Ivermectin

Soolantra 1% Cream

Soolantra (ivermectin) is a topical cream approved by the FDA to treat rosacea, characterized by facial bumps, skin marks, and pimples. It contains ivermectin, which may work by reducing inflammation and targeting tiny mites associated with the condition. The cream is applied once daily to the affected areas of the face, avoiding the eyes and lips. It’s available in a 1% concentration in various tube sizes. While effective for rosacea, Soolantra also has off-label uses for acne, dermatitis, and scabies. Important precautions include avoiding sensitive areas and potential interactions with other drugs like Warfarin.

Product Overview

Soolantra (ivermectin cream) is specifically formulated to treat inflammatory lesions caused by rosacea. This topical medication is believed to reduce inflammation and possibly target microscopic mites that contribute to the condition’s symptoms. Soolantra comes as a 1% cream and is applied in a thin layer once daily to each affected area of the face, such as the forehead, cheeks, nose, and chin. The cream is available in tube sizes of 30g, 45g, and 60g.

Although primarily used for rosacea, Soolantra is also utilized off-label for other skin conditions like acne, perioral dermatitis, seborrheic dermatitis, scabies, and eczema. It’s important to note that its effectiveness for eczema is not well-established. Patients must ensure the cream does not contact the eyes, lips, or inside of the mouth and should wash their hands before and after application. For those with a history of liver issues, careful dosage adjustments may be required. Soolantra may interact with medications such as Warfarin and should be used cautiously if other topical or systemic treatments are being administered.

In terms of safety, while mild side effects like skin irritation or burning may occur, severe allergic reactions are rare but require immediate medical attention. The drug’s safety during pregnancy and breastfeeding has not been conclusively determined, prompting a need for consultation with healthcare providers about potential risks. Additionally, various alternatives exist for treating rosacea, including azelaic acid, brimonidine tartrate gel, doxycycline, isotretinoin, metronidazole cream and gel, and oxymetazoline cream, providing options for those who may not respond well to Soolantra.

What Are the Uses of Soolantra?

It is used to treat the following conditions:

• Soolantra for Rosacea

This drug can be used or prescribed off label for some conditions. Those conditions are mentioned below: 

• Soolantra for scabies and mites 
• Soolantra for eczema
• Soolantra for perioral dermatitis 
• Soolantra for acne
• Soolantra for seborrheic dermatitis

What Are the Forms & Strengths of Soolantra?

• Form: Soolantra is available as a topical cream.
• Available Sizes: You can purchase Soolantra in three different tube sizes:
  • 30 grams (g)
  • 45 g
  • 60 g
• Strength: Soolantra cream comes in a single concentration of 1% ivermectin. This means that each gram of the cream contains 10 milligrams of the active ingredient, ivermectin.

What Are the Recommended Dosage of Soolantra?

Dosage for Rosacea

Soolantra 1% cream is prescribed for managing the symptoms of rosacea, such as bumps, lesions, and pimples on the face. Follow these instructions for proper application:

• Amount: Use a pea-sized amount of cream.
• Frequency: Apply once daily.
• Application Areas: Distribute one pea-sized amount on each affected part of your face, such as your nose and each cheek.
• Method: Gently spread the cream in a thin layer over the skin.

Important Precautions: Avoid contact with your eyes, lips, and the inside of your mouth to prevent irritation.

[Note: Remember, these recommendations may vary from person to person. Discuss it with your doctor, and they’ll customize your dosage accordingly.]

How to Use Soolantra? 

Always use this medication as your doctor prescribes. Refer to the medication label for precise dosage instructions.

