Crisaborole

Eucrisa Ointment 2%

Eucrisa (crisaborole) is a 2% topical ointment. It is approved by the FDA to treat mild to moderate atopic dermatitis (AD) and is suitable for adults & children 3 months and older. It works as a phosphodiesterase-4 (PDE-4) inhibitor, reducing skin inflammation by blocking PDE-4 activity. Eucrisa should be applied thinly twice daily to the affected areas. Common side effects can include burning, pain, or stinging at the application site. The safety of Eucrisa during pregnancy and breastfeeding is unknown. Consult your healthcare provider before using Eucrisa to discuss potential drug interactions and establish a safe treatment plan tailored to your needs.

Product Overview

Eucrisa (crisaborole) is an FDA-approved 2% topical ointment designed to manage mild to moderate atopic dermatitis (AD) in both adults and children aged 3 months and older. It belongs to the class of drugs known as phosphodiesterase-4 (PDE-4) inhibitors. By inhibiting PDE-4, Eucrisa helps reduce the levels of inflammation that contribute to the symptoms of AD, such as redness, itching, and irritation. Clinical studies have shown that many patients achieve clearer skin within four weeks of consistent use.

The recommended application involves a thin layer of ointment applied to the affected skin areas twice a day. The dosage is the same for both adults and children, and adherence to the application schedule is crucial for effective symptom management. While using Eucrisa, patients should be aware of possible side effects, including pain or a burning sensation at the application site, which is generally mild but may be severe in some cases.

It is vital to tell your health history to your healthcare provider before starting treatment, particularly if you have allergies to any of Eucrisa’s ingredients or if you are pregnant or breastfeeding, as its safety in these situations has not been established. Additionally, while there have been no confirmed drug interactions in clinical studies, a literature review suggests a potential interaction with riociguat (Adempas). Therefore, patients should inform their primary healthcare giver about all the drugs they are taking to avoid potential interactions. Eucrisa is part of a comprehensive approach to treating AD, and while it can be used as a standalone treatment, it may also be part of a broader therapeutic regimen that includes other medications, depending on the individual’s specific condition and response to treatment.

Uses of Eucrisa

• It is used to treat mild to moderate atopic dermatitis (AD) in adults and children (3 months or older).

How to Use Eucrisa?

Dosage

• Eucrisa is available as a topical ointment, which means it is applied directly to the skin. It is offered in one concentration: 2% strength. This formulation delivers 20 milligrams (mg) of the active ingredient, crisaborole, in every gram (g) of ointment.
• The Eucrisa ointment is packaged in tubes available in two sizes:
  • A 60-gram (g) tube.
  • A 100-gram (g) tube.

Recommended Dosage for Different Patients

Dosage for Eczema

• Eucrisa is approved for treating mild to moderate AD (atopic dermatitis), which is the most common form of eczema, affecting both adults and children aged 3 months and older.
• Dosage Instructions:
  • Apply a fine layer of Eucrisa ointment to the affected skin areas.
  • This application should be done twice per day.

Children’s Dosage

• The dosage for children aged 3 months and older is identical to that for adults. Just like adults, children should have a very fine (thin) layer of the ointment applied to the affected areas twice daily.
• It’s important to follow these guidelines consistently to effectively manage symptoms of AD and improve skin condition.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Eucrisa?

