

Mirtazapine OD is a prescription antidepressant used to treat major depressive disorder (MDD) in adults. It belongs to a class of antidepressants known as tetracyclic antidepressants. Mirtazapine OD is available as an orally disintegrating tablet (ODT), meaning it dissolves on the tongue and can be taken without water. It may be helpful for patients who have difficulty swallowing conventional tablets.
| Product Name (Generic) | Mirtazapine OD |
|---|---|
| Drug Type | Noradrenergic and specific serotonergic antidepressant (NaSSA), sometimes classified as a tetracyclic antidepressant |
| Available Forms | Orally disintegrating tablet (ODT) |
| Strengths Available | 15 mg, 30 mg, and 45 mg |
| Routes of Administration | Taken by mouth |
| Mirtazapine OD Uses | Treats major depressive disorder |
| Duration of Treatment | The duration of treatment varies depending on the patient's condition and the physician’s recommendation. |
| Mirtazapine OD Storage | Store at room temperature (15°C-30°C/ 59°F-86°F) |
| Pregnancy and Breastfeeding | Consult a doctor |
| Legal Status | Rx only |
| FDA Boxed Warning | Increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults (up to age 24) during early treatment. |
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Mirtazapine OD is FDA-approved to treat:
Mirtazapine OD works by influencing certain neurotransmitters in the brain that help regulate mood. It blocks central presynaptic alpha-2 adrenergic autoreceptors and heteroreceptors, thereby increasing the release of norepinephrine and serotonin. It also blocks 5-HT2 and 5-HT3 serotonin receptors, thereby enhancing beneficial serotonin activity. In addition, the medication blocks histamine (H1) receptors, which contributes to sedation and may increase appetite. These effects may improve mood and support appetite and sleep in some patients.
Keep the following Mirtazapine OD precautions in mind before taking the medication:
According to the FDA,
Before starting treatment with Mirtazapine OD, be aware of the following possible side effects:
| Common Side Effects of Mirtazapine OD | Serious Side Effects of Mirtazapine OD (seek medical help) |
|---|---|
| Dizziness | Irregular heartbeat |
| Increased appetite | Suicidal thoughts or behavior |
| Drowsiness | Agitation or confusion |
| Weight gain | Low white blood cell count (neutropenia or agranulocytosis) and serotonin syndrome |
| Constipation | Seizures |
| Dry mouth | Fainting |
| Fatigue | Severe dizziness |
| Headache | Severe skin reactions |
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Mirtazapine OD is contraindicated in patients who have:
Keep the following Mirtazapine OD dosage instructions in mind before starting the medication:
If you experience a Mirtazapine OD overdose, call the Poison Control Center at 1-800-222-1222 immediately. Seek emergency medical care if symptoms such as extreme drowsiness, confusion, rapid heart rate, or impaired memory occur.
If you are taking Mirtazapine OD for major depressive disorder, follow the regimen as directed. If you miss a dose of Mirtazapine OD, follow a simple set of instructions:
Keep the following Mirtazapine OD storage guidelines in mind to store the medication in proper condition:
The following medications may interact with Mirtazapine OD. However, the list of interactions is incomplete. Please consult your healthcare provider for the complete list of Mirtazapine OD interactions.
Use the following Mirtazapine OD alternatives in case of unavailability or if the medication doesn’t suit you:
Consult your healthcare provider before taking the alternative medication.
Mirtazapine OD can be costly if you purchase it from local U.S. pharmacies, especially if you don’t have insurance coverage. At Polar Bear Meds, we help you access your prescribed medications at more affordable prices by sourcing them through fully licensed Canadian and international pharmacy partners.
You can buy Mirtazapine OD online in Canada from Polar Bear Meds and can enjoy additional benefits:
At Polar Bear Meds, your prescription is filled through licensed pharmacy partners to ensure authenticity and safety. If you are looking for a reliable and affordable way to buy Mirtazapine OD online from Canada, Polar Bear Meds offers a convenient option.
The medical content provided about Mirtazapine OD is for informational and educational purposes only and is not intended to replace professional medical guidance, diagnosis, or treatment. Mirtazapine OD is a prescription-based medicine and should be used only under the supervision of a healthcare professional. Always consult your doctor before changing or stopping your Mirtazapine OD dosage.

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.
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