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Xarelto

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Product Details

What Is the Drug Xarelto Used For?

What Is the Drug Xarelto Used For?

Xarelto (rivaroxaban) is a prescription blood thinner (anticoagulant) approved by the FDA for preventing and treating blood clots.

Xarelto FDA-approved uses include:

  • Prevents stroke and blood clots in AFib (atrial fibrillation), which is not caused by a heart valve problem.
  • Treats deep vein thrombosis (DVT) and pulmonary embolism (PE).
  • Lowers the risk of recurrent DVT and PE after treatment.
  • Prevents blood clots after hip or knee replacement surgery.
  • Reduces risk of major cardiovascular events (cardiovascular death, stroke) in people with (CAD) coronary artery disease or PAD (peripheral artery disease) when used with aspirin.

Because Xarelto affects clotting, it must be taken exactly as directed and monitored carefully by a healthcare provider.

Quick Fact About Xarelto

Brand NameXarelto
Generic NameRivaroxaban
Prescription RequiredYes
Drug ClassAnticoagulant (Factor Xa inhibitor)
FDA Approval Year2011 (initial approval)
Dosage FormsFilm-coated oral tablets
Available Strengths2.5 mg, 10 mg, 15 mg, 20 mg tablets
FDA-Approved UsesPrevent stroke & blood clots in atrial fibrillation (AF/AFib, non-valvular)
Treat deep vein thrombosis (DVT)
Treat pulmonary embolism (PE)
Reduce risk of recurrent DVT & PE after initial treatment
Prevent blood clots after hip or knee replacement surgery
Reduce risk of major cardiovascular events (heart attack, stroke, death) in chronic coronary artery disease (CAD) or peripheral artery disease (PAD)
StorageStore at controlled room temperature (20°C–25°C / 68°F–77°F), away from moisture and heat

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Uses and Benefits

Uses and Benefits

Xarelto is a medicine prescribed for:

  • Reducing the chance of stroke and blood clots in adults with a condition called atrial fibrillation, which is not related to a heart valve issue. In atrial fibrillation, a part of the heart does not beat correctly, leading to blood clots that can cause a stroke or travel to other body parts.
  • Treating blood clots in the legs (known as deep vein thrombosis, or DVT) or in the lungs (called pulmonary embolism, or PE).
  • Lowering the risk of blood clots forming again in adults who are still at risk for DVT or PE after having been treated for blood clots for at least six months.
  • Helping to prevent blood clots in the legs and lungs in adults who have recently undergone hip or knee replacement surgery.
  • Assisting in preventing blood clots in certain adults who are hospitalized for a severe illness and after they leave the hospital. This is for those who are at risk of blood clots due to being less mobile (able to move around) and other clot risks and who do not have a high risk of bleeding.

Xarelto, when taken with a low dose of Aspirin, is used to:

  • Lower the chance of severe heart issues, heart attacks, and strokes in adults who have coronary artery disease (a situation where the blood supply in the heart is reduced or blocked).
  • Decrease the risk of a sudden reduction in major amputation, serious heart issues, blood flow to the legs, or strokes in adults with peripheral artery disease (a situation where the blood flow to the legs is reduced). This also includes adults who have recently undergone a procedure to enhance blood flow to their legs.

Xarelto is for children from newborns up to 17 years old. It is used to:

  • Treat or lower the chance of blood clots forming again in children. This is after they have already been treated with medicine given by injection or through an IV for at least five days.
  • Prevent blood clots in children aged two years and older who have heart disease they were born with following a heart surgery known as the Fontan procedure.

Xarelto has not been researched and is not advised for use in infants younger than six months if they:

  • Were born before reaching 37 weeks of pregnancy (before the gestation period),
  • Have been eating by mouth for less than ten days or
  • Their body weight is less than 5.7 pounds (2.6 kg).
Xarelto Dosage Guidelines

Xarelto Dosage Guidelines

Xarelto doses differ depending on the condition being treated. Always follow the exact dosing instructions provided by your provider.

