Galcanezumab

Emgality Auto-injector Prefilled Syr

Emgality Auto-injector, also known as Galcanezumab, belongs to a class of medications called monoclonal antibodies. It is used to prevent migraines & treat episodic cluster headaches. It is available in two strengths: 100mg/ml and 120mg/ml, provided as single-dose prefilled syringes and pens. The dosage of the medication is based on your condition and your body’s response to treatment. Galcanezumab works by binding to and blocking the calcitonin gene-related peptide (CGRP), which plays a crucial role in the pain cascade associated with migraines. Consult your healthcare provider with concerns or questions regarding Emgality’s usage, dosage, and storage. You can buy Emgality Auto-injector online from trusted sources to ensure your medication is authentic and genuine. 

Emgality Auto-injector Overview

Emgality Auto-injector, containing the active ingredient galcanezumab, is a monoclonal antibody used to prevent migraines and treat episodic cluster headaches. Galcanezumab works by binding to and blocking the calcitonin gene-related peptide (CGRP), which plays a crucial role in the pain cascade associated with migraines. Emgality is available in two strengths: 100mg/ml and 120mg/ml, provided as single-dose prefilled syringes and pens. For migraine prevention in adults, the initial dose is 240 mg administered subcutaneously as two consecutive 120 mg injections, followed by a maintenance dose of 120 mg monthly. 

For episodic cluster headache treatment, the recommended dose is 300 mg at the start of the cluster period, which is continued monthly until the period ends. This medication is suitable for adults but is contraindicated for individuals under 18 years, those with severe cardiovascular disease, and those with severe renal or hepatic impairment. Common side effects of Emgality Auto-injector may include injection site reactions, constipation, vertigo, and nausea. Adverse side effects, such as serious allergic reactions and cardiovascular events, require immediate medical attention. 

Before using Emgality, inform your doctor about any allergies or medical conditions. If you miss a dose, take it as soon as you remember unless it’s close to the next dose. In case of an overdose of the medication, seek emergency medical help. Store Emgality in the refrigerator between 2°C-8°C (36°F-46°F) and do not freeze. It can be kept at room temperature for up to seven days. Use each auto-injector only once and dispose of it properly. Consult your healthcare provider for concerns or questions regarding Emgality’s use and storage.

Uses of Emgality Auto-injector

It is used to prevent and treat:

• Migraines 
• Episodic cluster headache

Emgality Auto-injector Dosage

Emgality Auto-injector comes in two forms with strengths of 100mg/ml and 120mg/ml: 

• Single-dose prefilled syringes
• Single-dose prefilled pen

Recommended Emgality Auto-injector Dosage for Different Patients

For Migraine Prevention 

• The initial recommended dose of Emgality Auto-injector for adults is 240 mg administered subcutaneously as two consecutive doses of 120 mg.
• The maintenance dose for adults is 120 mg, administered as a subcutaneous injection once monthly. 

For Treatment of Episodic Cluster Headache

• At the onset of the cluster period, an adult should take 300 mg of Emgality Auto-injector. 
• Subsequent doses of Emgality Auto-injector are 300 mg once every month until the end of the cluster period. 

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Emgality Auto-injector?

• Before using the Emgality Auto-injector, carefully read and follow the instructions for use in the patient information leaflet that came with your prescription. Ask your doctor or pharmacist if you have any questions or concerns regarding the medication’s use. 
• This medication is taken as a subcutaneous injection once every month. When you first receive your prescription for  Emgality Auto-injector, your doctor or healthcare provider will explain how to inject the medication by yourself. 
• The first time you inject Galcanezumab subcutaneously, you may do it at your doctor’s office or in your home. You will need to give yourself two or three separate subcutaneous injections. After that, to prevent migraine headaches, you will give yourself one injection at home every month. To treat cluster headaches, you will give yourself three injections every month. 
• Emgality is available in two forms: single-dose prefilled syringes and pens. Both forms contain only one dose and are meant to be used once and disposed of. 
• Before using this medication, take it out of the refrigerator and let it warm for at least thirty minutes. Do not warm it in any other way, such as in the microwave or hot water. 
• Before using Emgality, check the product for any visual appearance. Do not use it if it has particles in it or is discolored. If either visual change is present, do not use the product. 
• Do not shake or freeze the Emgality Auto-injector. 
• Before injecting your prescribed dosage, you should clean the injection site with rubbing alcohol. Rotate the injection site every time you inject the medication subcutaneously. 
• You should not inject the medication where your skin is damaged, torn, tender, red, or hard. Also, avoid injecting in sites that have stretch marks or scars. 
• Inject the Emgality Auto-injector under the skin of your abdomen, front thighs, lower arms, or buttocks exactly as directed by your doctor. 
• The dosage of the medication is based on the condition being treated & the body’s response to treatment. 
• Use the Emgality Auto-injector regularly to get the most benefit from it. 
• Let your doctor know if your condition does not get better or if it gets worse.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Emgality Auto-injector Work?

