Conjugated Estrogens and Medroxyprogesterone Acetate

Premique

Premique is an FDA-approved hormone replacement therapy that contains two female hormones, estrogen, and progestogen. This combination medication is used to provide relief from menopausal symptoms and conditions such as hot flashes, dry mouth, and vaginal changes. It is available in a strength of 0.3 mg of conjugated estrogen and 1.5 mg of medroxyprogesterone acetate. It functions by supplementing estrogen levels in the body, which decline during menopause, while the progestin component helps counteract the potential adverse effects of estrogen on the uterus. Consult your doctor for personalized guidance and advice regarding medication usage. 

Product Overview

Premique contains a combination of conjugated estrogens and medroxyprogesterone acetate. Conjugated estrogens are used to treat symptoms of menopause, such as hot flashes & vaginal dryness. Medroxyprogesterone acetate is a type of progestin that helps regulate the effects of estrogen, reducing the risk of endometrial hyperplasia, which can lead to uterine cancer. Together, these ingredients help manage menopausal symptoms and support hormonal balance.

Premique is available in a strength of 0.3 mg of conjugated estrogen and 1.5 mg of medroxyprogesterone acetate. It is taken orally, typically once daily, with or without food, as directed by a medical provider. This medication is suitable for postmenopausal women who have not had a hysterectomy. It works by supplementing estrogen levels in the body, which decline during menopause, while the progestin component helps counteract the potential adverse effects of estrogen on the uterus.

Common side effects of Premique may include nausea, bloating, breast tenderness, headache, or weight changes. Patients are recommended to consult their medical provider if any side effects persist or worsen. Precautions should be taken for individuals with a history of blood clots, liver disease, or certain types of cancers. In the case of a missed dose, take it as soon as you remember unless it is almost time for your next dose. Avoid taking double or extra doses. In case of a Premique overdose, seek immediate medical attention. Store Premique at room temperature, away from light and moisture. For guidance, consult your healthcare provider to ensure Premique is suitable for you and to discuss any concerns regarding its use and potential risks.

What Are the Uses of Premique?

It is used to:

• Alleviate symptoms associated with menopause
• Prevent osteoporosis

What Are the Forms & Strengths of Premique?

It comes in the form of a modified release tablet, which comes in the strength of:

• 0.3 mg of conjugated estrogen
• 1.5 mg of medroxyprogesterone acetate

What Are the Recommended Dosage of Premique?

For Treatment of Menopausal Symptoms

• Adults: One tablet once daily for 28 days, then repeat the cycle.
• Children: Use is not recommended. 

For the Prevention of Osteoporosis

• Adults: One tablet once daily for 28 days, then repeat the cycle.
• Children: Use is not recommended. 

[Note: These recommendations may vary from person to person. Discuss them with your doctor, and they’ll customize your dosage accordingly.]

How to Use Premique? 

• Before using this medication, you should carefully read and follow the directions in the patient information leaflet and medication guide provided by your healthcare provider or pharmacist. You should consult your doctor if you have any questions or concerns regarding the medication use or do not understand any part of the leaflet. 
• Take Premique exactly as you are directed by your doctor. Do not take more or less than prescribed, in large quantities, or longer than recommended, as this can cause unwanted side effects. 
• Take Premique tablets orally, with or without meals, as instructed by your healthcare provider. If you experience an upset stomach, your doctor may recommend you take it with food or right after a meal. 
• The medication dosage is based on the condition being treated and the patient’s response to treatment. 
• Take your medication at the same time every day to help you remember to take and maintain consistency in dosage. 
• If you are not taking HRT or taking another period-free HRT, you may start taking this medication at any time. If you are switching from an HRT medication that makes you bleed monthly, you should start taking premium a day after you finish the course of the previous medication unless your doctor instructs you otherwise. 
• Start your medication by taking the first tablet for that day of the week. Then, follow the arrows on the blister pack to take one tablet each day until you have taken all 28 tablets. 
• While you are on this medication, you will have no tablet-free days. You should start the next pack the day after you finish the previous one. 
• Your doctor will recommend you take the lowest dose for the lowest duration possible to control your symptoms. 
• Let your doctor know if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Premique Work?

Premique is a hormone replacement therapy (HRT) used to alleviate menopausal symptoms. It contains two active ingredients: conjugated estrogens and medroxyprogesterone acetate. These compounds mimic the female sex hormones estrogen and progesterone. Premique supplements the hormone levels in your body. During menopause, estrogen levels decline, leading to symptoms like hot flashes, night sweats & vaginal dryness. By providing synthetic estrogen and progesterone, Premique helps alleviate these symptoms. It’s a period-free HRT, meaning you won’t experience monthly bleeding while taking it. 

