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Tenapanor Hydrochloride


Ibsrela is a prescription medication available as a brand-name drug. This FDA-approved drug helps patients treat irritable bowel syndrome with constipation (IBS-C). It is specifically prescribed for adult use, with a daily dose of 50 mg twice. Patients need to take their medicines before breakfast and dinner to avoid any future complications. It is important to note that Ibsrela is not advised for children’s use as its safety and efficacy are still not determined by medical professionals. Overlooking this condition may result in adverse reactions. While the medication has its benefits, it comes with certain setbacks also. If the dosage is not followed correctly, it can cause serious side effects.  

Ibsrela Overview

Ibsrela is a prescription medication specifically formulated to treat IBS-C, known as irritable bowel syndrome with constipation in adults. It contains the active ingredient Tenapanor, which acts as a sodium/hydrogen exchanger 3 (NHE3) inhibitor. This mechanism helps to increase bowel movements and alleviate symptoms associated with IBS-C. This medication is FDA-approved, which guarantees its safety and effectiveness when used as directed by a medical professional.

Ibsrela is available in tablet form, with each tablet containing 50 mg of Tenapanor. The usual prescribed dosage is one tablet taken twice a day, immediately before breakfast and dinner. It is important to swallow the tablet whole without crushing or chewing. Ibsrela is only prescribed for use by adults diagnosed with IBS-C and should be used under the guidance of a medical practitioner. It works by restricting NHE3 inhibitor, which reduces sodium absorption in the intestines, thereby increasing water content and promoting bowel movements.

However, there are certain side effects of Ibsrela, which may include diarrhea, abdominal distension, and flatulence. One important thing that patients need to be mindful of is to stay hydrated and report any severe or persistent symptoms to their healthcare provider. Before taking this medication, inform your doctor of any existing medical conditions or allergies and discuss your current medications. In case you forget to take a dose, you can ask your medical provider for any queries or concerns related to the situation. Ensure not to take double doses. If an overdose occurs, get medical help right away. Lastly, store your medication at room temperature and in its original packaging to maintain efficacy.

Uses of Ibsrela

It is used to treat IBS-C in adults, abbreviated as IBS-C. The medication helps in managing symptoms of IBS-C, including: 

  • Abdominal discomfort
  • Bloating, and
  • Constipation

Ibsrela Dosage

Strengths and Forms

Ibsrela is available in the market in a tablet form with a strength of 50 mg.

Recommended Dosage for Different Patients

The medication dosage is based on the patient’s needs and conditions. So, always follow the dosage mentioned on the prescription label or as directed by an expert. 

  • For Adults: The recommended dose of Ibsrela is 50 mg twice daily. Doctors generally advise taking one dose of Tenapanor just before breakfast or before having the first meal of the day and the second dose before dinner.
  • For Children: The safety and efficacy of Ibsrela have not yet been determined by doctors.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Ibsrela?

  • Before taking your medication, ensure that you follow the instructions that your doctor provides.
  • Read the prescription label or patient information leaflet thoroughly to know the administration instructions completely.
  • Take the medication orally by mouth, two times a day.
  • Take the tablets before your breakfast and dinner.
  • Swallow the tablets as a whole as directed by a medical professional.
  • Have a glass of water while swallowing the tablets.
  • Do not chew, break, or crush the medication.
  • If you are unable to swallow the tablets, consult a medical specialist. These experts will suggest other treatments or alternate options.
  • Do not exceed or subceed the daily dose of Ibsrela. This can cause adverse reactions.
  • If you are taking Ibsrela on a regular basis, try to maintain consistency. Take your medicines at the same time each day to avoid any future complications. Moreover, you will also remember to take your doses regularly.
  • If you have any doubts or questions regarding the dosage, talk to your medical provider. 
  • If your condition is improving or gets worse, visit your doctor. They may adjust your doses or discontinue the treatment.
  • Remember not to suddenly stop or alter your dosing schedule without discussing it with your healthcare provider first.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Ibsrela Work?

Ibsrela acts directly within the digestive system. This means the medication works locally by targeting the specific area of the body without traveling the areas outside of the digestive tract. Ibsrela functions by restricting a protein called sodium/hydrogen exchanger 3 (NHE3), which is found in the cell lining, colon, and small intestine. This protein controls the absorption of sodium (salt) from your diet. By blocking this receptor, the medication reduces sodium absorption, leading to an increased amount of water in the digestive tract. This additional water helps to soften the stool and encourages bowel movements.

