Mirabegron
Myrbetriq
Myrbetriq is a medication containing the active ingredient mirabegron, used to treat overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in children aged 3 years and older. It works by relaxing the bladder’s smooth muscle, increasing its capacity, and reducing symptoms like frequent urination and urgency. Available in extended-release oral tablets (25 mg and 50 mg) and granules (8 mg/ml), it is typically taken once daily. Dosage may vary based on individual conditions and response to treatment. Common side effects include increased blood pressure, nasal congestion, and headaches. Patients should follow their healthcare provider’s instructions and inform them of any other medications being taken. Myrbetriq should be stored at room temperature and used with caution in patients with severe kidney disease or uncontrolled high blood pressure.
Product Overview
Myrbetriq is a medication containing the active ingredient mirabegron, which is used for the treatment of overactive bladder (OAB) and neurogenic detrusor overactivity (NDO) in children aged 3 years and older. It is an FDA-approved medication that works by relaxing the bladder’s smooth muscle, increasing its capacity to hold urine, and reducing symptoms like frequent urination and urgency. Myrbetriq targets beta-3 adrenergic receptors, leading to improved bladder control and a decrease in the number of bathroom visits.
The medication comes in two forms: extended-release oral tablets with strengths of 25 mg and 50 mg and extended-release oral granules with a strength of 8 mg/ml. It is typically taken once daily, with or without food, and the dosage may vary based on the individual’s condition and response to the treatment. Both adults and children can use Myrbetriq, but the dosage for children is determined based on their body weight.
Common side effects of Myrbetriq include increased blood pressure, nasal congestion, urinary tract infections, headaches, and dizziness. Patients are advised to follow their healthcare provider’s instructions regarding dosage and to consult their doctor if they miss a dose or suspect an overdose. The medication should be stored at room temperature and kept out of reach of children. It is essential to inform the healthcare provider about any other medications being taken, as Myrbetriq may interact with other drugs. Patients with severe kidney disease, uncontrolled high blood pressure, or a history of angioedema should use caution when taking Myrbetriq.
Uses
Targeted Treatment
- Overactive bladder (OAB)
For specific population: Children aged 3 years and older can also take Myrbetriq to treat neurogenic detrusor overactivity (NDO).
Benefits
- Reduces symptoms of overactive bladder (OAB), such as frequent urination and urgency.
- Decreases the occurrence of involuntary bladder contractions.
- Improves bladder capacity and control.
[Note: Do not take Myrbetriq without consulting your doctor. They will determine whether you need this medication based on your conditions.]
Myrbetriq Dosage
Forms & Strengths
Form 1: Extended-release oral tablets
Strength: 25 mg & 50 mg
Form 2: Extended-release oral granules
Strength: 8 mg/ml
Recommended Dosages
Adult Dosage Recommendations
- Myrbetriq Monotherapy:
- Starting Dosage: 25 mg orally once daily.
- Maximum Dosage: Increase to 50 mg orally once daily after 4 to 8 weeks, if needed.
- Myrbetriq Combination Therapy with Solifenacin Succinate:
- Starting Dosage: Myrbetriq 25 mg and Solifenacin Succinate 5 mg, both taken orally once daily.
- Maximum Dosage: Increase to Myrbetriq 50 mg orally once daily after 4 to 8 weeks, if needed.
- Note: Refer to Solifenacin Succinate prescribing information for more details.
Pediatric Dosage Recommendations (Aged 3 Years and Older)
- For Children Weighing Less Than 35 kg:
- Product: Myrbetriq Granules.
- Starting Dose for 11 kg to <22 kg: 3 mL (24 mg).
- Maximum Dose for 11 kg to <22 kg: 6 mL (48 mg).
- Starting Dose for 22 kg to <35 kg: 4 mL (32 mg).
- Maximum Dose for 22 kg to <35 kg: 8 mL (64 mg).
- For Children Weighing 35 kg or More:
- Products: Either Myrbetriq or Myrbetriq Granules.
- Starting Dosage for Tablets: 25 mg orally once daily.
- Maximum Dosage for Tablets: Increase to 50 mg orally once daily after 4 to 8 weeks, if needed.
- Starting Dosage for Granules: 6 mL (48 mg) orally once daily.
- Maximum Dosage for Granules: Increase to 10 mL (80 mg) orally once daily after 4 to 8 weeks, if needed.
