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Sibofix 550 Mg

Sibofix 550 mg is an antibiotic containing Rifaximin used to treat hepatic encephalopathy and irritable bowel syndrome. It inhibits toxin-producing bacteria to prevent toxin buildup and hepatic encephalopathy. It also targets gut bacteria to ease diarrhea in irritable bowel syndrome. It is available in a strength of 550 mg tablet, typically prescribed one tablet orally thrice daily. Side effects may include nausea, vomiting, or abdominal pain. You should consult your doctor for severe reactions or allergies. Inform your doctor of any existing liver, kidney, or gastrointestinal conditions. If you miss a dose, take it soon unless near the next dose; seek immediate medical attention for a suspected overdose. Store Sibofix 550 mg at room temperature, away from moisture, heat, and children. You should strictly adhere to usage guidance provided by your healthcare provider for safe use.

Product Overview

Sibofix 550 mg is an antibiotic containing the active ingredient Rifaximin. It is FDA-approved for treating hepatic encephalopathy (a decline in brain function caused by toxins building up in the blood as a result of severe liver disease) and irritable bowel syndrome (a gastrointestinal disorder with abdominal pain and changes in bowel movements) in adults. It works by inhibiting the bacterial growth that produces toxins in the digestive tract, thus treating hepatic encephalopathy. This reduces toxin buildup in the blood and prevents disorders caused by toxin accumulation from developing or recurring. 

Additionally, it treats diarrhea caused by irritable bowel syndrome by killing the bacteria that cause infection in the gut. It comes in a strength of 550 mg tablets. The recommended dosage is usually one tablet orally 3 times a day for a specified duration, as prescribed by a healthcare professional. It may cause side effects such as nausea, abdominal pain, or headache. You should consult your doctor if you experience any severe side effects or allergies to the medicine. Also, let your doctor know about any existing medical conditions such as liver, kidney, or gastrointestinal disease. 

In case of a missed dose, it is advisable to take the medication as soon as remembered unless it is almost time for the next dose. However, if an overdose is suspected, immediate medical attention should be sought. Sibofix 550 mg should be kept at room temperature, away from heat, moisture, and children. You should strictly adhere to your doctor’s guidance for safe use.

Uses of Sibofix 550 Mg

Sibofix 550 mg is used for the treatment of:

  • Hepatic encephalopathy
  • Irritable bowel syndrome

How to Use Sibofix 550 Mg?


It is typically available in the form of an oral tablet of strength: 

  • Sibofix 550 mg

Recommended Dosage for Sibofix 550 Mg

For Adults with Irritable Bowel Syndrome (IBS-D):

  • It is recommended to take 550 mg three times daily for 14 days.

For Adults with Hepatic Encephalopathy (H.E.):

  • It is recommended to take 550 mg twice daily.

For Children (Below 18 Years): 

  • Not recommended.

[Note: Remember these recommendations may vary depending on person to person. Discuss it with your doctor, and they’ll customize your Sibofix 550 mg dosage accordingly.]

How to Take It?

  • Sibofix 550 mg should be taken orally.
  • Swallow the tablet whole with a full glass of water.
  • Take it as prescribed by your healthcare provider.
  • It is typically taken three times a day.
  • For optimal effectiveness, try to take it at evenly spaced intervals throughout the day.
  • Do not grind, break, or chew the tablet before swallowing.
  • If you have a problem swallowing tablets, consult your doctor for alternative options.

[Note: Your doctor will decide the right amount of Sibofix 550 mg for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Sibofix 550 Mg Work?

Sibofix 550 mg contains Rifaximin, an antibiotic that functions by inhibiting the growth of specific types of bacteria in the gastrointestinal tract. In hepatic encephalopathy, it reduces the production of toxins by bacteria, thereby preventing their accumulation in the bloodstream and minimizing the risk of associated neurological symptoms. For irritable bowel syndrome, Sibofix 550 mg targets gut bacteria responsible for the infection, helping alleviate symptoms such as diarrhea. By selectively targeting harmful bacteria while preserving beneficial gut flora, Sibofix 550 mg helps restore balance in the digestive system, ultimately leading to symptom relief.

Important Safety Information

Side Effects

Common side effects of Sibofix 550 mg may include:

  • Nausea
  • Abdominal pain
  • Headache
  • Skin rash or itching
  • Depressed mood
  • Swelling of ankles, feet, or fingers
  • Muscle cramps and joint pain

Mild side effects of Sibofix 550 mg may include:

  • Flatulence (gas)
  • Fatigue
  • Dehydration 
  • Dizziness
  • Dark urine

Severe side effects of Sibofix 550 mg may include:

  • Severe abdominal pain
  • Persistent nausea or vomiting
  • Yellowing of the skin or eyes (jaundice)
  • Clostridium difficile infection (prolonged or persistent diarrhea)
  • Unusual bruising or bleeding
  • Chest infections, including pneumonia
  • Cellulitis (inflammation of tissue under the skin)
  • Upper respiratory tract infections (nose, mouth, throat)

[Note: Remember, this list may not cover all possible side effects of Sibofix 550 mg. Always consult with your healthcare giver for medical advice about side effects.]


Allergic Reactions: You may have allergic reactions to Rifaximin, which can manifest as redness, itching, bumps, severe lightheadedness, or problem breathing. These symptoms occur and need medical attention immediately.

Clostridium Difficile-Associated Diarrhea (CDAD): Antibiotic treatment, including Rifaximin, can sometimes lead to the overgrowth of bacteria called Clostridium difficile. This bacteria causes severe diarrhea and potentially life-threatening inflammation of the colon. If persistent diarrhea occurs during or after treatment with Rifaximin, it’s essential to contact a healthcare professional.

