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Efavirenz

Efavirenz Tablets

Efavirenz is an FDA-approved medication that is typically used in combination with other antiretroviral drugs as part of a highly active antiretroviral therapy (HAART) regimen. This combination approach targets different stages of the HIV lifecycle, making it more difficult for the virus to develop resistance to any single drug. It contains Efavirenz as its active ingredient. The medication comes in the form of tablets and capsules with different strengths. The medication is indicated for use in children and adults with dosage adjustments based on weight and specific medical conditions. Before taking Efavirenz, you should consult your doctor to ensure a safe and efficient use of the medication. Call them if you have any queries or concerns regarding the medication use. You can buy Efavirenz tablets from Canada at the best prices for their authenticity. 

Product Overview

Efavirenz Tablets contain the active ingredient Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV. This medication works by inhibiting the virus’s ability to replicate, reducing viral load, and allowing the immune system to recover. Available in strengths of 50 mg and 200 mg capsules and 600 mg tablets, Efavirenz is typically taken once daily, with or without meal. Swallowing the Efavirenz tablets or capsules whole without crushing or chewing is essential. The capsule can be mixed with soft food for those with difficulty swallowing. 

Efavirenz is suitable for adults and children, with dosage adjustments based on weight and specific medical conditions. Common side effects include diarrhea, depression, dizziness, headache, and trouble sleeping. Serious side effects, such as liver problems and psychiatric issues, should be reported to a healthcare provider immediately. Precautions include avoiding the use of certain medications like elbasvir and grazoprevir and not breastfeeding while on Efavirenz. It is also critical to inform your doctor about all the medications and supplements you are taking to avoid potential drug interactions.

If you miss a dose, take it as soon as possible unless it is almost time for the next dose. Do not double up on doses. If an overdose occurs, seek immediate medical assistance. Store Efavirenz at a controlled room temperature, away from light and moisture, and out of reach of children and pets. Proper disposal of unused medication is essential to prevent accidental ingestion. You should contact a healthcare professional for personalized advice and guidance and read the patient information leaflet thoroughly.

Uses of Efavirenz Tablets

It is used to treat:

  • Human immunodeficiency virus (HIV) infection

Efavirenz Tablets Dosage

Form: Capsule

Strength: 50 mg and 200 mg 

Form: Tablet 

Strength: 600 mg 

Recommended Dosage for Efavirenz Tablets

  • Efavirenz tablets are taken orally by mouth, as directed by your doctor, typically once daily, with or without food. 
  • The recommended daily dose of Efavirenz Tablets for adults is 600 mg once every day.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Efavirenz Tablets?

  • Before you start taking this medication and each time you get a refill, carefully read and follow the directions for use given in the patient information leaflet your pharmacist gave. 
  • If you have any questions or concerns about using Efavirenz tablets, consult your pharmacist, physician, or healthcare provider. 
  • Taking this medication by mouth may increase the blood level, which can further cause a more significant risk of certain side effects. 
  • You should not crush, chew, or break the Efavirenz Tablets or capsules. Do not open the capsule. Try to swallow them whole. However, if you experience difficulty swallowing the capsule, you can open it and mix it with a small amount of soft food such as yogurt, grape jelly, or applesauce. 
  • After taking this mixed medication, add two more teaspoons of food to the empty container and swallow the remaining mixture to ensure you get the entire dose. 
  • Swallow the medication mixture within thirty minutes of mixing. 
  • You should not eat any meal for two hours after taking Efavirenz Tablets dose. 
  • For infants who cannot eat solid foods, the medication may be mixed with two tablespoons of infant formula and given to the baby using an oral syringe. 
  • The medication dosage is based on the condition being treated, the patient’s response to treatment, and other medications you are taking. In children, the dosage also depends on their weight. 
  • Tell your doctor about all the medications you may be taking, including all prescription medications, over-the-counter drugs, and herbal supplements. 
  • Efavirenz Tablets control HIV conditions but do not cure them. However, when combined with other medications, it helps lessen the quantity of viruses in your body and slow down the disease’s progression.
  • You should not miss any doses and alter your dose without consulting your doctor. 
  • Do not increase your dose; take it more frequently or stop even for a short period unless instructed otherwise. Changing or missing doses without discussing with your doctor can cause the virus to increase, making the infection more difficult to treat. This may worsen your side effects. You should take this medication at the same time every evening to get the best results, which will help you remember every day.  

