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Enbrel SureClick is a trusted treatment for autoimmune diseases like rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis. Available in various formulations, it contains etanercept, an FDA-approved biologic that targets tumor necrosis factor (TNF) to reduce inflammation and manage symptoms. Administered via prefilled autoinjectors, Enbrel SureClick offers convenience with dosages tailored to each condition: weekly injections for RA, PsA, and AS and initial twice-weekly doses for plaque psoriasis, transitioning to weekly maintenance. While effective, it’s crucial to follow usage guidelines to minimize common side effects such as injection site reactions and upper respiratory infections. Patients should discuss any existing health conditions or medications with their healthcare provider to ensure safe usage. Proper storage and disposal guidelines are essential to maintain medication efficacy and safety.

Enbrel Overview

Enbrel SureClick contains etanercept, a biologic medication that targets tumor necrosis factor (TNF), a protein involved in systemic inflammation. This medication is FDA-approved and widely prescribed for several autoimmune conditions that include rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) & plaque psoriasis. These conditions can cause significant joint inflammation, pain, and stiffness, impacting patients’ quality of life. Enbrel SureClick binds to TNF molecules, preventing them from activating inflammatory responses that lead to joint damage and other symptoms associated with these chronic diseases.

Enbrel SureClick is available in various formulations and strengths, including a prefilled autoinjector delivering 50 mg/mL of the medication. It is taken as a subcutaneous injection weekly for most conditions, with specific initial dosing regimens for plaque psoriasis. This treatment regimen is suitable for adults and certain pediatric patients diagnosed with polyarticular juvenile idiopathic arthritis (JIA). By targeting TNF, Enbrel SureClick helps reduce inflammation, slow disease progression, and improve physical function, offering relief and management for individuals suffering from these autoimmune disorders.

Common side effects of Enbrel SureClick include injection site reactions, upper respiratory infections, headaches, and mild nausea. Patients are advised to take precautions against infections and promptly report any signs of severe side effects to their healthcare provider. It’s crucial to follow the suggested dosage of Enbrel SureClick & administration guidelines to avoid complications such as missed doses or overdosing. Enbrel SureClick should be stored in a refrigerator but can also be kept at room temperature for short periods. Patients should carefully follow storage instructions to maintain medication efficacy and safety. Before starting Enbrel SureClick, patients should discuss their medical history & current medications with their healthcare provider to minimize risks and ensure safe treatment management.

Uses of Enbrel SureClick

  • Rheumatoid arthritis (RA)
  • Plaque psoriasis (PsO) and psoriatic arthritis (PsA)
  • Ankylosing spondylitis (AS)
  • Childhood arthritis (polyarticular juvenile idiopathic arthritis, JIA)

Enbrel Dosage

Enbrel SureClick injections come in the following formulations and dosage strengths:

  • Injection solution, prefilled syringe:
    • 25mg in 0.5mL
    • 50mg per mL
  • Injection solution, prefilled autoinjector:
    • 50mg per mL
  • Injection, lyophilized powder for reconstitution:
    • 25mg per vial
  • Injection, prefilled single-dose prefilled cartridge with reusable autoinjector:
    • 50mg per mL

Recommended Dosage of Enbrel SureClick for Different Patients

Ankylosing Spondylitis:

  • Purpose: To reduce signs and symptoms of active ankylosing spondylitis.
  • Dosage: 50 mg injected under the skin once a week.

Rheumatoid Arthritis:

  • Purpose: To lessen the signs and symptoms, induce a substantial clinical improvement, inhibit the advancement of joint damage, and boost physical functioning in patients experiencing moderate to severe rheumatoid arthritis.
  • Dosage: 50 mg injected under the skin once a week.

Psoriatic Arthritis:

  • Purpose: To reduce signs and symptoms, inhibit the progression of joint damage & improve physical function in patients with psoriatic arthritis.
  • Dosage: 50 mg injected under the skin once a week.

Plaque Psoriasis:

  • Purpose: For adults (18 years and older) with chronic moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy.
  • Initial Dosage: 50 mg injected under the skin twice weekly for the first three months.
  • Maintenance Dosage: 50 mg injected under the skin once a week.

[Note: These recommendations may vary depending on individual circumstances. Always discuss your dosage with your doctor, who will tailor the correct amount according to your specific needs.]

How to Take Enbrel SureClick?