• Additional Information: A patient leaflet with further instructions is provided with this medication. If you have any questions, consult your pharmacist.
• Ensure Proper Usage: If you’re unsure about how to apply the medication, seek clarification from your healthcare provider.
• Hand Hygiene: Wash your hands thoroughly before and after applying the medication.
• Prepare the Skin: Cleanse and dry the area where you will apply the medicine.
• Application: Apply a thin layer of the medication to the affected area and gently rub it in until it’s evenly absorbed.
• Avoid Sensitive Areas: Be careful to avoid contact with the eyes and lips.
• Handling Missed Doses: If you forget a dose, apply it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and resume your regular schedule. Do not apply two doses at once.

Instructions for Use

Important: Soolantra cream is intended for topical use on the face only. Avoid applying the cream to your eyes, mouth, or vagina.

• • Opening the Tube: To open the tube of Soolantra cream, press down gently on the child-resistant cap and twist it counterclockwise (in the direction of the arrow). Be careful not to squeeze the tube while opening or closing to prevent any cream from spilling.

• Applying the Cream: 

• • Squeeze a pea-sized amount of Soolantra cream from the tube onto your fingertip. 
  • Apply the cream to the affected areas of your face once daily. Use a separate pea-sized amount for each area of the face that is affected (e.g., forehead, chin, nose, each cheek). Spread the cream in a smooth and even thin layer. 
  • Be sure to avoid contact with your eyes and lips while applying.
• Closing the Tube: To close the tube, press down on the child-resistant cap and twist it clockwise.
• Additional Guidance: If you have any questions about how to use the medicine, or if you need clarification on any of the steps, do not hesitate to ask your healthcare provider for more information. Proper application is crucial for the effectiveness of the treatment and to avoid potential irritation.

[Note: Your doctor will decide the right amount for you based on your condition, following guidelines and studies on the drug. They’ll adjust it as needed over time.]

How Does Soolantra Work?

The exact mechanism by which Soolantra (ivermectin cream) treats rosacea is not entirely understood. However, it is known to effectively reduce inflammation and swelling associated with the condition. Current theories suggest that Soolantra may target tiny mites, known as Demodex, which are often found in higher numbers on the skin of individuals with rosacea. These mites are believed to contribute to the symptoms of rosacea, and ivermectin, the active ingredient in Soolantra, is known for its potent anti-parasitic properties that can kill these mites.

Soolantra starts to work as soon as it is applied to the skin. However, it may take some time before visible improvements are noticed. In clinical trials, Soolantra was evaluated over a period of 12 weeks, and many participants began to see significant improvements in their skin condition during this timeframe. It’s important to apply the cream consistently as directed by your doctor.

Important Safety Information for Using Soolantra

What Are the Side Effects of Soolantra?

Soolantra may cause both mild and serious side effects. While many side effects can resolve on their own within a few days to a couple of weeks, it’s important to monitor their severity and persistence. If side effects become more severe or do not go away, you should consult your doctor or pharmacist. They can provide advice and strategies to help manage and mitigate any bothersome side effects. Mild Side Effects of Soolantra include:

• Skin burning: A sensation of burning on the skin where the cream is applied.
• Skin irritation: Redness, itching, or discomfort at the site of application.

Serious side effects from using Soolantra are uncommon but can occur. Immediate medical attention is necessary if you experience serious side effects. If you encounter any of the following symptoms of a severe allergic reaction, call 911 or your local emergency number immediately, as these could be life-threatening:

• Swelling under your skin: This can occur in various parts of your body, such as your eyelids, lips, hands, or feet.
• Swelling of your tongue, mouth, or throat: This can lead to difficulty swallowing or speaking.
• Trouble breathing: Any breathing difficulties need immediate assessment by medical professionals.

Symptoms of a mild allergic reaction include:

• Itchy skin rash: Breakouts of rashes that are itchy and uncomfortable.
• Itchiness: General itching without an apparent rash.
• Flushing: Warmth and redness in your skin, often feeling hot to the touch.

If you experience any of these mild allergic reactions, contact your doctor right away for advice. For severe reactions, seek emergency medical care to ensure safety and receive the necessary treatment.

