Rizatriptan 

Rizatriptan ODT 

Rizatriptan ODT is a prescription medication approved by the FDA to treat migraine headaches. It is available in tablets and orally disintegrating tablets with strengths of 5 and 10 mg each. By targeting serotonin receptors, it helps narrow blood vessels around the brain. It reduces substances in the body that can trigger migraine symptoms, such as headaches, nausea, and sensitivity to light and sound. It is indicated for use in adults and children aged six and more suffering from acute migraine headaches, with or without aura. You should consult your medical provider for a safe and efficient use of this medication.  

Product Overview

Rizatriptan ODT (orally disintegrating tablet) is formulated primarily with rizatriptan benzoate, a selective serotonin receptor agonist used to relieve migraine symptoms. By targeting serotonin receptors, it helps narrow blood vessels around the brain & decreases substances in the body that may trigger migraine symptoms such as headaches, nausea & sensitivity to light and sound.

Available in strengths of 5mg and 10mg, Rizatriptan ODT is designed for rapid absorption without the need for water, making it convenient for patients experiencing nausea. It is indicated for adults and children aged six years and older who suffer from acute migraine headaches with or without aura. Patients should take a single dose at the onset of migraine symptoms. If symptoms persist or return, a second dose may be taken after two hours, not exceeding 30 mg in a 24-hour period.

Common side effects of Rizatriptan ODT may include dizziness, drowsiness, fatigue, and dry mouth. Patients are advised to use rizatriptan cautiously if they have a history of heart conditions or high blood pressure. In cases of a missed dose, take the medication as soon as you remember unless it is close to the time of your next dose. Do not double up on doses. For overdose, seek immediate medical attention. Store the Rizatriptan ODT tablets at room temperature, away from moisture and heat. Always follow medical guidance for use, and consult a healthcare provider for any concerns regarding its use or side effects.

What Are the Uses of Rizatriptan ODT?

It is used to treat:

• Migraines 

What Are the Forms & Strengths of Rizatriptan ODT?

It is available in the following forms and strengths.

Form: Tablets:

Strengths: 5 mg, 10 mg

Form: Orally Disintegrating Tablets (ODT):

Strengths: 5 mg, 10 mg

What Are the Recommended Dosage of Rizatriptan ODT?

For Migraines

• Initial dose: 5 mg or 10 mg
• Maximum single dose: 10 mg
• Maximum daily dose: 30 mg

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Rizatriptan ODT? 

• Before using Rizatriptan ODT, you should carefully read and follow the instructions for use given in the medication guide & patient information leaflet. If you have any queries or concerns or if you need help understanding any part of the patient information leaflet, ask an expert medical professional. 
• You should take this medication exactly as directed by your physician at the first signs and symptoms of a migraine. Do not take more or less of it, in large quantities, or for longer than prescribed. 
• You should pat dry your hands before handling the tablets. After removing it from the blister pack, place the tablet on your tongue, let it dissolve, and swallow the saliva. 
• You are not required to take Rizatriptan ODT with water or some other liquid. You can take it with or without food; however, it may work better when taken on an empty stomach. 
• You should not break or crush the Rizatriptan ODT tablets, and keep the container tightly closed when not in use. 
• The medication dosage is based on the medical condition being treated, age, response to treatment, and other medications you may be taking. For pediatric patients, the medication dosage is also based on weight. Make sure to tell your medical giver about all the medications you are using or plan to use alongside Rizatriptan ODT. This includes all the prescription, nonprescription, over-the-counter drugs, and herbal or vitamin supplements. 
• If your symptoms do not vitamin, you should not take double or extra doses of this tablet without consulting your doctor. If your condition is only partially relieved or if your headache returns, adult patients may take another dose at least 2 hours after the first dose. Pediatric patients should not be given more than one dose or 5 mg in one day. 
• If you are at an increased risk of cardiovascular conditions, your doctor may ask you to undergo certain tests before prescribing this medication. They may also advise you to take the first dose of Rizatriptan ODT in their office or clinic to monitor you closely for unwelcome side effects. 
• If you are taking migraine medications on ten or more days each month, it can actually make your headache worse. 
• Tell your doctor if your medication is not working as well as it should be, if you have to use it frequently, or if your condition has gotten worse.    