Important Safety Information for Using Premique

What Are the Side Effects of Premique?

Common Side Effects of Premique: Premique may cause side effects in some people. It is essential to mention that not everyone using this medication will experience these side effects. They disappear within a few days or weeks as your body adjusts to the medication. Your doctor has prescribed you this medication because they have decided that the benefits outweigh the potential risks associated with this medication use. Common side effects of this medication are as follows: 

• Breast tenderness or pain
• Bloating
• Nausea
• Headache
• Irregular vaginal bleeding or spotting
• Fluid retention
• Mood changes
• Weight changes

Mild Side Effects of Premique: Premique may cause mild side effects in some people, which don’t usually require medical attention and disappear within a few days. If you experience persistent or bothersome effects, you should immediately consult your healthcare provider and report any new or worsening symptoms to your doctor. 

• Dizziness
• Hair loss or increased hair growth
• Changes in libido
• Skin reactions, including rash & itching
• Leg cramps
• Indigestion
• Vaginal yeast infections
• Changes in vaginal discharge

Serious Side Effects of Premique: Rarely, Premique may cause serious side effects in some people. The likelihood of experiencing severe side effects may be based on various factors such as age, overall health & duration of use. Adverse side effects require immediate medical attention and may become fatal if not treated promptly. You should discontinue using this medication and call your doctor or 911 immediately if you experience any of the side effects given below. 

• Deep vein thrombosis or pulmonary embolism. Its symptoms may include leg pain, swelling, warmth, redness, sudden shortness of breath, and chest pain.
• Stroke. Symptoms include sudden numbness, confusion, trouble speaking, vision problems, or severe headache.
• Heart attack. Its symptoms may include chest pain, shortness of breath, nausea, and pain radiating to the arm or jaw.
• Long-term use of Premique may slightly increase the risk of breast cancer.
• Endometrial cancer
• Ovarian cancer
• Increased risk of gallstones and gallbladder inflammation
• Liver problems. Symptoms include jaundice, dark urine, abdominal pain, and fatigue.
• High blood pressure, which can further lead to other cardiovascular problems 
• Vision changes, partial or complete vision loss, double vision, or migraines. 
• Severe allergic reactions. Its symptoms may include swelling of the face & throat, difficulty breathing, and severe skin reactions.

[Note: This list may not cover all possible side effects. Always consult with your healthcare provider for medical advice about side effects.]

Are There Any Warnings for Premique?

• Estrogens, when used alone or with progestin, have caused adverse side effects in very rare cases. You should discuss the potential risks & benefits with your physician before starting a hormone replacement therapy. It is important to mention that you should not use estrogens & progestins to prevent heart disease or dementia. 
• Estrogen, when used with progestin in post-menopausal women, can increase the risk of stroke, certain heart diseases, serious blood clots in the legs or lungs, dementia, and cancer of the breast or ovaries. 
• Breakthrough bleeding & spotting may occur during the early days of therapy. If it continues despite ruling out endometrial abnormalities, consider using a higher dose of treatment or cyclic therapy as an alternative.
• Your risk of developing severe side effects may depend on your estrogen dose and the duration you are using it. The medication should be used at the lowest dose for the shortest length of time. Visit your doctor regularly to determine if you need to continue taking the medication or to look for unwanted side effects. If you are required to use this medication long-term, you should have physical exams on a regular basis as directed by your doctor. Before you have any medical exams, tell the medic that you are taking Premique, as it may affect certain tests such as endocrine tests and liver enzymes. 
• Do not intake grapefruit or grapefruit juice while you are using this medication as it may cause the amount of drug in the blood to be too high. 
• Premique may cause severe allergic reactions, including anaphylaxis and angioedema, which may be fatal and require immediate medical attention. 
• This medication may cause pancreatitis. Check with your doctor immediately if you experience sudden and severe abdominal pain, constipation, nausea or vomiting, fever, chills, or lightheadedness. 
• You should immediately discontinue using this medication and contact your doctor if you experience jaundice or deterioration of liver function, a significant increase in blood pressure, a new onset of migraine-type headache, and pregnancy. 
• This medication is not indicated for use in children. Keep it in a safe place, away from the sight and reach of children. 

What Are the Premique Precautions?

