Ketoprofen

Ketoprofen

Prescription Ketoprofen is an FDA-approved medication used to relieve pain, tenderness, inflammation, and stiffness caused by osteoarthritis and rheumatoid arthritis. It is also used to relieve pain, including menstrual pain. Nonprescription ketoprofen relieves toothaches, the common cold, minor aches and discomfort from headaches, menstrual periods, muscle aches, and backaches and reduces fever. It belongs to a class of medications called NSAIDs. It contains ketoprofen as its active ingredient that stops the body’s production of a substance that causes pain, fever, and inflammation. Before taking ketoprofen, you should consult a licensed physician or pharmacist for safe and efficient use of the medication and ask them if you have any queries or concerns regarding the medication. You can buy ketoprofen online from reputable sources to ensure its authenticity. 

Product Overview

Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID), contains the active ingredient ketoprofen. It is used to relieve pain, tenderness, inflammation, and stiffness caused by osteoarthritis & rheumatoid arthritis. It is also effective for managing pain from menstrual periods, headaches, toothaches, muscle aches, and backaches, as well as reducing fever. Ketoprofen works by inhibiting the production of substances that cause inflammation, pain, and fever.

Ketoprofen is available in various forms and strengths: oral capsules (50, 75, 100 and 200 mg extended-release), oral tablets (12.5, 25, 50, 75, 100, 150 mg extended-release, 200 mg extended-release), topical gel (2.5%, 5%), transdermal patch (20 mg, 30 mg), suppositories (100 mg), intramuscular injection (100 mg/2 ml), and oral solution (25 mg/5 ml). Adults typically take oral capsules three or four times daily, while extended-release capsules are taken once daily. It is important to take the medication by following the instructions provided by your physician or healthcare provider. Ketoprofen is not usually recommended for children under 16 years old. Common side effects of ketoprofen include diarrhea, dizziness, headache, nausea, and stomach pain. 

Serious side effects may involve allergic reactions, heart attack, stroke, gastrointestinal bleeding, kidney damage, and liver damage. Patients should avoid using ketoprofen before or after coronary artery bypass graft surgery. They should consult their doctor if they have a history of asthma, heart failure, liver, or kidney disease. In case of a missed dose, take it as soon as you remember, but do not double the dose. Store ketoprofen at room temperature, away from light and moisture, and out of reach of children. Dispose of unused medication properly through take-back programs. Always consult a licensed healthcare practitioner for personalized medical advice and read the prescription label carefully before using ketoprofen.

Uses of Ketoprofen

• Pain relief
• Inflammation reduction
• Fever reduction
• Management of musculoskeletal disorders
• Postoperative pain management
• Dental pain
• Headaches and migraines
• Sports injuries
• Gout attacks

How to Use Ketoprofen?

Dosage

Form: Oral Capsules

Strength: 50 mg, 75 mg, 100 mg, 200 mg (extended-release)

 

Form: Oral Tablets

Strength: 12.5 mg, 25, 50 mg, 75 mg & 100 mg, 150 mg (extended-release), 200 mg (extended-release)

 

Form: Topical Gel

Strength: 2.5% w/w, 5% w/w

 

Form: Transdermal Patch

Strength: 20 mg per patch, 30 mg per patch

 

Form: Suppositories

Strength: 100 mg

 

Form: Intramuscular Injection

Strength: 100 mg/2 mL

 

Form: Oral Solution

Strength: 25 mg/5 mL

Recommended Dosage for Different Patients/Ketoprofen

Adults (Oral):

• Mild to moderate pain: 25-50 mg every six to eight hours
• Rheumatoid arthritis or osteoarthritis: 75 mg thrice daily or 50 mg four times daily
• Maximum daily dose: 300 mg

Elderly patients:

• Generally, start with lower doses due to the increased risk of side effects
• The dosage adjustments should be made based on individual response and tolerability

Children:

• It is not typically recommended for children under 16 years old
• If prescribed, the dosage is usually based on weight and determined by a pediatrician

Patients with renal impairment:

• Dosage may need to be reduced
• Severe renal impairment: avoid use if possible

Patients with hepatic impairment:

• It may require dose reduction
• Severe liver disease: avoid use

Topical application (adults):

• Apply the topical solution in a thin layer to the affected area 2-4 times daily

Transdermal patch:

• Usually, one patch is applied daily

For acute conditions (e.g., dental pain, menstrual cramps):

• Initial dose of 100-200 mg, followed by 25-50 mg every 6-8 hours as needed

Extended-release formulations:

• Usually taken once daily, often 200 mg

Intramuscular injection:

• 100 mg once or twice daily, not to exceed 200 mg/day

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Take Ketoprofen?

