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Buy Methotrexate 2.5 Mg Tablets Online from a Canadian Pharmacy

What Is Methotrexate?

Methotrexate is a medication known as a DMARD, which stands for Disease-Modifying Anti-Rheumatic Drug. Its main purpose is to control how active your immune system is. Normally, your immune system defends your body against infections by creating inflammation. Inflammation can lead to swelling, warmth, redness, and pain. However, sometimes the immune system mistakenly attacks parts of your own body, like your joints, causing health problems.

What Does Methotrexate Use For?

Psoriasis Treatment: Methotrexate is effective for severe cases of psoriasis, a condition where red, scaly patches appear on the skin. It’s used when other treatments don’t work.

Rheumatoid Arthritis Management: For severe rheumatoid arthritis (RA), where the body’s immune system attacks its joints, causing pain and swelling, Methotrexate for rheumatoid arthritis is used in combination with rest, physical therapy, and sometimes other drugs. It’s chosen when certain other medications are ineffective.

Cancer Treatment: Methotrexate is also used in treating various cancers, including:

  • Cancers originate in tissues around a fertilized egg in the uterus.
  • Breast cancer.
  • Lung cancer.
  • Certain head and neck cancers.
  • Some lymphomas (cancers of the lymph system).
  • Leukaemia (white blood cell cancer).

How Does It Work?

As part of the antimetabolites drug class, Methotrexate functions by slowing down cell growth. In cancer treatment, it targets and slows the growth of cancer cells. For psoriasis, it reduces the speed of skin cell growth, helping prevent the formation of scaly patches. In rheumatoid arthritis, it decreases the immune system’s activity, thereby reducing joint inflammation and pain.

[Note: Methotrexate is a powerful medication and is typically prescribed when standard treatments for these conditions are not sufficient.]

Methotrexate Dose

Your physician might adjust your medication’s dosage to suit your specific needs. The amount of medicine you require is determined by its potency and the nature of your health condition. Below is a guide detailing the various conditions and their corresponding dosages:

Acute Lymphoblastic Leukemia (ALL): This is a medical condition that requires a special amount of medication. The starting dose for treatment is usually 20 milligrams for each square meter of the person’s body size. This amount of medicine is given once a week.

Mycosis Fungoides (for Adults): The dose ranges from 25 to 75 mg once a week when taken alone. When taken with other medicines, the dose is calculated based on body size, generally 10 mg per square meter, and given twice a week. 

Non-Hodgkin Lymphoma (for Adults): The dose is 2.5 mg, given 2 to 4 times a week. The total dose in a week should not be more than 10 mg. 

Polyarticular Juvenile Arthritis (pJIA) for Children: The amount of medication is determined based on the child’s body size. The starting dose is 10 mg per square meter once a week. The dose may be adjusted as needed, but only under a doctor’s supervision.

Psoriasis (for Adults): The initial dose is between 10 to 25 mg once a week. The maximum dose in a week should not exceed 30 mg.

Rheumatoid Arthritis (for Adults): The starting dose is 7.5 mg once a week. This may be adjusted as needed.

In any condition, only your doctor will decide if it can be used and what the dose should be in children. 

Usage & Storage Guidelines

General Instructions:

  • The Methotrexate dose varies for each individual.
  • Always follow your doctor’s prescription or the instructions on the medication label.
  • The details provided here are average doses; your specific dose may differ.
  • Do not alter your dose unless advised by your doctor.
  • Avoid using it more frequently or for longer periods than recommended.
  • This medication should not be used daily for non-cancer conditions.
  • Swallow the tablet whole without crushing, breaking, or chewing.
  • If you’re unable to swallow the tablet, do not take it.
  • For people with rheumatoid arthritis, psoriasis, and juvenile arthritis, doctors might prescribe folic acid or folinic acid supplements to mitigate side effects.

Missed Dose: It’s important to use this medicine on a set schedule. If you forget to take a dose, contact your doctor or pharmacist for advice.

Storing Instructions

  • Keep the medicine in its original container at normal room temperature.
  • Place it away from heat, moisture, and direct sunlight to protect it.
  • Ensure the medicine is not exposed to freezing temperatures.
  • Make sure it’s out of reach of children.
  • Don’t keep medicine that’s out of date or no longer needed. Your healthcare provider can guide you on how to safely dispose of it.