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Rizatriptan ODT Work?

Rizatriptan, available under brand names like Maxalt, is a headache medication that specifically targets migraines. It functions by narrowing blood vessels near the brain, which helps alleviate migraine symptoms. Additionally, rizatriptan reduces substances in the body that can trigger headaches, nausea, and sensitivity to light and sound. However, it’s essential to note that rizatriptan should only be used for confirmed migraine headaches, not tension headaches or other conditions. 

Important Safety Information for Using Rizatriptan ODT

What Are the Side Effects of Rizatriptan ODT?

Common Side Effects of Rizatriptan ODT: The following side effects are considered common when taking Rizatriptan ODT. These effects occur in a significant number of patients and are generally well-tolerated. While they may cause some discomfort, they usually do not need prompt medical attention unless they persist or become worse:

• Dizziness
• Drowsiness
• Tiredness or weakness
• Nausea
• Dry mouth
• Tingling or prickling sensations (paresthesia)
• Mild headache (paradoxical effect)
• The sensation of warmth or flushing 

Mild Side Effects of Rizatriptan ODT: Mild side effects of Rizatriptan ODT are less common than those listed above but still occur in some patients. These effects are generally not serious and often resolve by themselves. However, if they still persist or become bothersome, it’s advisable to consult a healthcare provider:

• Mild chest pain or tightness
• Muscle pain or stiffness
• Abdominal pain or discomfort
• Feelings of heaviness in parts of the body
• Mild sleep disturbances
• Mild anxiety or restlessness
• Temporary changes in taste
• Mild digestive issues  

Serious Side Effects of Rizatriptan ODT: While rare, serious side effects can occur with Rizatriptan ODT. These effects require immediate medical attention and may become fatal if not treated promptly. If you experience any of the following symptoms, discontinue taking the medication & seek immediate medical care.

• Severe chest pain or tightness: This may feel like intense pressure, squeezing, or fullness in the chest. It could be a sign of cardiovascular complications.
• Signs of heart attack: This may include arm or jaw pain, shortness of breath, cold sweats, nausea, or lightheadedness accompanying chest discomfort
• Signs of stroke: Sudden weakness or numbness, especially on one side of the body, slurred speech or difficulty speaking, sudden severe headache, vision problems in one or both eyes, or loss of balance or coordination
• Severe allergic reactions, including anaphylaxis: Its symptoms may include itching/hives, rash, swelling of the mouth, lips, face, tongue, or throat, trouble breathing or wheezing, rapid heartbeat, and dizziness or fainting
• Serotonin syndrome: This is a potentially fatal issue caused by excessive serotonin in the body. Symptoms include agitation or restlessness, hallucinations, rapid heartbeat, fever, excessive sweating, shivering or tremors, muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea.
• Severe stomach or abdominal pain: This could indicate serious gastrointestinal issues.
• Bloody diarrhea: This may be a sign of intestinal ischemia, a serious condition where blood flow to the intestines is reduced.
• Seizures: This is uncontrolled electrical activity in the brain that may cause convulsions, loss of consciousness, or changes in behavior.
• Severe dizziness or fainting: This could indicate problems with blood pressure or heart rhythm.
• Vision changes or vision loss, which may include temporary or permanent blindness, blurred vision, double vision, or blind spot in vision
• Medication overuse headache: While not immediately life-threatening, prolonged overuse of Rizatriptan can lead to chronic daily headaches, potentially worsening the migraine condition.
• Peripheral vascular ischemia: Reduced blood flow to extremities, which may cause coldness, numbness, or tingling in fingers or toes, color changes in affected areas, or pain in extremities.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings about Rizatriptan ODT? 

• You should not use Rizatriptan ODT if you have hypertension, cardiovascular issues, a history of stroke or heart attack, or other problems that may cause a lack of blood supply within your body. 
• You should not use Rizatriptan ODT within 24 hours before or after using other medications used to treat migraine headaches. 
• You should not use Rizatriptan ODT if you have used an MAO inhibitor in the past fourteen days, as it can lead to unwelcome side effects. 