  • Check the medication: Inspect the Enbrel SureClick autoinjector for damage or defects. Verify the expiration date and ensure the solution is clear and colorless to slightly yellow. Do not use it if it is cloudy, discolored, or contains particles.
  • Allow the autoinjector to reach room temperature: Remove the Enbrel SureClick from the refrigerator and let it sit at an average room temperature for 15 to 30 minutes before use. Do not heat the autoinjector in any other way.

Choose an injection site:

  • Select an appropriate injection site, typically the front of the thighs or the abdomen, avoiding the two-inch area around the navel. If you need assistance, you can also use the outer upper arm area.
  • Stay clear of injecting into bruised, tender, red, or hardened skin. Avoid using areas with scars or stretch marks for injections.

Clean the injection site:

  • Sanitize the injection site using an alcohol swab and wait for it to completely dry to decrease the likelihood of infection.

Injecting the medication:

  • Remove the cap from the Enbrel SureClick autoinjector.
  • Hold the autoinjector firmly against your skin to unlock it.
  • Press the button to begin the injection. You will hear a clicking sound.
  • Hold the button and wait for a second click, indicating the injection is complete, usually about 15 seconds.
  • Carefully lift the autoinjector away from your skin.

After the injection:

  • If there is bleeding, press a cotton ball or gauze pad on the injection site. Do not rub the injection site. You may cover it with a small adhesive bandage if necessary.
  • Dispose of the used autoinjector in a sharps disposal container immediately after use. Do not throw it in the household trash.

Monitor for side effects:

  • Be aware of any signs of infection or other side effects, and contact your healthcare provider if you have concerns.

[Note: Your doctor will determine the appropriate dosage for you based on your condition, following medical guidelines and studies on the medication. They will adjust the dosage as needed over time.]

How Does Enbrel SureClick Work?

Enbrel SureClick is a biologic medication designed to address autoimmune disorders by targeting and inhibiting tumor necrosis factor (TNF), which is responsible for its role in systemic inflammation. Enbrel binds to TNF molecules, preventing them from activating TNF receptors in the body. This process diminishes inflammation and aids in controlling symptoms associated with conditions like rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. By blocking the inflammatory processes, Enbrel helps slow disease progression, reduce joint damage, and improve physical function, making it a crucial treatment option for patients with these chronic autoimmune conditions.

Enbrel SureClick Side Effects

Common side effects of Enbrel SureClick may include:

  • Injection site reactions (redness, itching, pain, or swelling)
  • Upper respiratory infections
  • Headache
  • Dizziness
  • Mild nausea
  • Abdominal pain
  • Rash
  • Fatigue
  • Mild fever
  • Cough
  • Sore throat
  • Runny or stuffy nose
  • Mild allergic reactions
  • Back pain
  • Urinary tract infections

Serious side effects of Enbrel SureClick may include:

  • Fever, chills, and symptoms resembling the flu.
  • Pale skin, along with easy bruising or bleeding.
  • Continued pain, redness, or swelling at the injection site lasting longer than five days.
  • Symptoms of lymphoma: fever, night sweats, weight loss, stomach pain or swelling, and swollen glands in the neck, armpits, or groin.
  • The signs of tuberculosis include a persistent cough, night sweats, loss of appetite, weight loss & extreme fatigue.
  • New or worsening psoriasis: red skin, scaly patches, and raised pus-filled bumps.
  • Nerve issues: dizziness, numbness or tingling, vision problems, or weakness in the arms or legs.
  • Indications of heart failure: shortness of breath and swelling in the lower legs.
  • Symptoms of lupus-like syndrome include joint pain or swelling, chest discomfort, shortness of breath, and a rash on the cheeks or arms that becomes more pronounced in sunlight.
  • Liver complications: pain in the upper right stomach, vomiting, fatigue, loss of appetite, and jaundice (yellowing of the skin or eyes).

[Note: Additional side effects may not be listed here. Be sure to consult your healthcare provider for comprehensive medical advice about side effects.]