• Always use Eucrisa as your healthcare provider as directed.
• Apply a fine (thin) layer of the ointment to the skin that is affected twice a day.
• Do not use Eucrisa in the mouth, eyes, or vagina, as recommended by the manufacturer.
• Avoid applying a thick layer or using the ointment more than twice per day. Overuse does not improve results and may be harmful.
• Wash your hands after applying the ointment. If you are treating the skin on your hands, do not wash them immediately after application. If someone else applies the ointment for you, they should wash their hands afterward.
• Apply Eucrisa typically twice a day, such as in the morning before dressing and at night before bed.
• To ensure consistency in application, use medication reminders such as setting alarms, using timers, or downloading a reminder app on your phone.
• People with mild-to-moderate atopic dermatitis (AD) may experience periods of remission where there are no visible signs or symptoms of the condition.
• However, there may also be times when symptoms worsen, known as flare-ups.
• Some individuals may need to use Eucrisa only during flare-ups to manage symptoms. Once the symptoms subside, they might stop using the ointment as advised by their doctor.
• Others who experience constant symptoms might need to use Eucrisa for longer periods. This continuous use continues until a period of remission is achieved.
• If your AD symptoms do not improve or if they become severe, your doctor will likely reassess and modify your treatment plan.
• The decision to use Eucrisa short-term (only during flare-ups) or long-term will depend on how your AD responds to the treatment and if it is deemed safe and effective for you.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Eucrisa Work?

Eucrisa is classified as a phosphodiesterase-4 (PDE-4) inhibitor. While the exact mechanism of how it helps manage mild to moderate atopic dermatitis (AD) isn’t fully understood, it’s believed to play a crucial role in controlling skin inflammation. Typically, people with AD have higher levels of PDE-4 activity in their skin cells. PDE-4 is an enzyme that helps facilitate chemical processes in the body, including those that control inflammation, which is a key factor in AD and its associated skin symptoms.

By inhibiting the activity of PDE-4, Eucrisa increases the levels of a substance in the skin cells called cyclic adenosine monophosphate (cAMP). This increase helps in preventing the breakdown of cAMP and it potentially leads to reduced inflammation and alleviation of AD symptoms. The effectiveness of Eucrisa was demonstrated in clinical studies where individuals with mild to moderate AD used the drug for approximately four weeks, with many achieving clear or almost clear skin by the end of the study. However, the results from Eucrisa can vary based on several factors, including the severity of your symptoms and how closely you adhere to your AD treatment plan. It’s important to consult with your doctor to understand when you might expect to see improvements in your AD symptoms.

Important Safety Information

Eucrisa Side Effects

Common side effects of Eucrisa may include:

• Pain at the site where the ointment is applied (This pain may manifest as a stinging or burning sensation on the skin shortly after application.)

Serious side effects of Eucrisa may include:

• Allergic Reactions
• Burning or Stinging
• Worsening of Atopic Dermatitis (AD)
• Pain where the ointment has been applied can also be severe.
• Infection

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Eucrisa Warnings

Before using Eucrisa, it’s essential to discuss your complete health history with your doctor to determine if Eucrisa is suitable for you. Certain health conditions and factors may influence whether you should use this medication. Here are a few key precautions to consider:

• Allergic Reactions: If you have already experienced an allergic reaction to Eucrisa or any of its active or inactive ingredients, you should not use it. In such cases, consult your doctor for alternative treatments that may be safer for you.
• Pregnancy: The safety of Eucrisa during pregnancy is currently unknown. If you are pregnant or planning to get pregnant, it is vital to consult the potential risks and benefits of using Eucrisa with your healthcare provider.
• Breastfeeding: It is also not known whether Eucrisa is safe to use while breastfeeding. If you are breastfeeding, talk to your doctor about the best way to manage your treatment while ensuring the safety of your baby.

Discussing these aspects with your doctor can help ensure that Eucrisa is used safely and effectively, considering your individual health needs and conditions.