Liver Problems: Rifaximin can affect liver function in some individuals, particularly those with pre-existing liver conditions. Monitoring of hepatic function may be necessary during treatment.

Interaction with Other Medications: Rifaximin may interact with certain medications, including anticoagulants (blood thinners) like warfarin, leading to an increased risk of bleeding. It’s crucial to tell your healthcare provider about all medicines you are currently taking to avoid potential interactions.

Antibiotic Resistance: Prolonged or repeated use of Rifaximin may improve the risks of developing antibiotic resistance, which eventually decreases the efficacy of the medication in treating infections.

Pregnancy and Breastfeeding: The safety of Rifaximin during pregnancy and breastfeeding is not known. You should discuss with a healthcare professional before using Rifaximin if pregnant or breastfeeding.

Central Nervous System Effects: Some individuals may experience symptoms such as dizziness or headache while taking Rifaximin. If these symptoms are serious or constant, medical advice should be sought.


  • Tell your healthcare professional about any allergies you have, especially to antibiotics, before taking Sibofix 550 mg.
  • Let your doctor know if you have a history of liver disease or if you are currently experiencing liver problems.
  • Be cautious if you are taking other medications, especially blood thinners like warfarin, as they may interact with Sibofix 550 mg.
  • Monitor for any symptoms of allergic reactions such as rash, itching, swelling, or difficulty breathing while taking Sibofix 550 mg, and seek medical help if they occur.
  • Report any persistent or severe diarrhea during or after treatment with Sibofix 550 mg to your healthcare provider.
  • Avoid prolonged or repeated use of Sibofix 550 mg to reduce the risk of antibiotic resistance.
  • If you are pregnant or breastfeeding, consult your doctor before using Sibofix 550 mg to assess the potential risks and benefits.

Sibofix 550 Mg Contraindications

  • Hypersensitivity to Rifaximin or any other ingredient.
  • In patients with severe liver impairment.
  • In children below 18 years.

Missed Dose

If you realize you’ve missed a dose, take it as soon as you remember. However, if it’s close to the time for your next planned dose, ignore the missed one and continue with your usual dosing plan. Refrain from taking a double dose to make up for the missed one. Taking extra medication can lead to unwanted side effects.

[Note: If you have missed a dose of Sibofix 550 mg tablets and are still determining when to take the next one, immediately consult your doctor or pharmacist.]


Overdosing on Sibofix 550 mg may lead to symptoms such as severe stomach pain, nausea, vomiting, diarrhea, or dizziness. Do not attempt to treat an overdose at home without professional guidance. Avoid inducing vomiting unless instructed by a healthcare provider.

[Note: If you consumed more than the recommended dose of Sibofix 550 mg, get medical help right away or call the Poison Help line at 1-800-222-1222.]


  • Store Sibofix 550 mg at room temperature, away from extreme heat or cold.
  • Avoid exposure to direct sunlight or moisture.
  • Store Sibofix 550 mg out of reach of children and pets.
  • Consider using a high shelf or a locked cabinet.
  • Keep Sibofix 550 mg in its original container with the label intact.
  • Do not transfer the medication to other containers.
  • Avoid storing Sibofix 550 mg in the bathroom. Humidity may impact the stability of the medication.
  • Always check if it’s not expired before use.
  • Discard any expired or unused medication properly.

[Note: Discuss with your healthcare professional about the proper disposal of any unused Sibofix 550 mg tablets and any questions you may have regarding their storage.]

Sibofix 550 Mg Interactions

  • Warfarin
  • Rifampin
  • Cyclosporine
  • Erythromycin
  • Azithromycin
  • Diltiazem
  • Antifungal medications
  • Cholera vaccine
  • BCG vaccine

[Note: This isn’t a complete list, and there could be other drugs that interact with Sibofix 550 mg. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

Sibofix 550 Mg Alternatives

[Note: Your doctor will choose the best alternative of Sibofix 550 mg for you. Only use these alternative medications after consulting your healthcare provider. Taking them by yourself may cause serious side effects.] 

Frequently Asked Questions

How long does it take for Sibofix to work?

Sibofix 550 mg, an antibiotic, begins to show its effectiveness within an hour after ingestion. However, it is most efficient after three doses due to its poor absorption. The duration of action typically lasts for approximately 12 hours with the 550mg tablets. 

Should I take Sibofix tablet with food?

Sibofix 550 mg tablets can be taken orally with or without food. It’s best to swallow it whole with plenty of water. Avoid breaking, chewing, or crushing the tablet. If you’re having a meal, feel free to take it alongside your food. Follow the instructions given on the label or packing insert provided by your doctor.

What does the Sibofix tablet do for the liver?

Sibofix 550 mg Tablet decreases liver disease symptoms by slowing the bacterial growth in the gut. Liver disease increases the load of toxins traveling through the body due to the increased development of bacteria in the intestine. As a result, toxins can reach the brain and cause abnormal brain function. 

Can I take Sibofix 550 mg during pregnancy? 

Sibofix 550 mg tablet is not recommended during pregnancy due to limited information about its safety for pregnant women. You should always consult your healthcare professional before starting any medication during pregnancy.

Can I drink alcohol while taking Sibofix 550 mg?

Sibofix 550 mg Tablet is not known to interact with alcohol. However, it’s advisable to consult your physician if you regularly consume alcohol. They can give customized advice based on your specific health situation. 

Our Guarantee

At, we assure you the most affordable price to buy Sibofix 550 mg online from Canada. Rest easy knowing that your order will be dispatched from a reputable Licensed Canada Pharmacy Online, adhering to the highest standards of quality and authenticity. Our discounted medications are shipped directly from Canada to your doorstep, ensuring a swift and secure delivery experience. To conveniently access Sibofix 550 mg tablets at a substantial cost, call us at 1-888-779-2193 toll-free.


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