Enbrel SureClick Warnings

  • Serious Infections Risk with Enbrel SureClick: This medication increases the risk of severe or potentially life-threatening infections. This risk is heightened in older adults, individuals taking other immunosuppressive drugs, and those with chronic health conditions. Before starting Enbrel, ensure your healthcare provider is aware of your medical history, especially past infections like tuberculosis or hepatitis B. They will evaluate your risk before prescribing Enbrel. Contact your healthcare expert immediately if you experience persistent fever, difficulty breathing, chronic cough, night sweats, or confusion. Avoid using Enbrel if you are currently experiencing an active infection.
  • Cancer Risks Associated with Enbrel SureClick: Clinical trials have shown an increased occurrence of cancers, including lymphoma, leukemia, and melanoma, among users of Enbrel compared to non-users. Children and teenagers using Enbrel have also been reported to develop lymphomas and other serious cancers. Your healthcare provider will assess your cancer risk before initiating treatment with Enbrel and will continue to monitor you during treatment.
  • Nervous System Effects from Enbrel SureClick: Enbrel may rarely trigger or exacerbate neurological conditions such as multiple sclerosis and Guillain-Barré syndrome. If you have existing neurological issues, inform your provider, as they will need to monitor your condition closely during treatment with Enbrel. Report any new symptoms such as numbness, tingling, limb weakness, vision changes, or dizziness promptly. These symptoms can lead to severe and permanent neurological damage if not evaluated by a healthcare provider promptly.
  • Heart Failure and Enbrel SureClick: Use of Enbrel has been linked to new or worsening cases of heart failure. Notify your healthcare provider if you have a history of heart failure. They will consider the benefits and risks to determine if Enbrel suits you.
  • Risk of Bleeding and Infections with Enbrel: Although rare, Enbrel can cause a decrease in blood cells, impairing your ability to fight infections and increasing your risk of bleeding. Contact your healthcare specialist immediately if you notice persistent fever, easy bruising, pale skin, or unusual bleeding.

Enbrel SureClick Boxed Warning

  • Serious Infections:
      • Patients using Enbrel SureClick face a higher risk of serious infections that could require hospitalization or result in death. These infections include tuberculosis (TB), bacterial sepsis, invasive fungal infections, and infections from other opportunistic pathogens.
      • Avoid initiating Enbrel in patients with active infection, including chronic or localized infections.
      • Screening for latent TB is necessary before initiating Enbrel SureClick and throughout the therapy. Treat latent TB before beginning Enbrel.
      • Monitor patients closely for the emergence of infection signs and symptoms both during and after Enbrel therapy. If a serious infection or sepsis develops, Enbrel SureClick should be stopped.
  • Malignancies:
    • Reports indicate that lymphoma and other cancers, including fatal cases, have occurred in children and adolescents receiving TNF blockers like Enbrel SureClick.
    • Instances of acute and chronic leukemia have been reported in post-marketing studies of TNF blockers used for rheumatoid arthritis and various other indications.
    • Nearly half of these cases involved lymphomas. The potential risk of malignancies in patients on Enbrel is unknown, though an increased risk cannot be dismissed.

Enbrel SureClick Precautions

  • Inform your healthcare expert about any ongoing medical issues.
  • Disclose any medications you’re taking, including herbal supplements.
  • Do not start Enbrel if you have any infection unless your healthcare provider approves it.
  • Avoid starting Enbrel SureClick if you have open cuts or sores.
  • Diabetes, HIV, or a compromised immune system.
  • Tuberculosis (TB) exposure or history.
  • Residence or travel in regions with higher risks of TB or certain fungal infections (e.g., Ohio & Mississippi River valleys or the Southwest for histoplasmosis).
  • History of hepatitis B or heart failure.
  • Report any noticeable symptoms such as persistent fever, bruising, bleeding, or paleness.
  • History of severe nervous disorders, seizures, numbness, tingling, multiple sclerosis, or Guillain-Barré syndrome.
  • Inform if using Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide).
  • Scheduled surgeries or recent/planned vaccinations. Ensure all vaccines are up-to-date before starting Enbrel SureClick, and avoid live vaccines while on treatment.
  • If allergic to rubber or latex.
  • Mention to your doctor if you are pregnant, intend to become pregnant, or are breastfeeding.
  • Notify if you have been around someone with chickenpox.

Enbrel SureClick Contraindications

Contraindications refer to specific circumstances or health conditions where taking a medication could pose safety risks. If any of the following conditions apply to you, inform your healthcare provider, as Enbrel SureClick may not be safe for you:

  • Severe infection in the blood (sepsis).

Enbrel SureClick Missed Dose

If you miss a dose of Enbrel SureClick, administer it as soon as you remember. However, if it is almost time for your next scheduled dose, drop the missed dosage and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. Always follow your healthcare provider’s instructions regarding missed doses to ensure effective management of your condition.

[Note: If you miss a medication dose and are uncertain when to take the next one, promptly consult your doctor or pharmacist for guidance.]

