Mirabegron

Myrbetriq

Myrbetriq is a medication containing the active ingredient mirabegron, used to treat overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in children aged 3 years and older. It works by relaxing the bladder’s smooth muscle, increasing its capacity, and reducing symptoms like frequent urination and urgency. Available in extended-release oral tablets (25 mg and 50 mg) and granules (8 mg/ml), it is typically taken once daily. Myrbetriq dosage may vary based on individual conditions and response to treatment. Common Myrbetriq side effects include increased blood pressure, nasal congestion, and headaches. Patients should follow their healthcare provider’s instructions and inform them of any other medications being taken. Myrbetriq should be stored at room temperature and used with caution in patients with severe kidney disease or uncontrolled high blood pressure.

Product Overview

Myrbetriq is a medication containing the active ingredient mirabegron, which is used for the treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in children aged 3 years and older. It is an FDA-approved medication that works by relaxing the bladder’s smooth muscle, increasing its capacity to hold urine, and reducing symptoms like frequent urination and urgency. Myrbetriq targets beta-3 adrenergic receptors, leading to improved bladder control and a decrease in the number of bathroom visits.

The medication comes in two forms: extended-release oral tablets with strengths of 25 mg and 50 mg and extended-release oral granules with a strength of 8 mg/ml. It is typically taken once daily, with or without food, and the dosage may vary based on the individual’s condition and response to the treatment. Both adults and children can use Myrbetriq, but the dosage for children is determined based on their body weight.

Common side effects of Myrbetriq include increased blood pressure, nasal congestion, urinary tract infections, headaches, and dizziness. Patients are advised to follow their healthcare provider’s instructions regarding dosage and to consult their doctor if they miss a dose or suspect an overdose. The medication should be stored at room temperature and kept out of reach of children. It is essential to inform the healthcare provider about any other medications being taken, as Myrbetriq may interact with other drugs. Patients with severe kidney disease, uncontrolled high blood pressure, or a history of angioedema should use caution when taking Myrbetriq.

What Is Myrbetriq Medication Used For?

Targeted Treatment 

• Overactive bladder (OAB)

For specific population: Children aged 3 years and older can also take Myrbetriq to treat neurogenic detrusor overactivity (NDO). 

Benefits

• Reduces symptoms of overactive bladder (OAB), such as frequent urination and urgency.
• Decreases the occurrence of involuntary bladder contractions.
• Improves bladder capacity and control.

[Note: Do not take Myrbetriq without consulting your doctor. They will determine whether you need this medication based on your conditions.]

What Are the Forms & Strengths of Myrbetriq?

Form 1: Extended-release oral tablets

Strength: 25 mg & 50 mg

Form 2: Extended-release oral granules

Strength: 8 mg/ml

What Is the Recommended Dosage of Myrbetriq?

The dosage of Myrbetriq for overactive bladder treatment for different patients is individualized based on their age, tolerability, and needs. The recommended dosage given below applies to everyone. It can be harmful to change your dosage without first talking to your doctor. If your doctor has prescribed a different dose than the one you are taking, follow their instructions. Do not use it more or less than recommended, in large quantities, or more frequently, as it can cause unfavorable symptoms. 

Adult Dosage Recommendations

• Myrbetriq Monotherapy:

• • • Starting Dosage: 25 mg orally once daily.
    • Maximum Dosage: Increase to 50 mg orally once daily after 4 to 8 weeks, if needed.

• Myrbetriq Combination Therapy with Solifenacin Succinate:

• • Starting Dosage: Myrbetriq 25 mg and Solifenacin Succinate 5 mg, both taken orally once daily.
  • Maximum Dosage: Increase to Myrbetriq 50 mg orally once daily after 4 to 8 weeks, if needed.
  • Note: Refer to Solifenacin Succinate prescribing information for more details.

Pediatric Dosage Recommendations (Aged 3 Years and Older)

• For Children Weighing Less Than 35 kg:

• • • Product: Myrbetriq Granules.
    • Starting Dose for 11 kg to <22 kg: 3 mL (24 mg).
    • Maximum Dose for 11 kg to <22 kg: 6 mL (48 mg).
    • Starting Dose for 22 kg to <35 kg: 4 mL (32 mg).
    • Maximum Dose for 22 kg to <35 kg: 8 mL (64 mg).

