Orilissa

Orilissa is a prescription medication used for managing moderate-to-severe pain associated with endometriosis. It works by reducing estrogen levels, which can help alleviate symptoms such as painful periods, pelvic pain, and pain during sex. The typical dosage starts at 150 mg once daily, with adjustments for specific conditions and coexisting issues like dyspareunia or hepatic impairment. People can buy Orilissa 150 mg tablet from a trusted pharmacy but consult a medical expert, as it can cause various side effects like bone density loss, mood changes, and liver damage. It is not recommended during pregnancy and requires careful consideration of birth control methods while in use. Always consult a healthcare provider for personalized advice and treatment plans.

Orilissa (elagolix) is a medication specifically designed for women suffering from endometriosis, a condition characterized by the growth of endometrial tissue outside the uterus, causing pain and discomfort. The main ingredient, elagolix, acts as a gonadotropin-releasing hormone (GnRH) receptor antagonist, reducing the production of estrogen, a hormone that can exacerbate endometriosis symptoms. Orilissa is used to manage moderate-to-severe pain associated with endometriosis, including painful periods, pelvic pain between periods, and pain during sexual intercourse. It works by targeting the hormonal imbalance that contributes to the condition, providing relief from the discomfort and pain caused by endometriosis.

Orilissa is available in two strengths: 150 and 200 mg. The recommended dosage varies depending on the severity of the symptoms and the presence of coexisting conditions. For moderate-to-severe endometriosis pain, the starting dose is typically 150 mg once daily for up to 24 months. In cases of dyspareunia, a higher dose of 200 mg twice daily for up to 6 months may be considered. It’s important to note that Orilissa can be taken with or without food, and the tablets should be swallowed whole.

While Orilissa can be effective in managing endometriosis symptoms, it may also cause side effects such as bone density loss, changes in mood and menstrual bleeding, liver damage, and interactions with hormonal birth control. Patients with a history of osteoporosis, liver problems, or mental/mood disorders should exercise caution when using this medication. It is contraindicated in pregnant women and those with severe liver impairment. To minimize risks, patients should follow their healthcare provider’s instructions, use non-hormonal birth control methods during treatment, and store Orilissa tablets at a temperature range of 36°F to 86°F (2°C to 30°C) away from damp or wet areas.

This medication helps patients with various problems, including:

• Painful periods (endometriosis)
• Pelvic pain in between periods
• Pain with sex

Forms & Strengths of Orilissa?

It comes in the form of an oral tablet and has 2 strengths:

• 150 milligrams (mg)
• 200 mg

What Is the Recommended Dosage for Orilissa?

Every medication has a specific dosage recommendation that is usually decided by medical experts. Generally, these professionals prescribe a loading dose to see the medication’s effect and gradually adjust the dosage as per your response to the treatment. So, if you have a different dosage recommendation, do not change it without consulting your doctor. Doing so may cause adverse reactions. Here are some general recommendations for different patients:

Endometriosis Management: For moderate-to-severe pain, start with 150 mg orally once daily for up to 24 months.

Coexisting Conditions:

• For dyspareunia, take Orilissa 200 mg tablet twice daily for up to 6 months.
• For moderate hepatic impairment (Child-Pugh B), start with 150 mg once daily for up to 6 months. The 200 mg twice daily dosage is not recommended.

Dosage Modifications:

• • Renal Impairment: No adjustment is needed for any degree of renal impairment or end-stage renal disease (including dialysis).
• Hepatic Impairment:
• • Mild (Child-Pugh A): No dosage adjustment is required.
  • Moderate (Child-Pugh B): Only the 150-mg once-daily regimen is recommended, limited to 6 months.
  • Severe (Child-Pugh C): Contraindicated.

