Dexilant

Dexilant (dexlansoprazole) is a prescription proton pump inhibitor (PPI) used to lower stomach acid and treat acid-related conditions such as erosive esophagitis (EE) and gastroesophageal reflux disease (GERD). It helps relieve symptoms such as heartburn and acid reflux while giving the esophagus time to heal.

Below is a quick overview of important facts for patients and caregivers:

Dexilant is prescribed to treat certain acid-related conditions of the esophagus and stomach in patients 12 years of age and older.

• Healing of Erosive Esophagitis (EE): Used for healing acid-related damage to the esophageal lining for up to 8 weeks.
• Treatment of Symptomatic Non-Erosive GERD: Used to treat heartburn associated with gastroesophageal reflux disease (GERD) for about 4 weeks.
• Maintenance of Healed Erosive Esophagitis: Helps maintain esophagus healing and relieve heartburn symptoms for up to 6 months in adults and up to 16 weeks in patients aged 12-17 years.

Dexilant (dexlansoprazole) belongs to a class of medicines called proton pump inhibitors (PPIs) that lower stomach acid by blocking the final step of acid production.

• Proton pump inhibition: It blocks the (H+, K+)-ATPase enzyme, also known as the proton pump, located in the stomach’s parietal cells.
• Reduced acid production: By inhibiting this enzyme, Dexilant blocks the final step of gastric acid production, reducing stomach acidity and relieving acid-related symptoms.

It also uses a dual delayed-release formulation that releases the medication in two phases, helping provide extended acid suppression throughout the day.

Always follow your healthcare provider’s instructions. General guidelines include:

• Follow prescription instructions: Take the medication exactly as directed and do not change the dose without medical advice.
• Administration: It may be taken with or without food. Swallow the capsule whole without chewing or crushing it.
• Missed dose: Take the missed dose as soon as remembered. If it is close to the next dose, skip the missed dose and continue with the regular schedule. Do not take two doses at the same time.
• If you cannot swallow capsules, the capsule may be opened, and the granules sprinkled on applesauce, then swallowed immediately without chewing.

The recommended dosage of Dexilant depends on the condition being treated. The following table outlines the typical dosing guidelines for patients 12 years of age and older.

Dose adjustment:

Patients with moderate hepatic impairment (Child-Pugh Class B) may require a reduced dose of 30 mg once daily for up to 8 weeks for healing of erosive esophagitis. It is not recommended for patients with severe hepatic impairment (Child-Pugh Class C).

Taking more than the recommended dose may increase the risk of adverse reactions. Reported symptoms associated with high doses may include:

• High blood pressure (hypertension)
• Hot flashes
• Bruising (contusion)
• Throat or mouth pain (oropharyngeal pain)
• Weight loss

Dexlansoprazole is not expected to be removed by hemodialysis. Treatment of overdose is generally supportive and based on the patient’s symptoms. If an overdose is suspected, seek immediate emergency medical help or contact a poison control center.

Dexilant capsules may cause side effects in some patients. While many reactions are mild, certain symptoms may require medical attention.

Common Side Effects

Commonly reported side effects in adults include:

• Diarrhea
• Stomach pain
• Nausea
• Nasopharyngitis (common cold)
• Vomiting
• Gas

In patients 12 to 17 years old, common side effects may include:

• Headache
• Stomach pain
• Diarrhea
• Pain or swelling in the mouth, nose, or throat

Serious Allergic Reactions

Serious allergic reactions may occur in rare cases. Symptoms may include:

• Rash
• Swelling of the face
• Throat tightness
• Difficulty breathing

Serious Side Effects

Seek immediate medical attention if you experience any of the following:

• Vitamin B12 deficiency: Long-term use may reduce vitamin B12 absorption.
• Lupus erythematosus: Symptoms may include joint pain or a rash that worsens with sun exposure.
• Stomach growths (fundic gland polyps): Long-term PPI use may increase the risk of these growths.
• Kidney problems (acute tubulointerstitial nephritis): Symptoms may include reduced urination or blood in the urine.
• Severe skin reactions: Symptoms may include blistering, peeling skin, fever, body aches, or swollen lymph nodes.
• Bone fractures: Long-term use of proton pump inhibitors may increase the risk of fractures of the hip, wrist, or spine.
• Low magnesium levels: Symptoms may include dizziness, seizures, irregular heartbeat, muscle cramps, or weakness.
• Severe diarrhea: May be caused by Clostridium difficile infection. Symptoms can include persistent watery diarrhea, stomach pain, and fever.

This is not a complete list of side effects. Contact your healthcare provider for medical advice about adverse reactions. You may report side effects to the FDA at 1-800-FDA-1088 or visit MedWatch.

While taking this medication, the following warnings and precautions should be considered:

• Fundic gland polyps: Long-term PPI use may increase the risk of stomach polyps.
• Vitamin B12 deficiency: Long-term therapy may reduce vitamin B12 absorption.
• Bone fracture risk: Long-term or high-dose use may increase the risk of fractures.
• Methotrexate interaction: High-dose methotrexate may increase toxicity risk.
• Pediatric use: Not recommended in children under 2 years of age.
• Lupus erythematosus: May trigger or worsen lupus conditions.
• Low magnesium levels: Prolonged use may cause hypomagnesemia.
• Neuroendocrine tumor test interference: May affect chromogranin A lab tests.
• Clostridium difficile diarrhea: Increased risk of severe diarrhea.
• Gastric malignancy: Symptom relief does not rule out stomach cancer.
• Kidney inflammation: May cause acute tubulointerstitial nephritis.
• Severe skin reactions: Rare reactions such as SJS or TEN may occur.

Pregnancy and Breastfeeding

Dexilant capsules should be used during pregnancy only if clearly needed and prescribed by a healthcare provider. Available human data are limited, although studies with related medications have not shown a clear increase in congenital disabilities. It is not known whether this medication passes into human breast milk, so breastfeeding mothers should consult their healthcare provider before using it to evaluate potential risks and benefits.

Dexilant may interact with certain medications, which can affect how the drug works or increase the risk of side effects. Examples include:

• Rilpivirine-containing medications (should not be used together)
• Methotrexate, which may accumulate when used with PPIs
• Warfarin, which may increase bleeding risk
• Digoxin, which may have increased blood levels
• Tacrolimus, which may require monitoring of drug levels
• Atazanavir or nelfinavir, which may reduce the absorption of certain HIV medications
• Drugs requiring stomach acid for absorption (such as ketoconazole, itraconazole, or iron salts)

Patients should inform their healthcare provider about all supplements, over-the-counter drugs, and prescription medications they use before starting Dexilant capsules.

Several medications may be considered as alternatives for GERD or other acid-related conditions, depending on a patient’s response to treatment.

Brand availability may vary depending on location and pharmacy supply. A healthcare provider will determine the most appropriate option based on the patient’s symptoms and treatment response.

Both Dexilant and omeprazole are proton pump inhibitors (PPIs) used to reduce stomach acid, but they differ in formulation and duration of action.

A healthcare provider determines which medication is most appropriate based on the patient’s symptoms and treatment response.

Prescription medications for acid reflux and GERD may be costly at many U.S. retail pharmacies. Ordering Dexilant online from Polar Bear Meds may help reduce overall costs while maintaining safety, quality, and reliability.

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• Shipping timelines may vary depending on processing requirements and location.
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All Dexilant orders require a valid prescription. Medications are dispensed by licensed pharmacies that comply with applicable pharmacy regulations and safety standards.

• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9819f033-3bbe-442e-8e92-45fec77b237d
• https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022287s034lbl.pdf