• For Children Weighing 35 kg or More:

• • Products: Either Myrbetriq or Myrbetriq Granules.
  • Starting Dosage for Tablets: 25 mg orally once daily.
  • Maximum Dosage for Tablets: Increase to 50 mg orally once daily after 4 to 8 weeks, if needed.
  • Starting Dosage for Granules: 6 mL (48 mg) orally once daily.
  • Maximum Dosage for Granules: Increase to 10 mL (80 mg) orally once daily after 4 to 8 weeks, if needed.

Dosage Adjustments for Renal or Hepatic Impairment

• Adults with Renal Impairment:

• • • eGFR 30 to 89 mL/min/1.73 m^2: Start with 25 mg, maximum dose 50 mg.
    • eGFR 15 to 29 mL/min/1.73 m^2: Start and maintain at 25 mg.
    • eGFR <15 mL/min/1.73 m^2 or on dialysis: Not recommended.

• Adults with Hepatic Impairment:

• • • Child-Pugh Class A (Mild): Start with 25 mg, maximum dose 50 mg.
    • Child-Pugh Class B (Moderate): Start and maintain at 25 mg.
    • Child-Pugh Class C (Severe): Not recommended.

• Pediatric Patients with Renal or Hepatic Impairment Weighing Less Than 35 kg:

• • • Same dosing adjustments as adults, according to body weight and eGFR or hepatic impairment classification.

• Pediatric Patients with Renal or Hepatic Impairment Weighing 35 kg or More:

• • Follow the same guidelines as for adult patients with renal or hepatic impairment.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How Should Myrbetriq Be Taken?

Before using Myrbetriq for frequent urination treatment for the first time and each time you get a refill, you should carefully read and follow the information on Myrbetriq given on your prescription label, patient information leaflet, and, if available, medication guide. Take it exactly as your doctor has prescribed. If you have difficulty understanding any part of the leaflet or if you have any queries regarding the use of Myrbetric, discuss with your doctor and clear your concerns beforehand. 

• If you take Mybetriq with Solifenacin, an antimuscarinic, take both medications simultaneously every day. 
• Swallow the Myrbetriq tablet whole with a full glass of water; do not crush, chew, or break it.
• Adults may take the tablet with or without food.
• Children should take the tablet with food.
• Both adults and children should take Myrbetriq granules with food.
• After the pharmacist prepares the suspension, use Myrbetriq Granules within 28 days (4 weeks).
• Shake the suspension well before measuring a dose.
• Use the provided dosing syringe or a proper medicine dose-measuring device (not a kitchen spoon).
• If not using the suspension for 2 days or more, shake the bottle vigorously for 1 minute each day to keep the granules well mixed.
• Your doctor may recommend you have regular tests to monitor your blood pressure levels more often while using this medication. 
• It may take up to eight weeks to notice improvements in your symptoms. Tell your doctor if your condition does not get better or if it worsens. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

What Is the Mechanism of Action of Myrbetriq?

Myrbetriq (mirabegron) works by relaxing the smooth muscle of the bladder, specifically targeting the beta-3 adrenergic receptors. This relaxation increases the bladder’s capacity to hold urine, reducing the symptoms of overactive bladders, such as the urge to urinate frequently, the need to urinate urgently, and involuntary leakage of urine (urge incontinence). Myrbetriq helps improve bladder control and decreases the number of times a person needs to urinate.

Important Safety Information for Using Myrbetriq

What Are the Side Effects of Myrbetriq?

Common Myrbetriq side effects: Like other medications, Myrbetriq can also cause certain temporary side effects in some users. These side effects usually resolve on their own without any medical attention. However, if they persist or become worrisome, let your doctor know. If you are concerned about any risks associated with the use of Myrbetriq for bladder control, you should discuss with your doctor beforehand. Common side effects of Myrbetriq include: 

• Increased blood pressure: This is one of the most significant side effects of Myrbetriq. This medication can cause a mild increase in blood pressure, especially in those people with existing hypertension. This may be due to the stimulation caused by Myrbetriq in certain receptors in the body that can constrict blood vessels. You should monitor your blood pressure levels while using Myrbetriq on a regular basis. If you notice a significant rise, you should tell your doctor. They are most likely to change your dosage or medication. 

• Nasal congestion: This occurs due to the medication’s effect on the autonomic nervous system, which may lead to swelling in the nasal passages. This makes it harder for you to breathe through your nose. To help relieve this, you should use a saline spray or decongestants. Staying adequately hydrated & using a humidifier can also help. If the blocked nose persists or makes it difficult for you to breathe properly, talk to your doctor. 

