Heartgard Plus Chewable Medium Dog

Heartgard Plus Chewable for Medium Dogs (26-50 lbs) is a prescription monthly chew that prevents heartworm disease and treats and controls roundworms and hookworms. Each green chew contains 136 mcg of ivermectin and 114 mg of pyrantel pamoate and is indicated for dogs and puppies 6 weeks of age and older within the specified weight range.

Below is a quick overview of important facts for pet owners and caregivers:

Heartgard Plus (26-50 lbs) is indicated for the prevention of heartworm disease and the treatment and control of specific intestinal parasites in dogs.

• Prevention of canine heartworm disease
  • Eliminates the tissue stage of Dirofilaria immitis (heartworm larvae) for a duration of one month (30 days) following infection.
• Treatment and control of roundworms
  • Toxascaris leonina
  • Toxocara canis
• Treatment and control of hookworms
  • Uncinaria stenocephala
  • Ancylostoma caninum
  • Ancylostoma braziliense

Heartgard Plus Chewable tablets contain two active ingredients that work together to protect dogs from heartworms and intestinal parasites.

• Ivermectin works by eliminating the tissue stage of Dirofilaria immitis (heartworm larvae) acquired during the previous month, preventing them from developing into adult heartworms.
• Pyrantel pamoate acts on intestinal parasites by causing paralysis of roundworms and hookworms, allowing them to be expelled from the body.

This medication provides monthly protection against heartworm disease and controls common intestinal worms.

Always follow your veterinarian’s instructions. General guidelines include:

• Give one chewable tablet once monthly at the recommended dose for dogs weighing 26-50 lbs.
• Remove only one chew at a time from the foil blister and return the remaining chews to the box to protect from light.
• Offer the chew by hand or place it in a small amount of dog food.
• Ensure your dog chews the tablet rather than swallowing it whole.
• Observe your dog for a few minutes after dosing to confirm the full dose is consumed.
• If any portion of the dose is lost or rejected, consult your veterinarian regarding redosing.
• Administer monthly during mosquito season, or year-round as recommended by your veterinarian.
• If you are substituting a different heartworm preventive, give the initial dose within 30 days of the last dose of the previous product.
• If more than 30 days have passed since the last dose, give immediately and resume the monthly schedule.

Heartgard Plus Chewable tablets should be administered orally at monthly intervals at a minimum dose of 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) and 6 mcg of ivermectin per kg (2.72 mcg/lb) of body weight.

For dogs weighing 26-50 lbs, the recommended dose is:

• One chewable tablet once monthly
• Contains 136 mcg ivermectin
• Contains 114 mg pyrantel pamoate
• Green color-coded packaging

Additional dosing guidance:

• For dogs over 100 lbs, use the appropriate combination of chewable strengths
• Recommended for dogs and puppies six weeks of age and older.

Administer every month at regular intervals for continuous protection.

What If You Overdose on Heartgard Plus Chewable Medium Dog?

Accidental overdose of Heartgard Plus Chewable tablets may increase the risk of adverse reactions, particularly neurological effects associated with ivermectin. Signs of overdose may include neurologic symptoms such as:

• Lethargy or depression
• Vomiting
• Loss of appetite
• Dilated pupils (mydriasis)
• Disorientation
• Ataxia (uncoordinated movement)
• Tremors
• Hypersalivation
• Seizures

In reported safety studies, significantly elevated doses were required to produce serious toxicity in most dogs; however, certain breeds (such as Collies and other herding breeds) may be more sensitive to ivermectin at high doses. If an overdose is suspected, contact your veterinarian immediately. Treatment is supportive and based on clinical signs.

These chewable tablets are generally well tolerated when administered at the recommended monthly dose.

Common Side Effects

In clinical field trials, the following reactions were observed within 24 hours of dosing (approximately 1.1% of administered doses):

• Diarrhea
• Vomiting

Other Reported Adverse Reactions (Post-Approval Reports)

The following events have been reported in dogs after use:

• Diarrhea
• Vomiting
• Anorexia
• Lethargy
• Ataxia
• Seizures
• Hypersalivation
• Muscle tremors
• Pruritus

In some cases, intestinal obstruction or choking has been reported after administration. If you notice unusual symptoms after giving Heartgard Plus (26-50 lbs), contact your veterinarian. To report suspected adverse drug events or obtain additional safety information, contact the FDA Center for Veterinary Medicine (CVM) at 1-888-FDA-VETS.

The following precautions should be considered before and during administration:

• Adult heartworm limitation: It is not effective against adult Dirofilaria immitis.
• Microfilariae clearance limitation: It is not indicated for the clearance of microfilariae.
• Choking risk: Intestinal obstruction or choking has been reported following administration.
• Heartworm testing: All dogs should be tested for existing heartworm infection before treatment is initiated.
• Microfilariae reactions: Mild hypersensitivity reactions, including transient diarrhea, may occur in dogs with circulating microfilariae.
• Chewable administration: For dogs that swallow treats whole, chewables may be broken into smaller pieces to reduce the risk of choking.
• Pre-treatment of infected dogs: Dogs diagnosed with heartworm infection must be treated to eliminate adult heartworms and microfilariae before starting a preventive program.

Clinical studies support the safety of Heartgard Plus when used as labeled.

• Use in puppies: Safe for puppies 6 weeks of age and older.
• Use in breeding dogs: Safe for pregnant or breeding females and stud dogs.
• Margin of safety: Demonstrated a wide margin of safety at labeled dosage levels.
• Bioequivalence: Bioequivalent to Heartgard with respect to ivermectin bioavailability (6 mcg/kg), as demonstrated in clinical studies.
• High-dose tolerance: No signs of toxicity were observed in safety studies at 10 times the recommended dose in sensitive Collies.
• Breed sensitivity (Collies): Certain Collies may be more sensitive to ivermectin at doses greater than 16 times the recommended level.
• Concomitant use: It has been administered safely in combination with commonly used flea products, vaccines, antibiotics, steroids, and other veterinary medications.
• Parvovirus consideration: In one study involving puppies with parvovirus, reduced efficacy against intestinal nematodes was observed.

Several prescription heartworm preventives are available for dogs. Alternatives may differ in active ingredients, parasite coverage, and formulation (oral vs topical).

Brand availability may vary by location and inventory. The appropriate preventive should be selected by a licensed veterinarian based on the dog’s weight, parasite risk, medical history, and need for additional coverage such as flea or tick protection.

Prescription heartworm preventive may be costly at many U.S. veterinary clinics and retail pharmacies. Ordering Heartgard Plus Chewable Medium Dog online from Polar Bear Meds may help reduce overall costs compared with some veterinary clinics or retail pharmacies.

• Competitive pricing compared to many U.S. retail veterinary pharmacies.
• Medications sourced from licensed and reputable pharmacies.
• Properly dispensed, quality-controlled prescription products.
• Transparent pricing with no hidden fees.
• Simple online ordering with easy prescription upload.
• Discreet packaging with order tracking for added security.
• U.S. customers can order with a valid veterinarian's prescription.
• Shipping across the United States typically takes 3-5 business days via Xpress Post.
• Shipping timelines may vary depending on processing requirements and location.
• Dedicated customer support team to assist with prescriptions, orders, and delivery questions.
• Additional savings with coupon code WELCOMEPB10: 10% off your first order.

All Heartgard Plus Chewable Medium Dog orders require a valid prescription. Medications are dispensed by licensed pharmacies that comply with applicable pharmacy regulations and safety standards.

• https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=595a4883-6b37-4190-9579-a2c7ca4738eb
• https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/542