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Efavirenz Tablets Work?

Efavirenz Tablets are an antiviral medication that belongs to a class of medications known as NNRTIs or non-nucleoside reverse transcriptase inhibitors. It is used to treat human immunodeficiency virus. It prevents HIV from multiplying in your body by inhibiting the virus’s ability to replicate itself. It targets a key enzyme called reverse transcriptase, which the virus needs to convert its RNA into DNA, which can then be desegrated into the host cell’s genetic material, allowing the virus to replicate. By inhibiting reverse transcriptase, Efavirenz prevents HIV from reproducing and producing new viral particles. This helps to decrease the viral load and allows the immune system to recover and work more effectively.

Important Safety Information

Efavirenz Tablets Side Effects

Common side effects of Efavirenz may include: 

  • Diarrhea 
  • Depression
  • Dizziness 
  • Drowsiness 
  • Headache 
  • Increased sweating
  • Poor concentration
  • Skin rash or itching
  • Trouble sleeping

Mild side effects of Efavirenz may include: 

  • Abnormal dreams
  • Abnormal heartbeats
  • Difficulty concentrating
  • Drowsiness 
  • Liver failure
  • Muscle pain 
  • Increased cholesterol
  • Increased triglyceride levels.
  • Hallucinations 

Adverse side effects of Efavirenz may include: 

  • Seizures 
  • Hallucinations 
  • Nerve system problems which may include dizziness, drowsiness, trouble concentrating, confusion, insomnia, abnormal dreams or problems with balance, muscle movement or speech
  • Serious psychiatric problems such as paranoia, unusual behavior, hallucinations,  feeling sad or hopeless, anxiety or suicidal thoughts or behavior
  • Liver problems. Its symptoms may include stomach pain, nausea, dark urine, loss of appetite, clay-colored stools or jaundice.

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Efavirenz Tablets Warnings

  • Do not use Efavirenz tablets if you are already taking elbasvir and grazoprevir to treat hepatitis C.
  • Do not breastfeed if you are infected with HIV or taking Efavirenz.
  • If you have an infection of hepatitis B, your symptoms may get worse or become very serious if you stop taking Efavirenz. Consult your doctor if you plan to discontinue taking this medication. Your doctor will monitor your liver tests for several months after you stop taking this medication. Let your doctor know if you experience symptoms of worsening liver problems.

Efavirenz Tablets Boxed Warning

Efavirenz has a boxed warning issued by the FDA due to its risk of worsened hepatitis B (HBV). If you have HIV and HBV and stop this medication, it may increase your condition, which can further cause liver damage. For this reason, your doctor will ask for an HBV test before or immediately after you start taking this medication.  

