or potentially harmful.
• For any unused Clarithromycin, do not just throw it away. Check with your healthcare provider for appropriate disposal methods that are safe for the environment and meet local regulations.
• Keep Clarithromycin in a closed container at room temperature in a dry area away from heat, moisture, and direct light. Ensure that it does not freeze.
• Do not refrigerate or freeze the oral liquid form of Clarithromycin. Any mixed medicine not used within 14 days should be discarded as it may no longer be effective.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

When Clarithromycin is used in combination with certain medications, it can lead to serious and potentially dangerous interactions. Here is a detailed explanation of the interactions and risks associated with combining Clarithromycin with specific drugs:

• Colchicine: This drug is commonly used in the treatment of gout. If you have kidney or liver problems, it is advised not to take colchicine (Colcrys) alongside Clarithromycin. In patients with these conditions, colchicine levels can become elevated, increasing the risk of toxicity. When combined with Clarithromycin, the risk of colchicine’s side effects, such as severe muscle pain and weakness, significantly increases due to higher drug concentrations in the body.
• Sildenafil, Tadalafil, and Vardenafil: These medications, known respectively as Viagra, Cialis, and Levitra, are used to treat erectile dysfunction. When taken with Clarithromycin, the levels of these drugs may increase in the body. This buildup can enhance their effects and side effects, such as headaches, flushing, and in severe cases, can lead to significant drops in blood pressure.
• Ergotamine and Dihydroergotamine: Ergotamine (Ergomar) and dihydroergotamine (Migranal) are drugs used to treat migraines. Taking these medications with Clarithromycin can cause a sudden narrowing of blood vessels, known as vasospasm. This condition can severely reduce blood flow to the arms, legs, and other parts of the body, leading to pain and potentially serious vascular problems.
• Pimozide: This medication is used primarily to treat psychiatric conditions such as Tourette’s syndrome. Combining pimozide with Clarithromycin is particularly risky as it can lead to serious, life-threatening heart arrhythmias. This interaction affects the electrical activity of the heart and can lead to irregular heart rhythms, posing a significant health risk.
• Certain HIV Drugs: When Clarithromycin is taken in combination with certain HIV medications, it can lead to significant drug interactions. Medications like atazanavir (Reyataz), nelfinavir (Viracept), lopinavir, and ritonavir (Norvir) can either accumulate in the body or increase the levels of Clarithromycin. This heightened concentration can enhance the likelihood of experiencing adverse effects and may compromise the therapeutic efficacy of both the antibiotic and the HIV drugs.
• Antifungal Drugs: The co-administration of Clarithromycin with antifungal medications, such as ketoconazole, itraconazole (Sporanox), and voriconazole (Vfend), can also lead to increased drug levels in the body. Similar to the interaction with HIV drugs, this build-up can potentially elevate the risk of side effects and reduce the effectiveness of either the antifungal agents or Clarithromycin.
• Lurasidone: The interaction between lurasidone (Latuda) and Clarithromycin is particularly concerning. When taken together, lurasidone can accumulate in the body, potentially leading to severe side effects. This accumulation necessitates careful monitoring and possible adjustment of the lurasidone dosage to manage the risk of adverse reactions effectively.
• Benzodiazepines: Using benzodiazepines such as triazolam (Halcion) and midazolam in conjunction with Clarithromycin may enhance the sedative effects of these drugs. This can result in increased drowsiness and sedation, which might affect your ability to perform tasks that require alertness, such as driving or operating machinery.
• Insulin and Certain Oral Diabetes Drugs: The interaction between Clarithromycin and diabetes medications, particularly insulin and oral drugs like pioglitazone (Actos), nateglinide, and repaglinide, can lead to a significant drop in blood sugar levels. This interaction requires close monitoring of blood sugar levels and may necessitate adjustments in the dosing of the diabetes medications to prevent hypoglycemia.
• Warfarin: When Warfarin (Jantoven), a medication used for blood clot prevention, is taken together with Clarithromycin, there is an increased risk of bleeding. This combination can enhance the effects of Warfarin, potentially leading to serious bleeding events. Due to this risk, healthcare providers closely monitor patients taking both medications, adjusting the Warfarin dosage as needed to maintain safe blood clotting times.
• Certain Statins: Clarithromycin can interact with specific statins such as Atorvastatin (Lipitor) and Pravastatin, drugs commonly prescribed to manage cholesterol levels. This interaction may increase the risk of muscle-related side effects, including pain, weakness, or a severe condition known as rhabdomyolysis. Doctors might adjust the statin dosage or select a different cholesterol-lowering medication to avoid these complications while you are being treated with Clarithromycin.
• Quinidine and Disopyramide: The combination of Clarithromycin with Quinidine or Disopyramide (Norpace) can lead to serious cardiac issues, specifically abnormal heart rhythms. This dangerous side effect necessitates careful monitoring of heart function and blood levels of Quinidine and Disopyramide during the course of treatment with Clarithromycin to ensure heart rhythm remains within a safe range.
• Calcium Channel Blockers: When used with Clarithromycin, calcium channel blockers such as Verapamil (Verelan), Diltiazem (Cardizem), Amlodipine (Norvasc), and Nifedipine (Procardia XL)—all of which are medications to control high blood pressure—may cause a significant drop in blood pressure and lead to kidney issues. Monitoring of blood pressure and renal function is recommended for patients needing both treatments to manage interactions and prevent complications.
• Theophylline: Clarithromycin can affect how the body processes Theophylline, a drug used to treat respiratory diseases such as asthma and COPD. Due to this interaction, doctors often monitor blood levels of Theophylline when it is prescribed concurrently with Clarithromycin to ensure therapeutic levels are maintained without reaching toxicity.
• Carbamazepine: Taking Carbamazepine (Equetro), a medication used for controlling seizures and certain types of nerve pain, along with Clarithromycin, may alter Carbamazepine blood levels. Regular monitoring by healthcare providers is essential to adjust the dose of Carbamazepine appropriately and avoid potential side effects such as dizziness, double vision, or nausea.
• Digoxin: Clarithromycin can increase the absorption and concentration of Digoxin (Lanoxin), a drug used to treat heart conditions such as atrial fibrillation and heart failure. This interaction may necessitate monitoring of Digoxin levels in the blood to prevent symptoms like nausea, dizziness, or heart rhythm disturbances.
• Quetiapine: Taking Quetiapine (Seroquel), an antipsychotic medication, along with Clarithromycin may exacerbate side effects like sleepiness, orthostatic hypotension (low blood pressure upon standing), confusion, and additional heart rhythm issues. Doctors should monitor patients closely when these drugs are used together to manage any adverse effects efficiently.

