Indacaterol/Glycopyrronium

Ultibro Breezhaler

Ultibro Breezhaler is a prescription inhaler specially formulated to treat COPD patients. This inhaler combines the action of two medications, indacaterol and glycopyrronium. These drugs work simultaneously to improve the symptoms of COPD patients and make breathing easier for them. These medications are available in the form of dry powder capsules with a strength of 110/50 mcg of indacaterol and glycopyrronium per dose and can be inhaled through the Breezhaler device. The inhaler ensures that the medicine is delivered directly to the lungs of the patients. Since Ultibro is FDA-approved, its safety and effectiveness are ensured. However, patients need to consult a medical professional before considering treatment with this medication.    

Product Overview

Ultibro Breezhaler is an FDA-approved medication specifically designed for the long-term management of COPD (chronic obstructive pulmonary disease). The inhaler combines two active ingredients: indacaterol, which is a long-acting bronchodilator, and glycopyrronium, an anticholinergic. This combination of medications works together to improve lung function and ease breathing difficulties. Moreover, Ultibro Breezhaler is a prescription medication inhaler that is trusted by medical experts for its effectiveness in reducing COPD symptoms and flare-ups.

Ultibro Breezhaler is available as a dry powder in a single-use capsule form, with a strength of 110/50 mcg of indacaterol and glycopyrronium per dose. Patients can inhale the medication using their Breezhaler device, ensuring the drug is delivered directly to the lungs for optimal results. It is typically taken twice daily and is suitable for adult patients with COPD. However, proper inhalation technique is essential to effectively use the device.

Besides its healing qualities, the medication has common side effects, such as cough, headache, and sore throat. Patients should consult their healthcare provider if side effects persist or worsen. It is advised to take Ultibro Breezhaler as prescribed, and if you missed a dose, take it as soon as possible, but avoid doubling doses. In case of an overdose, reach out to a medical expert. For prolonged use of the medication, store it in a cool, dry place, away from direct light and moisture, and keep it out of reach of children.

What Are the Uses of Ultibro Breezhaler?

The main uses of this Ultibro Breezhaler are as follows:

• Maintenance Treatment: It helps manage and relieve symptoms of COPD.
• Bronchodilation: The medication used in the breezhaler helps widen the airways, thus making it easier for patients with COPD to breathe.
• Symptom Relief: It aids in relieving the symptoms, including wheezing, coughing, and shortness of breath.
• Prevention of Flare-Ups: The medication prevents exacerbations of COPD symptoms.
• Improved Lung Function: The dual action of indacaterol and glycopyrronium helps enhance overall lung function.

What Are the Forms & Strengths of Ultibro Breezhaler?

Ultibro Breezhaler contains two active ingredients: indacaterol and glycopyrronium. It has the following form and strength:

• Hard Capsules: 110 mcg of indacaterol and 50 mcg of glycopyrronium

What Is the Recommended Dosage for Ultibro Breezhaler?

The dose of Ultibro Breezhaler will be different for each patient. The amount of medicine each individual takes depends on the medicine’s strength. However, certain other factors, including the severity of the condition, the medical problems, and the form of the medicine, also affect the doses of the medication. So, it is important to consult a medical professional before you start taking a particular drug. They will tell you:

• The number of doses you need to take on each day
• The interval between each dose and 
• The duration of the treatment

The following dosage recommendations may not be the same as your dosage schedule. Do not try to change your dosing without consulting a medical expert.

• Adults: Inhale one capsule through your Ultibro Breezhaler once a day unless your healthcare practitioner advises otherwise.
• Children: The use and safety of this medication have not yet been determined. If necessary, ask a medical practitioner for a dosage recommendation.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Ultibro Breezhaler?

• Before jumping to the administration steps, ensure to read the medication guide or PIL (patient information leaflet) thoroughly provided by your healthcare provider. Doing so will give you detailed insights on how to properly use the breezhaler. If you have any questions, visit your doctor.
• Follow the dosing schedule exactly as your medical practitioner prescribes.
• Do not change the doses without consulting your doctor. This can cause a high risk of side effects.
• These capsules are not for oral consumption. They are meant for oral inhalation and should be used only with a special inhaler that comes with the medication. 
• Do not let the medication get in contact with your eyes. It may cause eye irritation, pain, or temporary blurred vision.
• If you are using alternate inhalers, wait at least a minute before using the other inhaler.
• If you are using a quick-relief inhaler on a daily basis like albuterol, stop using it and only use the quick-relief inhaler when needed for sudden attacks.