What Are the Rizatriptan ODT Precautions?

• Before taking rizatriptan, inform your doctor or pharmacist if you are allergic to it or have any other allergies. This medication might have inactive ingredients that could cause allergic reactions or other issues. Your pharmacist can provide more details.
• Share your complete medical history with your physician or pharmacist before using Rizatriptan, particularly if you have blood circulation problems , specific types of migraines (hemiplegic or basilar), heart conditions, liver disease, or a history of stroke or mini-stroke.
• Certain conditions can increase your risk of heart problems. Let your doctor know if you have any of these conditions: high cholesterol, high blood pressure, diabetes, a family history of cardiovascular disease, are overweight, smoke, are a postmenopausal woman, or are a man over 40.
• This drug may cause dizziness or drowsiness. Alcohol or marijuana (cannabis) can worsen these effects. Avoid driving a car, using heavy machinery, or doing anything that requires alertness until you are sure you can do so safely. Limit consumption of alcohol and talk to your doctor if you use marijuana (cannabis).
• If this medication contains aspartame, and you have phenylketonuria or other conditions that require you to limit or avoid aspartame, consult your doctor or pharmacist on how to use this medication safely.
• Before surgery, inform your doctor, surgeon, or dentist about all the products you use, including prescription medications, over-the-counter drugs, and herbal supplements.
• The chance of cardiovascular disease, liver disease, and hypertension increases with age. Elderly patients may be more sensitive to the side effects of this drug, particularly increased blood pressure and heart problems.
• This medication should only be used if absolutely necessary during pregnancy. Discuss the risks & benefits of Rizatriptan with your doctor.
• It is not known whether Rizatriptan passes into your breast milk. Consult your doctor before breastfeeding.

What Are the Contraindications of Rizatriptan ODT? 

Rizatriptan ODT is contraindicated for use in patients who have:

• Ischemic heart disease
• Uncontrolled hypertension
• Peripheral vascular disease
• Hemiplegic or basilar migraine
• Severe hepatic impairment
• Concurrent use with MAO inhibitors

What If You Missed a Dose of Rizatriptan ODT?

• If you have missed a dose of Rizatriptan ODt, you should take it as soon as you remember. 
• However, if the time to take your next dose is almost here, you can omit the missed dose and continue taking your medication according to your regular dosage. 
• You should not take double or extra doses of the same medication to compensate for the missed dose. 
• You should set a medication reminder on your phone to prevent missing doses further. 
• If you are still uncertain about when to take your medication, you should contact your medical provider. 

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Rizatriptan ODT?

The maximum recommended single dose of Rizatriptan is 10 mg, and no more than 30 mg should be taken in any 24-hour period. If you suspect an overdose, you should seek immediate medical attention. You can call your doctor, 911, or poison control helpline. You can also head to the nearest emergency room.  

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Rizatriptan ODT?

• You should keep Rizatriptan ODT in its original blister pack at a controlled room temperature, away from direct light, moisture, and excess heat, unless you are ready to use it. 
• You should not allow it to freeze or expose it to extreme temperatures and moisture. 
• You should keep all medications, including Rizatriptan ODT, in a secure place, away from the sight and reach of children and pets. 
• You should not keep medications that are outdated or no longer needed. Discard them safely. 
• You should dispose of unwanted medications in such a way that prevents children, animals, and other people from consuming them. 
• You should not pour it into wastewater, flush it down the toilet, or throw it into trash. 
• The best way to eliminate outdated or no longer needed medications is to give them in the medicine take-back program. 
• For more information on properly disposing of unwanted medications, you should consult your pharmacist or healthcare provider. 

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Rizatriptan ODT?

Rizatriptan ODT can interact with several medications, potentially leading to adverse effects or reduced efficacy. Before using this medication, you should tell your medical team about all the medications you are currently using or plan to use alongside Rizatriptan ODT. This information will help them identify and prevent drug interactions. Here’s a list of important drug interactions:

• Almotriptan
• Amitriptyline
• Amphetamine
• Bromocriptine
• Dihydroergotamine
• Eletriptan
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Frovatriptan
• Isocarboxazid
• Linezolid
• Lisuride
• Metergoline
• Methylene Blue
• Methylergonovine
• Methysergide
• Naratriptan
• Nicergoline
• Oliceridine
• Ondansetron
• Oxycodone
• Oxymorphone
• Phenelzine
• Procarbazine
• Propranolol
• Sumatriptan
• Tranylcypromine
• Zolmitriptan

What Are the Other Rizatriptan ODT Interactions?