Emgality (galcanezumab) is a monoclonal antibody that prevents migraines and cluster headaches by binding to calcitonin gene-related peptide (CGRP). It blocks CGRP from attaching to its receptors, disrupting the pain cascade. Administered monthly, Emgality maintains consistent levels in the bloodstream, providing ongoing prevention. This approach aims to reduce headache frequency, severity, and duration, potentially improving the quality of life for sufferers.

Important Safety Information

Emgality Auto-injector Side Effects

Common side effects of Emgality Auto-injector may include:

• Constipation
• Injection site reactions like redness, pain, itching

Mild side effects of Emgality Auto-injector may include:

• Vertigo
• Itching
• Rash
• Nausea
• Fatigue

Adverse side effects of Emgality Auto-injector may include:

• Severe allergic reactions such as anaphylaxis
• Hypersensitivity reactions
• Cardiovascular events in patients with a history of heart disease

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Emgality Auto-injector Warnings

• Your doctor, nurse, or healthcare provider will show you how to prepare and inject Emgality Auto-injector using a prefilled syringe. You should not inject yourself or someone else until you have been shown how to inject it. Consult your doctor, physician, or healthcare provider if you have any questions or concerns. 
• Emgality Auto-injector is for one-time use only. You should not share or reuse your prefilled syringe even if it has medication left in it. 
• Your doctor or healthcare provider may help you decide when and where to inject Emgality Auto-injector. 
• Do not use the Emgality Auto-injector without help from a caregiver if you have vision problems. 
• Caution is advised when using Emgality Auto-injector in patients with severe kidney or liver problems.

Emgality Auto-injector Precautions

• Before using this medication, let your doctor or healthcare provider know if you are allergic to it or if any other ingredients are present in the medication. Also, tell them if you have any other allergies. Emgality Auto-injector may contain inactive ingredients that can cause hypersensitivity reactions or other problems. Ask your physician, pharmacist, or healthcare provider for the full list of medications. 
• Before using this medication, share your complete medical history with your doctor or healthcare provider. 
• If you plan to have surgery, including a dental procedure, tell your doctor, surgeon, or dentist about all your medications, including the Emgality Auto-injector. Also, tell them about all the prescription, non-prescription, and over-the-counter drugs & herbal supplements you are taking or planning to take. 
• This medication should only be needed during pregnancy when it is clearly needed. Before starting to take this medication while pregnant, you should discuss all potential risks & benefits with your doctor. 
• It is not known if galcanezumab passes into your breastmilk. Consult your doctor before breastfeeding a baby while you are taking this medication. 

Emgality Auto-injector Contraindications

Emgality Auto-injector is contraindicated for use in patients who have:

• Hypersensitivity
• Pregnancy
• Breastfeeding
• Individuals less than 18 years of age 
• Severe cardiovascular disease
• Latex allergy
• Severe renal or hepatic impairment

Emgality Auto-injector Missed Dose

• If you have missed a scheduled monthly dose of Emgality Auto-injector, you should take it as soon as you remember. 
• However, if it is almost time to take your next dose, you may omit the missed dose and continue taking your medication according to your regular monthly dosing schedule.
• Do not take double or extra doses to compensate for the missed dose. 
• You may set a reminder on your phone to prevent missing your medication dosage. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

Emgality Auto-injector Overdose

If you suspect an overdose of Emgality Auto-injector, you should immediately seek medical assistance. If someone has severe symptoms such as trouble breathing, seizures, and passing out, you should call 911 or the poison control helpline. You can also head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Emgality Auto-injector Storage