• Urinary tract infection (UTI): While Myrbetriq helps control overactive bladder symptoms, it can sometimes increase the risk of a urinary tract infection. This may be due to changes in bladder function or urinary retention. To reduce the risk, you should stay hydrated, practice good hygiene & regularly empty your bladder. If you notice signs and symptoms of a UTI, you should seek medical attention right away to avoid complications. 

• Headache: Headaches are a fairly common side effect, especially when starting Myrbetriq or increasing the dose. They might be linked to changes in blood pressure or the medication’s effects on the nervous system. Over-the-counter pain relief medications like acetaminophen may help manage mild headaches. If the headaches become frequent or severe, a doctor may adjust your treatment to reduce this side effect.

• Dizziness: While using Myrbetriq, some patients may feel dizzy, particularly when standing up quickly. This is often due to changes in blood pressure or blood flow. To reduce the risk of this symptom, you should get up slowly from sitting or lying down for extended period. Staying adequately hydrated may also help minimize dizziness. If dizziness continues or becomes troublesome, speak with your doctor. 

• Nausea: Nausea can occur with Myrbetriq, especially when starting the medication or after a dosage increase. It’s often due to irritation of the stomach or digestive tract. Taking the medication with food or adjusting the timing of the dose can help manage this. If nausea becomes persistent, it’s important to consult your doctor to see if a different approach is needed.

• Constipation: Constipation is another side effect of Myrbetriq, as it can slow down your digestive system. This may result in less frequent bowel movements and discomfort. To manage constipation, eating a fiber-rich diet, drinking plenty of water, and staying active is helpful. If constipation becomes severe, over-the-counter stool softeners may help, but it’s best to consult with your doctor before using them.
• Dry mouth: Dry mouth is a common issue with Myrbetriq, as the medication can reduce saliva production. This can make swallowing, speaking, and even tasting food more difficult. Drinking plenty of water, chewing sugar-free gum, and avoiding alcohol & caffeine can help keep your mouth moist. If dry mouth continues or becomes bothersome, your doctor may recommend alternative treatments to alleviate the symptoms.

Serious side effects of Myrbetriq: In rare cases, Myrbetriq can cause severe side effects in some people using it, requiring emergency medical assistance immediately. If you experience any of the following side effects, immediately seek medical attention by calling a medical professional or 911. These severe side effects can become fatal if not treated promptly. Your doctor has prescribed Myrbetriq for overactive bladder treatment after deciding that its benefits outweigh the risks associated with its use. Severe Myrbetriq side effects include: 

• Increased Blood Pressure: Myrbetriq can cause a significant increase in blood pressure or worsen the symptoms if you have a history of high blood pressure. Regular monitoring is recommended. If you monitor your blood pressure and if the systolic BP is 180mm higher or diastolic is 120mm higher, seek prompt medical attention. An increase in blood pressure may not be noticeable for everyone, but you should look out for any signs and symptoms such as chest pain, sudden severe headache, dizziness, difficulty breathing, nausea, anxiety, nosebleeds, and buzzing in the ears. 
• Urinary Retention: Individuals with bladder outlet obstruction or those taking antimuscarinic medications for overactive bladder have an increased risk for such symptoms. Inform your healthcare provider if you cannot pee or cannot produce a normal amount of urine. 
• Severe Allergic Reactions: This medication can cause an allergic reaction in some people, which may be severe. Discontinue using Myrbetriq if you have any of the following symptoms, and call your doctor immediately. Symptoms can include swelling of the face, lips, throat, or tongue, hives, and difficulty breathing.
• Angioedema: A potentially life-threatening condition characterized by swelling of deeper layers of skin, often around the eyes and lips. Discontinuation of Myrbetriq is advised, so call your doctor or healthcare provider if you have this kind of swelling. If angiodema causes breathing problems, seek emergency medical attention.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Myrbetriq?