• This medication comes in the form of a capsule and an extended-release capsule to be taken orally by mouth. The capsules are typically taken three or four times daily for arthritis or every six to eight hours as required. 
• The extended-release capsules are generally taken once daily. 
• If you are taking Ketoprofen on a regular basis, you should maintain consistency in medication dosage and try to take it around the same time every day to help you remember to take it.
• Non-prescription ketoprofen is available as a tablet to be taken orally by mouth with a full glass of water or any other liquid daily every six to eight hours or as required. 
• Before using ketoprofen, you should carefully read and follow the directions for use given on the prescription label or package that came with the medication. 
• If you do not understand any part of the instructions or have any questions or concerns regarding medication use, you should ask your doctor or healthcare provider. 
• Use ketoprofen exactly as directed by your healthcare provider or physician. Do not take it more frequently, in large quantities, or more or less than prescribed. 
• Do not break, chew, open, or crush the tablets or capsules. Instead, try to swallow them whole. 
• You may take this medication with food or milk to prevent an upset stomach. You may also be recommended to take ketoprofen with an antacid to reduce stomach upset. 
• The medication’s dosage will initially be low. Still, it will gradually increase or decrease depending on how well your body responds to the treatment and the side effects you are experiencing. 
• You should discontinue taking the medication if you experience new or unexpected symptoms, if your existing symptoms worsen, if your pain lasts more than ten days, or if your fever lasts more than three days. 

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Ketoprofen Work?

Ketoprofen works as an NSAID by inhibiting the COX-1 and COX-2 enzymes, which produce prostaglandins that cause inflammation, pain, and fever. By reducing prostaglandins, ketoprofen decreases inflammation, lessens pain, and lowers fever. It may also inhibit lipoxygenase enzymes, adding to its anti-inflammatory effects, and has some central nervous system action for pain relief. Ketoprofen is rapidly absorbed, reaching peak levels in 0.5 to 2 hours, but has a short half-life of about 2 hours, requiring frequent dosing. It is highly protein-bound in plasma, affecting its distribution and elimination.

Important Safety Information

Ketoprofen Side Effects

Common side effects of Ketoprofen may include:

• Diarrhea or constipation
• Dizziness or drowsiness
• Gas or heartburn
• Headache
• Nausea and vomiting
• Rash
• Upset stomach or stomach pain

 

Adverse/Serious side effects of Ketoprofen may include:

• Severe Allergic Reactions: This medication can cause allergic reactions, including a certain type called DRESS. Its symptoms may include:
  • Breathing problems or wheezing
  • Dark colored urine
  • Dizziness, feeling lightheaded or fainting
  • Fever or general ill feeling
  • Itching, skin rash, or hives
  • Joint pain
  • Nausea or vomiting
  • Rapid heartbeat
  • Stomach cramps
  • Swelling of the face, mouth, lips, tongue, or throat
  • Swollen lymph nodes
  • Trouble swallowing or throat tightness
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
• Heart Attack and Stroke. Its symptoms may include:
  • Angina or pressure
  • Difficulty breathing
  • Excessive sweating
  • Pain in your back, jaw, throat, or arm
  • Rapid or abnormal heartbeat
  • Slurred speech or trouble understanding speech
  • Sudden weakness on one side of your body
  • Sudden and severe headache
  • Upset stomach, vomiting, or dizziness
• Hypertension. Its symptoms may include:
  • Anxiety
  • Blurry or other changes to the vision
  • Buzzing in the ears
  • Chest pain
  • Dizziness or confusion
  • A feeling of skipped heartbeats
  • Nausea/vomiting
  • Nosebleed
  • Sudden severe headache
  • Trouble breathing
• Heart Failure. Its symptoms may include:
  • Shortness of breath or difficulty breathing, especially while lying down
  • Swelling in your feet, ankles, or legs
  • Rapid unusual weight gain
  • Unusual fatigue 
• Bleeding 
• Stomach Bleeding. Its symptoms may include:
  • Black or tarry poop
  • Feel faint
  • Stomach pain that does not go away
  • Upset stomach
  • Vomit blood
• Kidney Damage. Its symptoms may include:
  • Difficulty catching your breath
  • Chest pain or pressure
  • Confusion
  • Nausea
  • Reduced need to pee
  • Seizures
  • Swelling in your feet, ankles, or legs
  • Weakness or unusual fatigue 
• Liver Damage. Its symptoms may include:
  • Dark-colored urine
  • Fever
  • Itching
  • Light-colored stool
  • Nausea or vomiting
  • Reduced appetite
  • Stomach or belly pain
  • Weakness or unusual fatigue 
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)
• Severe Skin Reactions. Its symptoms may include: 
  • Flat red rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes
  • Painful red or purple skin that looks charred and peels off
• Anemia. Its symptoms may include: 
  • Dizziness, lightheadedness, or feeling like passing out. 
  • Unusual fatigue or weakness 
  • Cold hands and feet 
  • Pale or yellowish skin 
  • Rapid abnormal heartbeat
  • Shortness of breath 