Efavirenz Tablets Precautions

  • Inform your doctor and pharmacist if you are allergic to Efavirenz, any other medications, or any ingredients in Efavirenz capsules or tablets. Request a list of ingredients from your doctor or pharmacist.
  • Be aware that Efavirenz is also available in combination with another medication under the brand name Atripla. Notify your doctor if you are taking Atripla to avoid receiving duplicate medication.
  • Inform your doctor if you are taking elbasvir and grazoprevir (Zepatier), as you should not take Efavirenz with these medications.
  • Inform your doctor and pharmacist about all the prescription medications, over-the-counter drugs, vitamins, and supplements you are currently taking or plan to take. Pay special attention to the following: antidepressants, artemether & lumefantrine (Coartem), atorvastatin (Lipitor, in Caduet), atazanavir (Reyataz), atovaquone & proguanil, carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), bupropion (Wellbutrin, Zyban, others, in Contrave), clarithromycin (Biaxin, in Prevpac), cyclosporine (Gengraf, Neoral, Sandimmune), diltiazem (Cardizem CD, Cartia XT, Diltzac, Taztia XT), delavirdine (Rescriptor), etravirine (Intelence), etonogestrel (Implanon, Nexplanon, Nuvaring), ethinyl estradiol and norgestimate (Estarylla, Ortho-Tri-Cyclen, Sprintec, others), felodipine, itraconazole (Sporanox), fosamprenavir (Lexiva), indinavir (Crixivan), levonorgestrel (Mirena, Plan B One-Step, Skyla, in Climera Pro, Seasonale, others), lopinavir (in Kaletra), maraviroc (Selzentry), anxiety medications, methadone (Dolophine, Methadose), medications for mental illnesses, seizure medications, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia XL), nevirapine (Viramune), phenobarbital, norelgestromin (in Xulane), pravastatin (Pravachol), posaconazole (Noxafil), phenytoin (Dilantin, Phenytek), rifampin (Rifadin, Rimactane, in Rifamate, Rifater), rilpivirine (Edurant, in Complera, Odefsey), rifabutin (Mycobutin), ritonavir (Norvir, in Kaletra, Technivie, Viekira), saquinavir (Invirase), verapamil (Calan, Covera, Verelan, in Tarka), sertraline (Zoloft), simvastatin (Zocor, in Vytorin), sirolimus (Rapamune), sedatives, simeprevir (Olysio), sleeping pills, tacrolimus (Envarsus XR, Prograf), tranquilizers, and voriconazole (Vfend), and warfarin (Coumadin, Jantoven). Your doctor might need to adjust the doses or monitor you for side effects. Other medications may also interact with Efavirenz or increase the risk of an irregular heartbeat, so make sure your doctor knows all medications you are taking, even those not listed.
  • Inform your doctor of any herbal products you are using, especially St. John’s wort.
  • Tell your doctor if you have a history of prolonged QT interval, irregular heartbeat, heart problems, heavy alcohol use, drug abuse, or overuse of prescription medications. Also, inform them if you have depression or other mental illnesses, seizures, hepatitis, or any other liver disease.
  • If you are pregnant or planning to become pregnant, inform your doctor. You should not get pregnant while receiving treatment and for twelve weeks after the last dose. If you can become pregnant, you will need a negative pregnancy test before starting Efavirenz and must use effective birth control during treatment. Efavirenz can reduce the effectiveness of hormonal contraceptives, so use a barrier method alongside other birth control methods. Consult your doctor to determine the method that works best for you. If you become pregnant while taking Efavirenz, contact your doctor immediately.
  • Efavirenz may cause drowsiness, dizziness, or difficulty concentrating. Do not drive a vehicle, operate heavy machinery, or engage in activities that require attention or clear vision until you know how it affects you.
  • Discuss with your doctor the safe use of alcohol while taking Efavirenz, as it can worsen side effects.
  • Be aware that treating HIV with Efavirenz can strengthen your immune system, which may then fight infections already in your body or cause new conditions. Report any new or worsening symptoms to your doctor.
  • Efavirenz can cause changes in body fat distribution, such as increased fat in the upper back, neck, and stomach and decreased fat in the face, legs, and arms.
  • Efavirenz may affect your mental health and behavior. Contact your physician immediately if you experience depression, suicidal thoughts or behavior, aggressive behavior, hallucinations, loss of touch with reality, or other unusual thoughts.
  • Efavirenz can cause serious nervous system issues, including encephalopathy, months or years after starting treatment. Contact your doctor immediately if you experience balance or coordination problems, confusion, memory issues, or other brain function difficulties at any time during treatment. Your doctor may advise you to stop taking Efavirenz.

Efavirenz Tablets Contraindications

Efavirenz Tablets are contraindicated for use in individuals who have:

  • A known hypersensitivity to the medication or any of its ingredients
  • A history of prolonged QT interval 

Efavirenz Tablets Missed Dose

  • If you miss doses of Efavirenz, your condition may become more difficult to treat. Maintaining consistency and taking the medication around the same time every day is crucial. 
  • If you missed a dose of Efavirenz, you should take it as soon as you remember. 
  • However, if it is almost time for your next dose, you may omit the missed dose and take the medication dosage on the scheduled dosage time. 
  • Do not take two doses of the same medication to compensate for the missed dose. 
  • You can set a reminder on your phone to prevent missing doses further.