• Myrbetriq should not be used if you have any of the following conditions. If there is a concern about the health of the organs in your body, including kidneys and heart, you should consult your healthcare provider. They will recommend you undergo certain tests to determine if they are working well enough to use this medicine. 
  • End-stage renal disease (kidney failure)
  • Severe kidney disease
  • Severe uncontrolled high blood pressure

• Do not use Myrbetriq if you have an allergy to mirabegron or any other ingredient listed in the product. Myrbetriq contains certain active and inactive ingredients which can cause hypersensitivity reactions or other complications. Before using this product, you should be aware of the ingredients present in it. If you are not sure about what components it includes, ask your pharmacist or healthcare provider to provide you with the complete list of ingredients present in the product. Do not use Myrbetriq if you have ever had a hypersensitivity reaction to any of its excipients. 

• Do not use this medication if your liver is not working as well as it should. If you have any concerns regarding your liver, talk to your healthcare provider. They will make you undergo certain tests to determine if it is functioning properly to take Myrbetriq. 
• Angioedema, a condition that causes swelling of the face, lips, tongue, and throat, can occur after taking Myrbetriq. This can be life-threatening and requires immediate emergency attention if symptoms appear.
• It may take up to 8 weeks for your symptoms to improve. Continue using Myrbetriq as prescribed and inform your doctor if there is no improvement after 8 weeks of treatment.

What Precautions Should Be Taken When Taking Myrbetriq?

• Before starting this medication, ensure it is safe for you by informing your doctor if you have any of the following conditions:
  • High blood pressure
  • A bladder obstruction
  • Difficulty emptying your bladder, indicated by very little urine or a weak stream
  • Kidney disease
  • Liver disease
• Additionally, tell your doctor if you are pregnant or breastfeeding.
• Myrbetriq is not recommended for children under the age of 3 years.

What Are the Contraindications for Myrbetriq? 

• Do not take Myrbetriq tablets or granules if you have a known allergy to Mirabegron or any of its inactive components.

What If You Miss a Dose of Myrbetriq?

• If you miss a dose of Myrbetriq, take it as soon as you remember.
• If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do not take two doses of Myrbetriq at the same time to make up for a missed dose.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Myrbetriq?

An overdose of Myrbetriq can lead to various symptoms and potentially serious health issues. If you suspect an overdose, it is important to seek immediate medical attention. Treatment for a Myrbetriq overdose typically involves supportive care to manage symptoms and may require hospitalization, depending on the severity of the overdose. 

[Note: If you consumed more than the recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

What Are the Storage Conditions for Myrbetriq?

Myrbetriq Tablets:

• Store at room temperature between 68°F and 77°F (20°C to 25°C).
• Keep the bottle tightly closed.
• Dispose of expired or unneeded medication.

Myrbetriq Granules:

• Store between 68°F and 77°F (20°C and 25°C) to maintain properties.
• After preparation of the suspension by a pharmacist, use Myrbetriq Granules within 28 days (4 weeks).

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Myrbetriq?

Myrbetriq has interactions with a total of 230 drugs, as well as four disease interactions and two alcohol/food interactions. Here are some medications that may interact with Myrbetriq:

• Aspirin
• Amlodipine
• Albuterol
• Atorvastatin
• Baclofen
• Duloxetine
• Furosemide
• Gabapentin
• Hydrochlorothiazide
• Levothyroxine
• Lisinopril
• Losartan
• Melatonin
• Meloxicam
• Metformin
• Metoprolol
• Montelukast
• Omeprazole
• Oxybutynin
• Pantoprazole
• Potassium chloride
• Prednisone
• Rosuvastatin
• Synthroid (levothyroxine)
• Tamsulosin
• Tramadol
• Trazodone
• Vitamin B12 (cyanocobalamin)
• Vitamin C (ascorbic acid)
• Vitamin D3 (cholecalciferol)

[Note: This isn’t a complete list, and there could be other drugs that interact with Myrbetriq. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Other Myrbetriq Interactions?

Myrbetriq (mirabegron) can interact with certain foods, beverages, herbs, and supplements, which can reduce its effectiveness or cause certain unfavorable side effects. You should be mindful of such interactions and discuss with your doctor if you have any queries. They will ask you to make certain dietary and lifestyle changes to manage such interactions. These include: 

• Alcohol: It is recommended to limit alcohol consumption while on Myrbetriq, as alcohol can increase the risk of side effects like dizziness.
• Food & Beverages: No significant food interactions have been noted. However, you should limit your intake of greasy and spicy food. You can take Mybetriq with or without food exactly as your doctor has recommended you. 
• Herbs or Supplements: While there are no well-established interactions with specific herbs or supplements, you should always consult your doctor before combining herbs with medicines, especially those that affect the liver or bladder. 
• Disease Interactions: There are three disease interactions that you should consider while using Myrbetriq, including: 
  • Hepatic Impairment: Myrbetriq should be used with caution in patients with liver issues, as it may affect metabolism.
  • Renal Impairment: Dosage alterations may be required for those with severe kidney problems.
  • Bladder Obstruction: Caution is needed in patients with bladder outlet obstruction or other urinary retention disorders.