Enbrel SureClick Overdose 

If you suspect an overdose of Enbrel SureClick, seek immediate medical attention. While specific symptoms of an Enbrel overdose are not well-documented, overdosing may exacerbate side effects such as infections or allergic reactions. It’s crucial to strictly follow the suggested dosage to avoid potential health risks. Contact your healthcare expert or local poison control center, or visit the nearest emergency room if an overdose is suspected to ensure prompt and appropriate management of any adverse effects.

[Note: If you have taken more than the recommended dose, seek immediate medical assistance or call the Poison Help line at 1-800-222-1222.]

Enbrel SureClick Storage

  • Store Enbrel SureClick in the refrigerator at 36°F to 46°F.
  • Keep the prefilled syringes and autoinjectors in their original carton to protect them from light and physical damage.
  • Enbrel SureClick may be stored at room temperature (up to 77°F or 25°C) for a maximum of 14 days.
  • Once Enbrel has reached room temperature, do not place it back in the refrigerator. It must be discarded if it has not been used within 14 days.
  • Do not freeze Enbrel SureClick. If accidentally frozen, it should not be used and must be discarded.
  • Avoid exposure to heat or direct sunlight.
  • Keep Enbrel SureClick out of the reach of children.
  • Do not shake the prefilled syringes or autoinjectors.
  • Dispose of used syringes and autoinjectors in a puncture-resistant sharps container, adhering to local medical waste disposal regulations.

[Note: Talk to your healthcare provider about properly disposing of unused medication and any questions you may have about storing it.]

Enbrel SureClick Interactions

  • Immunosuppressants: Enbrel may enhance the effects of other immunosuppressive drugs, increasing the risk of infection.
  • Biologics and Live Vaccines: Caution is advised when using Enbrel SureClick with other biologic drugs that suppress the immune system, such as anakinra or abatacept, and with live vaccines. Using Enbrel in combination with these can increase the risk of serious infections.
  • Cytokine Modulators: Combining Enbrel with other cytokine modulators can lead to an additive immune suppression effect.
  • Warfarin (Anticoagulant): Enbrel SureClick can potentially alter the levels of warfarin in the blood, necessitating more frequent monitoring of blood coagulation levels.
  • Cyclophosphamide: Some evidence suggests that Enbrel can reduce the clearance of cyclophosphamide from the body, potentially increasing its toxicity.
  • Anti-diabetic Medications: Enbrel may impact blood glucose levels, requiring adjustments to diabetic medication dosages.

[Note: This list isn’t comprehensive; other medications may interact with Enbrel SureClick. Make sure to inform your doctor about all prescription drugs, over-the-counter medications & herbal supplements you are taking.]

Enbrel SureClick Alternatives

[Note: Your doctor will select the appropriate medication for you. Do not take any alternative medications without consulting your healthcare provider, as this can cause serious side effects.] 

Frequently Asked Questions

Are Enbrel SureClick (etanercept) and Humira (adalimumab) the same medication?

No, Enbrel SureClick and Humira are not the same medication, although they are both types of monoclonal antibodies and function in similar ways. They treat several overlapping conditions, such as rheumatoid arthritis and psoriasis. However, Humira has additional approvals for treating Crohn’s disease, ulcerative colitis, hidradenitis suppurativa, and uveitis. While both drugs are administered via subcutaneous injection, their dosing schedules and potential side effects may differ.

What are the safety considerations for taking Enbrel SureClick?

Enbrel may increase your risk of infections and other severe health issues. In certain situations, your healthcare provider may advise you to discontinue Enbrel SureClick if the risks outweigh the potential benefits. Maintaining consistent appointments and lab visits is vital for your provider to monitor your health and determine any risks associated with the medication.

Can I consume alcohol while on Enbrel SureClick?

Moderate alcohol consumption may be acceptable while taking Enbrel, but heavy drinking can damage your liver. Additionally, using Enbrel can increase the risk of severe complications, including death, if you have liver damage from alcohol use. Consult your healthcare provider before combining Enbrel SureClick with alcohol.

What are the recommended injection sites for Enbrel?

Enbrel SureClick can be injected into the abdomen, thigh, or outer upper arm. Each form of Enbrel, whether vials, syringes, or autoinjectors, has specific usage instructions. Ensure you are properly trained on how to use each device before beginning treatment. If you need a refresher on the injection technique, refer to the instructions for use provided with your medication.

Are Enbrel SureClick injections painful?

While some individuals may experience mild pain or discomfort, such as itching, swelling, or bruising from Enbrel injections, these symptoms generally do not deter continued use of the medication. Allowing the solution to reach average room temperature before injecting can help reduce any discomfort.

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