To use the inhaler:

• Ensure that your hands are dry before using this machine.
• Take out the capsules only when you are ready to use them.
• Avoid pushing the capsules through the foil to remove them from the packet.
• Now, open the inhaler base and tilt the mouthpiece to open it.
• Place the capsule in its chamber.
• Once the capsule is in its position, close the inhaler. You will hear a clicking sound, which means the capsule is in the right place.
• Now, hold the mouthpiece parallel to your lips. Press both buttons at the same time, only once. You will hear a clicking sound as the capsule is being pierced.
• Exhale completely. Avoid breathing into the mouthpiece directly.
• Place the mouthpiece between your lips and inhale deeply. 
• While breathing, you should hear the capsule moving inside. You may also feel a sweet taste.
• If you hear a whirring sound, the capsule is stuck. Open the inhaler and gently tap the inhaler base. 
• Once you have finished inhaling, remove the device from your mouth and hold your breath for at least 5-10 seconds or as long as you are comfortable.
• Remove the empty capsule from the inhaler and dispose of it properly.
• Clean the device and replace the cover.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Ultibro Breezhaler Work?

Ultibro Breezhaler is a combination inhaler containing two active ingredients: indacaterol and glycopyrronium. It is used to manage COPD symptoms, including emphysema and chronic bronchitis. Indacaterol is a long-acting bronchodilator that loosens the muscles in the airways, and glycopyrronium is an anticholinergic that helps in reducing airway constriction. That’s why doctors recommend using Ultibro Breezhaler, as when you inhale the medication, the dual action of these drugs opens the airways, making breathing easier and reducing COPD symptoms, such as wheezing and breathing. The inhaler ensures that the medication is delivered directly to the lungs, providing quick and instant relief. You can use the device twice daily to maintain better lung functioning.

Important Safety Information for Using Ultibro Breezhaler

What Are the Side Effects of Ultibro Breezhaler?

Common Side Effects of Ultibro Breezhaler: The breezhaler contains two medications that can cause various side effects if not used properly. While these effects are usually temporary, lasting from a few days to weeks, they can become severe if overlooked. So, if you notice any of the following reactions getting intense or persisting for more than the mentioned period, contact a medical practitioner. Common side effects of Ultibro Breezhaler may include:

• Runny nose
• Sore throat
• Back pain
• Cough
• Headache
• Fever
• Cavities
• Upset stomach
• Indigestion
• Muscle pain or joint pain
• Nose bleeds
• Muscle spasms
• Dry mouth
• Nausea
• Vomiting
• Difficulty sleeping
• Pain in extremities, like arms or legs
• Tiredness
• Decreased skin sensitivity
• Voice alteration or hoarseness

Serious Side Effects of Ultibro Breezhaler: Besides the above common side effects, indacaterol and glycopyrronium can cause several adverse reactions that can cause life-threatening situations. If you notice any unusual signs that seem concerning, talk to a medical provider. Serious side effects of Ultibro Breezhaler may include:          

• Allergic reactions. Its signs are:
  • Itching or hives
  • Swelling on the face, tongue, or lips
  • Skin rash
• Breathing problems
• Vision changes
• Eye pain
• Muscle cramps
• Muscle pain
• Nervousness
• Difficulty passing urine
• Change in the amount of urine
• Sudden change in heartbeat or heart rhythm. Its symptoms are:
  • Chest pain
  • Dizziness
  • Fast heartbeats
  • Palpitations
  • Fainting
  • Lightheadedness
  • Breathing problems
• High blood sugar. Its signs are:
  • Dry mouth
  • Dry skin
  • Fruity breath
  • Nausea
  • Stomach pain
  • Feeling hungry or thirsty
• Tremor 
• Increased eye pressure
• Upper respiratory tract infection. Its symptoms are:
  • Blocked nose
  • Sneezing
  • Cough
  • Headache with or without fever

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Ultibro Breezhaler? 