Ibsrela may have additional mechanisms of action. In patients with IBS, the digestive tract can be overly sensitive. The medication may help by decreasing this sensitivity, thereby easing abdominal pain. Furthermore, in people with IBS, the lining of the digestive tract can become more absorbent, commonly referred to as a “leaky gut.” This condition allows more bacteria and toxins to enter the bloodstream. In such situations, this drug works by reducing the permeability of the digestive tract lining, helping to address the leaky gut, which is believed to contribute to IBS symptoms.

Important Safety Information

Ibsrela Side Effects

Common side effects of Ibsrela may include:

  • Flatulence or gas
  • Diarrhea
  • Bloating in your abdomen
  • Dizziness
  • Mild allergic reaction. Its symptoms may include:
    • Skin rash
    • Itchiness
    • Skin flushing

Serious side effects of Ibsrela may include:

  • Severe diarrhea, causing dehydration. Sings may include:
    • Difficulty urinating
    • Confusion
    • Weak but fast heart rate
  • Serious allergic reactions. Its signs are:
    • Swelling under the skin, especially eyelids, hands, feet, or lips
    • Difficulty while breathing
    • Swelling of tongue, throat, or mouth
    • Hives
  • Rectal bleeding
  • Irregular heartbeats
  • Nausea
  • Vomiting
  • Nervousness
  • The heaviness of the legs

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Ibsrela Warnings

  • Diarrhea: Ibsrela can cause severe diarrhea. So, if you are experiencing excessive diarrhea, discontinue the medication and contact your medical practitioner right away.
  • Bowel Movements: Increased bowel movements can result in a higher risk of dehydration. Therefore, make sure you are taking plenty of fluids to prevent this condition.
  • Allergies: Ibsrela may cause allergic reactions in patients. So, it is always better to be aware of the signs of allergic reactions, like rash, itching, swelling, severe dizziness, or trouble breathing. Get medical help if these symptoms occur.
  • Abdominal Pain: If you are noticing severe abdominal pain, stop using your medication and talk to your healthcare provider immediately.
  • Electrolyte Imbalance: Monitor for signs of electrolyte imbalance, like muscle cramps, weakness, or irregular heartbeat, and inform your medical practitioner if they occur.
  • Livery and Kidney Function: Regularly monitor liver and kidney function if you have existing conditions affecting these organs while taking Ibsrela.

Ibsrela Boxed Warning

Ibsrela has received a boxed warning from the Food and Drug Administration (FDA) that alerts doctors and patients about its serious complications. The authority has issued a warning about the risk of severe dehydration in certain children. The medication may result in diarrhea in adults, causing dehydration if the condition is severe in patients or persists for a prolonged period. Besides, the condition can become more severe and fatal, especially in children. Due to this reason, Ibsrela is only allowed for use in patients aged 18 years.

Several animal studies have been conducted in young rats that reported death after starting the treatment with Ibsrela, and the deaths were due to dehydration only. While animal studies do not always accurately predict human results, it is still risky to let children consume this medication. Therefore, doctors usually do not prescribe Ibsrela for children.

Ibsrela Precautions

  • When undergoing surgery or any medical procedure, tell your doctor about the products you use. This list includes all prescription drugs, nonprescription drugs, and herbal products.
  • Before starting your treatment with Ibsrela, be sure to tell your medical provider if you have any allergies or are allergic to any of the medication’s ingredients. The product may contain certain inactive components that can cause severe allergic effects.
  • This medication can result in harmful reactions in patients with certain medical conditions. This is called a drug-condition interaction. Therefore, talk to your healthcare practitioner about your history. Make sure to tell them if you have any of the following conditions:
    • Blockage in your GI tract
    • Previous reaction to Ibsrela
    • Pregnancy 
    • Breastfeeding
    • Chronic kidney disease
  • There is no specific alcohol interaction while taking Ibsrela; it is generally safe to consume alcohol during your treatment. 
  • Avoid driving or using machines that require alertness, as the medication may cause dizziness, and doing such activities after taking this drug can cause harm to patients.
  • If you are pregnant or planning to have a baby, talk to a medical professional before starting your treatment with Ibsrela, as it is not known whether the medication is safe for the baby or not. Discuss every risk and benefit with an expert practitioner.
  • It is still unknown how much drug passes into the breast milk and how it will affect the breastfed child. Therefore, lactating women are advised to consult with a medical professional about whether they should continue breastfeeding while taking Ibsrela. The expert will suggest appropriate options and treatments for the same.

Ibsrela Contraindications 

There are certain conditions in which Ibsrela is contraindicated. These are:

  • When the patients are below 6 years of age, this group of people is highly likely to experience dehydration.
  • When the patients have known or are exposed to developing mechanical gastrointestinal obstruction.