[Note: This list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Ketoprofen Warnings

• Do not use ketoprofen right before or after a coronary artery bypass graft (CABG) surgery.
• NSAIDs, including ketoprofen, increase the risk of serious gastrointestinal (GI) events, including ulceration, perforation, and bleeding of the stomach or intestines, which can be life-threatening. Such events can occur during any time while using this medication and without bothersome symptoms. Elderly patients above age 75 are at a higher risk for serious gastrointestinal events.
• Long-term use of NSAIDs has resulted in renal papillary necrosis and other renal injury.
• Abnormal results of one or more liver tests may occur. Rare cases of severe liver reactions, including jaundice, fatal fulminant hepatitis, liver necrosis, and liver failure, have been reported.
• NSAIDs such as Ketoprofen may lead to the onset of new hypertension or worsening of existing hypertension, contributing to the raised incidence of cardiovascular events.
• Edema and fluid retention have been observed in some individuals taking NSAIDs.
• As with other NSAIDs, anaphylactoid reactions can happen to patients who have never taken ketoprofen. 
• NSAIDs, including ketoprofen, can cause serious skin reactions such as exfoliative dermatitis, Stevens-Johnson Syndrome, and toxic epidermal necrolysis, which can be fatal.
• Due to the possibility of the fetal ductus arteriosus closing too soon, pregnant women should refrain from using NSAIDs, such as ketoprofen, beginning in the third trimester of their pregnancy.
• Ketoprofen may pass into your breast milk. Because of the potential risk of unfavorable reactions in infants, a decision should be made whether to pause nursing or to discontinue the drug, considering the drug’s importance to the mother.

Ketoprofen Boxed Warning

Cardiovascular Risk:

Patients taking NSAIDs such as ketoprofen may have a greater risk of stroke or heart attack as compared to people not taking these medications. It may happen suddenly and cause death. The risk may be higher if you have been taking this medication for a long time. Patients with heart-related disease or risk factors for cardiovascular disease may be at greater risk.

Gastrointestinal Risk:

NSAIDs, including ketoprofen, cause an increased risk of serious gastrointestinal adverse (GI) events such as bleeding, ulceration, and perforation of the intestines or stomach, which may be life-threatening. These GI events may happen at any time during treatment and without any prior warning signs. Geriatric patients have an increased risk for serious gastrointestinal events. 

Ketoprofen Precautions

• Before starting to take ketoprofen, let your physician or pharmacist know that you are allergic to ketoprofen or other NSAIDs or to any other medications. Also, tell them if you are allergic to inactive ingredients listed on the product label. Ask your physician, pharmacist or healthcare provider for the complete list of ingredients. 
• Before taking ketoprofen, tell your pharmacist or physician about all the medications you are taking, including all prescription, non-prescription, and over-the-counter drugs and herbal supplements you are currently taking or planning to take. 
• Before taking ketoprofen, you should share your complete medical history with your doctor, especially if you have the following conditions: 
  • Asthma 
  • Heart failure 
  • Swelling of arms, hands, ankles, feet, or lower legs. 
  • Liver disease
  • Kidney disease
• Tell your doctor if you are pregnant, suspect a pregnancy, or planning to become pregnant while taking ketoprofen. If you get pregnant while you are taking this medication, you should consult your doctor. This medication may cause fetal harm or problems with delivery if it is taken around twenty weeks of pregnancy or after that. Only take this medication while pregnant only when instructed to do so by your doctor. 
• Ketoprofen may pass into breast milk. Consult your doctor before breastfeeding a baby while taking this medication. 
• Elderly patients above 75 should consult their doctor or healthcare provider regarding this medication’s potential risks and benefits. Do not take ketoprofen for a long time or at a higher dose than prescribed. 
• If you are planning to have surgery, including a dental procedure, you should tell your doctor, surgeon, or dentist about all the medications you are taking, including ketoprofen.  

Ketoprofen Contraindications

Ketoprofen is contraindicated for use in patients who:

• Have hypersensitivity to ketoprofen or any of its components.
• Have a history of asthma, urticaria, or allergic-type reactions triggered by aspirin or other NSAIDs.
• Have acute peptic ulcer 
• Have inflammatory bowel disease
• Have blood clotting disorders 
• Have severe liver or kidney dysfunction 

Ketoprofen Missed Dose

• To get the best results from your medication, it is important to maintain consistency in dosage and take it around the same time every day. 
• If you have missed a dose of ketoprofen, you should take it as soon as you remember. 
• However, if it is almost time for your next dose, you may omit the missed dose and continue taking your medication according to your regular dosing schedule. 
• Do not simultaneously take double or extra doses of the same medication to compensate for the missed dose. 
• To further prevent missing your dosage, you can set a reminder on your phone. 