Eucrisa Precautions

• Alcohol: Drinking alcohol does not impact the effectiveness of Eucrisa, a topical medication used for treating mild to moderate atopic dermatitis (AD) in specific individuals. “Topical” simply means it is applied directly to the skin. However, it’s important to note that alcohol can trigger flare-ups of AD in some people. If you consume alcohol, it’s advisable to discuss with your doctor how this might affect your AD or interfere with your treatment plan with Eucrisa. This conversation can help you manage your condition more effectively while considering your lifestyle choices.
• Birth Control: The safety of using Eucrisa during pregnancy is not currently known. If you are sexually active and there is a possibility that you or your partner could become pregnant, it’s important to have a discussion with your doctor. They can provide guidance on effective birth control methods to use while you are being treated with Eucrisa. This conversation will help ensure that you are well-informed about how to manage your reproductive health during treatment.
• Breastfeeding: The safety of using Eucrisa while breastfeeding has not been established as there are no clinical studies on its effects during breastfeeding. The medication is absorbed into the bloodstream when used, but it is not known whether Eucrisa can be transferred to breast milk or if it might affect milk production. If you are currently breastfeeding or plan to breastfeed, it is crucial to consult your doctor. They may advise you on the safest approach for feeding your child while you are undergoing treatment with Eucrisa.
• Pregnancy: Currently, no clinical studies have been conducted on the use of Eucrisa during pregnancy, so it’s unclear whether it is safe for pregnant women. Animal studies have shown that Eucrisa did not harm fetuses when pregnant animals received doses a few times higher than the recommended human dosage. However, adverse effects on fetuses were observed when the animals received doses significantly higher than what is used in humans. If you are pregnant or planning to get pregnant, it is important to consult your doctor about this. They will help you comprehend the potential risks and benefits of using Eucrisa during your pregnancy.

Eucrisa Missed Dose

• Apply when it’s possible (as soon as): If you forget to apply Eucrisa, put it on as soon as you remember.
• Skip if it’s close to the next dose: If it’s nearly time for your next scheduled application, just skip the missed dose. Do not apply the ointment.
• Stick to your regular schedule: Continue with your next dose at the regular time.
• Do not double up: Never apply more ointment than usual to make up for a missed dose.
• Set alarms: Use alarms or timers on your phone to remind you.
• Use reminder apps: Download and use a medication reminder app.
• Kitchen timer: A simple kitchen timer can also serve as a reminder.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Eucrisa Overdose

It’s essential not to use more Eucrisa than prescribed by your doctor. Using too much of any medication can lead to serious side effects or an overdose. If you suspect that you have applied too much Eucrisa, you should contact your doctor immediately for advice. Alternatively, you can reach out to the American Association of Poison Control Centers by calling their helpline number or using their online tool for guidance.

In cases where symptoms from an overdose are severe, do not hesitate to call 911 or your visit the nearest emergency room or local emergency number right away. Taking these steps promptly can help manage any potential risks effectively.

[Note: If you consumed more than recommended dose, get medical help right away, or call the Poison Help line at 1-800-222-1222.]

Eucrisa Storage

• Store Eucrisa ointment at room temperature, between 68°F-77°F (20°C-25°C), in its original tube. Ensure the tube is sealed tightly to preserve the ointment’s integrity.
• If you have leftover Eucrisa that you no longer need, dispose of it properly. This is important to prevent accidental use by others, including children and pets, and to avoid environmental harm.
• When you receive Eucrisa from the pharmacy, the pharmacist will mark an expiration date on the prescription label found on the tube or its outer packaging. This date is usually one year from when the medication was dispensed.
• The expiration date ensures the medication remains effective up to that time. The Food & Drug Administration (FDA) advises against using medications past their expiration date.
• If you have Eucrisa that has expired, consult your pharmacist before using it. They can provide guidance on whether it is safe to use or how to dispose of it appropriately.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Eucrisa Interactions

Although Eucrisa is applied topically to the skin, it is absorbed into the body and bloodstream, which raises the possibility of interactions with other medications. Current clinical studies have not identified any drug interactions with Eucrisa. However, a literature review from a trusted source suggests a potential interaction between Eucrisa and riociguat (Adempas), a medication used to treat certain types of pulmonary hypertension.

There are no known interactions between Eucrisa and any supplements or foods. Before starting Eucrisa, it is important to discuss with your doctor and pharmacist all the medications you are currently taking. This includes prescription drugs, over-the-counter medications, vitamins, herbs, and supplements. Providing this information can help prevent potential interactions and ensure safe usage of Eucrisa. If you have any concerns about how Eucrisa might interact with other medications or supplements you are using, do not hesitate to ask your doctor or pharmacist for advice.