IndicationDosageAdministration Notes
IndicationAtrial fibrillation (non-valvular)20 mg once daily with evening meal (15 mg once daily with evening meal if CrCl 15–50 mL/min)Take at the same time each day; food improves absorption
IndicationTreatment of DVT/PE (initial)15 mg twice daily for 21 daysAfter 21 days, switch to 20 mg once daily with food
IndicationPrevention of recurrent DVT/PEAfter initial treatment, continue 20 mg once dailyTake with food
IndicationPost-hip or knee replacement surgery (VTE prophylaxis)10 mg once dailyDuration: 12 days (knee) or 35 days (hip)
IndicationCAD/PAD (with aspirin)2.5 mg twice daily + aspirin (75–100 mg once daily)Combination therapy reduces the risk of major cardiovascular events

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How to Take Xarelto Tablets

How to Take Xarelto Tablets

  • Take Xarelto exactly as prescribed. Do not change your dose without your doctor’s approval.
  • Doses of 15 mg & 20 mg must be taken with food to ensure proper absorption.
  • Xarelto 10 mg and 2.5 mg can be taken with or without food.
  • Swallow tablets whole with water; do not break or chew.
  • Tablets may be crushed and mixed with applesauce if swallowing is difficult, as directed by a healthcare professional.
  • Try to take it at the same time each day to maintain steady blood levels.
How Xarelto Works (Mechanism of Action)

How Xarelto Works (Mechanism of Action)

Xarelto (rivaroxaban) works by blocking Factor Xa, an important protein in the blood-clotting process. By inhibiting this factor, Xarelto reduces the body’s ability to form clots. This targeted action helps prevent dangerous blood clots while allowing normal healing in most cases or as directed by the provider.

Possible Xarelto Side Effects

Possible Xarelto Side Effects

Common Side EffectsSerious Side EffectsRare Side Effects
NosebleedsMajor bleeding (gastrointestinal, intracranial)Liver problems (yellowing of skin/eyes, dark urine)
Easy bruisingBlood in urine or stoolSevere skin reactions (Stevens-Johnson syndrome)
HeadacheCoughing or vomiting bloodLoss of bladder or bowel control (linked to spinal/epidural hematoma)
DizzinessSpinal/epidural hematoma (numbness, weakness, paralysis)
Stomach upset (nausea, indigestion, abdominal pain)Severe allergic reactions (rash, swelling, difficulty breathing)
Back pain, muscle painProlonged bleeding after injury or surgery

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How Long Should I Take Xarelto?

ConditionLength of Treatment
Prevent DVT after knee replacement surgery12 days
To prevent DVT after hip replacement surgery35 days
To treat DVT or PE (initial treatment)At least 3 months (longer if risk factors persist)

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FDA Xarelto Warning

FDA Xarelto Warning

Xarelto Boxed Warning:

  • Premature discontinuation of Xarelto increases the risk of blood clots, including stroke. Stopping Xarelto without adequate alternative anticoagulation may lead to serious or life-threatening thrombotic events. If Xarelto must be stopped for reasons other than bleeding, another blood thinner should be considered as directed by your healthcare provider.
  • Spinal or epidural blood clots (hematomas) may occur in people receiving Xarelto who undergo spinal procedures. These blood clots may cause long-term or permanent paralysis. The risk is higher in patients with indwelling epidural catheters, those taking other medications that affect bleeding, or those with a history of spinal surgery or spinal deformity.
Xarelto Important Safety Information

Xarelto Important Safety Information

  • Before taking Xarelto, tell your doctor if you have:
    • Kidney disease or reduced kidney function
    • Liver disease or liver impairment
    • A history of bleeding problems or stomach ulcers
    • High blood pressure
    • Any recent surgery, spinal procedures, or planned medical/dental operations
    • Are pregnant, planning pregnancy, or breastfeeding (safety not established)
  • Bleeding risk may occur, especially in patients on other blood thinners, antiplatelet drugs, or NSAIDs.
  • Do not stop Xarelto suddenly without medical advice, as this increases the risk of stroke or blood clots.
  • Do not use Xarelto if you:
    • Have active pathological bleeding
    • Have severe liver disease associated with clotting problems
    • Are allergic to rivaroxaban or any of its ingredients
  • Your doctor may monitor your kidney function closely and watch for signs of bleeding.
  • Seek medical help immediately if you notice unusual bruising, nosebleeds, blood in urine/stool, coughing up blood, or prolonged bleeding.
  • If taking 15 mg twice daily, take the missed dose immediately to ensure a total of 30 mg per day. If a once-daily dose is missed, take it immediately on the same day; do not double the next day.

An overdose of Xarelto may cause serious bleeding. If you notice Xarelto overdose symptoms such as prolonged bleeding, dizziness, fainting, or weakness, call a poison control center or seek medical help right away.