Not every medication is suitable for each individual. Similarly, Ultibro Breezhaler is not an ideal treatment option for every patient with COPD. This is because each patient has different medical problems and allergies. What is beneficial for one person is not suitable for another. So, there are several warnings that patients need to be mindful of if they are considering treatment with Ultibro Breezhaler:

• Deterioration of Disease and Acute Episodes: This medication should not be used by patients who have acute episodes or exacerbation of COPD symptoms. It is important to note that this device is unsuitable for relieving sudden symptoms like severe breath shortness. To get quick relief, use a short-acting inhaler instead of Ultibro Breezhaler. So, if you want relief from sudden COPD attacks, talk to a medical professional. Do not use any inhaler as it can worsen the condition.
• Use with Other LABA and LAMA Products: Ultibro Breezhaler should not be used at higher doses than the prescribed dosage. Additionally, avoid using this product in combination with other long-acting beta-adrenergic agonists or long-acting muscarinic antagonists. 
• Excessive Use: Do not overuse Ultibro Breezhaler, as it can cause serious cardiovascular effects, even leading to death. 
• Diabetes: This medication can raise blood sugar levels or may affect glucose tolerance. People with diabetes should consult a healthcare practitioner before using Ultibro Breezhaler and discuss how the medication can affect the dosing and effectiveness of this medication. 
• Glaucoma: Glycopyrronium, one of the active ingredients of Ultibro Breezhaler, may worsen the symptoms of glaucoma. If you have this condition, talk to a medical practitioner and ask them how their medical condition may affect the dosing of the medication and if any special monitoring is required.

What Are the FDA Boxed Warning for Ultibro Breezhaler?

Black box warnings, also known as boxed warnings, are among the strictest warnings issued by the FDA for a particular product or medication. These warnings usually alert doctors and patients about the harmful effects of a drug, which can be fatal in some situations. Ultibro Breezhaler, containing indacaterol and glycopyrronium, has the following FDA warning:

• Asthma-related Death: It has been observed that long-acting beta2-adrenergic agonists or LABA can increase the risk of asthma-related deaths. According to a large study in the US, patients using LABA (salmeterol) have more deaths associated with asthma than those using a placebo. Therefore, the experts believed that all LABAs, including indacaterol maleate, used in Ultibro Breezhaler may cause such deaths. Therefore, Ultibro Breezhaler is only approved for treating COPD. Its safety and effectiveness for asthma patients have not been determined, so patients should avoid using this device for asthma.

What Are the Ultibro Breezhaler Precautions?

When considering treatment with an Ultibro Breezhaler, patients should discuss every risk and benefit with their medical practitioner. Here are some of the precautions that you can take before using Ultibro Breezhaler to treat COPD:

• Before using this medication, tell your medical provider if you have any allergies or are allergic to any active ingredients (indacaterol and glycopyrrolate). The product may also contain certain inactive components such as milk proteins, which can cause severe allergic reactions. 
• When considering using Ultibro Breezhaler, tell your doctor about your or your family’s medical history, especially of: 
  • High blood pressure
  • Heart problems
  • Seizures
  • Overactive thyroid
  • Diabetes
  • Glaucoma
  • Difficulty urinating
  • Kidney disease
• If you are undergoing surgery or any medical procedure, inform your surgeon or doctor about the products you use. This includes all prescription drugs, nonprescription medications, and herbal products.
• Indacaterol and glycopyrrolate may cause dizziness or blurred vision. So, if you are thinking of driving or operating a heavy machine that requires alertness after using your inhaler, don’t do it, as it is not safe or may cause accidental injuries.
• If you use multiple inhalers, you should know which one you should use regularly or which one you should use for sudden attacks. 
• Use the medication regularly to get the most benefit out of it.
• If you are using your medication more than the prescribed dosage, your condition may be worsening. In such a situation, take immediate action and visit a doctor.
• Glycopyrronium and indacaterol can alter your heart’s normal rate and rhythm, known as QT prolongation. This serious condition can cause seizures, fainting, and even death. If you have this condition, are at risk for heart problems, or are taking medicines that can cause heart rhythm problems, talk to your doctor.  
• An impaired kidney may result in medication buildup in the body, causing severe side effects. So, patients with reduced kidney function should consult a medical professional on the safety and effectiveness of the medication on their medical condition.
• The medication may reduce your potassium levels. While it is a rare side effect, visit your doctor frequently. They will monitor your potassium levels during your treatment with Ultibro Breezhaler.
• People with a history of seizures may experience seizures more often after using this medication. If you have this condition, discuss it with your healthcare provider and ask them how the medication may impact your medical condition and if you require any special monitoring.
• Patients with an overactive thyroid gland (hyperthyroidism) are more sensitive to the effects of indacaterol. If you have this medical condition, consult a medical professional. Discuss every risk and benefit associated with it.
• It is unknown whether the medication used in Ultibro Breezhaler may pass into the breast milk. If you are a nursing mother, talk to a medical practitioner; they will tell you if it is safe to breastfeed your child during treatment with this medication.
• This medication should only be used during pregnancy when needed. If you are pregnant or planning to have a baby, talk to a medical professional and discuss every associated risk and benefit.

