Metronidazole

Noritate

Noritate is a topical medication that is exclusively applied to the skin. Dermatologists widely prescribe it to treat skin problems associated with rosacea, a long-term medical condition that causes various problems, such as redness and small bumps. Noritate may also be used for other skin conditions, but you have to ask your medical provider about that. Using this medication without consulting a professional can lead to serious complications. This medication is suitable for adults and children over 12 years of age, but their dosage may vary depending on the severity of the medical condition and their body needs. Therefore, patients are advised not to follow their prescription label for dosage guidance. 

Product Overview

Noritate is a topical medication for treating various skin conditions, including rosacea and acne. It contains metronidazole, an antibiotic that helps reduce inflammation and bacterial growth on the skin. Metronidazole is FDA-approved and commonly used for its anti-inflammatory & antimicrobial properties, making it helpful in managing skin redness, swelling, and lesions associated with these conditions.

This medication is available in various forms with 1 and 0.75% strengths. To use, apply a thin layer on the infected area once or twice daily, as directed by your dermatologist. This medication is suitable for adults and children 12 years of age and above under medical supervision. Noritate works by restricting the growth of bacteria and reducing inflammation, thereby improving the appearance of the skin and alleviating symptoms associated with rosacea and acne. Although the medication has various uses, it can have several side effects, which may include mild skin irritation, dryness, or redness at the application site. If you notice severe irritation or allergic reactions, quit this medicine and consult a professional.

Moreover, precautions should be taken to avoid contact with the eyes, mouth, and open wounds. In case you missed a dose, apply it as soon as possible, but skip it if it’s almost time for the next dose. Do not double up to make up for missed applications. Similarly, if you have overdosed or applied too much medication, seek medical attention right away. Store Noritate at room temperature, away from light and moisture, and keep it out of reach of children and pets. Always follow your healthcare provider’s instructions for optimal results and safety.

What Are the Uses of Noritate?

It is used to treat the following skin conditions:

• Rosacea Treatment: Noritate is used topically to treat inflammatory lesions, pustules, and erythema associated with rosacea.
• Acne Rosacea: It helps reduce swelling and redness caused by acne rosacea.
• Other Skin Conditions: Noritate may also be used for other skin conditions as a medical professional prescribes.

What Are the Forms & Strengths of Noritate?

This medication is available in different forms with different strengths:

Topical Gel

• 1% (MetroGel)

Topical Cream

• 0.75% (MetroCream)
• 1% (Noritate)

Topical Lotion

• 0.75% (MetroLotion)

What Are the Recommended Dosage of Noritate?

Dosage for Acne Rosacea

For Adults

• 1% Topical Cream or Gel: Apply a thin layer of Noritate cream or gel to the affected area once daily and rub it gently.
• 0.75% Topical Cream, Gel, or Lotion: Apply a layer of your topical medication on the infected area or areas two times a day, usually in the morning and evening.

For Children

• Safety and efficacy are not yet determined.

Dosage for Bacterial Vaginosis

For Adults 

• 1.3% Vaginal Gel: Insert one applicatorful in your vagina once at bedtime.
• 0.75% Vaginal Gel: Administer one applicatorful intravaginally once or twice daily at bedtime for five days.

For Females 12 Years and Older

• 1.3% Vaginal Gel: Insert one applicatorful in the vagina once at bedtime.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Noritate?

• Read the patient information leaflet, or PIL included with your medication thoroughly and talk to your healthcare provider if you have any questions.
• Use this medication exactly as your medical provider prescribes. 
• Do not apply more or less medication; avoid using it for longer or shorter periods. Follow the duration your provider has fixed. Doing so can result in unwanted skin issues, like irritation and redness.
• Use Noritate on the skin only. Avoid getting in contact with the eyes, nose, or mouth. If it gets in any of these areas, rinse it off immediately with water.
• Wash your hands thoroughly with soap and water before using the cream, gel, or lotion. Once you have applied the medication, repeat the process.
• Clean and dry the infected area before you put on your medication.
• Then, put a thin layer of your cream, lotion, or gel on the affected area.
• If you want cosmetics on your skin, apply them after your medication.
• Do not use Noritate for other skin conditions that have not been examined by a professional yet.
• Keep using the medicine even if your condition improves. Discontinuing the course in between can lead to various skin problems or recurring conditions.
• If the condition does not improve or worsen over time, contact your medical practitioner right away.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Noritate Work?

Noritate is a topical antibiotic cream containing metronidazole, used primarily to treat rosacea. It works by reducing inflammation, redness, and the number of pimples associated with this skin condition. Noritate slows down the growth of bacteria and decreases skin irritation. Applied directly to the impacted area, it helps improve the skin’s appearance and health over time. For best results, follow the prescribed usage instructions and consult your dermatologist for any concerns.