Xarelto Interactions

Xarelto Interactions

Always tell your doctor about all medications, supplements, or herbal products before starting Xarelto. This medication can interact with several medications, some of which are as follows:

  • Other anticoagulants
    • Warfarin
    • Heparin
    • Dabigatran
    • Apixaban
    • Edoxaban
  • Antiplatelet drugs
    • Clopidogrel
    • Ticagrelor
  • NSAIDs
    • Ibuprofen
    • Naproxen
    • Diclofenac
  • Strong CYP3A4 and P‑gp inhibitors
    • Ketoconazole
    • Ritonavir
    • Clarithromycin
  • Strong CYP3A4 inducers
    • Rifampin
    • Carbamazepine
    • Phenytoin
    • St. John’s Wort
  • Statins (not major interactions, monitor only)
    • Atorvastatin
    • Rosuvastatin
Xarelto Alternatives

Xarelto Alternatives

If Xarelto is not suitable, doctors may prescribe other anticoagulants depending on the condition:

AlternativeGeneric NameType
EliquisApixabanDOAC (Factor Xa inhibitor)
PradaxaDabigatranDOAC (Direct thrombin inhibitor)
SavaysaEdoxabanDOAC (Factor Xa inhibitor)
WarfarinCoumadinVitamin K antagonist
Heparin / LMWH (Lovenox)EnoxaparinInjectable anticoagulant

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Xarelto Vs. Other Blood Thinner Medicines

Below is a Xarelto head‑to‑head comparison with other anticoagulants, highlighting their mechanisms, dosing schedules, monitoring needs, advantages, and limitations:

MedicineTypeDosingMonitoringProsCons
Xarelto (rivaroxaban)Factor Xa inhibitor (DOAC)Once daily (most doses)No routine INR monitoringConvenient dosing, effective for AFib, DVT/PE, CAD/PADHigher GI bleeding risk vs Eliquis; costlier than Warfarin
Eliquis (apixaban)Factor Xa inhibitor (DOAC)Twice dailyNo routine INR monitoringLower bleeding risk than Xarelto; effective stroke preventionTwice-daily dosing may reduce adherence
Pradaxa (dabigatran)Direct thrombin inhibitor (DOAC)Twice dailyNo routine INR monitoringSpecific reversal agent (idarucizumab) availableGI upset is common; it must be stored carefully
Savaysa (edoxaban)Factor Xa inhibitor (DOAC)Once dailyNo routine INR monitoringSimple dosing; effective for clot preventionLess effective if kidney function is very good (CrCl >95 mL/min)
Warfarin (Coumadin)Vitamin K antagonistOnce daily (variable dose)Requires INR monitoringInexpensive; long history of use; reversal with vitamin KFrequent monitoring, food/drug interactions, variable dosing;
Heparin / LMWH (Lovenox)Injectable anticoagulantInjection (daily or twice daily)No INR monitoringUseful in hospital or pregnancy; short-actingRequires injection; not practical long-term

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Why Buy Xarelto from Polar Bear Meds

Why Buy Xarelto from Polar Bear Meds

U.S. patients who need ongoing anticoagulant therapy can choose to order Xarelto from Canada for personal use when a valid prescription is provided. Every prescription is reviewed and verified before the medication is dispensed, helping ensure safe and appropriate use.

Polar Bear Meds works with licensed Canadian pharmacies to provide patients with dependable access to genuine prescription medications. This approach allows patients to receive their prescribed treatment through a regulated pharmacy network while following established prescription verification standards.

Shipping Xarelto from Canada to the U.S.

When you order Xarelto online through Polar Bear Meds, you enjoy:

  • We use Xpress Post for fast delivery, with most orders arriving within 3-5 business days.
  • Real‑time tracking so you can follow your package every step of the way.
  • Dedicated customer support is available to assist with shipping, delivery, or order status at any time.

Xarelto Cost, Coupon & Savings

  • First-time customers may receive 10% off their initial order by using an Xarelto coupon code such as WELCOMEPB10 at checkout.
  • The cost of Xarelto in Canada can start at around $215.00, though prices may vary depending on the strength selected and current availability.
  • Ordering through Polar Bear Meds may allow customers to save up to 80-90% compared to typical U.S. retail pharmacy prices.

A price match guarantee is offered to help ensure competitive pricing compared with other qualifying pharmacies.

Xarelto FAQs

Xarelto FAQs

Important Notice

Important Notice

This information is for educational purposes only and does not replace any professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare expert before starting, stopping, or changing Xarelto dosages. Individual results, dosing, and Xarelto side effects may vary.

Dr. Jackson Miller

Medically Reviewed by Dr. Jackson Miller (M.D)

Dr. Jackson Miller is a board-certified medicine physician & hospitalist. He is a healthcare professional with a strong background in patient care. With years of experience and a patient-first approach, he believes the foundation of good health is a patient who feels informed and empowered. He contributes to medical content review, drawing on his background in clinical practice and patient education. He focuses on presenting health information in a clear, accurate, and accessible way to help readers make informed decisions. His work emphasizes clarity, evidence-based guidance, and understandable explanations of medical topics.

Find Dr. Jackson Miller on:LinkedIn

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