Here are some key considerations for using this medicine:

Allergies: If you’ve had unusual or allergic reactions to this medicine or any others in the past, inform your doctor. Also, mention if you have allergies to specific foods, dyes, preservatives, or animals.

Non-Prescription Products: If you’re using over-the-counter products, read the ingredient list carefully to check for potential allergens.

Pediatric Consideration: Studies show that Methotrexate can be useful in treating acute lymphoblastic leukemia and polyarticular juvenile idiopathic arthritis in children. However, its safety and effectiveness for other pediatric conditions haven’t been established.

Geriatric Consideration: Research to date indicates that older adults can use Methotrexate without specific age-related risks.

Breastfeeding Considerations: Studies have shown that this medication can harm breastfeeding infants. If you are breastfeeding, your doctor may advise an alternative medication, or you might need to stop breastfeeding while using this medicine.

Side Effects of Methotrexate

Sunlight Sensitivity: While taking Methotrexate, your skin may become very sensitive to sunlight, leading to sunburn-like reactions. To lower this risk, avoid direct sunlight, use sunscreen with SPF 30 or higher, and wear sun-protective clothing. Avoid sunlamps and tanning beds.

Common Side Effects (occurring in more than 1 in 100 people)

  • Decreased appetite
  • Nausea or vomiting
  • Stomach pain or indigestion
  • Diarrhea
  • Headaches
  • Fatigue or drowsiness
  • Hair loss

Serious Side Effects (rare, less than 1 in 10,000 people)

  • Yellowing of the eyes or skin (especially important to note in darker skin tones) – potential liver issues
  • Persistent cough, chest pain, difficulty breathing or shortness of breath – may indicate lung inflammation.
  • Swelling of hands, ankles, or feet, changes in urination frequency or inability to urinate – could signal kidney problems.
  • High temperature, chills, muscle aches, sore throat – signs of infection
  • Bleeding gums, vomiting blood, blood in urine, or unexplained bruising – could be a blood disorder.

Serious Allergic Reaction: In very rare cases, Methotrexate can cause a severe allergic reaction (anaphylaxis). If you suspect you’re having an allergic reaction, seek immediate medical attention.

Methotrexate Interactions

When using Methotrexate, it’s crucial to be aware of its interactions with other drugs. There are certain vaccines that should generally not be used alongside Methotrexate. These include:

  • Measles Virus Vaccine
  • Rotavirus Vaccine
  • Mumps Virus Vaccine
  • Varicella Virus Vaccine
  • Rubella Virus Vaccine
  • Zoster Vaccine

Your doctor might choose not to use Methotrexate or change other medications you are taking. Additionally, there are some medicines that, when used with Methotrexate, might increase the risk of side effects. However, in some situations, your doctor may find it best to prescribe both. These medicines include:

  • Eltrombopag
  • Rofecoxib
  • Etoricoxib
  • Rolapitant
  • Procarbazine
  • Theophylline

Frequently Asked Questions

How long does 2.5 mg of Methotrexate stay in your system?

Methotrexate generally gets cleared out of a non-pregnant adult’s system within a week after you’ve taken your last dose. If we’re talking about low doses, it typically takes around 16 to 55 hours to get rid of it completely. However, for higher doses, it might take a bit longer, ranging from 44 to 83 hours.

Can you get Methotrexate over the counter?

Methotrexate is a type of medication classified as an antineoplastic, which is commonly used in cancer treatment. It works by blocking a specific enzyme that cells require to survive, thereby inhibiting the growth of cancer cells, leading to their eventual destruction by the body. This medication is not available over the counter; you need a prescription from your doctor to obtain it.

What foods should you avoid while taking Methotrexate?

When you’re taking Methotrexate, there aren’t any particular foods that you absolutely have to steer clear of. However, since Methotrexate can lower your immune system’s ability to tackle infections, it’s wise to stay away from unpasteurized milk and soft cheeses. Also, try to limit your caffeine intake, which you can find in things like coffee, tea, cola, energy drinks, and chocolate. Just keep these tips in mind for your well-being.

What painkillers can I take with Methotrexate?

It’s generally safe to use painkillers like paracetamol when you need them unless your doctor has given you different advice. However, you should be cautious with non-steroidal anti-inflammatory drugs (NSAIDs), like aspirin or ibuprofen, or any medicines that contain NSAIDs, including common cold remedies available over the counter. It’s a good idea to check with your doctor before using these.

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