[Note: If you have missed a medication dose and are unsure when to take the next one, immediately consult your doctor or pharmacist.]

Efavirenz Tablets Overdose 

If someone has taken extra or double doses of the medication and is having severe symptoms such as difficulty breathing, trouble breathing, passing out, or seizures, you should promptly seek medical attention. You can call 911 or head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Efavirenz Tablets Storage

  • Keep Efavirenz Tablets at a controlled room temperature below 30°C. Keep them in a cool and dry place in their original container tightly closed, away from direct sunlight, excess heat, and moisture. 
  • Keep all medication, including Efavirenz tablets, in a safe place, away from the sight and reach of children and pets. 
  • Do not keep medications that are outdated or no longer needed. Discard them safely. 
  • With that said, do not throw it in your household garbage bin, pour it into the drain or wastewater, or flush it down the toilet. 
  • You should dispose of unwanted medications in a way that prevents children, animals, and others from consuming them. 
  • The best way to eliminate unwanted medications is to give them away in the medicine take-back program. Consult your physician, pharmacist, or healthcare provider for more information. 
  • For more information on how to safely discard unwanted medications, consult your pharmacist, healthcare provider, or local waste disposal company. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Efavirenz Tablets Interactions

  • Atorvastatin
  • Bepridil
  • Carbamazepine
  • Caspofungin
  • Cisapride
  • Dasabuvir
  • Diltiazem
  • Dronedarone
  • Elbasvir
  • Etonogestrel
  • Grazoprevir
  • Levoketoconazole
  • Lonafarnib
  • Lopinavir
  • Maraviroc
  • Mavacamten
  • Mesoridazine
  • Norgestimate
  • Ospemifene
  • Paritaprevir
  • Pimozide
  • Piperaquine
  • Pravastatin
  • Ritonavir
  • Saquinavir
  • Simvastatin
  • Sparfloxacin
  • St John’s Wort
  • Terfenadine
  • Thioridazine
  • Voriconazole
  • Ziprasidone

[Note: This isn’t a complete list, and there could be other drugs that interact with Efavirenz Tablet. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

Efavirenz Tablets Alternatives

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How does Efavirenz interact with other medications?

Efavirenz can interact with various medications, including certain antidepressants, antiretrovirals, and medications for heart rhythm disorders. These interactions can alter the effectiveness of Efavirenz or increase the risk of adverse effects. To manage these interactions safely, it is crucial to tell your healthcare provider about all the prescription or nonprescription medications, supplements like vitamins, and herbal products you are taking or planning to take.

What should I do if I experience serious side effects while taking Efavirenz?

If you experience severe side effects such as liver problems (e.g., jaundice, dark urine), severe psychiatric symptoms (e.g., suicidal thoughts, hallucinations), or signs of an allergic reaction (e.g., rash, difficulty breathing), seek immediate medical assistance. Contact a licensed healthcare professional to discuss the symptoms and adjust your treatment plan if necessary.

Can Efavirenz be used during pregnancy?

Efavirenz is not recommended for use during pregnancy because of an increased risk of fetal harm. Females of childbearing age should use effective methods of contraception while receiving treatment and for 12 weeks after the last dose. If you become pregnant while taking Efavirenz, contact your healthcare provider immediately to discuss alternative treatments.

How should Efavirenz Tablets be stored and disposed of?

Store Efavirenz Tablets at a controlled room temperature below 30°C, away from direct sunlight, moisture, and heat. Keep the Efavirenz Tablets in their original container, tightly closed, in a safe place that is out of sight and reach of children and pets. Do not dispose of Efavirenz Tablets in household garbage or wastewater. Instead, use a medicine take-back program or consult your pharmacist for safe disposal methods.

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