• Before using Premique, inform your doctor if you have an allergy to it, to any other medication, or if you have any other allergies. This medication contains certain inactive ingredients that may cause severe allergic reactions or similar problems. Ask your physician, pharmacist, or healthcare provider for the complete list of ingredients. 
• Before using this medication, share your complete medical history with your doctor, especially if you have the following conditions:
  • Unknown vaginal bleeding 
  • Cancer of the breast, uterus, or ovaries
  • Stroke
  • Blood clots 
  • Heart disease 
  • Liver disease
  • Kidney disease
  • Family medical history, especially cancer, breast lumps, or blood clots
  • Family or personal history of certain swelling disorders, such as angioedema
  • High blood pressure 
  • Diabetes
  • Blood clotting disorders such as protein S or protein C deficiency
  • Underactive thyroid 
  • Mineral imbalance
  • Uterus problems
  • Gallbladder problems
  • Asthma 
  • Migraines 
  • Seizures
  • Porphyria 
  • Mental/mood disorders such as depression or dementia 
• You should not use tobacco or cigarettes. Estrogens combined with smoking can further increase your risk of blood clots, high blood pressure, stroke, and heart attack, especially in women aged more than 35. 
• Inform your doctor if you just had or plan to have surgery or if you will be confined to sitting on a chair or bed for a long time, as these conditions can increase the chance of blood clots, especially if you are using estrogen. You may be required to discontinue using this medication for some time or take special precautions. 
• This medication may cause melasma or blotchy, dark areas on your face and skin. While using this medication, you should limit your time under the sun and avoid sunlamps and tanning booths. When outdoors, use sunscreen & wear protective clothing. 
• If someone is near-sighted or wears contact lenses, they may have vision problems or trouble wearing them. Contact an ophthalmologist if you have these problems or other vision problems. 
• It is unlikely for a postmenopausal woman to become pregnant. But you should know that this medication may cause harm to the unborn baby. You should not use this medication while being pregnant. If you become pregnant while using Premique or suspect that you may be pregnant, you should tell your doctor immediately. 
• Premique passes into your breast milk and reduces the quality and amount of breast milk production. You should consult a licensed medical professional before breastfeeding while using this medication. 
• This medication should be used with caution in individuals with severe hypocalcemia.

What Are the Contraindications of Premique? 

Premique is contraindicated for use in patients with:

• Hypersensitivity to the active substances or any of the ingredients present in the medication
• Known history or suspected breast cancer
• Known or suspected estrogen-dependent malignant tumors, including endometrial cancer
• Undiagnosed genital bleeding 
• Untreated endometrial hyperplasia 
• History of pulmonary embolism (PE) or deep vein thrombosis (DVT)
• Known thrombophilic disorders such as protein C, protein S, or antithrombin deficiency
• Active or recent arterial thromboembolic disease, including angina or myocardial infraction
• Acute hepatic disease or history of liver disease
• Porphyria  

What If You Missed a Dose of Premique?

• If you have missed a dose of Premique, you should take it as soon as you remember. 
• Missed medication may cause breakthrough bleeding. 
• You can take the missed dose for up to 12 hours afterward. 
• However, if it has been more than twelve hours since your missed dose, you may omit it and continue taking your medication according to your regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose, which can lead to undesirable side effects. 
• You may set a reminder on your phone to prevent missing your dose. Medication reminders work best for this purpose.  

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Premique?

Overdose of Premique may lead to nausea, vomiting, and withdrawal bleeding. If you suspect a Premique overdose, you should immediately contact your doctor, call 911, or poison control helpline. If someone has taken the medication more than recommended and is experiencing severe side effects such as difficulty breathing, seizures, and passing out, you may also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Premique?

• You should keep the Premique blister pack in its original carton tightly closed at room temperature, away from direct sunlight, moisture, and excess heat. 
• Do not keep it in the bathroom or near the sink.
• Keep all medications, including Premique, in a safe place, away from the sight and reach of children and pets. 
• Don’t keep medications that are outdated or no longer needed. Dispose of them safely. 
• You should not discard unwanted medications by pouring them into the drain, flushing them down the toilet, or throwing them into the household garbage bin.
• You should eliminate unwanted medications in such a way that prevents children, animals, and other people from consuming them.
• Consult your pharmacist, healthcare provider, or local waste disposal company to learn more about the proper ways to discard unwanted medications. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Premique?