[Note: Remember, this list may not cover all possible side effects. Always consult with your healthcare giver for medical advice about side effects.]

Are There Any Warnings for Soolantra? 

Below are some warnings for people using Soolantra. If you have any questions, talk to a doctor.

• Soolantra and Pregnancy: The safety of using Soolantra during pregnancy has not been established. There have been no direct studies on the effects of Soolantra in pregnant women. However, in animal studies where the drug was administered orally at doses significantly higher than those used in humans, some negative outcomes were observed. These included lower birth weights, birth defects, and, in rare instances, maternal death. It’s crucial to note that animal studies do not always accurately predict human responses, and Soolantra is typically applied topically, not taken orally as in these studies. If you are pregnant or planning to become pregnant, it is important to discuss with your doctor the potential risks and benefits of using Soolantra. Your doctor can also provide guidance on alternative treatment options for your condition.
• Soolantra and Alcohol: There are no known interactions between Soolantra and alcohol. However, research from the American Academy of Dermatology indicates that alcohol consumption may increase the risk of developing rosacea, although the exact reasons for this are not fully understood, and further research is needed. If you notice that consuming alcohol exacerbates your rosacea symptoms, it might be beneficial to avoid alcohol while using Soolantra. This precaution can help ensure that the medication is as effective as possible in treating your condition. If you have concerns or questions about alcohol consumption while using Soolantra, it’s important to discuss them with your doctor.
• Soolantra and Birth Control: The safety of using Soolantra during pregnancy has not been confirmed. If you are sexually active and there is a possibility of pregnancy, it is essential to discuss birth control options with your doctor while you are using Soolantra. This conversation will help ensure that you are fully informed about the potential risks and can take appropriate precautions.
• Soolantra and Breastfeeding: It is generally not recommended to use Soolantra while breastfeeding. Clinical studies involving the oral form of ivermectin (the active ingredient in Soolantra) have shown that ivermectin can pass into breast milk when taken orally. Although it’s not clear if the same occurs when ivermectin is applied topically, the findings from oral administration suggest potential risks. In studies with lactating animals given oral ivermectin, high levels of the drug were found in the newborns, leading to serious birth defects, particularly affecting the brain. While animal studies do not always directly translate to human outcomes, they do raise concerns about potential risks.

If you are breastfeeding and need treatment for rosacea, it’s crucial to discuss with your doctor the best approach. Your doctor can provide information on alternatives to Soolantra or other safe methods to feed your child while managing your condition.

What Are the Soolantra Precautions?

When using Soolantra, there are several important precautions to keep in mind to ensure safe and effective treatment:

• Do not allow Soolantra to come into contact with your eyes, nose, mouth, or vagina. If the medication does accidentally reach these areas, rinse them gently with water.
• Use Soolantra strictly according to your doctor’s instructions. Do not apply more than the recommended dose or use the medication for a longer period than prescribed without consulting your doctor.
• Soolantra can be harmful if swallowed. If you or someone else may have ingested it, contact your local poison control center or go to the emergency room immediately.
• If you become pregnant while using Soolantra, notify your doctor right away. You will need to discuss the potential benefits and risks of continuing the medication during pregnancy.
• It is not confirmed whether Soolantra passes into breast milk following topical application. To be safe, avoid breastfeeding while using this medication. Discuss with your doctor any concerns you have about the impact of Soolantra on breastfeeding.

What If You Missed a Dose of Soolantra?

• Handling Missed Doses: If you forget to apply Soolantra on a given day, simply apply your next dose at the usual time the following day.
• Avoid Doubling Doses: Do not apply extra cream to make up for the missed dose, as this could lead to increased side effects.
• Daily Use: Soolantra is typically used once daily. You can choose to apply it either in the morning or at night, based on what suits your routine best; its effectiveness remains the same regardless of the time of application.
• Preventing Missed Doses: To ensure you remember to apply your medication, consider using a medication reminder. This could be an alarm on your phone, a reminder app, or even a kitchen timer.