Dosing Considerations:

• Confirm that the patient is not pregnant before starting or begins elagolix within 7 days from the start of menstruation.
• Use the lowest effective dose based on the severity of symptoms and treatment goals.
• Limit the duration of use due to the risk of bone loss.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

• Before you consider using Orilissa 150 mg tablet, read the medication guide carefully for detailed administration steps.
• Take Orilissa exactly as prescribed by your healthcare provider.
• The usual dosage is one tablet taken orally once or twice daily, depending on your specific condition and treatment plan.
• Orilissa can be taken with or without food. Choose a consistent time of day to take your dose to help you remember.
• Swallow the tablet whole with a glass of water.
• Do not crush, chew, split, or break the tablet, as it may release the drug at once.
• If you are unable to swallow the medication, consult a medical professional. They will suggest alternate options suiting your needs.
• Keep regular appointments with your doctor to monitor your progress and make any necessary adjustments to your treatment.
• Do not stop taking Orilissa without consulting your healthcare provider, as it may worsen your condition.
• If your condition worsens or does not improve, talk to your medical practitioner.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

Orilissa (elagolix) works by reducing the production of estrogen, a hormone that can contribute to the development of endometriosis symptoms. It acts as a gonadotropin-releasing hormone (GnRH) receptor antagonist, which helps to decrease the levels of estrogen and alleviate symptoms such as pelvic pain associated with endometriosis. By targeting the hormonal imbalance, Orilissa can provide relief from the discomfort and pain caused by this condition.

Common Side Effects of Orilissa: This medication can cause various side effects that may appear at the initial stage of the treatment. These reactions are generally temporary and last for a few days to weeks. However, if these side effects stay for a longer period of time or get intense, do not overlook this situation and reach out to your doctor. Common side effects of elagolix 150 mg tablet may include:

• Night Sweats: Orilissa helps reduce estrogen levels to manage endometriosis pain, thus causing night sweats. If you experience night sweats during your treatment with this medication, consult a medical professional.
• Hot Flashes: These are indicated by excessive heat around the neck, chest, head, and upper back. It is one of the most common side effects of Orilissa. If you take a high dose, you are more likely to experience hot flashes.
• Headache: Orilissa 200 mg dosing helps lower estrogen levels, affecting how your brain and blood vessels works. This can lead to headaches in some patients. Headaches can range from minor to severe, which disappear in a few days. However, if it continues, talk to your doctor. 
• Nausea: It is an unsettled feeling of vomiting that you feel in the stomach. People often confuse nausea with vomiting, which is not the same. Vomiting is when you actually throw up. So, when you take Orilissa 150 mg tablet, you may experience nausea.
• Insomnia: It is a sleeping disorder in which you face trouble sleeping or staying asleep. In such a disorder, you will not get quality sleep and often wake up too early. If you are experiencing major sleep problems, consult your doctor before using this medication.
• Joint Pain: Orilissa may affect your joint and bone health due to changes in hormonal levels. This can cause joint pain in certain patients. 
• Diarrhea: Loose or watery stools occurring more than usual are indicated as diarrhea. There are many reasons for this side effect and one of the common reasons is that it affects hormone levels. Its signs may include belly cramps, bloating, loss of appetite, and mucus in the blood.
• Menstrual Changes: Orilissa aids in lowering estrogen levels. This estrogen reduction impacts the menstrual cycle, leading to a temporary stop in periods. However, after some time, you will get your period like usual, but consult a medical expert if it does not happen.
• Weight Gain: Although rare, this medication can also cause weight gain, as it alters hormone levels. Due to this, your metabolism and appetite can be affected, resulting in weight gain. If you notice any significant weight changes, talk to a doctor. 

Serious Side Effects of Orilissa: Other than the basic side effects, Orilissa also has some adverse reactions, which, if left untreated, can become life-threatening. So, if you suspect any unusual signs that seem concerning, talk to your healthcare practitioner. Serious side effects of Orilissa may include:

• Bone Density Loss: Orilissa makes your estrogen levels low, leading to reduced bone mineral density. If you already have such a condition or you developed it during your treatment, consult a medical expert. Overlooking this factor can lead to bone fractures.
• Mood Changes: This medication can also cause mood changes and depression. If you are noticing symptoms like anxiety and suicidal thoughts, reach out to your practitioner right away.
• Liver Problems: Orilissa can cause liver problems by raising liver enzymes. As a result, you may experience symptoms like fatigue and stomach pain. 
• Changes in Menstrual Bleeding: Orilissa lower estrogen levels, leading to changes in menstrual bleeding. These changes may include lighter or shorter periods, amenorrhea (complete stop in menstruation), and irregular bleeding.
• Allergic Reactions: The medication contains certain ingredients that can cause allergic reactions. If you have any allergies, discuss it with your doctor.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Yes, Orilissa has some warnings that can cause life-threatening situations if left untreated. So, when considering treatment with Orilissa 200 mg tablet, consult a medical professional. Here are some of its warnings:

• Bone Loss: Risk increases with a history of osteoporosis or higher doses of Orilissa. May cause irreversible bone loss. Use may be limited to 6 or 24 months to reduce the risk. Consider calcium and vitamin D supplements during treatment.
• Changes in Menstrual Bleeding: Orilissa can alter bleeding patterns during periods. May require pregnancy tests before and during treatment. Monitor for other pregnancy signs and stop Orilissa if pregnancy is suspected.
• Suicidal Thoughts and Mood Changes: Higher risk for those with a history of depression or suicidal behavior. Monitor for new or worsening mood changes and suicidal thoughts. Consult your healthcare provider if you notice unusual mood or behavior changes.
• Liver Damage: Increased risk with higher doses or existing liver problems. Regular lab monitoring is recommended. Seek immediate medical help if symptoms of liver problems occur.
• Interactions with Hormonal Birth Control: Orilissa may reduce the effectiveness of birth control containing estrogen. Hormonal birth control might also reduce Orilissa’s effectiveness. Discuss alternative birth control options with your provider while taking Orilissa.

What Are the FDA Boxed Warning for Orilissa?

Boxed warnings are among the strict guidelines issued by the FDA for a particular drug. These guidelines alert the patients and doctors about the harmful effects of the medication, which are life-threatening. However, Orilissa does not have any boxed warnings, meaning it is safe to use as long as you are following your doctor’s precautions.

Orilissa’s effects differ for each patient due to their varying medical conditions. This makes it important for people to discuss their health problems with a medical professional to avoid any potential risks. They will suggest a few precautionary steps that will help you get the most benefit out of your medication. These precautions are as follows:

• Inform your doctor or pharmacist if you are allergic to elagolix or have any other allergies, as this medication may contain inactive ingredients that could cause allergic reactions.
• Disclose your medical history to your healthcare provider, particularly if you have liver problems, bone loss (osteoporosis), or mental/mood disorders like depression.
• Before undergoing surgery, notify your doctor or dentist about all the medications you’re taking, including prescription and over-the-counter drugs, as well as herbal products.
• Do not use elagolix during pregnancy, as it may harm the unborn baby. Discuss reliable non-hormonal birth control methods, such as condoms or spermicide, to use while on this medication and for 4 weeks after stopping treatment. Due to the impact of elagolix on menstruation, it may be challenging to detect pregnancy. Inform your doctor immediately if you suspect you are pregnant.
• The safety of elagolix during breastfeeding is uncertain. Consult your doctor before breastfeeding while taking this medication.
• When considering using Orilissa 200 mg tablet, ensure you visit your doctor frequently. Check your blood-urine progress reports regularly and share them with a medical professional to avoid unwanted effects.
• Avoid using Orilissa in combination with cyclosporine or gemfibrozil, as this co-administration may increase the risk of side effects.
• This medication can lead to osteoporosis (weakened bones). If you notice back pain, restrained height growth, or pain in your arms, ribs, or legs, take immediate action and talk to a medical professional.
• Orilissa may alter your menstrual cycle, making it hard for females to recognize a pregnancy. If you have any concerns related to this, consult your medical practitioner.
• If you are experiencing suicidal thoughts, nervousness, anger issues, or restlessness, get immediate medical assistance.
• This medicine may cause liver problems in certain patients. If you notice symptoms like pain in the upper stomach, not feeling hungry, nausea, dark urine, jaundice, vomiting, or pale stools, talk to your doctor right away.

Orilissa should not be used in patients who:

• Are pregnant
• Have osteoporosis
• Have a severe liver impairment
• Are taking strong inhibitors of the organic anion transporting polypeptide (OATP) 1B1, such as cyclosporine and gemfibrozil

Generally, patients are recommended to take their doses regularly at the same time for best results. However, there are times when you forget to take the tablets. In such cases, you can follow the below points:

• If you remember the missed dose later in the day, go ahead and take it.
• If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take two doses at the same time.
• Use medication apps or set phone reminders to avoid missing doses.
• If you are unsure, talk to your doctor. They will suggest alternatives or may adjust your Orilissa 200 mg dosing schedule as needed.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Overdosing any medication can lead to serious side effects. Similarly, if you take an exceeding amount of Orilissa, you may experience several overdose symptoms, causing life-threatening situations. Some of the overdose symptoms are:

• Hot flashes
• Anxiety
• Dizziness
• Headache
• Irritability
• Nausea

Moreover, if you have discontinued Orilissa medication and no longer need it, it’s crucial to dispose of it properly. Safe disposal prevents accidental ingestion by children or pets and avoids environmental harm.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

The shelf life of a medication can vary based on various factors, including storage conditions. Here are the basic storage requirements that you must know to maintain the effectiveness of this medication:

• Orilissa tablets should be stored in a refrigerator at a temperature range of 36°F to 86°F (2°C to 30°C).
• Protect the medication from heat, moisture, and light.
• Avoid storing Orilissa in damp or wet areas, such as bathrooms, to maintain its effectiveness.
• Do not flush the medication down the toilet.
• Keep it away from the reach and sight of children.
• Avoid storing the medication under direct sunlight.
• Do not use the medication once its expiration date has passed. The expiration date is the last day of the month mentioned on the back of the prescription label or carton.
• You should dispose of the medications in such a way that children and animals cannot consume them, as it may cause accidental overdose and death if someone else consumes them.
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.
• You can ask your healthcare practitioner or pharmacist how to discard the product properly without harming the environment.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Although it is recommended not to combine two medications together due to potential interactions, sometimes your doctor may advise you to co-administer more than two medicines together. If they do, they may adjust the dosage and suggest precautions to avoid risks in the future. However, it is important to note that you are taking two medicines together under the supervision of your medical professional. Besides, there are certain drugs that you must avoid taking with Orilissa, as they may either increase the risk of serious side effects or impact the effectiveness of the medications. These drugs are:

• Hormonal Contraceptives: Co-administering Oriliisia 150 mg tablet with other estrogen-containing contraceptive medications may reduce the effectiveness of Orilissa. Some of the examples of estrogen contraceptive pills are:
  • Angeliq
  • Natazia
  • Vestura
  • Yaz
  • Nortrel
• Drugs Affecting Orilissa: Many drugs may alter the working of Orilissa or affect how your body breaks down the medicine. These drugs may either raise the chances of experiencing side effects or increase the Orilissa buildup in the body. These drugs may include: 
  • Biaxin
  • Neoral
  • Lopid
  • Ketoconazole
• Some of the other drugs that can interact with Orilissa may include:
  • Lupron Depot (leuprolide acetate)
  • Zoladex (goserelin acetate)
  • Synarel (nafarelin acetate)
  • Danocrine (danazol)
  • Visanne (dienogest)
  • Aygestin (norethindrone acetate)

What Are the Other Orilissa Interactions?

Besides the drugs mentioned above, the elagolix 150 mg tablet can interact with several other herbs, supplements, medical conditions, or any lifestyle change. These interactions are as follows:

• St. John’s Wort: Taking this herb with Orilissa may lower the drug’s levels in the body, making it less effective.
• Foods: Consumption of foods like grapefruit or beverages like grapefruit juice in combination with Orilissa may raise the drug’s level in the body, increasing the risk of adverse side effects.
• Alcohol: While there is no specific data on alcohol interaction, it is possible that consuming alcohol during your treatment with Orilissa may exacerbate some side effects of this medication. This may include mood changes, hot flashes, headaches, and nausea.
• Medical Conditions: Certain health problems may also affect the medication’s effects on the body. Patients with the following conditions should talk to their doctors to avoid any serious interactions:
  • Osteoporosis
  • Mental problems, including suicidal thoughts or depression
  • Liver diseases

[Note: This isn’t a complete list, and there could be other drugs that interact with Orilissa. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Drug alternatives offer patients a convenient option to use the medication suitable for their body needs. If you cannot take Orilissa due to medical problems or are not achieving the desired results, you can take substitutes for Orilissa. However, ensure you consult a medical professional before using any alternatives. Some of its alternatives are:

• Lupron Depot (leuprolide acetate)
• Zoladex (goserelin acetate)
• Synarel (nafarelin acetate)
• Danocrine (danazol)
• Aygestin (norethindrone acetate)
• Visanne (dienogest)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

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