Ibsrela Missed Dose

Patients are generally recommended not to miss or skip their doses. However, if someone has forgotten about their doses, they are advised to:

  • Skip the missed dose & take the next dose at the scheduled time. 
  • Stick to your regular dosing schedule to avoid any complications.
  • Do not take double doses simultaneously just to make up for the missed dose. 
  • Use medication apps or set phone reminders to avoid missing doses.  

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

Ibsrela Overdose

Exceeding the maximum daily dose of your medication can cause harmful effects on your body. Therefore, patients should avoid overdosing on any medicine. In case you have mistakenly taken extra doses of Ibsrela and experiencing any unusual symptoms, report to your healthcare provider or get medical assistance by calling 911. Symptoms of overdose include severe diarrhea, leading to dehydration in patients. 

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

Ibsrela Storage

  • Read the product’s label thoroughly for detailed storage instructions.
  • Store the medication at a specific room temperature of 20°C and 25°C.
  • Make sure the tablets are kept in their original container.
  • Protect the medication from heat and moisture by keeping them in a tightly closed container.
  • Avoid repacking or storing tablets in another container.
  • The Ibsrela container has a desiccant canister that protects the tablets from moisture and keeps them dry. Do not remove that desiccant from the container.
  • Avoid keeping the medication in damp areas like the bathroom or near the sink.
  • Do not flush the medication down the toilet. 
  • Keep them away from the reach and sight of children.
  • Do not refrigerate the medication.
  • Discard the tablets when it is of no use or reaches its expiration date.
  • Ask an expert practitioner or pharmacist how to properly dispose of the container or medication without harming the environment.
  • Avoid keeping the medication under direct sunlight.

[Note: Discuss with your healthcare professional the proper disposal of any unused medicine and any questions you may have regarding its storage.]

Ibsrela Interactions

Durg interactions change the functioning and effectiveness of your medication, thus increasing the chances of serious side effects. Therefore, patients need to know which drug can interact with their medication so that they can avoid potentially life-threatening situations. The following interaction list does not contain all possible drugs:

  • Atorvastatin (Atorvaliq, Lipitor)
  • Fluvastatin (Lescol XL)
  • Pitavastatin (Livalo, Zypitamag)
  • Pravastatin
  • Rosuvastatin (Crestor)
  • Aliskiren (Tekturna)
  • Enalapril (Epaned, Vasotec)
  • Atenolol (Tenormin)
  • Fexofenadine (Allegra)
  • Midazolam (Nayzilam, Seizalam)
  • Montelukast (Singulair)
  • Sulfasalazine (Azulfidine)
  • Sumatriptan (Imitrex, Tosymra, others)
  • Telmisartan (Micardis)
  • Bosentan
  • Conjugated estrogens
  • Enalapril
  • Glyburide
  • Sodium polystyrene sulfonate
  • Asunaprevir
  • Mesalazine

[Note: This isn’t a complete list, and there could be other drugs that interact with Ibsrela. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Ibsrela Alternatives

  • Linaclotide (Linzess)
  • Plecanatide (Trulance)
  • Lubiprostone (Amitiza)
  • Polyethylene glycol 3350 (MiraLax)
  • Prucalopride (Motegrity)
  • Tegaserod (Zelnorm)
  • Lotronex
  • Alosetron Hcl
  • Viberzi

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Is Ibsrela a long-term medication?

Yes, Ibsrela is prescribed for long-term use in managing irritable bowel syndrome with constipation (IBS-C). It should be taken as prescribed by your healthcare provider to maintain its benefits. Frequent check-ups with your physician are essential to monitor your condition & adjust the treatment plan as necessary.

How much time does Ibsrela take to start working?

Ibsrela can start to relieve symptoms within the first week of treatment. However, it may take a few weeks to experience the full benefits. Consistent use as prescribed by your medical provider is essential for achieving optimal results & managing your symptoms effectively. 

If I have kidney problems, can I take Ibsrela?

If you have kidney problems, consult your healthcare provider before taking Ibsrela, as patients with low kidney function are most likely to experience severe diarrhea and dehydration. Your doctor will examine you for any problems and determine if the medication is safe & appropriate for you, considering your overall health and any potential associated risks.

What happens if I suddenly stop taking Ibsrela?

If you suddenly stop taking Ibsrela, your IBS-C symptoms may return. It is important to follow your doctor’s advice on how to discontinue the medication, if necessary, to avoid any sudden worsening of symptoms. Always consult your doctor before making changes to your medication regimen.

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