[Note: If you have missed a medication dose and are still determining when to take the next one, immediately consult your doctor or pharmacist.]

Ketoprofen Overdose

If someone has taken double or extra doses of ketoprofen simultaneously, it is crucial to seek medical help immediately. Symptoms associated with overdose are blurred vision, nausea, diarrhea, difficulty breathing, or headache. A mild overdose of ketoprofen may lead to stomach pain and vomiting, but a large overdose can cause internal bleeding, potentially requiring a blood transfusion. You should not induce vomiting unless advised by a licensed healthcare professional or poison control. You can call 911 or head to the nearest emergency room. 

[Note: If you consumed more than the recommended dose, get medical help immediately or call the Poison Help line at 1-800-222-1222.]

Ketoprofen Storage

• Keep ketoprofen at a controlled room temperature in a tightly closed container away from moisture, direct sunlight, and excess heat. 
• Do not allow the medication to freeze. 
• Keep all medications in a safe place away from the sight and reach of children and pets.
• Do not keep medications that are outdated or no longer needed. Discard them safely. 
• Do not flush it in the toilet, pour it down the drain, or throw it in the household garbage bin. 
• Discard unwanted medications in such a way that children, animals, or others cannot consume them. 
• The best way to eliminate unwanted medications is to give them away in the medicine take-back program. 
• For more information on properly disposing of unwanted medications, you can consult your pharmacist, healthcare provider, or local waste management company. 

[Note: Discuss with your healthcare professional the proper disposal of unused medicine and any questions you may have regarding its storage.]

Ketoprofen Interactions

• Acebutolol
• Atenolol
• Azilsartan
• Azilsartan Medoxomil
• Benazepril
• Betaxolol
• Bisoprolol
• Candesartan
• Captopril
• Carteolol
• Carvedilol
• Celiprolol
• Enalapril
• Enalaprilat
• Eprosartan
• Esmolol
• Fosinopril
• Irbesartan
• Ketorolac
• Labetalol
• Levobunolol
• Lisinopril
• Losartan
• Metipranolol
• Metoprolol
• Moexipril
• Nadolol
• Nebivolol
• Olmesartan
• Oxprenolol
• Penbutolol
• Perindopril
• Pindolol
• Propranolol
• Quinapril
• Ramipril
• Sotalol
• Spirapril
• Telmisartan
• Timolol
• Trandolapril
• Valsartan

[Note: This isn’t a complete list, and there could be other drugs that interact with Ketoprofen. Tell your doctor about prescription, over-the-counter medicines, and herbal products.]

Ketoprofen Alternatives

• Cyclobenzaprine
• Naproxen
• Diclofenac
• Ibuprofen
• Tylenol
• Etodolac

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

Can Ketoprofen be used to manage sports injuries?

Yes, Ketoprofen effectively manages pain and inflammation associated with sports injuries. It helps reduce swelling and provides pain relief, allowing for a quicker recovery. However, it is important to consult a licensed healthcare professional to decide the suitable dosage and form of Ketoprofen for your specific condition.

What are the risks of long-term use of Ketoprofen?

Long-term use of Ketoprofen may increase the risk of severe heart-related conditions, such as heart attack and stroke, as well as gastrointestinal issues like ulcers and bleeding. It may also cause renal and liver damage. Regular monitoring of the condition by a healthcare provider is necessary to manage these risks effectively.

How does Ketoprofen interact with other medications?

Ketoprofen can interact with various medications, including ACE inhibitors, beta-blockers, and other NSAIDs, potentially reducing their effectiveness or raising the risk of adverse effects. To avoid harmful interactions, it is crucial to tell your doctor or healthcare provider about all prescription, non-prescription medications, over-the-counter drugs and supplements you are taking. 

Is Ketoprofen safe for use in elderly patients?

While Ketoprofen can be used in elderly patients, they are at a higher risk of experiencing severe side effects, such as kidney impairment and gastrointestinal bleeding. Lower doses are typically recommended, and close monitoring by a licensed healthcare professional is essential to ensure safety.

Can Ketoprofen be used for dental pain management?

Yes, Ketoprofen is effective in managing dental pain, including pain after dental procedures. It reduces inflammation and provides pain relief. Using it under healthcare professional guidance is crucial to avoid side effects and medication interactions.

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