What Are the Other Clarithromycin Interactions?

Clarithromycin is an antibiotic that can interact with other medications, herbal supplements, and iron supplements:

• Herbal Supplements: St. John’s wort, a popular herbal supplement often used for treating depression, can have significant interactions with Clarithromycin. This nonprescription supplement may affect how your body processes the antibiotic, potentially leading to altered effectiveness or increased side effects. If you are considering using St. John’s wort while on Clarithromycin, it is essential to consult your healthcare provider to discuss any possible risks and adjustments that may be needed in your treatment plan.
• Iron Supplements: Iron is an essential mineral that helps in oxygen transport in the blood; however, it should be cautiously timed when taking Clarithromycin. To ensure optimal absorption and effectiveness of both the antibiotic and the iron supplement, avoiding iron supplements within two hours before or after your Clarithromycin dose is recommended. This spacing helps prevent iron from interfering with the absorption of the antibiotic, ensuring that both treatments work as intended.
• Other Supplements: When taking Clarithromycin, it’s important to manage the timing of certain other supplements to avoid interactions. Multivitamins, calcium supplements, antacids, or laxatives should not be taken within two hours before or after Clarithromycin. These substances can bind with the antibiotic in the digestive system, reducing its absorption and effectiveness. By spacing the doses appropriately, you can maintain the therapeutic levels of Clarithromycin in your body for better health outcomes.
• Alcohol Consumption: While there is no direct contraindication to consuming alcohol during treatment with Clarithromycin, it is advisable to use caution. Alcohol can increase the sedative effects of many medications, potentially enhancing drowsiness, sedation, and decreased motor skills that some individuals might experience with Clarithromycin. If you choose to drink alcohol while on this medication, it is best to do so in moderation and be aware of how your body responds to the combined effects of alcohol and the antibiotic.

[Note: This isn’t a complete list, and there could be other drugs that interact with Clarithromycin. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

If you’re looking for alternatives to Clarithromycin, here are some other antibiotics that might be considered, depending on the specific infection and individual health considerations:

• Zithromax (azithromycin)
• Ery-Tab (erythromycin)
• Vibramycin (doxycycline)
• Amoxil (amoxicillin)
• Cipro (ciprofloxacin)
• Levaquin (levofloxacin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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