[Note: If you have missed a dose of your medication and are unsure about when to take the next one, immediately consult your doctor or pharmacist.]

What Happens If You Take Too Much of Soolantra?

Exceeding the recommended dosage of Soolantra can result in serious side effects. It is crucial to use Soolantra strictly as prescribed by your doctor. Remember, Soolantra is intended for topical use on the face only and should not be applied inside the mouth, inhaled, injected, or used internally in any other areas, such as the vagina. Misusing Soolantra in ways not directed by your healthcare provider can lead to severe adverse effects. One possible serious side effect from misuse is dangerously low blood pressure, which could necessitate emergency treatment in a hospital. Always follow the dosage and application instructions provided by your doctor to avoid such risks.

“Accidental ingestion” of Soolantra occurs when the drug is used in a manner not prescribed by your doctor. For example, applying it accidentally to your mouth would qualify as accidental ingestion. Symptoms of an overdose or accidental ingestion can include:

• Diarrhea
• Fluid retention (bloating)
• Dizziness
• Rash
• Low blood pressure
• Headache
• Nausea and vomiting

If you suspect that you have used too much Soolantra or have applied it in a way not directed by your doctor, it is crucial to seek medical advice promptly. You should call your doctor immediately. Additionally, you can contact the American Association of Poison Control Centers at 800-222-1222 or use their online tool for guidance. However, if your symptoms are severe, do not hesitate to call 911 or go to the nearest emergency room right away.

[Note: If you consumed more than the recommended dose, get medical help right away or call the Poison Help line at 1-800-222-1222.]

How to Store a Soolantra?

• Ideal Storage Temperature: Keep Soolantra at room temperature, between 68°F to 77°F (20°C to 25°C).
• Temporary Storage Flexibility: When traveling, it’s acceptable to store Soolantra temporarily between 59°F and 86°F (15°C and 30°C).
• Avoid Moisture: Do not store the medication in damp or wet areas, such as bathrooms, to prevent degradation.
• Safe Disposal: If you have unused Soolantra, dispose of it properly to ensure it does not harm others or the environment. This prevents accidental ingestion by children or pets and minimizes environmental impact.

[Note: Discuss with your healthcare professional about the proper disposal of any unused medicine and any questions you may have regarding its storage.]

What Medications Interact with Soolantra?

Medications That Interact with Soolantra: Soolantra (ivermectin cream) can interact with various medications and supplements. It is crucial to inform your doctor and pharmacist about all the mentioned things above you are currently using, including prescription drugs, over-the-counter medicines, vitamins, and herbal or dietary supplements. The list provided here is not exhaustive, but it highlights a significant potential interaction:

• Warfarin: Using Soolantra in conjunction with warfarin may increase the risk of certain side effects. However, the combination of these medications might be necessary for your treatment. If both Soolantra and warfarin are prescribed, your doctor may adjust the dosage or the frequency of use for one or both medications to manage the interaction effectively and safely. 

Always follow your doctor’s instructions and discuss any concerns you may have regarding Soolantra and other medications or supplements you are taking. This ensures that your treatment plan is both safe and effective.

[Note: This isn’t a complete list, and there could be other drugs that interact with Soolantra. Make sure to tell your doctor about any prescription, over-the-counter medicines, and herbal products you’re taking.]

What Are the Soolantra Alternatives?

There are various medications available that can manage inflammatory lesions such as bumps, skin marks, and pimples caused by rosacea. Depending on your specific condition and health profile, some treatments might be more suitable for you than others. If you are considering alternatives to Soolantra, it’s important to consult your doctor. They can provide guidance on other effective medications for treating rosacea.