• Refrigerate Emgality Auto-injector at 36°F-46°F or two °C to 8°C. 
• Do not allow the medication to freeze. Do not use it if frozen. Discard it safely. 
• Emgality Auto-injector can be stored at room temperature up to 86°F or 30°C for up to seven days. Discard it if it is not used within seven days at room temperature. 
• Keep the Emgality Auto-injector in its original container to protect it from direct sunlight. 
• Store it away from direct light, moisture, and excess heat. 
• Do not shake Emgality Auto-injector. 
• Remove the Emgality Auto-injector from the refrigerator thirty minutes before injection to allow it to reach room temperature. Do not use any heat source, such as a microwave or hot water, to warm it.
• Do not use this medication if its expiration date has passed, even if it is refrigerated. 
• Before using the Emgality Auto-injector, check for any change in visual appearance. Do not use it if the solution is cloudy, discolored, or contains particles. 
• Emgality auto-injectors are for single use only. Discard them after one use, even if medication is left in them. 
• Dispose of used auto-injectors in an FDA-approved sharps disposal container. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Emgality Auto-injector Interactions

• Other CGRP antagonists
• Erenumab
• Fremanezumab
• Eptinezumab 
• Triptans such as sumatriptan, rizatriptan, zolmitriptan
• Ergotamines such as ergotamine, dihydroergotamine
• NSAIDs such as ibuprofen, naproxen, aspirin
• Antidepressants
• SSRIs, SNRIs, TCAs
• Anticonvulsants
• Beta-blockers
• Botulinum toxin
• Oral contraceptives
• Vaccines
• Monoclonal antibodies
• CYP450 substrates

[Note: This isn’t a complete list, and there could be other drugs that interact with Emgality Auto-injector. Tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Emgality Auto-injector Alternatives

• Aimovig (erenumab)
• Ajovy (fremanezumab)
• Vyepti (eptinezumab)
• Qulipta (atogepant)
• Nurtec ODT (rimegepant)
• Topiramate (topiramate)
• Propranolol (propranolol hydrochloride)
• Amitriptyline (amitriptyline)
• Botox (onabotulinumtoxin A)
• Verapamil (verapamil)
• Valproic acid (valproic acid)
• Metoprolol (metoprolol)
• Candesartan (candesartan)
• Gabapentin (gabapentin)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

What should I do if I experience severe side effects from the Emgality Auto-injector?

If you experience severe side effects such as anaphylaxis, hypersensitivity reactions, or cardiovascular events, seek immediate medical attention. Call your doctor, pharmacist, or healthcare provider to discuss your symptoms and receive appropriate care. Always inform your doctor about any side effects you experience, especially if they are adverse or persistent.

How does the Emgality Auto-injector compare to other migraine treatments?

Emgality (galcanezumab) is a monoclonal antibody specifically targeting CGRP, a molecule involved in migraine attacks. It differs from other treatments such as triptans, ergotamines, and NSAIDs by focusing on prevention rather than acute symptom relief. Studies have shown that Emgality can significantly reduce the occurrence of migraine days compared to placebo. Discuss with your doctor how Emgality fits into your overall treatment plan and how it compares to other available options.

Can I use the Emgality Auto-injector if I have pre-existing health conditions?

Before using Emgality, inform your healthcare provider about any pre-existing health conditions, particularly severe cardiovascular disease, renal impairment, or hepatic impairment. Emgality may not be suitable for individuals with these conditions, and your doctor will need to evaluate the risks and benefits. Also, inform your physician or healthcare provider of any other prescription, non-prescription, or over-the-counter medications or supplements to avoid potential interactions.

What are the guidelines for storing and disposing of Emgality Auto-injector?

Store the Emgality Auto-injector in the refrigerator at 2 °C-8°C (36°F to 46°F) and protect it from light and moisture. Do not freeze the medication. It can be stored at room temperature (up to 30°C or 86°F) for up to seven days if needed. Use the auto-injector only once and dispose of it in an FDA-approved sharps disposal container. Follow local regulations and your healthcare provider’s instructions for proper disposal.

How should I manage a missed dose of Emgality Auto-injector?

If you miss a scheduled dose of Emgality, take it as soon as you remember unless it is almost time for your next dose of Emgality Auto-injector. In that case, you may omit the missed dose and resume taking your medication as per your regular dosing schedule. You should not take double doses to compensate for the missed one. To avoid missing doses, consider setting reminders on your phone or calendar. If you are unsure when to take your next dose, consult your healthcare provider for guidance.

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