Certain medications may interact with Premique and affect how it may work. Before taking this medication, you should consult your doctor or pharmacist and inform them about all the medications you are taking or plan to take, including all prescription, non-prescription, over-the-counter drugs, and herbal or vitamin supplements. The list given below does not include all possible interactions of Premique, and there may be other drugs that interact with Premique. Your doctor may change your dosage of one or both medications or suggest you take some alternative medications. Drug interactions with Premique are as follows: 

• Amifampridine
• Apalutamide
• Aprepitant
• Armodafinil
• Artemether
• Belzutifan
• Bexarotene
• Bosentan
• Bupropion
• Carbamazepine
• Cenobamate
• Clobazam
• Cosyntropin
• Dabrafenib
• Darunavir
• Dexamethasone
• Donepezil
• Efavirenz
• Elagolix
• Elvitegravir
• Enasidenib
• Encorafenib
• Enzalutamide
• Eslicarbazepine Acetate
• Etoricoxib
• Etravirine
• Fosaprepitant
• Fosphenytoin
• Ginseng
• Griseofulvin
• Isotretinoin
• Ivosidenib
• Lesinurad
• Levothyroxine
• Licorice
• Lorlatinib
• Lumacaftor
• Mavacamten
• Meropenem
• Mitapivat
• Mitotane
• Mobocertinib
• Modafinil
• Mycophenolic Acid
• Nafcillin
• Nevirapine
• Oxcarbazepine
• Phenobarbital
• Phenylbutazone
• Phenytoin
• Pitolisant
• Prednisone
• Primidone
• Red Clover
• Repotrectinib
• Rifabutin
• Rifampin
• Rifapentine
• Ritonavir
• Rufinamide
• Secobarbital
• St John’s Wort
• Sugammadex
• Tazemetostat
• Telaprevir
• Theophylline
• Tipranavir
• Topiramate
• Tovorafenib
• Tranexamic Acid
• Ulipristal

What Are the Other Premique Interactions?

You should not use certain medications at or around the time of eating food or consuming certain types of food items since interactions may occur. Consuming alcohol or tobacco with certain medications may also cause interactions. The interactions given below have been selected on the basis of their significance and are not exhaustive. Using this medication with any of the following herbs, supplements, food items, and beverages may cause an increased risk of certain side effects. Still, in some cases, it may be unavoidable. When both medications are used in combination, your doctor may change the dose or frequency of one or more medications or give you special instructions regarding dietary changes. 

• Caffeine  
• Grapefruit
• Grapefruit juice 

[Note: This isn’t a complete list, and there could be other drugs that interact with Premique. Tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Premique Alternatives?

People look for alternative medicines to Premique when it does not suit them or they do not get the desired results. There are many effective medicines for Premique available in the market. However, you should consult your healthcare provider or physician before changing your medication or starting a new one. Some popular alternatives to Premique are as follows:

• Femring
• Angeliq (estradiol, drospirenone)
• Climara Pro (estradiol hemihydrate)
• Estrace cream (estradiol)
• Alendronate

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Premique Cost & Coupons

The cost of Premique and options for obtaining it at a lower price depend on several factors, including health insurance coverage. Many Americans find that their health insurance does not cover medications like Premique, leading to high out-of-pocket expenses. To manage these costs, some Americans turn to services like Polar Bear Meds, where they can buy Premique from Canada at a reduced price. Customers can also use the Premique coupon code WELCOMEPB10 to receive a 10% discount on their first order. This option helps alleviate the financial burden for those needing this medication, making it more accessible and affordable.

Frequently Asked Questions

Can Premique help with bone density improvement?

Yes, Premique can help improve bone density in postmenopausal women by supplementing estrogen levels, which decline during menopause. Estrogen plays a prominent role in maintaining bone density. By replenishing estrogen, Premique can reduce the risk of osteoporosis and related fractures. Always consult your healthcare provider or physician for personalized advice and treatment options.

Does Premique affect cholesterol levels?

Premique can influence cholesterol levels. Estrogen in Premique may help increase HDL (good) cholesterol and decrease LDL (bad) cholesterol. However, individual responses can vary & some patients may experience different effects. Regular monitoring of cholesterol levels is recommended while using Premique. Discuss any concerns with your healthcare provider to make sure it is safe and effective for your condition.

Is weight gain a common side effect of Premique?

Weight gain can be a side effect of Premique, although not everyone experiences it. Hormonal changes due to estrogen and progestogen may cause fluid retention and changes in body weight. Maintaining a healthy, nutritious diet & regular physical exercise can help manage potential weight changes. If you experience significant weight gain, consult your healthcare provider for further evaluation and management.

Can Premique be used in patients with a history of breast cancer?

Premique is generally not recommended for patients with a history of breast cancer, as estrogen can stimulate the growth of certain kinds of breast cancer cells. If you have a history of breast cancer or other hormone-sensitive conditions, discuss alternative treatments with your healthcare provider. They can provide guidance on safe & effective options tailored to your medical history.

Is long-term use of Premique safe?

Long-term use of Premique can be associated with increased risks of certain health problems, such as heart disease, breast cancer & dementia. It’s crucial to have check-ups with your healthcare provider on a regular basis to determine the risks and benefits of continued therapy and to discuss any concerns.

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