Dosage Adjustments for Renal or Hepatic Impairment
- Adults with Renal Impairment:
- eGFR 30 to 89 mL/min/1.73 m^2: Start with 25 mg, maximum dose 50 mg.
- eGFR 15 to 29 mL/min/1.73 m^2: Start and maintain at 25 mg.
- eGFR <15 mL/min/1.73 m^2 or on dialysis: Not recommended.
- Adults with Hepatic Impairment:
- Child-Pugh Class A (Mild): Start with 25 mg, maximum dose 50 mg.
- Child-Pugh Class B (Moderate): Start and maintain at 25 mg.
- Child-Pugh Class C (Severe): Not recommended.
- Pediatric Patients with Renal or Hepatic Impairment Weighing Less Than 35 kg:
- Same dosing adjustments as adults, according to body weight and eGFR or hepatic impairment classification.
- Pediatric Patients with Renal or Hepatic Impairment Weighing 35 kg or More:
- Follow the same guidelines as for adult patients with renal or hepatic impairment.
[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]
How to Take It?
- Swallow the Myrbetriq tablet whole with a full glass of water; do not crush, chew, or break it.
- Adults may take the tablet with or without food.
- Children should take the tablet with food.
- Both adults and children should take Myrbetriq granules with food.
- After the pharmacist prepares the suspension, use Myrbetriq Granules within 28 days (4 weeks).
- Shake the suspension well before measuring a dose.
- Use the provided dosing syringe or a proper medicine dose-measuring device (not a kitchen spoon).
- If not using the suspension for 2 days or more, shake the bottle vigorously for 1 minute each day to keep the granules well mixed.
- Follow any specific Instructions for Use provided with your medicine.
- Consult your doctor or pharmacist if you have any questions about the instructions.
[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]
How Does Myrbetriq Work?
Myrbetriq (mirabegron) works by relaxing the smooth muscle of the bladder, specifically targeting the beta-3 adrenergic receptors. This relaxation increases the bladder’s capacity to hold urine, reducing the symptoms of overactive bladders, such as the urge to urinate frequently, the need to urinate urgently, and involuntary leakage of urine (urge incontinence). Myrbetriq helps improve bladder control and decreases the number of times a person needs to urinate.
Important Safety Information
Side Effects
Common side effects of Myrbetriq may include:
- Increased blood pressure
- Nasal congestion
- Urinary tract infection (UTI)
- Headache
- Dizziness
- Nausea
- Constipation
- Dry mouth
Serious side effects of Myrbetriq may include:
- Increased Blood Pressure: Myrbetriq can cause a significant increase in blood pressure. Regular monitoring is recommended.
- Urinary Retention: Especially in individuals with bladder outlet obstruction or those taking antimuscarinic medications for overactive bladder.
- Allergic Reactions: Symptoms can include swelling of the face, lips, throat, or tongue, hives, and difficulty breathing.
- Angioedema: A potentially life-threatening condition characterized by swelling of deeper layers of skin, often around the eyes and lips.
[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]
Warnings
- End-stage renal disease (kidney failure)
- Severe kidney disease
- Severe uncontrolled high blood pressure
- Angioedema, a condition that causes swelling of the face, lips, tongue, and throat, can occur after taking Myrbetriq. This can be life-threatening and requires immediate emergency attention if symptoms appear.
- It may take up to 8 weeks for your symptoms to improve. Continue using Myrbetriq as prescribed and inform your doctor if there is no improvement after 8 weeks of treatment.
Precautions
- Do not use Myrbetriq if you have an allergy to mirabegron.
- Before starting this medication, ensure it is safe for you by informing your doctor if you have any of the following conditions:
- High blood pressure
- A bladder obstruction
- Difficulty emptying your bladder, indicated by very little urine or a weak stream
- Kidney disease
- Liver disease
- Additionally, tell your doctor if you are pregnant or breastfeeding.
- Myrbetriq is not recommended for children under the age of 3 years.
Contraindications
- Do not take Myrbetriq tablets or granules if you have a known allergy to Mirabegron or any of its inactive components.
Missed Dose
- If you miss a dose of Myrbetriq, take it as soon as you remember.
- If it’s close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.
- Do not take two doses of Myrbetriq at the same time to make up for a missed dose.
[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]
Overdose
An overdose of Myrbetriq can lead to various symptoms and potentially serious health issues. If you suspect an overdose, it is important to seek immediate medical attention. Treatment for a Myrbetriq overdose typically involves supportive care to manage symptoms and may require hospitalization, depending on the severity of the overdose.