What Are the Contraindications of Ultibro Breezhaler? 

It is contraindicated in patients with:

• Hypersensitivity reactions to indacaterol maleate, glycopyrronium, or any of the ingredients present in the formulation of the medication.
• Allergic reactions to lactose or milk proteins.
• Conditions like asthma.

What If You Missed a Dose of Ultibro Breezhaler?

Patients are usually advised not to miss their doses of any medication, and when it comes to controlling symptoms of COPD, taking medication on time becomes more important. However, if somehow you forget to use your Ultibro Breezhaler:

• Take your medication at the same time every day to get the most benefit from it.
• Take the missed dose as soon as possible unless your doctor advises otherwise.
• Call your doctor for specific instructions on what to do next.
• Remember not to take double doses to make up for the missed one. 
• If it is almost time for the next dose, you may omit the missed dose and continue your regular dosing schedule.
• Use medication apps or set phone reminders to avoid missing doses.
• Make sure to get your prescription refilled before you run out of medicine. This will ensure that you do not miss any doses.
• If you have any questions or concerns about it, ask your medical practitioner. They will suggest alternate options that suit your body’s needs.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Ultibro Breezhaler?

It is important for patients to understand the complications of overdose. Exceeding the prescribed dosage of any medication can cause various life-threatening situations. If you have mistakenly overdosed on Ultibro Breezhaler, look for unusual signs like:

• High blood pressure
• Increased heart rate
• Headache
• Nause
• Vomiting
• Drowsiness
• Visual disturbances
• Constipation
• Difficulty urinating

If you notice any such overdose symptoms, visit the nearest clinic or get immediate medical assistance by calling 911.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store an Ultibro Breezhaler?

• Store Ultibro Breezhaler at room temperature within 15-25°C.
• Do not keep it above the mentioned temperature.
• Protect it from moisture or direct sunlight.
• Keep the product somewhere safe, away from reach, and out of sight for children and pets.
• Avoid keeping it in moist or damp places like the bathroom or near the sink.
• Store the capsules in their original packaging to protect them from any moisture.
• When you are using a new medication package, discard the old device and use the one that comes with the new packaging.
• Do not flush the medication down the toilet.
• Do not use the product if it is damaged or tampered with. Replace it and get a new one from your pharmacist.
• Do not use a medication if its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• Ask a medical professional how to dispose of the product properly without damaging the environment.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Ultibro Breezhaler?