Important Safety Information for Using Noritate

What Are the Side Effects of Noritate?

Noritate can result in various side effects that can be temporary, lasting from a few days to weeks. If you notice any unusual side effects that continue beyond the mentioned period or exacerbate, consult a medical practitioner. Common side effects of Noritate may include:

• Mild stinging or burning after application
• Skin irritation
• Skin dryness or redness
• Metallic taste in the mouth
• Nausea
• Headache
• Numbness feeling in the hand or feet
• Cough
• Sore throat
• Cold
• Stuffy nose
• Vaginal itching or discharge
• Scaly or itchy skin
• Worsening of rosacea
• Infection in the nose or throat 
• Upset stomach
• Cramps
• Constipation

Noritate can lead to serious side effects. If you experience any of the following serious side effects, talk to a medical professional right away. If these side effects appear fatal or life-threatening, call 911 or your local emergency number. It is important to note that the below list does not include all possible serious side effects. Serious side effects of Noritate may include:   

• Hives
• Blisters
• Difficulty while breathing
• Swelling on the lips, face, tongue, or throat
• Extreme stinging or burning post-application of the medication
• Vision loss
• Blurred vision
• Irregular heartbeats
• Sudden dizziness
• Slurred speech 
• Confusion
• Muscle stiffness
• Skin allergies
• Nerve problems, including peripheral neuropathy
• Eye redness
• Eye discomfort
• Eye tearing

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Noritate? 

Noritate (metronidazole) can cause various serious health problems if left overlooked. These warnings can be a high-risk factor for certain patients. Therefore, it is important for people to be aware of the below warnings to avoid adverse complications in the future.

• Eye Irritation: Metronidazole can cause severe irritation and tearing if it comes in contact with the eyes. Therefore, patients should ensure to wash their hands thoroughly before and after applying the medication and avoid touching their eyes during application. If the medicine accidentally comes in contact with the eyes, rinse them immediately with water. If the irritation does not go away or becomes severe, contact your medical provider right away.
• Allergic Reaction: Certain patients have also reported allergic reactions or skin rashes during their treatment with Noritate. So, if you notice any unusual signs of allergic reactions, including itching, redness, or rash, stop using this medication and contact your healthcare practitioner immediately.
• Numbness and Tingling in the Hands and Feet: While this side effect is more prevalent with oral metronidazole use, topical use of Noritate can also occasionally cause numbness or tingling in the hands and feet. So, if any patient experiences this side effect, along with weakness, notify your doctor immediately.
• Neurologic Disease: Peripheral neuropathy, characterized by numbness or tingling in the extremities, has been reported with both systemic and topical use of metronidazole. If you develop any unusual neurologic symptoms while using Noritate, seek medical advice promptly. Use this medication cautiously in patients with existing central nervous system disorders.
• Blood Dyscrasias: Noritate (metronidazole) is a nitroimidazole that should be used cautiously in patients with evidence of or history of blood dyscrasias. Monitor for any signs of blood dyscrasia, such as unusual bleeding or bruising, and inform your medical provider if these occur.
• Contact Dermatitis: Both irritant & allergic contact dermatitis have been reported with the use of Noritate. If you develop any signs of dermatitis, such as itching, redness, or swelling, discontinue use and talk to your healthcare provider for proper management.

What Are the FDA Boxed Warning for Noritate?

Black box warnings, also known as boxed warnings, are the most severe warnings issued by the FDA (Food and Drug Administration) related to the harmful effects of a particular medication. These warnings alert doctors and patients about the severe side effects of a drug. Noritate, despite its severe warnings and side effects, does not have any boxed warnings.   

What Are the Noritate Precautions?