Alternatives for Rosacea

Here are some examples of other drugs that may be used to treat rosacea:

• Metrogel (metronidazole 1% gel)
• Rhofade (oxymetazoline 1% cream)
• Finacea (azelaic acid)
• Mirvaso (brimonidine tartrate gel)
• Doxycycline (doxycycline)
• Soolantra (ivermectin)
• Retinol (isotretinoin)
• Metrocream (metronidazole 0.75% cream)

[Note: Your doctor will choose what’s best for you. Don’t use any of these alternative medications without consulting your healthcare provider. Taking them by yourself may cause serious side effects.]

Soolantra Cost & Coupons

Rosacea is a condition that, while not life-threatening, can significantly affect an individual’s quality of life. Unfortunately, the retail cost can be prohibitively expensive, often exceeding $800 per month. To make this medication more accessible to the US residents, discounts through manufacturer coupons or rebates can be beneficial, though they are not available that easily. For U.S. residents, options to buy Soolantra online from Canada are viable and can lead to substantial savings. One reliable source is Polar Bear Meds, known for offering competitive prices. Patients can get Soolantra in the USA from Canada by using the Soolantra coupon code “WELCOMEPB10” at checkout to receive a 10% discount on their first order. Want some additional benefits? Join our referral program and get a free coupon on your next purchase.

Frequently Asked Questions

What are Demodex mites, and do they cause rosacea?

Demodex mites are tiny parasites that reside on human skin. Research suggests that these mites might be involved in the development of rosacea. People with rosacea often have a higher number of Demodex mites compared to those without the condition. An excessive presence of these mites can lead to inflammation, which may manifest as swelling and damage associated with rosacea. The active ingredient in Soolantra, ivermectin, is classified as an antiparasitic medication. It is specifically effective in eliminating Demodex mites. If you have concerns or further questions about the role of Demodex mites in rosacea, it is advisable to discuss them with your doctor.

Can Soolantra make my rosacea worse?

Clinical trials have not shown Soolantra to worsen rosacea. Nonetheless, if you notice your rosacea symptoms intensifying while using Soolantra, it is important to consult your doctor. Your doctor can help identify the cause of the worsening symptoms and suggest appropriate measures to alleviate the condition.

Can Soolantra help smooth out wrinkles?

Soolantra has not been studied or approved for smoothing out wrinkles, and it is not intended to be used as an anti-wrinkle cream. If you are looking for treatments specifically for wrinkles, it is best to consult your doctor for appropriate recommendations and effective solutions.

Do I need to stay out of the sun while using Soolantra?

Using Soolantra does not increase your skin’s sensitivity to the sun. However, since sun exposure is a well-known trigger for rosacea flare-ups, it is advisable to use sunscreen to protect your skin. When selecting a sunscreen, ensure that its ingredients do not contain any substances known to trigger rosacea. If you have concerns or questions about which sunscreen products are safe to use with Soolantra, consult your doctor for guidance.

Can I apply moisturizer or makeup after using Soolantra?

Yes, it is permissible to apply moisturizer or makeup after using Soolantra. However, ensure that the Soolantra cream is fully dry on your skin before applying any other products. Soolantra itself acts as a moisturizer. The cream is a combination of the active ingredient ivermectin and a moisturizing base known as a “vehicle” cream, which includes skin-hydrating components like glycerin. Using an additional moisturizer can be beneficial, especially for managing rosacea, as it helps shield your skin from environmental triggers such as cold temperatures and wind, which can exacerbate rosacea symptoms. When choosing a moisturizer, carefully check its ingredients to avoid any that might worsen your rosacea. For advice on compatible products to use with Soolantra, consult your dermatologist or healthcare provider.

How long does Soolantra take to clear rosacea?

Soolantra begins to act from the first dose you apply. Nonetheless, it may require up to 12 weeks of regular use to observe noticeable improvements in your rosacea symptoms. It’s important to monitor any changes in your condition and maintain communication with your doctor, especially if you do not see progress or if your symptoms persist. This will help your doctor evaluate the effectiveness of the treatment and make any necessary adjustments.

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