[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]
Storage
Myrbetriq Tablets:
- Store at room temperature between 68°F and 77°F (20°C to 25°C).
- Keep the bottle tightly closed.
- Dispose of expired or unneeded medication.
Myrbetriq Granules:
- Store between 68°F and 77°F (20°C and 25°C) to maintain properties.
- After preparation of the suspension by a pharmacist, use Myrbetriq Granules within 28 days (4 weeks).
[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]
Myrbetriq Interactions
Myrbetriq has interactions with a total of 230 drugs, as well as four disease interactions and two alcohol/food interactions. Here are some medications that may interact with Myrbetriq:
- Aspirin
- Amlodipine
- Albuterol
- Atorvastatin
- Baclofen
- Duloxetine
- Furosemide
- Gabapentin
- Hydrochlorothiazide
- Levothyroxine
- Lisinopril
- Losartan
- Melatonin
- Meloxicam
- Metformin
- Metoprolol
- Montelukast
- Omeprazole
- Oxybutynin
- Pantoprazole
- Potassium chloride
- Prednisone
- Rosuvastatin
- Synthroid (levothyroxine)
- Tamsulosin
- Tramadol
- Trazodone
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
[Note: This isn’t a complete list, and there could be other drugs that interact with Myrbetriq. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]
Myrbetriq Alternatives
- Ditropan XL (oxybutynin)
- Vesicare (solifenacin)
- Toviaz (fesoterodine)
- Detrol (tolterodine)
- Sanctura (trospium)
- Darifenacin (darifenacin hydrobromide)
- Gemtesa (vibregron)
- Botox (botulinum toxin)
[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]
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Frequently Asked Questions
Is it necessary to take Myrbetriq daily?
Yes, you should take one Myrbetriq tablet daily as prescribed by your healthcare provider. It’s important to take it consistently every day, not just when you’re experiencing symptoms or before a long car journey. The tablet should be taken with water and swallowed whole without chewing, breaking, or crushing it.
Does taking Myrbetriq (mirabegron) increase the frequency of urination?
No, Myrbetriq (mirabegron) does not cause you to urinate more frequently. Instead, it helps manage symptoms of overactive bladder by relaxing the bladder muscles, which allows the bladder to retain more urine. This action effectively reduces the number of times you need to visit the bathroom.
Does Myrbetriq cause weight gain as a side effect?
No, weight gain is not a reported side effect of Myrbetriq. However, if you experience difficulty emptying your bladder (urinary retention), it may lead to apparent weight gain due to fluid retention. Symptoms of urinary retention that may accompany weight gain include severe lower abdominal pain, an urgent need to urinate, and swelling of the lower abdomen. If you suspect you have urinary retention, consult your doctor. They may advise stopping Myrbetriq or switching to a different medication. If you’re concerned about weight gain while taking Myrbetriq, talk to your doctor. They can assist you in creating a diet and exercise plan to help manage your weight if needed.
How long does Myrbetriq remain in your system?
The elimination half-life of Myrbetriq is approximately 50 hours, meaning that it takes about 50 hours for half of the drug to be cleared from your system. Based on this half-life, it typically takes about 5 to 6 days for Myrbetriq to be eliminated from your body after you stop taking it. The actual time may vary depending on factors such as your metabolism, kidney function, and the dosage taken. It’s crucial to adhere to your healthcare provider’s instructions regarding Myrbetriq and to consult them if you have any concerns about its effects or how long it stays in your system.
Can Myrbetriq cause hair loss?
Hair loss is not typically reported as a side effect of Myrbetriq. However, individual responses to medication can differ, and some individuals might experience rare or unexpected side effects. If you notice hair loss while taking Myrbetriq or any other medication, it’s important to discuss this with your healthcare provider. They can assess your symptoms, review your medical history and medications, and determine the possible cause of the hair loss. If needed, they may also explore alternative treatment options for your condition.
Who should avoid taking Myrbetriq (mirabegron)?
Individuals with uncontrolled high blood pressure should avoid using Myrbetriq, as it may worsen blood pressure levels. Regular monitoring of blood pressure is recommended for all users. Additionally, suppose you have a bladder blockage or are taking certain other medications for overactive bladders, such as solifenacin (Vesicare). In that case, you may find it difficult to empty your bladder, which can pose further health risks.
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