• Before starting your treatment with Noritate (metronidazole) topical medication, it is important to discuss your medical condition with a professional healthcare provider or dermatologist. So, below are a few precautions to consider:
• When considering using this topical medication, let your doctor know the details of your allergies. This may include your general allergies if you are allergic to Noritate and experienced allergic reactions, or even if you are allergic to any of the medication’s ingredients. The product may contain certain inactive components that can cause severe side effects.
• If you are undergoing any surgery or medical procedure, inform your medical provider or dermatologist about the products you use. This includes all prescription drugs, nonprescription drugs, vitamins or minerals, herbal products, and other supplements. Doing so will help determine the right medication for your medical condition.
• Before starting your treatment with Noritate, tell your healthcare professional about your or your family’s medical history, especially of:
  • Nervous System Problems: Before starting this medication, consult with a professional medical practitioner if you have any nervous system problems, including peripheral neuropathy. Peripheral neuropathy occurs when the external brain and spinal cord nerves (peripheral nerves) are damaged.  
  • Blood Disorders: If you have blood disorders, including blood dyscrasias, talk to a medical practitioner. This condition can affect the blood cells, leading to serious complications. Therefore, patients with such blood disorders should use this medication cautiously.  
  • Other Medicines and Supplements: Noritate may interact with other medications and supplements. Oral metronidazole has been known to increase the anticoagulant effects of coumarin and warfarin, leading to an extended prothrombin time. Additionally, oral metronidazole can react with alcohol, causing a disulfiram-like reaction. While such a response has not been reported with the topical application of metronidazole, there remains a potential for interaction with alcohol.
• Avoid altering your dosage or discontinuing the Noritate treatment without consulting a medical professional. Doing so can lead to various complications or recurring skin problems.
• If you are pregnant or planning to have a baby, avoid using this medication unless it is clearly needed. Talk to your professional physician and discuss every risk and benefit of taking this medication, as it is not known if it can harm the baby or not.
• It is unclear whether the drug passes into the breast milk or not. Talk to a medical practitioner before using medication to know if you can breastfeed the baby or not.
• This medication is only for external use. So, patients should exercise caution while using Noritate on the skin.

What Are the Contraindications of Noritate?

Noritate is contraindicated in patients who have a history of hypersensitivity to metronidazole, parabens, or any of the ingredients in the medication’s formulation. 

What If You Missed a Dose of Noritate?

Typically, patients are recommended not to miss any doses or application of their Noritate medication, but if someone forgets to use their medication, they can:

• Use the medicated cream or lotion as soon as possible or whenever you remember.
• If it is almost time for the next application, patients can skip the missed dose and follow their usual dosing schedule as instructed by a licensed dermatologist.
• Do not apply Noritate (metronidazole) twice simultaneously just to catch up for the missed application. This may cause adverse side effects, including skin irritation and redness.
• Use medication apps or set phone reminders on your mobile phones to avoid skipping doses.
• Patients can choose the times they want to use their medicated lotion or gel unless directed otherwise. Using the medication on the same day/time helps avoid skipping doses. This way, they will get the most benefit out of their medication.
• If you are still trying to decide about the missed doses, consult a medical practitioner. They will guide you and suggest alternate options or treatments.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Noritate?

While patients are educated enough to know the complications of overdose, there are times when they mistakenly apply too much Noritate cream. In such cases, people are advised not to panic, be calm, and observe unusual side effects. Although there are no human reports of overdosage of metronidazole topical medication, the excessive ingestion of Noritate cream may result in vomiting and slight disorientation. In such cases, patients should visit the nearest clinic or get medical assistance immediately by calling 911, as no specific antidote can be used at home.   

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Noritate?

• Store your Noritate cream at a room temperature of 20 to 25°C.
• You can expose the medication to temperatures within 15 to 30°C for a shorter period of time, like when traveling.
• Try to keep it in a cool or dry place. 
• Avoid storing under direct sunlight, heat, or moisture.
• Do not keep it in damp places, like the bathroom or near the sink.
• Avoid refrigerating the medication.
• Do not flush the medication or its tube/container down the toilet.
• Ensure to keep your medication out of sight and reach of children and pets.
• Make sure to store your medicated cream/lotion/gel somewhere safe to avoid other people using it.
• There are certain medications that are not child-proof. So, place a safety lock on your product’s cap to avoid poisoning your child or pet.
• Discard the product once it reaches its expiry date. The expiration date is the last day of the month mentioned on the back of your product or carton. To clarify things, certain products mention only the month and year of expiration, which can confuse people about the expiration date. For example, if your medication expires on September 2024, you can use the product until September 31st, 2024.
• Talk to a medical provider or pharmacist about how to dispose of the product properly without harming the environment.
• Ensure that you are discarding the medication in such a way that it does not harm children or animals. 
• The best way to eliminate unwanted medications is to give them in the medicine take-back program.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Noritate?