 Beyond medication interactions, Rizatriptan ODT can have other important interactions that patients and healthcare providers should be aware of, particularly food items, beverages, herbs, supplements, and diseases. Always consult with a medical giver or pharmacist about potential interactions, especially if you have any pre-existing conditions or are taking other medications or supplements. They can provide personalized guidance & advice based on your specific situation. Below are some significant interactions you should be aware of before using Rizatriptan ODT.

• Alcohol
• Caffeine
• Grapefruit juice
• Tobacco 
• Hormonal contraceptives 

[Note: This isn’t a complete list, and there could be other drugs that interact with Rizatriptan ODT. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Rizatriptan ODT Alternatives?

While Rizatriptan ODT is an effective medication for treating migraines, it may not be suitable for everyone. The choice of alternative depends on factors such as the frequency and severity of migraines, individual response to treatments, side effect profiles, and any coexisting medical conditions. If you plan to change your medication, consult with your doctor. They will help you determine the medication that works best for you. Some of the most effective alternative medicines to Rizatriptan ODT are as follows:

• Almotriptan
• Eletriptan
• Sumatriptan
• Zolmitriptan
• Memantine
• Maxalt
• OnabotulinumtoxinA
• Ubrogepant

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Rizatriptan ODT Cost & Coupons

The cost of Rizatriptan ODT can be a significant concern for many individuals, especially if health insurance does not provide coverage. To alleviate the financial burden, some turn to alternatives like Polar Bear Meds, which offers Rizatriptan ODT at a lower price when purchased from Canada. For those looking to save even more, using the coupon code WELCOMEPB10 at checkout can provide an additional 10% discount on the first order. This option can make a substantial difference for individuals managing migraine treatments, allowing them to access necessary medication at a more affordable rate without compromising on quality.

Frequently Asked Questions

What is Rizatriptan ODT used for?

Rizatriptan ODT is primarily used to treat acute migraine with/without aura in patients over 18 and children aged six years and older. It is designed to relieve migraine symptoms such as intense headaches, nausea & sensitivity to light and sound. The orally disintegrating tablet (ODT) form allows for quick absorption, providing fast relief from migraine attacks, often within two hours of taking the medication.

Can you swallow ODT Rizatriptan?

Yes, Rizatriptan ODT can be swallowed after it dissolves on your tongue. The tablet is designed to disintegrate in the mouth without the need for water, making it convenient for those who may experience nausea during a migraine attack. Once dissolved, the medication can be swallowed along with your saliva, allowing for rapid absorption and quicker relief from migraine symptoms.

What does Rizatriptan do to the brain?

Rizatriptan works by targeting serotonin receptors in the brain, which helps narrow blood vessels around the brain. This action reduces the release of substances that can trigger migraine symptoms, such as headache, nausea & sensitivity to light and sound. By stabilizing these processes, Rizatriptan effectively alleviates migraine symptoms, providing relief and allowing patients to return to their normal activities.

Will Rizatriptan put me to sleep?

Rizatriptan may cause drowsiness or fatigue as a side effect, but it is not specifically intended to induce sleep. The degree of drowsiness varies from person to person, and while some individuals may feel sleepy after taking Rizatriptan, others may not experience this effect. It’s important to monitor how your body reacts to the medication and avoid activities requiring alertness, such as driving until you know how it affects you.

How long does Rizatriptan ODT take to work?

Rizatriptan ODT typically begins to work within 30 minutes to 2 hours after taking the dose. The orally disintegrating tablet form allows for faster absorption compared to traditional tablets, making it a quick and convenient option for relieving acute migraine symptoms. However, the exact time frame for relief may differ depending on certain factors, such as the severity of your migraine and how quickly the medication is taken after the onset of symptoms.

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