What Are the Myrbetriq Alternatives?

While Myrbetriq is an effective treatment option for overactive bladder, it is not suitable or effective for a patient. In such cases, patients look for alternatives to Myrbetriq. While there are several alternatives available, you should not use them without consulting with your doctor first. If you plan to change your existing prescription or start a new one, your doctor will help you determine the best treatment plan based on your needs and health profile. Some of the alternatives to Myrbetriq for managing overactive bladder include: 

• Ditropan XL (oxybutynin)
• Vesicare (solifenacin)
• Toviaz (fesoterodine)
• Detrol (tolterodine)
• Sanctura (trospium)
• Darifenacin (darifenacin hydrobromide)
• Gemtesa (vibregron)
• Botox (botulinum toxin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Myrbetriq Cost & Coupons

Several factors, including the health insurance coverage and the pharmacy you choose to buy Myrbetriq online from, can influence the cost of this medication. Some individuals find that their health insurance does not include medications for managing overactive bladder, leading to high out-of-pocket expenses. To manage this financial burden, some individuals turn to online platforms such as Polar Bear Meds, which allows users to obtain authentic, affordable Myrbetriq for urinary urgency in the USA from Canada at a reduced price. Additionally, first-time buyers can buy Myrbetriq with coupon WELCOMEPB10 for a 10% discount on their first purchase. 

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Frequently Asked Questions 

Is it necessary to take Myrbetriq daily?

Yes, you should take one Myrbetriq tablet daily as prescribed by your healthcare provider. It’s important to take it consistently every day, not just when you’re experiencing symptoms or before a long car journey. The tablet should be taken with water and swallowed whole without chewing, breaking, or crushing it.

Does taking Myrbetriq (mirabegron) increase the frequency of urination?

No, Myrbetriq (mirabegron) does not cause you to urinate more frequently. Instead, it helps manage symptoms of an overactive bladder by relaxing the bladder muscles, which allows the bladder to retain more urine. This action effectively reduces the number of times you need to visit the bathroom.

Does Myrbetriq cause weight gain as a side effect?

No, weight gain is not a reported side effect of Myrbetriq. However, if you experience difficulty emptying your bladder (urinary retention), it may lead to apparent weight gain due to fluid retention. Symptoms of urinary retention that may accompany weight gain include severe lower abdominal pain, an urgent need to urinate, and swelling of the lower abdomen. If you suspect you have urinary retention, consult your doctor. They may advise stopping Myrbetriq or switching to a different medication. If you’re concerned about weight gain while taking Myrbetriq, talk to your doctor. They can assist you in creating a diet and exercise plan to help manage your weight if needed.

How long does Myrbetriq remain in your system?

The elimination half-life of Myrbetriq is approximately 50 hours, meaning that it takes about 50 hours for half of the drug to be cleared from your system. Based on this half-life, it typically takes about 5 to 6 days for Myrbetriq to be eliminated from your body after you stop taking it. The actual time may vary depending on factors such as your metabolism, kidney function, and the dosage taken. It’s crucial to adhere to your healthcare provider’s instructions regarding Myrbetriq and to consult them if you have any concerns about its effects or how long it stays in your system.

Can Myrbetriq cause hair loss?

Hair loss is not typically reported as a side effect of Myrbetriq. However, individual responses to medication can differ, and some individuals might experience rare or unexpected side effects. If you notice hair loss while taking Myrbetriq or any other medication, it’s important to discuss this with your healthcare provider. They can assess your symptoms, review your medical history and medications, and determine the possible cause of the hair loss. If needed, they may also explore alternative treatment options for your condition.

Who should avoid taking Myrbetriq (mirabegron)?

Individuals with uncontrolled high blood pressure should avoid using Myrbetriq, as it may worsen blood pressure levels. Regular monitoring of blood pressure is recommended for all users. Additionally, suppose you have a bladder blockage or are taking certain other medications for overactive bladders, such as solifenacin (Vesicare). In that case, you may find it difficult to empty your bladder, which can pose further health risks.

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