[Note: This isn’t a complete list, and there could be other drugs that interact with Eucrisa. Make sure to tell your doctor any prescription, over-the-counter medicines, and herbal products you’re taking.]

Eucrisa Alternatives

• Protopic (tacrolimus)
• Elidel (pimecrolimus)
• Dupixent (dupilumab)
• Xeljanz (tofacitinib)
• Xeljanz XR (tofacitinib citrate)
• Sandimmune (cyclosporine)
• Imuran (azathioprine)
• Betamethasone dipropionate (betamethasone dipropionate)
• Triamcinolone acetonide (triamcinolone acetonide)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Frequently Asked Questions

Does Eucrisa come as a cream or only as an ointment?

Eucrisa is only available as an ointment, not as a cream. Being a topical medication, it is applied directly to the skin. Ointments are beneficial because they help retain moisture in the skin and provide a protective barrier, which can be particularly useful for managing symptoms of atopic dermatitis (AD), the most common form of eczema. These symptoms often include dry, crusted, or irritated skin. If you have any questions about using Eucrisa or other treatment options for AD, it’s important to discuss them with your doctor.

Does Eucrisa treat psoriasis, acne, or rosacea?

Eucrisa is not approved by the Food & Drug Administration (FDA) to treat acne, psoriasis, or rosacea. While atopic dermatitis (AD), which Eucrisa is approved to treat, can share some symptoms with these conditions, and even some treatments like topical corticosteroids, they are distinct in their own ways. Currently, Eucrisa is only approved for treating mild to moderate AD in adults & children 3 months and older.

However, a recent clinical study has shown that crisaborole 2% ointment, which has the same active ingredient as Eucrisa, was effective in treating psoriasis, specifically in sensitive areas such as the face, skin folds (like the groin) and skin around the anus or external genitals. Based on this, doctors might consider prescribing Eucrisa off-label for psoriasis in these areas and potentially for other skin conditions like rosacea. If you have psoriasis, acne, or rosacea, it’s important to consult with your doctor to discuss the best treatment options for your specific skin condition.

How quickly does Eucrisa (crisaborole) work to clear eczema?

Eucrisa (crisaborole) typically begins to show results in treating eczema within a week for some people, according to clinical studies. However, it usually takes about 4 weeks of consistent use to see significant improvements, with skin becoming clear or almost clear. It’s important not to get discouraged if you don’t notice immediate improvement. Consistency in following the treatment plan as prescribed by your healthcare provider is crucial. If you are using Eucrisa and feel that it is not working effectively for you, discuss this with your healthcare provider to potentially adjust your treatment strategy.

Can I use lotions and moisturizers with Eucrisa (crisaborole)?

Yes, you can use lotions and moisturizers with Eucrisa (crisaborole), but it’s important to consult with your healthcare provider first. Because the effectiveness and absorption of Eucrisa can be influenced by other products applied to the same area, your provider can guide you on the best practices for using them together. They can recommend whether it’s safe to apply other creams or lotions concurrently and how best to incorporate them into your skincare routine to ensure Eucrisa remains effective.

Is cancer a side effect of Eucrisa?

Cancer is not known to be a side effect of Eucrisa. There have been no reports of cancer in the clinical trials for Eucrisa, nor have there been any reported cases since it was approved by the Food & Drug Administration (FDA) in 2016. However, it’s important to note that other treatments for atopic dermatitis, like pimecrolimus cream (Elidel) and tacrolimus ointment (Protopic), have been linked to potential cancer risks. These medications come with a boxed warning, the strongest warning issued by the FDA, due to rare reports of skin cancer and lymphoma (a type of blood cancer) associated with long-term use.

If you have concerns about using Eucrisa or the risk of cancer, it is essential to discuss these with your doctor. They may provide detailed information about the risks and benefits associated with using Eucrisa for your condition.

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