Drug interactions occur when one or more medications are taken simultaneously. These interactions can either raise the risk of developing side effects in certain patients or affect the functioning of one of the drugs. Either way, it results in adverse reactions. Therefore, patients need to be aware of the drugs that may interact with their Ultibro Breezhaler medication. Below are some of the drugs that can interact with Ultibro Breezhaler (indacaterol and glycopyrronium): 

• Anti-depressants Medications 
  • Monoamine oxidase inhibitors
  • Tricyclic anti-depressants
• Other Long-Acting Beta Agonists (LABA)
  • Formoterol
  • Indacaterol
  • Vilanterol
  • Salmeterol
  • Olodaterol
• Other Long-Acting Muscarinic Antagonists (LAMA) 
  • Ipratropium
  • Tiotropium
  • Glycopyrronium
  • Aclidinium
  • Umeclidinium
• Other Drugs
  • Hydrochlorothiazide
  • Methylxanthines
  • Theophylline
  • Prednisolone
  • Propranolol
  • Timolol
  • Ketoconazole
  • Ritonavir
  • Erythromycin
  • Verapamil

[Note: This isn’t a complete list, and there could be other drugs that interact with Ultibro Breezhaler. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Ultibro Breezhaler Alternatives?

People usually take alternative drugs for many reasons. In some cases, the prescribed medication may not be an ideal option for them due to their medical conditions. On the other hand, they may not achieve the results they are aiming for. Therefore, you should talk to a medical professional before you start a particular treatment or if you want to change your medication. They may help you decide which medication is best suited for you. Some of the alternatives of Ultibro Breezhaler (indacaterol and glycopyrronium) are as follows:

• Advair
• Breo Ellipta
• Trelegy Ellipta
• Dulera
• Pulmicort
• Serevent
• Alvesco
• Aerobid
• Symbicort
• Brovana
• Spiriva
• Atrovent HFA

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Ultibro Breezhaler Cost & Coupons

Generally, the cost of Ultibro Breezhaler is not the same in every region. The actual cost of these inhalers can be influenced by different factors, including the location, insurance coverage, and the pharmacies you use. Ultibro Breezhaler, with its healing qualities, can be expensive for certain patients. Here, insurance coverage plays a significant role. You can buy your medication at affordable rates with an insurance coverage plan. However, not all drugs/medications are covered under the insurance plan. If you are residing in America and searching for affordable pharmacies to manage your medication’s cost, reach out to Polar Bear Meds. Here, you can buy Ultibro Breezhaler online from Canada in the USA at discounted rates. Moreover, first-time buyers can use the Ultibro Breezhaler coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

Is Ultibro Breezhaler a bronchodilator?

Yes, Ultibro Breezhaler is a bronchodilator. It is a combination of two active ingredients: indacaterol and glycopyrronium. These drugs work by relaxing the muscles in the airways, thus making breathing easier for the patients. Indacaterol is a long-acting beta2-agonist (LABA), and glycopyrronium is a long-acting muscarinic antagonist (LAMA). Together, they help open the airways, reducing symptoms like breathlessness in patients with chronic obstructive pulmonary disease (COPD).

Can I use Ultibro Breezhaler twice daily?

The recommended dosage for using this breezhaler is usually once a day. The inhaler contains long-acting components that provide 24-hour relief from symptoms. So, using it more than once a day is not recommended. If you overuse the device, you are increasing the of side effects and complications. Therefore, always follow your healthcare provider’s instructions for proper dosing and consult them if you have any concerns.

When is the best time to use Ultibro Breezhaler?

There are no specific timings for using Ultibro Breezhaler. You just need to use the device at the same time each day, preferably in the morning, unless your doctor advises otherwise. Consistency in timing ensures that the medication maintains its effectiveness throughout the day, helping to manage symptoms of COPD. However, taking it in the morning may help you to check how your body is responding to the medication throughout the day. It is essential to follow your medical provider’s specific instructions for the best results.

How long does the effect of Ultibro Breezhaler last?

Ultibro Breezhaler lasts for over 24 hours as it contains long-acting bronchodilators that provide constant relief from COPD symptoms, including wheezing and breathlessness. Its prolonged duration of action helps patients manage their condition effectively with a single dose each day. 

Is Ultibro Breezhaler good for asthma?

Ultibro Breezhaler is not typically prescribed for asthma. It is specially designed for treating COPD, which includes chronic bronchitis and emphysema. Although it is a bronchodilator, its specific combination of active ingredients is beneficial for managing COPD rather than asthma. Asthma treatment often requires different medications and management strategies. If you have asthma, consult your healthcare provider for the most appropriate treatment options.

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