Drug interactions happen when two or more medications interact with each other. These interactions can happen in two ways. It can either change the medication’s functioning by affecting its ingredients or increase the risks of adverse side effects. Therefore, patients need to be aware of the drugs they take to avoid any complications in the near future. The below drug list does not contain all possible metronidazole drug interactions, but here are some of them:

• Amprenavir
• Bepridil
• Cisapride
• Disulfiram
• Dronabinol
• Dronedarone
• Levoketoconazole
• Mesoridazine
• Pimozide
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Besides the above-mentioned drugs, there are certain medicines that are usually not recommended to use in combination with metronidazole but may be required in some cases. So, if your doctor prescribes any of the below medications in combination with metronidazole, they may alter the dosage or duration of each medicine. These are:

• Capecitabine
• Ceritinib
• Chloroquine
• Chlorpromazine
• Cholera Vaccine, Live
• Cimetidine
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clofazimine
• Clomipramine
• Clothiapine
• Clozapine
• Crizotinib
• Cyclobenzaprine
• Dabrafenib
• Dasatinib
• Degarelix
• Fluconazole
• Fluorouracil
• Fluoxetine
• Formoterol
• Foscarnet
• Fosphenytoin
• Fostemsavir
• Galantamine
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Histrelin
• Hydroquinidine
• Hydroxychloroquine
• Triclabendazole
• Trimipramine
• Triptorelin
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Vorinostat
• Warfarin
• Zotepine

What Are the Other Noritate Interactions?

Other than the drug interactions, metronidazole has certain disease interactions:

• Alcoholism
• Blood dyscrasias
• Liver disease
• Neurologic toxicity

[Note: This isn’t a complete list, and there could be other drugs that interact with Noritate. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Noritate Alternatives?

People usually take alternative medicines when either the prescribed drugs do not suit their medical conditions or when they are not achieving the results they are aiming for. That’s why patients should consult with a medical professional before starting their treatment with any medication. These experts will help you determine the most suitable drug for your medical needs. Some of the alternatives of Noritate are:

• Doxycycline
• Finacea
• Oracea
• Loteprednol ophthalmic
• Soolantra
• Minocycline
• Clindamycin Hcl
• Ivermectin
• Vibramycin
• Cleocin-T
• Brimonidine-Dorzolamide

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Noritate Cost & Coupons

It is important to note that the cost of Noritate 1% is not the same everywhere. The actual cost of this medication is based on different factors, such as your insurance plan, location, and the pharmacies you use. Noritate, with its practical skin-treating qualities, can be a bit expensive for certain individuals. Here, insurance coverage plays an important role. With an insurance coverage plan, you can buy your medication at a discounted price. However, not all drugs or medications are covered under the insurance plan. To manage these costs, you can buy from reputed and licensed pharmacies like Polar Bear Meds, where you can buy Noritate online from Canada at affordable prices. Moreover, first-time buyers can use the Noritate coupon code WELCOMEPB10 to receive a 10% discount on their first order.

Frequently Asked Questions

Is Noritate a steroid medication?

No, Noritate is not a steroid medication. It is a topical antibiotic cream containing metronidazole, primarily used to treat rosacea. It works by reducing inflammation, redness, and pimples associated with this skin condition. Unlike steroid creams, which can thin the skin and cause other side effects with long-term use, Noritate targets bacterial growth and reduces skin irritation without the risks associated with steroid treatments. However, it is important always to follow your healthcare provider’s instructions when using Noritate.

Is Noritate cream and ointment the same?

Noritate is available primarily as a cream, not an ointment. Creams and ointments differ in their composition and texture. Creams, like Noritate, are typically lighter, less greasy, and easier to apply on large areas of the skin. They are absorbed more quickly and are suitable for treating inflamed or weeping skin conditions. Ointments are thicker, greasier, and take longer to absorb, making them better for dry or scaly skin conditions. Consult an experienced dermatologist for the appropriate formulation.

Can I use Noriate every day?

Yes, Noritate is usually prescribed for daily use. Apply it as directed by your healthcare provider, typically once or twice a day, usually in the morning or evening. Consistent daily application is important for effectively managing the symptoms of rosacea. Follow the instructions provided with your prescription label, and ensure you apply it to clean dry skin. If you experience any adverse effects or have concerns about daily use, talk to an experienced practitioner for expert advice and possible adjustments to your treatment plan.

Can I use moisturizer before or after applying Noritate?

You can use a moisturizer along with Noritate, but it’s important to apply it correctly. First, apply Noritate to clean, dry skin and allow it to absorb completely. This usually takes a few minutes. Once the medication has been absorbed, you can apply your moisturizer. Using the moisturizer afterward helps to prevent the medication from being diluted and ensures its effectiveness. Remember to always use gentle, non-irritating moisturizers to avoid exacerbating rosacea symptoms.

What foods should I avoid when using Noritate?

There are no specific dietary restrictions associated with using Noritate. However, some individuals with rosacea may find that certain foods and beverages can trigger flare-ups or worsen symptoms. Common triggers include spicy foods, alcohol, hot beverages, and certain dairy products. Therefore, it is advisable to monitor your diet and identify any personal triggers that may affect your skin condition. Maintaining a balanced diet & staying hydrated can also support overall skin health. Asking your healthcare practitioner for a personalized diet chart is always the best option.

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